KEGG   ENZYME: 2.7.11.10
Entry
EC 2.7.11.10                Enzyme                                 

Name
IkappaB kinase;
CHUK;
IKBKA;
IKBKB;
IKK;
IKK-1;
IKK-2;
inhibitor of NFkappaB kinase;
inhibitor of NF-kappaB kinase;
STK12;
TANK-binding kinase 1;
TBK1
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
Sysname
ATP:[IkappaB protein] phosphotransferase
Reaction(IUBMB)
ATP + [IkappaB protein] = ADP + [IkappaB phosphoprotein]
Reaction(KEGG)
(other) R00162
Substrate
ATP [CPD:C00002];
[IkappaB protein]
Product
ADP [CPD:C00008];
[IkappaB phosphoprotein]
Comment
The enzyme phosphorylates IkappaB proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway. Subsequent degradation of the IkB complex (IKK) activates NF-kappaB, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis. If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably.
History
EC 2.7.11.10 created 2005 (EC 2.7.1.37 part-incorporated 2005)
Orthology
K04467  inhibitor of nuclear factor kappa-B kinase subunit alpha
K05410  TANK-binding kinase 1
K07209  inhibitor of nuclear factor kappa-B kinase subunit beta
K07211  inhibitor of nuclear factor kappa-B kinase subunit epsilon
Genes
HSA: 1147(CHUK) 29110(TBK1) 3551(IKBKB) 9641(IKBKE)
PTR: 450673(CHUK) 452047(TBK1) 472749(IKBKB) 742813(IKBKE)
PPS: 100989390(IKBKB) 100990211(TBK1) 100992569(IKBKE) 100995228(CHUK)
GGO: 101125384(IKBKE) 101137405(CHUK) 101138038(TBK1) 101141659(IKBKB)
PON: 100174735(CHUK) 100433568(TBK1) 100440586(IKBKB) 100448480(IKBKE)
NLE: 100582856(TBK1) 100588081(IKBKB) 100596225(CHUK) 100605137(IKBKE)
MCC: 695607(IKBKE) 704683(IKBKB) 709511(CHUK) 717427(TBK1)
MCF: 102115964(CHUK) 102126428(IKBKE) 102144774(TBK1) 102146604(IKBKB)
CSAB: 103215686(IKBKB) 103216382(CHUK) 103230198(IKBKE) 103238638(TBK1)
CATY: 105576636(IKBKE) 105581830(CHUK) 105595759(IKBKB) 105600541(TBK1)
PANU: 100998877(CHUK) 100999858(TBK1) 101001355(IKBKE) 101016447(IKBKB)
RRO: 104656469(CHUK) 104661734(IKBKE) 104666046(IKBKB) 104680828(TBK1)
RBB: 108529966(TBK1) 108535077(CHUK) 108535149(IKBKE) 108540719(IKBKB)
TFN: 117068535(CHUK) 117074249(IKBKE) 117089816(TBK1) 117095630(IKBKB)
PTEH: 111522719(IKBKE) 111538794(CHUK) 111539247 111544093(IKBKB) 111551230(TBK1)
CJC: 100392518(IKBKE) 100393096(IKBKB) 100399701(TBK1)
SBQ: 101027871(IKBKE) 101044006(CHUK) 101052971(IKBKB) 101053608(TBK1)
MMUR: 105867131 105868963(IKBKE) 105873508(CHUK) 105878144(IKBKB) 105880966(TBK1)
MMU: 12675(Chuk) 16150(Ikbkb) 56480(Tbk1) 56489(Ikbke)
MCAL: 110285285(Chuk) 110300158(Ikbkb) 110301565(Ikbke) 110303265(Tbk1)
MPAH: 110321718(Ikbke) 110326206(Tbk1) 110334538(Chuk) 110336182(Ikbkb)
RNO: 299827(Tbk1) 309361(Chuk) 363984(Ikbke) 84351(Ikbkb)
