KEGG   ENZYME: 2.7.1.3
Entry
EC 2.7.1.3                  Enzyme                                 
Name
ketohexokinase;
ketohexokinase (phosphorylating)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:D-fructose 1-phosphotransferase
Reaction(IUBMB)
ATP + D-fructose = ADP + D-fructose 1-phosphate [RN:R00866]
Reaction(KEGG)
R00866;
(other) R03819
Substrate
ATP [CPD:C00002];
D-fructose [CPD:C00095]
Product
ADP [CPD:C00008];
D-fructose 1-phosphate [CPD:C01094]
Comment
D-Sorbose, D-tagatose and 5-dehydro-D-fructose and a number of other ketoses and their analogues can also act as substrates [4].
History
EC 2.7.1.3 created 1961
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00846  ketohexokinase
Genes
HSA3795(KHK)
PTR740614(KHK)
PPS100986057(KHK)
GGO101134632(KHK)
PON100447147(KHK)
NLE100601410(KHK)
MCC698328(KHK)
MCF102130504(KHK)
MTHB126933748
CSAB103220615(KHK)
CATY105578479(KHK)
PANU101024620(KHK)
TGE112605240(KHK)
RRO104668507(KHK)
RBB108532700(KHK)
TFN117062578(KHK)
PTEH111554479(KHK)
CJC100415528(KHK)
SBQ101036824(KHK)
CSYR103255514(KHK)
MMUR105884390(KHK)
LCAT123636711(KHK)
OGA100952079(KHK)
MMU16548(Khk)
MCAL110294244(Khk)
MPAH110324630(Khk)
RNO25659(Khk)
MCOC116080048(Khk)
MUN110547704(Khk)
CGE100763359(Khk)
MAUA101841804(Khk)
PLEU114696665(Khk)
MORG121432942 121439688
MFOT126492250
AAMP119807601(Khk)
NGI103735676(Khk)
HGL101705832(Khk)
CPOC100719336(Khk)
CCAN109679815(Khk)
DORD105983747(Khk)
DSP122122441(Khk)
NCAR124963299
OCU100351729(KHK)
OPI101535757(KHK)
TUP102484270(KHK)
CFA100170647(KHK)
CLUD112664644(KHK)
VVP112908466(KHK)
VLG121491348(KHK)
AML100467138(KHK)
UMR103671661(KHK)
UAH113270973(KHK)
UAR123799921(KHK)
ELK111158431
LLV125109981
MPUF101673434(KHK)
ORO101384115(KHK)
EJU114205994(KHK)
ZCA113937330(KHK)
MLX118007686(KHK)
NSU110587197(KHK)
FCA101080375(KHK)
PYU121044244(KHK)
PBG122497345(KHK)
LRUF124503306
PTG102962169(KHK)
PPAD109267095(KHK)
AJU106967844(KHK)
HHV120235807(KHK)
BTA614868(KHK)
BOM102268699(KHK)
BIU109566299(KHK)
BBUB102390464(KHK)
CHX102184448(KHK)
OAS101113479(KHK)
ODA120851570(KHK)
CCAD122441958(KHK)
SSC100523241(KHK)
CFR102511333(KHK)
CBAI105063841(KHK)
CDK105098529(KHK)
VPC102543330(KHK)
BACU103010435(KHK)
LVE103091631(KHK)
OOR105747917(KHK)
DLE111174970(KHK)
PCAD102990262(KHK)
PSIU116764167(KHK)
ECB100055449(KHK)
EPZ103546444(KHK)
EAI106837028(KHK)
MYB102258355(KHK)
MYD102771838(KHK)
MMYO118669187(KHK)
MLF102437431(KHK)
MNA107534324(KHK)
PKL118717199(KHK)
HAI109381471(KHK)
DRO112297774(KHK)
SHON119001354(KHK)
AJM119050390(KHK)
PDIC114500763(KHK)
PHAS123822406(KHK)
MMF118630772(KHK)
RFQ117033363(KHK)
PALE102893977(KHK)
PGIG120621856(KHK)
PVP105289740(KHK)
