KEGG   ENZYME: 2.7.1.52
Entry
EC 2.7.1.52                 Enzyme                                 
Name
fucokinase;
fucokinase (phosphorylating);
fucose kinase;
L-fucose kinase;
L-fucokinase;
ATP:6-deoxy-L-galactose 1-phosphotransferase;
ATP:L-fucose 1-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:beta-L-fucose 1-phosphotransferase
Reaction(IUBMB)
ATP + L-fucose = ADP + beta-L-fucose 1-phosphate [RN:R03161]
Reaction(KEGG)
R03161
Substrate
ATP [CPD:C00002];
L-fucose [CPD:C01019]
Product
ADP [CPD:C00008];
beta-L-fucose 1-phosphate [CPD:C02985]
Comment
Requires a divalent cation for activity, with Mg2+ and Fe2+ giving rise to the highest enzyme activity. Forms part of a salvage pathway for reutilization of L-fucose. Can also phosphorylate D-arabinose, but more slowly.
History
EC 2.7.1.52 created 1972, modified 2004
Pathway
ec00051  Fructose and mannose metabolism
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K05305  fucokinase
K25314  fucokinase / fucose-1-phosphate guanylyltransferase
K25315  arabinokinase / fucokinase / arabinose-1-phosphate guanylyltransferase / fucose-1-phosphate guanylyltransferase
Genes
HSA197258(FCSK)
PTR468015(FUK)
PPS100981840(FCSK)
GGO101132289(FCSK)
PON100454490(FUK)
NLE100606422(FCSK)
MCC709226(FCSK)
MCF102127748(FCSK)
MTHB126943706
CSAB103233158(FUK)
CATY105575740(FUK)
PANU101007309(FCSK)
TGE112613739(FUK)
RRO104677820(FCSK)
RBB108527441(FUK)
TFN117088031(FCSK)
PTEH111541444(FCSK)
CJC100413891(FUK)
SBQ101049340(FUK)
CSYR103265659(FUK)
MMUR105875427(FUK)
LCAT123625450(FCSK)
OGA100943770(FUK)
MMU234730(Fcsk)
MCAL110300446(Fuk)
MPAH110337388(Fuk)
RNO307848(Fcsk)
MCOC116070183(Fcsk)
MUN110546023(Fuk)
CGE100752219(Fcsk)
MAUA101836110(Fcsk)
PLEU114708091(Fcsk)
MORG121447232(Fcsk)
MFOT126503037
AAMP119801916(Fcsk)
NGI103735635(Fuk)
HGL101722039(Fuk)
CPOC100717941(Fuk)
CCAN109684986(Fuk)
DORD105983169(Fuk)
DSP122126111(Fcsk)
NCAR124966567
OCU100348059(FUK)
OPI101520333(FCSK)
TUP102491737(FUK)
CFA489715(FCSK)
CLUD112646619(FCSK)
VVP112929501(FUK)
VLG121499799(FCSK)
AML100481849(FCSK)
UMR103673574(FUK)
UAH113252471(FUK)
UAR123800542(FCSK)
ELK111152994
LLV125089059
MPUF101676203(FUK)
ORO101383814(FUK)
EJU114200381(FUK)
ZCA113936638(FCSK)
MLX118023586(FCSK)
NSU110593981(FCSK)
FCA101094896(FUK)
PYU121009773(FCSK)
PBG122494442(FCSK)
LRUF124511475
PTG102956046(FUK)
PPAD109270645(FUK)
AJU106983746(FUK)
HHV120223359(FCSK)
BTA519181(FCSK)
BOM102267499(FUK)
BIU109572530(FUK)
BBUB102389555(FCSK)
CHX102173959(FUK)
OAS101114636(FUK)
ODA120872856(FCSK)
CCAD122421751(FCSK)
SSC100625448(FUK)
CFR102513917(FCSK)
CBAI105073650(FUK)
CDK105097707(FCSK)
VPC102538555(FCSK)
BACU103019486(FUK)
LVE103084623(FUK)
OOR101282658(FUK)
