KEGG ENZYME: 2.7.11.19

ENZYME: 2.7.11.19

Entry

EC 2.7.11.19                Enzyme

Name

phosphorylase kinase;
dephosphophosphorylase kinase;
glycogen phosphorylase kinase;
PHK;
phosphorylase b kinase;
phosphorylase B kinase;
phosphorylase kinase (phosphorylating);
STK17

Class

Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases

Sysname

ATP:phosphorylase-b phosphotransferase

Reaction(IUBMB)

2 ATP + phosphorylase b = 2 ADP + phosphorylase a [RN:R00076]

Reaction(KEGG)

R00076

Substrate

ATP [CPD:C00002];
phosphorylase b [CPD:C02308]

Product

ADP [CPD:C00008];
phosphorylase a [CPD:C02307]

Comment

Requires Ca2+ and calmodulin for activity. The enzyme phosphorylates a specific serine residue in each of the subunits of the dimeric phosphorylase b. For muscle phosphorylase but not liver phosphorylase, this is accompanied by a further dimerization to form a tetrameric phosphorylase. The enzyme couples muscle contraction with energy production via glycogenolysis---glycolysis by catalysing the Ca2+-dependent phosphorylation and activation of glycogen phosphorylase b [5]. The gamma subunit of the tetrameric enzyme is the catalytic subunit.

History

EC 2.7.11.19 created 1961 as EC 2.7.1.38, transferred 2005 to EC 2.7.11.19

Orthology

K00871

phosphorylase kinase gamma subunit

Genes

HSA:	5260(PHKG1) 5261(PHKG2)

PTR:	741602(PHKG2) 746486(PHKG1)

PPS:	100983464(PHKG2) 100986631(PHKG1)

GGO:	101125302(PHKG2)

PON:	100453698(PHKG1) 100455717(PHKG2)

NLE:	100588039(PHKG2) 100594015 115830981(PHKG1)

MCC:	100423096(PHKG2) 703091(PHKG1)

MCF:	102125953(PHKG1) 102128006(PHKG2)

CSAB:

103226033(PHKG1) 103231924(PHKG2)

CATY:

105571983(PHKG1) 105599267(PHKG2)

PANU:

101017842(PHKG2) 101023830(PHKG1)

TGE:	112613788(PHKG2) 112620149(PHKG1)

RRO:	104661547(PHKG2) 104675874(PHKG1)

RBB:	108526509(PHKG1) 108530886(PHKG2)

TFN:	117073532 117083595 117087666(PHKG2)

PTEH:

111525612(PHKG2) 111528016(PHKG1)

CJC:	100412760(PHKG2) 100414478(PHKG1)

SBQ:	101045885(PHKG2) 101048522(PHKG1)

CSYR:

103264376(PHKG2) 103272711(PHKG1)

MMUR:

105871018(PHKG1) 105871065(PHKG2)

LCAT:

123632666(PHKG1) 123632711(PHKG2)

OGA:	100942099(PHKG2) 100953265(PHKG1)

MMU:	18682(Phkg1) 68961(Phkg2)

MCAL:

110294811(Phkg1) 110298655(Phkg2)

MPAH:

110312993(Phkg1) 110337850(Phkg2)

RNO:	140671(Phkg2) 29353(Phkg1)

MCOC:

116068481(Phkg1) 116103020(Phkg2)

MUN:	110547989(Phkg2) 110560975(Phkg1)

CGE:	100750910(Phkg2) 100754334(Phkg1)

MAUA:

101828949(Phkg2) 101840125(Phkg1)

PLEU:

114693674(Phkg1) 114704378(Phkg2)

MORG:

121445879(Phkg1) 121458032(Phkg2)

AAMP:

119807018(Phkg2) 119825273(Phkg1)

NGI:	103726346(Phkg2) 103738953(Phkg1)

HGL:	101700591(Phkg2) 101707775(Phkg1)

CPOC:

100714336(Phkg2) 100732648(Phkg1)

CCAN:

109677759(Phkg1) 109682498(Phkg2)

DORD:

105982215(Phkg2) 105998474(Phkg1)