RAY107502157(KHK)
MJV108391207(KHK)
TOD119259481(KHK)
SARA101546756(KHK)
LAV100654223(KHK)
TMU101357800
DNM101439355(KHK)
MDO100025922(KHK)
GAS123237082(KHK)
SHR116421501(KHK)
PCW110206493(KHK)
OAA100078974(KHK)
GGA107053156(KHK)
PCOC116230626(KHK)
MGP104915942(KHK)
CJO107312319(KHK)
NMEL110396880(KHK)
AFUL116487544(KHK)
TGU115493320(KHK)
LSR110478492(KHK)
PMOA120502937(KHK)
OTC121338768 121338774 121338775
PRUF121360659(KHK)
FAB101819131(KHK)
PHI102102222(KHK)
PMAJ107198696(KHK)
CBRC103623661(KHK)
ETL114070004(KHK)
FPG101916509(KHK)
FCH102052292(KHK)
CLV102091341(KHK)
TALA122154502(KHK)
ACHC115351046(KHK)
DPUB104304367(KHK)
CUCA104068785(KHK)
NPD112959031(KHK)
ASN102372834(KHK)
AMJ102559964(KHK)
CMY102943037(KHK)
CPIC101931226(KHK)
TST117870257 117870260
CABI116824659(KHK)
MRV120402357(KHK)
ACS100561006(khk)
PVT110086983(KHK)
SUND121919532(KHK)
PBI103057572(KHK)
PMUR107286452(KHK)
CTIG120309160(KHK)
TSR106545882(KHK)
PGUT117667637(KHK)
VKO123018753(KHK)
PMUA114593444 114595007
ZVI118082918(KHK)
GJA107113758(KHK)
STOW125443646(KHK)
XLA447317(khk.S)
XTR100492918(khk)
NPR108803683(KHK)
RTEM120935941(KHK)
BBUF120996978(KHK)
DRE436909(khk)
SRX107725530 107729261
SANH107681984 107693158
SGH107586608(khk) 107589689
CCAR109062640 109106840(khk)
CAUA113060728 113060936 113117637 113117645
PPRM120480151(khk)
MAMB125268589(khk)
IPU108269966(khk)
PHYP113525410(khk)
SMEO124389799(khk)
TFD113638525(khk)
AMEX103034968(khk)
EEE113571086(khk)
TRU101064289(khk)
TNGGSTEN00010148G001
LCO104938896(khk)
CGOB115005968(khk)
ELY117256298(khk)
EFO125888238(khk)
PLEP121939837
SLUC116062617(khk)
ECRA117941371(khk)
ESP116685272(khk)
PFLV114554453(khk)
GAT120834570(khk)
PPUG119230067(khk)
MSAM119886740(khk)
CUD121507476(khk)
ALAT119021595(khk)
MZE101480218 112434039
ONL100700794(khk)
OAU116316674(khk)
OLA101158269(khk)
OML112144984(khk)
XMA102233542(khk)
XCO114136256(khk)
XHE116709919(khk)
PRET103460363(khk)
PFOR103132390(khk)
PLAI106934512(khk)
PMEI106905671(khk)
GAF122834661(khk)
CVG107102976(khk)
CTUL119788657(khk)
GMU124856934(khk)
NFU107384879(khk)
KMR108251243(khk)
ALIM106531860 106536394
NWH119412027(khk)
AOCE111566822(khk)
MCEP125007208(khk)
CSEM103386816(khk)
POV109643312(khk)
SSEN122768797(khk)
HHIP117762171(khk)
HSP118104944(khk)
LCF108890712
SDU111219447(khk)
SLAL111649710 111657341(khk)
XGL120782897(khk)
HCQ109522373(khk)
BPEC110170273(khk)
MALB109966909(khk)
BSPL114855201(khk)
SASA100306748(khk)
STRU115172940(khk)
OTW112262142(khk)
OMY110498227(khk)
OGO124001486(khk)
ONE115133268(khk)
SALP112071068(khk)
SNH120060143(khk)
CCLU121539049(khk)
ELS105015956(khk)
SFM108933631(khk)
PKI111857675(khk)
AANG118220588(khk)
LOC102684437(khk)
