KEGG   ENZYME: 2.7.1.223
Entry
EC 2.7.1.223                Enzyme                                 
Name
aminoimidazole riboside kinase;
STM4066 (locus name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:5-amino-1-(beta-D-ribosyl)imidazole 5'-phosphotransferase
Reaction(IUBMB)
ATP + 5-amino-1-(beta-D-ribosyl)imidazole = ADP + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole [RN:R12245]
Reaction(KEGG)
R12245
Substrate
ATP [CPD:C00002];
5-amino-1-(beta-D-ribosyl)imidazole [CPD:C22030]
Product
ADP [CPD:C00008];
5-amino-1-(5-phospho-beta-D-ribosyl)imidazole [CPD:C03373]
Comment
The enzyme, characterized from the bacterium Salmonella enterica, can phosphorylate exogeneously-provided 5-amino-1-(beta-D-ribosyl)imidazole to form 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole (AIR), an important intermediate in the production of both purine mononucleotides and the hydroxymethyl pyrimidine moiety of thiamine.
History
EC 2.7.1.223 created 2018
Orthology
K23147  aminoimidazole riboside kinase
Genes
STYSTY3804
STTt3552
SEXSTBHUCCB_37350
SENTTY21A_17945
STMSTM4066
SEOSTM14_4890
SEVSTMMW_40311
SEYSL1344_4015
SEMSTMDT12_C42130
SEJSTMUK_4051
SEBSTM474_4248
SEFUMN798_4410
SETUSTU288_20480
SETCCFSAN001921_20090
SENRSTMDT2_39291
SENDDT104_40751
SENICY43_21265
SEENSE451236_00560
SPTSPA3909
SEKSSPA3637
SPQSPAB_05039
SEISPC_4173
SECSCH_3957
SEHSeHA_C4397
SHBSU5_0164
SENHCFSAN002069_11740
SEEHSEEH1578_06590
SEESNSL254_A4395
SENNSN31241_46210
SEWSeSA_A4283
SEASeAg_B4312
SENSQ786_19970
SEDSeD_A4464
SELSPUL_3598
SEGASPUCDC_3584
SETSEN3856
SENAAU38_19935
SENOAU37_19950
SENVAU39_19970
SENQAU40_22275
SENLIY59_20430
SENJCFSAN001992_13355
SEECCFSAN002050_03220
SEEBSEEB0189_022015
SENBBN855_41410
SENEIA1_19785
SENCSEET0819_04175
SALZEOS98_21980
KMIVW41_00365
KLWDA718_00640
KGRJJJ10_00575
KPASLUW96_06020
RONTE10_01710
CAMAF384_21510
CFARCI104_24190
CIRC2U53_10880
CTELGBC03_05735
CLAPNCTC11466_04506(iolC_2)
AHNNCTC12129_04849(iolC_3)
ASUBNLZ15_21650
IZHFEM41_06220
SFWWN53_14485
SOFNCTC11214_00360(iolC_1)
DAAAKL17_4383
ARFAR1Y2_1679
ACACEYQ97_09235
AMAUDSM26151_01060(rbkS_1)
MAUMicau_4254
MTUACSH63_03360
BLFBLIF_1540
BLBBBMN68_1805
BLGBIL_02100
BLZBLGT_07945
BBVHMPREF9228_1467
BBRUBbr_1426
BBRVB689b_1442
BBRNB2258_1405
BBRSBS27_1451
BLEMBL8807_05360
TRSTerro_3093
BLQL21SP5_01080(iolC)
SLISlin_1088
SPIKEXU85_13095
SPIBG8759_24160
FIBA6C57_12050
HTSHMJ29_11980
AFLAFHG64_10450
MZIHWN40_11890
 » show all
Reference
1  [PMID:12486071]
  Authors
Dougherty M, Downs DM
  Title
The stm4066 gene product of Salmonella enterica serovar Typhimurium has aminoimidazole riboside (AIRs) kinase activity and allows AIRs to satisfy the thiamine requirement of pur mutant strains.
  Journal
J Bacteriol 185:332-9 (2003)
DOI:10.1128/JB.185.1.332-339.2003
  Sequence
[stm:STM4066]
Reference
2  [PMID:15458630]
  Authors
Zhang Y, Dougherty M, Downs DM, Ealick SE
  Title
Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica:  implications for the evolution of the ribokinase superfamily.
  Journal
Structure 12:1809-21 (2004)
DOI:10.1016/j.str.2004.07.020
  Sequence
[stm:STM4066]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.223
IUBMB Enzyme Nomenclature: 2.7.1.223
ExPASy - ENZYME nomenclature database: 2.7.1.223
BRENDA, the Enzyme Database: 2.7.1.223

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