DSP:	122096289(Phkg2) 122114880(Phkg1)

NCAR:

124970212 124970758

OCU:	100009297(PHKG1) 100355661(PHKG2)

OPI:	101517824(PHKG2) 101520150(PHKG1)

TUP:	102476302(PHKG1) 102480103(PHKG2) 102498323

CFA:	489784(PHKG1) 607275(PHKG2)

VVP:	112929247(PHKG2) 112934117(PHKG1)

VLG:	121487929(PHKG2) 121487998(PHKG1)

AML:	100477667(PHKG1) 100478501(PHKG2)

UMR:	103657874(PHKG2) 103670188(PHKG1)

UAH:	113267697(PHKG2) 113267739(PHKG1)

UAR:	123784657(PHKG2) 123784697(PHKG1)

ELK:	111146405 111162228

LLV:	125090418 125090709

MPUF:

101673513(PHKG1) 101682961(PHKG2)

ORO:	101366392(PHKG1) 101373618(PHKG2)

EJU:	114214357(PHKG1) 114214412(PHKG2)

ZCA:	113933425(PHKG2) 113933683(PHKG1)

MLX:	117999543(PHKG1) 117999585(PHKG2)

FCA:	101081184(PHKG1) 101092572(PHKG2)

PYU:	121017789(PHKG1) 121022214(PHKG2)

PBG:	122471390(PHKG1) 122471437(PHKG2)

PTG:	102958678(PHKG2) 102965580(PHKG1)

PPAD:

109250661(PHKG1) 109258973(PHKG2)

AJU:	106972855(PHKG1) 106979102(PHKG2)

HHV:	120235665(PHKG1) 120242267(PHKG2)

BTA:	512670(PHKG2) 540682(PHKG1)

BOM:	102266225(PHKG1) 102279229(PHKG2)

BIU:	109578248(PHKG1) 109578294(PHKG2)

BBUB:

102408486(PHKG2) 102414182(PHKG1)

CHX:	100861337(PHKG2) 102185139(PHKG1)

OAS:	100217403(PHKG2) 101109323(PHKG1)

ODA:	120876938(PHKG2) 120877899(PHKG1)

CCAD:

122432793(PHKG1) 122433072(PHKG2)

SSC:	100310801(PHKG2) 397548(PHKG1)

CFR:	102509900(PHKG1) 102517940(PHKG2)

CBAI:

105082757(PHKG1) 105082793(PHKG2)

CDK:	105089705(PHKG1) 105102728(PHKG2)

VPC:	102526926(PHKG2) 102535063(PHKG1)

BACU:

103011969(PHKG1) 103020540(PHKG2)

LVE:	103069260(PHKG1) 103082932(PHKG2)

OOR:	101270202(PHKG1) 101281573(PHKG2)

DLE:	111182088(PHKG1) 111182126(PHKG2)

PCAD:

102978084(PHKG2) 102982207(PHKG1)

PSIU:

116739983(PHKG1) 116740362(PHKG2)

ECB:	100061404(PHKG1) 100065274(PHKG2)

EPZ:	103547228(PHKG2) 103566047(PHKG1)

EAI:	106831860(PHKG1) 106831907(PHKG2)

MYB:	102249201(PHKG2) 102254502(PHKG1)

MYD:	102751284(PHKG2) 102760309(PHKG1)

MMYO:

118655777(PHKG2) 118656819(PHKG1)

MLF:	102423171(PHKG1) 102441572(PHKG2)

MNA:	107524377(PHKG1) 107542003(PHKG2)

PKL:	118702918(PHKG1) 118704829

HAI:	109374179(PHKG2) 109376279(PHKG1)

DRO:	112304780(PHKG2) 112314866(PHKG1)

SHON:

118976256(PHKG1) 118997397

AJM:	119041148(PHKG2) 119055031(PHKG1)

PDIC:

114493851(PHKG2) 114505420(PHKG1)

PHAS:

123806334(PHKG1) 123825658

MMF:	118641943(PHKG1) 118642446(PHKG2)