DLE111179534(FCSK)
PCAD102986794(FCSK)
PSIU116743476(FCSK)
ECB100054844(FUK)
EPZ103552406(FUK)
EAI106823440(FCSK)
MYB102253257(FUK)
MYD102756628(FUK)
MMYO118674849(FCSK)
MLF102422485(FUK)
MNA107524486(FUK)
PKL118720764(FCSK)
HAI109388833(FUK)
DRO112300761(FUK)
SHON118999269(FCSK)
AJM119055876(FCSK)
PDIC114515479(FCSK)
PHAS123805782(FCSK)
MMF118638435(FCSK)
RFQ117034519(FCSK)
PALE102895323(FUK)
PGIG120593881(FCSK)
PVP105305829(FUK)
RAY107520544(FUK)
MJV108397075(FUK)
TOD119249057(FCSK)
SARA101538149(FUK)
LAV100672550(FUK)
TMU101342284
DNM101419623(FUK)
MDO100617318(FUK)
GAS123236719(FCSK)
SHR100931802(FCSK)
PCW110192405(FUK)
OAA100075033(FCSK)
GGA770049(FUK)
PCOC116243977(FCSK)
MGP100546052(FCSK)
CJO107319068(FCSK)
NMEL110404250(FUK)
APLA101793742(FUK)
ACYG106033121(FCSK)
AFUL116494061(FCSK)
TGU100228545(FCSK)
LSR110476215(FCSK)
SCAN103816829(FCSK)
PMOA120508114(FCSK)
OTC121334088(FCSK)
PRUF121348942(FCSK)
GFR102042406(FUK)
FAB101820082(FUK)
PHI102104108(FUK)
PMAJ107209808(FCSK)
CCAE111934535(FUK)
CCW104687567(FCSK)
CBRC103620284(FUK)
ETL114063446(FUK)
ZAB102065902(FUK)
ACHL103809428(FUK)
FPG101919068(FUK)
FCH102046401(FUK)
CLV102092541(FUK)
EGZ104130289(FUK)
NNI104017497(FUK)
PCAO104047931(FUK)
ACUN113484326(FUK)
TALA116960326(FCSK)
AFOR103908470(FUK)
ACHC115346487(FCSK)
DPUB104305084(FUK)
CVF104284892(FUK)
CUCA104067258(FUK)
AAM106492724(FUK)
AROW112976869(FUK)
NPD112943208(FUK)
DNE112987451(FUK)
ASN102368059(FUK)
AMJ102572043(FUK)
CPOO109310453(FUK)
GGN109289669(FUK)
CMY102943730(FCSK)
CPIC101941728(FCSK)
TST117886477(FCSK)
CABI116833719(FCSK)
MRV120384758(FCSK)
ACS100558701(fuk)
PVT110081311(FUK)
SUND121937553(FCSK)
PBI103061608(FUK)
PMUR107284158(FCSK)
CTIG120312618(FCSK)
TSR106547771(FUK)
PGUT117670471(FCSK)
VKO123025389(FCSK)
PMUA114601860(FCSK)
ZVI118087179(FCSK)
GJA107117655(FUK)
STOW125443260(FCSK)
XLA100137687(ffcskk.L)
XTR100497304(fcsk)
NPR108803447(FUK)
RTEM120917782(FCSK)
BBUF120980875(FCSK)
BGAR122920756(FCSK)
DRE100150934(fuk)
SRX107720764 107740890(fuk)
SANH107673265(fuk) 107680117
SGH107559996
CCAR109050606 109050614
CAUA113043695 113066689 113074844
PPRM120477766
MAMB125247452
IPU108274775
PHYP113530125(fuk)
SMEO124392425
TFD113654016(fcsk)
AMEX103035161(fuk)
EEE113573662(fuk)
TRU101074270(fcsk)
TNGGSTEN00003752G001
LCO104937043(fuk)
ELY117261974
EFO125888022
SLUC116059836
PFLV114560129
GAT120809105
PPUG119195810
MSAM119893164
CUD121515235
ALAT119024492
MZE101463615(fuk)
ONL100689720(fuk)
OAU116327755
OLA101172159(fuk)
OML112151867(fcsk)
XMA102237071(fuk)
XCO114152782(fuk)
XHE116731393(fcsk)
PRET103466785(fuk)
PFOR103148639(fuk)
PLAI106955229(fuk)
PMEI106921953(fuk)
GAF122836161
CVG107100402(fuk)
CTUL119781646
GMU124880620