MCOC: 116069014(Ikbkb) 116076589(Tbk1) 116098877(Ikbke) 116103881(Chuk)
MUN: 110549049(Tbk1) 110550327(Ikbke) 110552966(Chuk) 110556613(Ikbkb)
CGE: 100750488(Ikbkb) 100754432(Chuk) 100761646(Ikbke) 100770091
PLEU: 114693293(Tbk1) 114698057(Ikbke) 114705738(Ikbkb) 114706431(Chuk)
NGI: 103725939(Ikbke) 103726621(Ikbkb) 103730726(Tbk1) 103743976(Chuk)
HGL: 101697947(Ikbke) 101711077(Ikbkb) 101713766(Tbk1) 101719306(Chuk)
CCAN: 109681514(Chuk) 109696400(Ikbkb) 109697216(Ikbke) 109698137(Tbk1)
OCU: 100354455(IKBKE) 100355888(CHUK) 100356401(IKBKB) 100358771(TBK1)
OPI: 101517015(IKBKB) 101524697(TBK1) 101529588(IKBKE) 101536073(CHUK)
TUP: 102467954(IKBKB) 102481203(IKBKE) 102484078(TBK1) 102501308(CHUK)
CFA: 477796(CHUK) 478950(IKBKE) 481145(TBK1) 482839(IKBKB)
VVP: 112914364(IKBKE) 112914804(CHUK) 112916156(IKBKB) 112922304(TBK1)
VLG: 121484113(CHUK) 121489510(IKBKB) 121491543(TBK1) 121501599(IKBKE)
AML: 100464675(CHUK) 100465112(IKBKE) 100471679(IKBKB) 100484104(TBK1)
UMR: 103656833(TBK1) 103658916(CHUK) 103671004(IKBKE) 103677059(IKBKB)
UAH: 113242466(IKBKE) 113245546(IKBKB) 113251823(CHUK) 113256330(TBK1)
ORO: 101362394(TBK1) 101364103(CHUK) 101366827(IKBKE) 101375346(IKBKB)
MPUF: 101676992(TBK1) 101680658(CHUK) 101686932(IKBKB) 101689805(IKBKE)
EJU: 114205217(CHUK) 114214962(TBK1) 114221921(IKBKE) 114224851(IKBKB)
MLX: 118008624(TBK1) 118009921(IKBKB) 118014127(IKBKE) 118024839(CHUK)
FCA: 100142682(IKBKB) 101086282(IKBKE) 101091955(TBK1) 101095617(CHUK)
PYU: 121012848(IKBKB) 121021584(IKBKE) 121037105(CHUK) 121040822(TBK1)
PBG: 122472994(IKBKB) 122473944(TBK1) 122476520(IKBKE) 122493134(CHUK)
PTG: 102949289(CHUK) 102960158(TBK1) 102963614(IKBKE) 102963734(IKBKB)
PPAD: 109257640(IKBKE) 109262264(IKBKB) 109270431(TBK1) 109272766(CHUK)
AJU: 106966935(CHUK) 106972924(IKBKE) 106981360(TBK1) 106990012(IKBKB)
HHV: 120228866(IKBKE) 120233179(TBK1) 120233999(IKBKB) 120243217(CHUK)
BTA: 281073(CHUK) 281854(IKBKB) 533141(TBK1) 533216(IKBKE)
BOM: 102271506(IKBKE) 102279479(TBK1) 102281443(IKBKB) 102281886(CHUK)
BIU: 109553086(CHUK) 109553353(IKBKB) 109559273(TBK1) 109570721(IKBKE)
BBUB: 102398659(IKBKE) 102398886(IKBKB) 102399613(CHUK) 102403644(TBK1)
CHX: 102177406(IKBKB) 102181262(CHUK) 102181474(TBK1) 102183809(IKBKE)
OAS: 101110830(TBK1) 101111143(CHUK) 101116923(IKBKE) 780484(IKBKB)
ODA: 120857688(TBK1) 120865846(IKBKB) 120873530(CHUK) 120879941(IKBKE)
CCAD: 122427358(TBK1) 122432633(IKBKB) 122446045(CHUK) 122451810(IKBKE)
SSC: 100101471(IKBKB) 100125828(TBK1) 100135662(CHUK) 100519508(IKBKE)
CFR: 102503497(CHUK) 102508142(IKBKB) 102514948(TBK1) 102519234(IKBKE)