RFQ:	117019729(PHKG2) 117024807(PHKG1)

PALE:

102879938(PHKG1) 102882222(PHKG2)

PGIG:

120591810(PHKG1) 120620078(PHKG2)

PVP:	105296734(PHKG1) 105304523(PHKG2)

RAY:	107503972(PHKG2) 107507449(PHKG1)

MJV:	108385379(PHKG2) 108405955(PHKG1)

TOD:	119241473(PHKG1) 119241726(PHKG2)

SARA:

101543506(PHKG2) 101553368(PHKG1)

LAV:	100660711(PHKG2) 100663820(PHKG1)

TMU:	101347179 101351533

DNM:	101427602(PHKG2) 101435143(PHKG1)

MDO:	100012992(PHKG2) 100013442(PHKG1)

GAS:	123233610(PHKG2) 123244550(PHKG1)

SHR:	100920220(PHKG1) 100927663(PHKG2)

PCW:	110221270(PHKG1) 110223219(PHKG2)

OAA:	100088260(PHKG1) 100093441(PHKG2)

GGA:	417543(PHKG1)

PCOC:

116228111(PHKG1)

MGP:	100546214(PHKG1)

CJO:	107322445(PHKG1)

NMEL:

110407838(PHKG1)

APLA:

101793068(PHKG1)

ACYG:

106041427(PHKG1)

AFUL:

116497307(PHKG1)

TGU:	100221300(PHKG1)

LSR:	110482022(PHKG1)

SCAN:

103820093(PHKG1)

PMOA:

120507819(PHKG1)

OTC:	121345767(PHKG1)

PRUF:

121361655(PHKG1)

GFR:	102038175(PHKG1)

FAB:	101811164(PHKG1)

PHI:	102104524(PHKG1)

PMAJ:

107212749(PHKG1)

CCAE:

111937725(PHKG1)

CCW:	104691086(PHKG1)

ETL:	114060505(PHKG1)

ZAB:	102075324(PHKG1)

FPG:	101920077(PHKG1)

FCH:	102054686(PHKG1)

CLV:	102085380(PHKG1)

EGZ:	104131918(PHKG1)

NNI:	104016101(PHKG1)

PLET:

104614147(PHKG1)

ACUN:

113487119(PHKG1)

TALA:

104359193(PHKG1)

PADL:

103925605(PHKG1)

ACHC:

115347122(PHKG1)

AROW:

112978577(PHKG1)

NPD:	112945399(PHKG1)

DNE:	112987390(PHKG1)

ASN:	102372756(PHKG1) 102380957(PHKG2)

AMJ:	102572090(PHKG2) 102574725(PHKG1)

CPOO:

109317058(PHKG1)

GGN:	109293440(PHKG1)

PSS:	102445349(PHKG2) 102455436(PHKG1)

CMY:	102934958(PHKG2) 102939493(PHKG1)

CPIC:

101932837(PHKG1) 101949847(PHKG2)

TST:	117867504(PHKG1) 117876272(PHKG2)

CABI:

116815071(PHKG2) 116821327(PHKG1)

MRV:	120387084(PHKG1) 120403179(PHKG2)

ACS:	100557980(phkg2)

PVT:	110084500(PHKG1) 110090073(PHKG2)

SUND:

121916974(PHKG1) 121934241(PHKG2)

PBI:	103061914(PHKG2) 103065315(PHKG1)

PMUR:

107287056(PHKG1) 107300286

TSR:	106552842(PHKG2)

PGUT:

117666808(PHKG2) 117667539(PHKG1)

VKO:	123032249(PHKG2) 123036661(PHKG1)

PMUA:

114583711(PHKG2) 114585912(PHKG1)

ZVI:	118094673(PHKG2) 118097034(PHKG1)

GJA:	107111216(PHKG2) 107112491(PHKG1)

STOW:

125444796(PHKG2) 125445464(PHKG1)

XLA:	108708334(phkg1.L) 373780(phkg1.S) 496328(phkg2.L)

XTR:	448255(phkg1) 779740(phkg2)

NPR:	108799187(PHKG1) 108803931(PHKG2)