NFU107389126(fuk)
KMR108229648
ALIM106527958(fuk)
NWH119415472
AOCE111578064(fuk)
MCEP125015307
CSEM103379717(fuk)
POV109647017
HHIP117763271
HSP118109868
LCF108893719(fcsk)
SDU111231882(fuk)
SLAL111649731 111653431
XGL120793790
HCQ109518183(fuk)
BPEC110155087(fuk)
MALB109969135(fuk)
BSPL114856805
SASA106560702(fuk)
STRU115197198(fcsk)
OTW112218386(fcsk)
OMY110490736(fcsk)
OGO124040748
ONE115134625(fcsk)
SALP111960937(fuk)
SNH120066026
CCLU121532005
ELS105026607(fcsk)
SFM108934685(fcsk)
PKI111841211(fuk)
AANG118215577
LOC102688745(fuk)
PSPA121296736
ARUT117424690
LCM102347730(FUK)
CMK103186660(fcsk)
RTP109913035(fuk)
BFO118418081
BBEL109473716
CIN100182438
SCLV120338241 120339898
SPU100892878
APLC110975638
SKO102802389
DPXDAPPUDRAFT_202910
DMK116924933
PVM113811739
PJA122267420
PCHN125044353
HAME121868856
PCLA123770624
PTRU123509882
HAZT108675927
EAF111707340
DSV119445608
RSAN119377852
RMP119174164
VDE111249168
VJA111268466
CSCU111642164
PTEP107443266
SDM118195782
HROHELRODRAFT_181660
LGILOTGIDRAFT_217536
PCAN112576778
BGT106068288
GAE121388594
HRF124113137
HRJ124282926
CRG105323794
MYI110463342
PMAX117338592
MMER123549440
OBI106869576 106872675
OSN115220697
LAK106156384 106169504
NVE5510800
EPA110233424
ATEN116306898
ADF107342267
AMIL114977194 114977201
PDAM113666965 113666975
SPIS111332602
DGT114517288
XEN124436743
HMG101234558
TADTRIADDRAFT_55543 TRIADDRAFT_55544
ATHAT1G01220(FKGP)
ALY9328144
CRB17876572
CSAT104738672 104754265 104759313
EUSEUTSA_v10006637mg
BRP103843778
BNA106352534 106377357
BOE106312465
RSZ108862914
THJ104815884
CPAP110808528
CIT102607405
CICCICLE_v10018702mg
PVY116142159
MINC123223163
TCC18613941
GRA105763919
GHI121224126
GAB108479543
DZI111304857
EGR104445349
GMX100776147 100803620
GSJ114398035 114407822
PVUPHAVU_006G115200g
VRA106754135
VAR108343062
VUN114187899
CCAJ109796650
APRC113861369
MTR11435147
CAM101489062
PSAT127132088
LJALj1g3v5038190.1(Lj1g3v5038190.1) Lj1g3v5038190.2(Lj1g3v5038190.2)
ADU107491927
AIP107646095
AHF112695289 112758493
LANG109333340
FVE101313747
RCN112182084
PPER18785393
PMUM103332228
PAVI110757650
PDUL117617124
MDM103439376
PXB103927198
ZJU107423663
MNT21406234
CSV101204338
CMO103483166
BHJ120083429
MCHA111016303
CMAX111473620 111475081
CMOS111441674
CPEP111800352
RCU8282132
JCU105642816
HBR110632095
MESC110614294
POP7486785
PEU105135437
PALZ118041222
JRE109010378
QSU111983257
QLO115955796
TWL120004064
VVI100258719
VRI117932264
SLY101258193
SPEN107007997
SOT102590041
SSTN125877598
CANN107839347
NTA107766622 107817245
NSY104228145
NTO104121367
NAU109227812
INI109150877
ITR115996628
SIND105173828
OEU111409933
EGT105963921
SSPL121795310 121798840
HAN110937555
ECAD122594409
LSV111894586
CCAV112526343