PSPA121317148(khk)
ARUT117410856(khk)
LCM102364548(KHK)
CMK103184052(khk)
RTP109935513
BFO118409339 118409679
BBEL109469714 109469831 109471704
CIN100181324
SCLV120329809 120331054 120331099
SPU588197
APLC110986199
SKO100372840
DMEDmel_CG12289(CG12289) Dmel_CG7328(CG7328) Dmel_CG7335(CG7335) Dmel_CG7551(CG7551)
DER6544584 6544585 6545892 6545893
DSE6616242 6616243
DSIDsimw501_GD12218(Dsim_GD12218) Dsimw501_GD12219(Dsim_GD12219) Dsimw501_GD12805(Dsim_GD12805) Dsimw501_GD14306(Dsim_GD14306)
DYADyak_GE20217 Dyak_GE21811 Dyak_GE22430 Dyak_GE22431 Dyak_GE23230 Dyak_GE28062
DSR110178551 110178560 110180400 110180402 110181236 110181237
DPO4812990 4813134 4813430 6900764
DPE6595995 6595996 6598983 6598987 6598990
DMN108151013 108151015 108153686
DWI6639377 6639549
DGR6557183 6557818 6557829
DMODmoj_GI11611 Dmoj_GI13697 Dmoj_GI13699 Dmoj_GI13769 Dmoj_GI13771
DAZ108613124 108613130 108614724 108614745
DNV108650288 108650597 108651097 108651102 115562088
DHE111593110 111593120 111593132 111601003 111601005
CCAT101452934
RZE108367049
MDE101899690
SCAC106093057
LCQ111686313
LSQ119612805
HIS119653422
AGAAgaP_AGAP002483
CQUCpipJ_CPIJ012838
CPII120423223
CNS116347802
BCOO119084044
AME726522
ACER107995754
ALAB122718035
BIM100747606
BBIF117211341
BVK117237372
BVAN117160951
BTER100645568
BPYO122572406
CCAL108622813
OBB114878576
MGEN117225478
NMEA116435153
CGIG122404478
SOC105200104
MPHA105832626
AEC105146862
ACEP105625149
PBAR105429597
VEM105567044
HST105189958
DQU106750649
CFO105251485
FEX115235874
LHU105676183
PGC109857528
OBO105278224
PCF106785626
PFUC122526578
VPS122628672
NVI100115525
CSOL105360991
TPRE106654468
MDL103575270
CGLO123260662
FAS105262917
DAM107047921
AGIF122847542
CCIN107271343
CFEL113376470
DCI103506375 103523340
HHAL106692469
NLU111045343 111053451
FOC113218251
TPAL117652360
CSEC111870634
FCD110853817
DPXDAPPUDRAFT_213561
PVM113811632 113813578
PJA122266729
PCHN125033576
HAME121874495
PCLA123747357
PTRU123507379
HAZT108671300
EAF111712438
PPOI119109739
TUT107371958
CSCU111624977
PTEP107455070
SDM118191013
BMYBM_BM8063(Bm8063)
LOALOAG_12304
LGILOTGIDRAFT_122584 LOTGIDRAFT_204853
PCAN112557004 112566312
BGT106058846 106067489 106073367
GAE121371100
HRF124132391 124132401
HRJ124274206 124274242 124277887 124285187 124290977
CRG105331023
MYI110448125 110448126
PMAX117333210 117333211
MMER123533252 123534919
OBI106876478
OSN115227052
LAK106157266 106157428 106167802
NVE116602276 116602281 116617953 5518877 5518890
EPA110254087
ATEN116288370
ADF107351357
AMIL114962520
PDAM113679033
SPIS111332978
DGT114532790
XEN124437270
HMG100206260
TADTRIADDRAFT_58015
AQU100637048
NCRNCU03742
NTENEUTE1DRAFT144445(NEUTE1DRAFT_144445)