CBAI: 105071245(IKBKB) 105075432(IKBKE) 105081359(TBK1) 105081887(CHUK)
CDK: 105084316(CHUK) 105086448(IKBKB) 105089261(TBK1) 105098613(IKBKE)
BACU: 103013353(TBK1) 103013616(IKBKE) 103015119(IKBKB) 103015414(CHUK)
LVE: 103080924(IKBKE) 103081814(TBK1) 103085220(CHUK) 103088633(IKBKB)
OOR: 101273673(IKBKE) 101281072(CHUK) 101285763(IKBKB) 101290315(TBK1)
DLE: 111172396(CHUK) 111173552(IKBKB) 111173795(TBK1) 111184753(IKBKE)
PCAD: 102976706(IKBKB) 102977668(CHUK) 102994478(IKBKE) 102994775(TBK1)
ECB: 100050167(IKBKB) 100051650(TBK1) 100055384(IKBKE) 100070393(CHUK)
EPZ: 103553835(IKBKE) 103557811(TBK1) 103562903(IKBKB) 103567228(CHUK)
EAI: 106823378(IKBKE) 106824389(TBK1) 106828957(IKBKB) 106846705(CHUK)
MYB: 102241250(TBK1) 102248515(IKBKE) 102261405(IKBKB) 102261467(CHUK)
MYD: 102760291(IKBKE) 102760888(CHUK) 102769631(TBK1) 102773824(IKBKB)
MMYO: 118650776(IKBKB) 118651925(TBK1) 118669852(CHUK) 118672786(IKBKE)
MNA: 107523913(IKBKB) 107527094(TBK1) 107538891(IKBKE) 107542599(CHUK)
PKL: 118719404(CHUK) 118721500(IKBKE) 118728482(IKBKB) 118730716(TBK1)
HAI: 109379632(CHUK) 109381695(TBK1) 109386279(IKBKB) 109386512(IKBKE)
DRO: 112300474(CHUK) 112318201(IKBKE) 112319039(TBK1) 112321547(IKBKB)
SHON: 118993207(IKBKB) 118998723(TBK1) 118999523(CHUK) 119001656(IKBKE)
AJM: 119045546(TBK1) 119047140(IKBKB) 119056820(IKBKE) 119064546(CHUK)
MMF: 118622317(IKBKB) 118624185(TBK1) 118632312(CHUK) 118637482(IKBKE)
PALE: 102878859(TBK1) 102879469(CHUK) 102889768(IKBKE) 102893261(IKBKB)
PGIG: 120595665(IKBKB) 120605013(TBK1) 120609204(CHUK) 120617936(IKBKE)
RAY: 107499756(CHUK) 107501353(IKBKB) 107502229(IKBKE) 107508222(TBK1)
MJV: 108390202(IKBKE) 108399262(TBK1) 108399795(IKBKB) 108409586(CHUK)
TOD: 119233588(CHUK) 119234149(IKBKE) 119248120(TBK1) 119257853(IKBKB)
LAV: 100657363(IKBKB) 100661026(TBK1) 100663886(IKBKE) 100664361(CHUK)
MDO: 100019578(IKBKE) 100027952(CHUK) 100033031(IKBKB)
SHR: 100913624(CHUK) 100915362(TBK1) 100928932(IKBKB) 100934784(IKBKE)
PCW: 110196387(IKBKB) 110211020(TBK1) 110213919(CHUK) 110219596(IKBKE)
OAA: 100076520(TBK1) 100077063(IKBKE) 100078925(IKBKB) 100082351(CHUK)
GGA: 417825(TBK1) 423669(CHUK) 426792(IKBKB) 430480(IKBKE)
PCOC: 116226617(TBK1) 116234507(IKBKB) 116234780(CHUK) 116236999(IKBKE)
MGP: 100542478(CHUK) 100542558(IKBKB) 100542773(TBK1) 100548215(IKBKE)
CJO: 107310131(TBK1) 107315625(CHUK) 107323740(IKBKB) 107324928(IKBKE)
NMEL: 110387184(IKBKB) 110388051(IKBKE) 110390496(CHUK) 110392745(TBK1)
APLA: 101790255(IKBKB) 101800085(TBK1) 101800153(IKBKE)
ACYG: 106030064(CHUK) 106041301(IKBKE) 106044397(IKBKB) 106047239(TBK1)
TGU: 100221281(CHUK) 100225072(IKBKB) 100225715(TBK1) 100228860(IKBKE) 116807244