DCR108209637
CSIN114290101
BVG104907115
SOE110786573
CQI110713928 110731719
NNU104604718
MING122081866
TSS122667273
PSOM113297710 113301503
NCOL116263426
OSA4331392
DOSAOs03t0115100-01(Os03g0115100)
OBR102713062
BDI100826076
ATS109785929
TDC119292137 119304223
TAES123093854 123099075 123106030
TUA125511496
SBI8078003
ZMA100381824
SITA101773659
SVS117840567
PVIR120647567 120687885
PHAI112878344
PDA103719462
EGU105043452
MUS103970309
DCT110094703
PEQ110030506
AOF109825030
ATR18447674
PPP112278448
OTAOT_ostta07g01230
MPPMICPUCDRAFT_57613
MBRMONBRDRAFT_15021
SREPTSG_11727
DDIDDB_G0269678
DPPDICPUDRAFT_49164
DFADFA_01669
ACANACA1_232880
PTIPHATRDRAFT_bd1431
FCYFRACYDRAFT_232262(FUK1)
TPSTHAPSDRAFT_11189
EHXEMIHUDRAFT_453358
GTTGUITHDRAFT_146616
TCR508379.10
LMALMJF_16_0440 LMJF_16_0480
LIFLINJ_16_0450 LINJ_16_0490
LDOLDBPK_160450
LMILMXM_16_0440 LMXM_16_0480
LBZLBRM_16_0500
LPANLPMP_160480
ROBCK5_28240
BLABEYS05_17015
RTORTO_22660
RGNRGna_00050
SGYSgly_1597
FGIOP10G_0382
SUSAcid_0569
PFERIRI77_32210
BTHBT_2128
BTHOBtheta7330_00915(hddA_1)
BFRBF2586
BFSBF9343_2526
BFGBF638R_2601
BFBVU15_11545(fkp)
BHLBache_1982
BXYBXY_11610
BOABovatus_02192(hddA_1)
BCELBcellWH2_05118(hddA)
BCACCGC64_18450(fkp)
BCAEA4V03_13765(fkp)
BISDXK01_014525(fkp)
BUNBun01g_30610
BFEK6V30_25045(fkp)
BNOK8P02_12605(fkp)
BVUBVU_1606
BSABacsa_0234
BDOEL88_02950(fkp)
BDHGV66_08320(fkp)
PCOPI6J50_07580(fkp)
PBTING2E5B_0495
PMUCING2E5A_2839(FUK)
PETPEIBARAKI_4442
PSACPSM36_0195
PROJKDN43_10215(fkp)
PDIBDI_1573
PARCCI960_12140(fkp)
PMERINE87_01603
PGOLK6V26_04000(fkp)
PJOLK449_10460(fkp)
DUNFDZ78_02420(fkp)
PRUPRU_0129
PDTPrede_2699
PEOAS203_09210(fkp)
ALQC7Y71_002115(fkp)
AITAI2BBH_01730
MCOSGM418_23895(fkp)
ASXCDL62_10010(fkp)
MGKFSB76_14330(fkp)
FBEFF125_11410(fkp)
 » show all
Reference
1  [PMID:5646161]
  Authors
Ishihara H, Massaro DJ, Heath EC.
  Title
The metabolism of L-fucose. 3. The enzymatic synthesis of beta-L-fucose 1-phosphate.
  Journal
J Biol Chem 243:1103-9 (1968)
Reference
2  [PMID:2986701]
  Authors
Butler W, Serif GS.
  Title
Fucokinase, its anomeric specificity and mechanism of phosphate group transfer.
  Journal
Biochim Biophys Acta 829:238-43 (1985)
DOI:10.1016/0167-4838(85)90193-1
Reference
3  [PMID:9488699]
  Authors
Park SH, Pastuszak I, Drake R, Elbein AD.
  Title
Purification to apparent homogeneity and properties of pig kidney L-fucose kinase.
  Journal
J Biol Chem 273:5685-91 (1998)
DOI:10.1074/jbc.273.10.5685
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.52
IUBMB Enzyme Nomenclature: 2.7.1.52
ExPASy - ENZYME nomenclature database: 2.7.1.52
BRENDA, the Enzyme Database: 2.7.1.52
CAS: 37278-00-5

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