SMPSMAC_02593
PANPODANSg8149
TTTTHITE_2107054
MTMMYCTH_2116851
CTHRCTHT_0065770
MGRMGG_15061
SSCKSPSK_10998
FPUFPSE_04113
FVRFVEG_16233
NHENECHADRAFT_48854
TRETRIREDRAFT_53989
TRRM419DRAFT_68938
MAWMAC_00511
MAJMAA_11256
CMTCCM_05591
VALVDBG_04219
VDAVDAG_01448
CFJCFIO01_06771
CLUPCLUP02_08234
CHIGCH63R_04360
SAPOSAPIO_CDS10423
PFYPFICI_12080
ANIAN0344.2
ACTACLA_032210
NFINFIA_022430
AORAO090005000876
ANGANI_1_774014(An01g06030)
AFVAFLA_003692
ALUCAKAW2_20704S
ACHEACHE_11850S
APUUAPUU_11758A
PCSPc22g22030
TMFPMAA_084000
TRGTRUGW13939_08233
CIMCIMG_03621
CPWCPC735_006510
UREUREG_06285
PBLPAAG_01961
PBNPADG_00630
AJEHCAG_00040
BGHBDBG_06300
PNOSNOG_00283
PTEPTT_11946
BZECOCCADRAFT_36990
BSCCOCSADRAFT_87238
BORCOCMIDRAFT_24285
AALTCC77DRAFT_977803
PFJMYCFIDRAFT_210004
FFUCLAFUR5_04982
WSEWALSEDRAFT_59637
AAFAURANDRAFT_4866
PIFPITG_02500
PSOJPHYSODRAFT_467118 PHYSODRAFT_470432
SPARSPRG_00529
EHXEMIHUDRAFT_117776 EMIHUDRAFT_203243
TCXTcr_1488
HTREPV75_07980
HMARHVMH_1610
TCYThicy_1233
TAOTHIAE_02530
THIOAYJ59_05930
MEJQ7A_2986
MECQ7C_1302
THIGFE785_07600
TXAHQN79_08485
TSETHMIRHAS_08630
TZOTHMIRHAT_17430
TIGTHII_2182
THISHZT40_09915
TUNJ9260_07775
NOCNoc_2848
NHLNhal_0504
NWANwat_0240
NWRE3U44_01960
TMBThimo_2207
MPURMARPU_01580
TEETel_15560
NTTTAO_0241
TSYTHSYN_22105
NTGNSCAC_1404(khk)
THIPN838_25015
THIMKFB96_15770
TBOGLT988_14285
HHAHhal_0921
EBSECTOBSL9_1159
TGRTgr7_0113
TKMTK90_0283
TNITVNIR_3462(ydjH_[C])
TTITHITH_14855
TVRTVD_01845
APRSBI364_00505
HNAHneap_0029
HAZA9404_09215
GHLGM160_00165
TTCFOKN1_2948
THICTspCOW1_28460
TBNTBH_C0398
REVHUE57_18300
ENMEBS_2134(khk)
AMICAmi3637_01690
MOXDAMO_2523(KHK)
 » show all
Reference
1  [PMID:14858418]
  Authors
CORI GT, OCHOA S, SLEIN MW, CORI CF.
  Title
The metabolism of fructose in liver; isolation of fructose-I-phosphate and inorganic pyrophosphate.
  Journal
Biochim Biophys Acta 7:304-17 (1951)
DOI:10.1016/0006-3002(51)90032-7
Reference
2  [PMID:13208667]
  Authors
HERS HG.
  Title
[Liver fructokinase.]
  Journal
Biochim Biophys Acta 8:416-23 (1952)
DOI:10.1016/0006-3002(52)90067-x
Reference
3  [PMID:13449068]
  Authors
PARKS RE Jr, BEN-GERSHOM E, LARDY HA.
  Title
Liver fructokinase.
  Journal
J Biol Chem 227:231-42 (1957)
Reference
4  [PMID:193556]
  Authors
Raushel FM, Cleland WW.
  Title
Bovine liver fructokinase: purification and kinetic properties.
  Journal
Biochemistry 16:2169-75 (1977)
DOI:10.1021/bi00629a020
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.3
IUBMB Enzyme Nomenclature: 2.7.1.3
ExPASy - ENZYME nomenclature database: 2.7.1.3
BRENDA, the Enzyme Database: 2.7.1.3
CAS: 9030-50-6

DBGET integrated database retrieval system