LSR: 110473091(IKBKE) 110473406(IKBKB) 110474031(CHUK) 110479843(TBK1)
SCAN: 103814234(CHUK) 103820400(TBK1) 103822391(IKBKE) 103822735(IKBKB)
PMOA: 120497659(IKBKE) 120499710(CHUK) 120499842(TBK1) 120504880(IKBKB)
OTC: 121336198(CHUK) 121339472(TBK1) 121345534(IKBKE) 121346776(IKBKB)
PRUF: 121349785(IKBKE) 121352548(TBK1) 121358096(CHUK) 121359273(IKBKB)
GFR: 102035648(IKBKB) 102042264(CHUK) 102043917(IKBKE) 102044344(TBK1)
FAB: 101809300(TBK1) 101809821(IKBKB) 101812706(CHUK) 101814828(IKBKE)
PHI: 102100562(IKBKB) 102105384(IKBKE) 102107801(CHUK) 102112102(TBK1)
PMAJ: 107204371(TBK1) 107206726(CHUK) 107213912(IKBKB) 107214767(IKBKE)
CCAE: 111932465(TBK1) 111938770(IKBKB) 111939780(IKBKE)
CCW: 104692514(IKBKE) 104694916(IKBKB) 104695067(CHUK) 104698356(TBK1)
ETL: 114059395(TBK1) 114063148(IKBKE) 114066442(IKBKB) 114067570(CHUK)
FPG: 101911068(TBK1) 101911668(IKBKE) 101922064(IKBKB)
FCH: 102050482(IKBKE) 102051211(TBK1) 102053491(CHUK) 102058892(IKBKB)
CLV: 102084658(CHUK) 102085310(TBK1) 102087238(IKBKB) 102088357(IKBKE)
EGZ: 104122201(TBK1) 104125140(CHUK) 104134342(IKBKE) 104135306(IKBKB)
NNI: 104011019(TBK1) 104013118(IKBKE) 104016028(IKBKB)
ACUN: 113481883(CHUK) 113488090(IKBKB) 113488792(IKBKE) 113491384(TBK1)
PADL: 103919787(IKBKE) 103919972(TBK1) 103920554(IKBKB) 103924297(CHUK)
AAM: 106482786(IKBKE) 106487776(IKBKB) 106488940(TBK1) 106495295(CHUK)
AROW: 112962239(CHUK) 112968150(TBK1) 112971687(IKBKE) 112974186(IKBKB) 112977217
NPD: 112944634(IKBKE) 112948431(CHUK) 112953853(IKBKB) 112958829(TBK1)
DNE: 112978730(TBK1) 112981613 112990380(IKBKE) 112990458(IKBKB)
ASN: 102372815(IKBKE) 102374729(CHUK) 102377560(IKBKB) 102383892(TBK1)
AMJ: 102560016(IKBKE) 102561936(IKBKB) 106736873(CHUK) 106737001(TBK1)
CPOO: 109315543(TBK1) 109317391(IKBKB) 109317718(IKBKE) 109318435(CHUK)
GGN: 109293915(CHUK) 109295258(IKBKE) 109295691(TBK1)
PSS: 102454064(CHUK) 102454676(IKBKB) 102457979(TBK1) 102464043(IKBKE)
CMY: 102930512(IKBKE) 102932073(IKBKB) 102932800(CHUK) 102938424(TBK1)
CPIC: 101931080(CHUK) 101934458(IKBKE) 101945515(IKBKB) 101947523(TBK1)
TST: 117873054(IKBKB) 117875769(IKBKE) 117877447(TBK1) 117879818(CHUK)
CABI: 116819035(IKBKB) 116821811(TBK1) 116832079(IKBKE) 116834403(CHUK)
ACS: 100551699(ikbkb) 100553575(tbk1) 100562496(ikbke) 100565922(chuk)
PVT: 110072148(IKBKB) 110075119(TBK1) 110087236(CHUK) 110088412(IKBKE)
PBI: 103049737(TBK1) 103052688(IKBKB) 103055936(IKBKE) 103061898(CHUK)
PMUR: 107287960(IKBKB) 107291445(CHUK) 107291767(TBK1) 114923654
TSR: 106548060(TBK1) 106548462(CHUK) 106550867
PGUT: 117655703(TBK1) 117667309(CHUK) 117676049(IKBKB)
PMUA: 114596983(CHUK) 114599921(IKBKE) 114602842(IKBKB) 114605270(TBK1)