RTEM:

120926616(PHKG1) 120942880(PHKG2)

BBUF:

120995534(PHKG1) 121008526(PHKG2)

BGAR:

122932805(PHKG1) 122945299(PHKG2)

DRE:	393937(phkg2) 554046(phkg1b) 565379(phkg1a)

SRX:	107715340 107730984 107743765 107747678 107754103 107756070

SANH:

107655811 107669401 107675026 107677094 107677866 107699969

SGH:	107563781 107566018 107567175 107567581 107574034

CCAR:

109069376 109069379 109097561 109097759

CAUA:

113063635 113074328 113079985 113098387 113111475(phkg2) 113115331

PPRM:

120464696(phkg1a) 120474564(phkg2) 120494635(phkg1b)

MAMB:

125248481(phkg1a) 125252630(phkg1b) 125255993(phkg2)

IPU:	108273676(phkg2) 108280550(phkg1a)

PHYP:

113527058(phkg2) 113541799 113543328(phkg1)

SMEO:

124388593(phkg2) 124402848(phkg1a)

TFD:	113638930(phkg2) 113652847(phkg1a)

AMEX:

103023937 103041098(phkg2) 103046290

EEE:	113573644(phkg1) 113583965(phkg2) 113584646

TRU:	101077385(phkg2) 101080204(phkg1)

TNG:	GSTEN00024080G001 GSTEN00035702G001

LCO:	104923220(phkg2) 104936522(phkg1)

NCC:	104946331(phkg2) 104964917

CGOB:

115017640(phkg1) 115025091(phkg2)

ELY:	117246647(phkg2) 117260119(phkg1a)

PLEP:

121943338 121959332(phkg2)

SLUC:

116044288(phkg2) 116047992(phkg1a)

ECRA:

117937148(phkg2) 117942209(phkg1a)

PFLV:

114548023(phkg2) 114549461(phkg1)

GAT:	120819044(phkg2) 120835316

PPUG:

119213401(phkg2) 119221840(phkg1a)

MSAM:

119882387 119915987(phkg2)

CUD:	121523885 121528945(phkg2)

ALAT:

119009517(phkg2) 119030366(phkg1a)

MZE:	101469795(phkg1) 101485765(phkg2)

ONL:	100694651(phkg1) 100694837(phkg2)

OAU:	116316002 116319882(phkg2)

OLA:	101165598(phkg2) 101167060(phkg1)

OML:	112149621 112154320(phkg2)

XMA:	102229601(phkg2) 102233585(phkg1)

XCO:	114133398(phkg1) 114157788(phkg2)

XHE:	116708153(phkg1) 116727743(phkg2)

PRET:

103474557(phkg1) 103481060(phkg2)

PFOR:

103155081 103155198(phkg1)

PLAI:

106942046 106957239(phkg1)

PMEI:

106907820 106927278(phkg1)

GAF:	122822788(phkg2) 122833177

CVG:	107088313(phkg1) 107089513

CTUL:

119782813 119793720(phkg2)

GMU:	124875028(phkg2) 124884141

NFU:	107380364(phkg1) 107388054 107388073(phkg2)

KMR:	108237211(phkg2) 108246020(phkg1a)

ALIM:

106515467(phkg1) 106517365

NWH:	119410594(phkg1a) 119423417(phkg2)

AOCE:

111564740(phkg1) 111584911(phkg2)

CSEM:

103378132(phkg1) 103381724(phkg2)

POV:	109627136(phkg2) 109629980(phkg1)

SSEN:

122759311(phkg2) 122760604

HHIP:

117753024(phkg2) 117773232(phkg1a)

HSP:	118100551(phkg2) 118105810(phkg1a)

LCF:	108886377(phkg1) 108886752(phkg2)

SDU:	111219834(phkg2) 111228039(phkg1)

SLAL:

111650931(phkg1) 111658612(phkg2)

XGL:	120791493 120794168(phkg2)

HCQ:	109525437(phkg1) 109530189(phkg2)

BPEC:

110154096 110159624(phkg2)

MALB:

109960264(phkg1) 109963558(phkg2)

BSPL:

114845723(phkg2) 114868105(phkg1a)

SASA:

100195216(phkg2) 106581056 106612828

OTW:	112223679(phkg2) 112265471(phkg1a)

OMY:	110491588(phkg2) 110507716(phkg1a)

OGO:	123992778(phkg1a) 124048338(phkg2)

ONE:	115106549 115136794(phkg1)

SALP:

111956767 111977401 111982583

SNH:	120018218 120028957 120046243(phkg2)

ELS:	105021305 105030287(phkg1)

SFM:	108922452(phkg1)

PKI:	111847182(phkg1)

AANG:

118220570(phkg2) 118235967

LOC:	102695754(phkg1)

PSPA:

121306827(phkg2) 121308581(phkg1b)

ARUT:

117429493 117430719 117967194(phkg2)

LCM:	102345800(PHKG1) 102362563

CMK:

103188445

RTP:	109917579 109938585

BFO:

118426605

BBEL:

109466676

CIN:

100182979

SCLV:

120346799

SPU:

582497

APLC:

110980692

SKO:

102804634

DME:	Dmel_CG1830(PhKgamma)

DER:

6551326

DSE:

6619897

DSI:	Dsimw501_GD17041(Dsim_GD17041)

DYA:	Dyak_GE15660

DAN:

6503515

DSR:

110184224

DPO:	Dpse_GA14880

DPE:

6600411

DMN:

108153016

DWI:

6641221

DGR:

6566254

DMO:	Dmoj_GI16230

DAZ:

108618638

DNV:

108656298

DHE:

111605130

DVI:

6634800

CCAT:

101455500

BOD:

106619549

MDE:

101900257

SCAC:

106082103

LCQ:

111686460

LSQ:

119606995

HIS:

119656302

AGA:	AgaP_AGAP002647

ACOZ:

120952908

AARA:

120908442

ASTE:

118504952

AAG:

5578562

AALB:

109418342 115253710

CQU:	CpipJ_CPIJ014338 CpipJ_CPIJ014339

CPII:

120420459

CNS:

116349901

BCOO:

119074758

AME:	107964213 550645

ACER:

107994806

ALAB:

122715414

BIM:	100745483 105682157

BBIF:

117213926

BVK:

117237598

BVAN:

117157564

BTER:

100644069

BPYO:

122572599

CCAL:

108628393

OBB:	114878897 114878899

MGEN:

117227035

NMEA:

116429195

CGIG:

122400146

SOC:

105203941

MPHA:

105838151

AEC:

105144123

PBAR:

105434370

VEM:

105560950

HST:

105183521

DQU:

106749081

CFO:

105255564

FEX:

115246089

LHU:

105667336

PGC:

109856378

OBO:

105280515

PCF:

106790636

PFUC:

122513387

VPS:

122637122

NVI:

100117602

CSOL:

105365361

TPRE:

106659158

MDL:

103571859

CGLO:

123271665

FAS:

105263642

DAM:

107043954

AGIF:

122852244

CCIN:

107268633

TCA:

655530

DPA:

109543742

SOY:

115881572

ATD:

109600150

CSET:

123319992

AGB:

108913185

LDC:

111502690

NVL:

108565553

APLN:

108743885 112903987

PPYR:

116162573

OTU:

111417464

BMOR:

101743489

BMAN:

114240512

MSEX:

115446834

DPL:	KGM_212724

BANY:

112049934

PMAC:

106707485 106709848

PPOT:

106109289

PXU:

106117943

PRAP:

110998330

ZCE:

119836322

HAW:

110380614

TNL:

113503033

SLIU:

111360141

OFU:

114364767

PXY:

105380550

API:

100168501

DNX:

107163272

AGS:

114120380

RMD:

113549900

BTAB:

109036818

DCI:

103524519

CLEC:

106665838

HHAL:

106679629

NLU:

111045286

PHU:	Phum_PHUM607620

FOC:

113205730

TPAL:

117643052

ZNE:

110830693

FCD:

110853985

DPX:	DAPPUDRAFT_303518

DMK:

116931076

PVM:

113815105

PJA:

122252910

PCHN:

125042074

HAME:

121853966

PCLA:

123773457

PTRU:

123520633

HAZT:

108672972

EAF:

111697010

LSM:	121114117 121119945

PPOI:

119112076 119112204

ISC:	IscW_ISCW015509

DSV:

119446828

RSAN:

119389346

RMP:

119183669

VJA:

111259722

TUT:

107369709

DPTE:

113791735

DFR:

124493425

CSCU:

111622314 111622331

PTEP:

107439334

SDM:

118205337

CEL:	CELE_Y50D7A.3(Y50D7A.3)

CBR:

CBG_15711

BMY:	BM_BM6708(Bm6708)

LOA:	LOAG_17265 LOAG_17266

NAI:	NECAME_03497

TSP:

Tsp_00128

HRO:	HELRODRAFT_185431 HELRODRAFT_82909

LGI:	LOTGIDRAFT_209139

PCAN:

112561347

BGT:	106056379 106060923 106070907

GAE:

121368874

HRF:	124133390 124137517

HRJ:

124289263

CRG:

105317472

MYI:

110462867

PMAX:

117332829

MMER:

123534419 123534848

OBI:

106871486

OSN:

115213407

LAK:	106157129 106172511

SMM:	Smp_098840

SHX:	MS3_0014654

OVI:	T265_09098

EGL:

EGR_05948

NVE:

5516534

EPA:

110233083

ATEN:

116297762

ADF:

107344746

AMIL:

114960188

PDAM:

113665510

SPIS:

111344824

DGT:	114523818 114524037

XEN:

124434835

HMG:

100207615

AQU:

100641898

PTM:	GSPATT00035369001 GSPATT00035512001 GSPATT00036542001

PTI:	PHATRDRAFT_14702

PIF:	PITG_02565

PCU:	PC_RS05430

» show all

Reference

1 [PMID:13315361]

Authors

KREBS EG, FISCHER EH.

Title

The phosphorylase b to a converting enzyme of rabbit skeletal muscle.

Journal

Biochim Biophys Acta 20:150-7 (1956)
DOI:10.1016/0006-3002(56)90273-6

Reference

2 [PMID:13538949]

Authors

KREBS EG, KENT AB, FISCHER EH.

Title

The muscle phosphorylase b kinase reaction.

Journal

J Biol Chem 231:73-83 (1958)

Reference

3 [PMID:13315351]

Authors

RALL TW, WOSILAIT WD, SUTHERLAND EW.

Title

The interconversion of phosphorylase a and phosphorylase b from dog heart muscle.

Journal

Biochim Biophys Acta 20:69-76 (1956)
DOI:10.1016/0006-3002(56)90264-5

Reference

4 [PMID:4029141]

Authors

Nikolaropoulos S, Sotiroudis TG.

Title

Phosphorylase kinase from chicken gizzard. Partial purification and characterization.

Journal

Eur J Biochem 151:467-73 (1985)
DOI:10.1111/j.1432-1033.1985.tb09125.x

Reference

5 [PMID:1931956]

Authors

Farrar YJ, Carlson GM.

Title

Kinetic characterization of the calmodulin-activated catalytic subunit of phosphorylase kinase.

Journal

Biochemistry 30:10274-9 (1991)
DOI:10.1021/bi00106a027

Reference

6 [PMID:7673209]

Authors

Dasgupta M, Blumenthal DK.

Title

Characterization of the regulatory domain of the gamma-subunit of phosphorylase kinase. The two noncontiguous calmodulin-binding subdomains are also autoinhibitory.

Journal

J Biol Chem 270:22283-9 (1995)
DOI:10.1074/jbc.270.38.22283

Sequence

[ocu:100009297]

Reference

7 [PMID:9362479]

Authors

Lowe ED, Noble ME, Skamnaki VT, Oikonomakos NG, Owen DJ, Johnson LN

Title

The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition.

Journal

EMBO J 16:6646-58 (1997)
DOI:10.1093/emboj/16.22.6646