ZVI: 118085966(IKBKB) 118088913(IKBKE) 118091139(TBK1) 118096210(CHUK)
GJA: 107107812(IKBKB) 107110994(TBK1) 107115324(IKBKE) 107117758(CHUK)
XLA: 108709484(ikbke.S) 108712371(tbk1.S) 432200(ikbkb.L) 444556(chuk.S) 446351(tbk1.L) 734896(ikbke.L)
XTR: 100216212(tbk1) 100487744(ikbke) 448125(ikbkb) 549654(chuk)
NPR: 108791446(IKBKB) 108797654(CHUK) 108804572(TBK1)
DRE: 393287(chuk) 437024(ikbke) 563560(ikbkb) 692289(tbk1)
CCAR: 109074335(tbk1) 109087965 109092137 109095150(ikbkb) 109100658(chuk)
IPU: 108255225(ikbke) 108263650(chuk) 108265675(ikbkb) 108279669(tbk1)
PHYP: 113532072(tbk1) 113533569(ikbkb) 113539673(ikbke) 113542836(chuk)
AMEX: 103023014(tbk1) 103033415(chuk) 103040024(ikbkb) 103047687(ikbke)
EEE: 113579176 113582078(chuk) 113584916(ikbkb) 113586262(tbk1)
TRU: 101062431(ikbkb) 101068225 101069880 101071013(tbk1) 101074146(ikbke)
LCO: 104921662(ikbkb) 104925246(ikbke) 104928982 104930409 104933406(tbk1)
CGOB: 115008674(ikbke) 115013798(ikbkb) 115019941 115024640
ELY: 117247242 117247863 117249427(tbk1) 117252591(ikbkb) 117256447(ikbke)
PLEP: 121944151(ikbkb) 121953671(ikbke) 121954423 121958640 121961280(tbk1)
SLUC: 116034681(tbk1) 116053123 116054000(ikbkb) 116060936 116066925(ikbke)
ECRA: 117936511 117943776(ikbke) 117945478(ikbkb) 117960217
PFLV: 114548159 114550466(tbk1) 114554004(ikbke) 114555052(ikbkb) 114571888
GAT: 120817720(tbk1) 120819606 120820624 120830767(ikbkb) 120834558(ikbke)
PPUG: 119210711(tbk1) 119213096 119214000 119224939(ikbkb) 119229939(ikbke)
MSAM: 119886536(ikbke) 119891193(ikbkb) 119895285(tbk1) 119915458 119917364
CUD: 121505465(tbk1) 121507196(ikbke) 121510304(ikbkb) 121511183 121528381
MZE: 101472803(ikbkb) 101472997(ikbke) 101474803(tbk1) 101486267 101487089
ONL: 100692869 100695544(ikbke) 100698072(ikbkb) 100698148 100711888(tbk1)
OAU: 116311015(ikbkb) 116321245 116321846(tbk1) 116322782 116326446(ikbke)
OLA: 101159621 101168192(tbk1) 101168283(ikbke) 101170684(ikbkb) 101171857
OML: 112145751(ikbke) 112148770(ikbkb) 112154264(chuk) 112157575(tbk1) 112162018
PRET: 103459804(tbk1) 103464875(ikbke) 103470025(ikbkb) 103476976 103481753
CVG: 107083313(ikbke) 107086576 107089566 107089660(ikbkb) 107092989(tbk1)
CTUL: 119778144(ikbkb) 119782488 119790587(tbk1) 119790655 119791731(ikbke)
NFU: 107375593 107385596(ikbke) 107387313(chuk) 107387745(tbk1) 107394259(ikbkb)
KMR: 108229325(tbk1) 108233707(ikbkb) 108234021 108235567(ikbke) 108250658
ALIM: 106513309(ikbke) 106521989(chuk) 106529896 106533626 106536414(ikbkb)
AOCE: 111566565(ikbke) 111567460 111576738(tbk1) 111577292(ikbkb) 111581409
CSEM: 103382474(tbk1) 103386082(ikbke) 103387400 103397763(ikbkb) 103398848
LCF: 108881598(ikbkb) 108882406(tbk1) 108890009(ikbke) 108891107 108892003
SDU: 111220255 111221468(ikbke) 111229518(tbk1) 111234378 111236497(ikbkb)
SLAL: 111655428 111658207 111665990(ikbkb) 111667666(ikbke) 111671054(tbk1)
XGL: 120783001(ikbke) 120794257 120796054 120800421(tbk1) 120805086(ikbkb)
MALB: 109956286 109956664(ikbkb) 109961044 109962729(kctd2) 109967667(tbk1)
SFM: 108920198(ikbkb) 108931981(tbk1) 108933554(chuk) 108938249(ikbke)
PKI: 111836749(chuk) 111847018(tbk1) 111854363(ikbkb) 111854439(ikbke)
AANG: 118206636(ikbkb) 118211103(ikbke) 118220615(chuk) 118232151(tbk1)
LOC: 102687024(tbk1) 102690045(ikbkb) 102691336(chuk) 102692331(ikbke)
LCM: 102356087(TBK1) 102358966(IKBKB) 102361819(CHUK) 102364129(IKBKE)
CMK: 103179820(tbk1) 103181859(chuk) 103182410(ikbke)
RTP: 109918795(chuk) 109927975(ikbkb) 109935579
CIN: 778650(ikk-epsilon) 778921
DME: Dmel_CG2615(IKKepsilon) Dmel_CG4201(IKKbeta)
DSI: Dsimw501_GD20310(Dsim_ird5) Dsimw501_GD24274(Dsim_GD24274)
DYA: Dyak_GE12340 Dyak_GE26340(Dyak_ird5)
PBAR: 105426672
TPRE: 106659803
TCA: 100141977 655324 658218(ik2) 658393(ikkb)
ATD: 109595698
APLN: 108739858
ZCE: 119831974
API: 100168269
DNX: 107165510
AGS: 114121351
RMD: 113555489
DCI: 103512606
DSV: 119436697
TUT: 107368313
BMY: BM_BM9065(Bm9065)
EPA: 110254140
ADF: 107358025
PDAM: 113678513
SPIS: 111325021
AQU: 100636688
 » show all
Reference
1  [PMID:9244310]
  Authors
Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M
  Title
Identification and characterization of an IkappaB kinase.
  Journal
Cell 90:373-83 (1997)
DOI:10.1016/S0092-8674(00)80344-X
  Sequence
[hsa:1147]
Reference
2  [PMID:9346484]
  Authors
Mercurio F, Zhu H, Murray BW, Shevchenko A, Bennett BL, Li J, Young DB, Barbosa M, Mann M, Manning A, Rao A.
  Title
IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.
  Journal
Science 278:860-6 (1997)
DOI:10.1126/science.278.5339.860
  Sequence
[hsa:1147 3551]
Reference
3  [PMID:9346241]
  Authors
Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M.
  Title
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation.
  Journal
Cell 91:243-52 (1997)
DOI:10.1016/S0092-8674(00)80406-7
Reference
4  [PMID:15653325]
  Authors
Viatour P, Merville MP, Bours V, Chariot A.
  Title
Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation.
  Journal
Trends Biochem Sci 30:43-52 (2005)
DOI:10.1016/j.tibs.2004.11.009
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.10
IUBMB Enzyme Nomenclature: 2.7.11.10
ExPASy - ENZYME nomenclature database: 2.7.11.10
BRENDA, the Enzyme Database: 2.7.11.10

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