KEGG   ENZYME: 2.7.11.19
Entry
EC 2.7.11.19                Enzyme                                 
Name
phosphorylase kinase;
dephosphophosphorylase kinase;
glycogen phosphorylase kinase;
PHK;
phosphorylase b kinase;
phosphorylase B kinase;
phosphorylase kinase (phosphorylating);
STK17
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
Sysname
ATP:phosphorylase-b phosphotransferase
Reaction(IUBMB)
2 ATP + phosphorylase b = 2 ADP + phosphorylase a [RN:R00076]
Reaction(KEGG)
R00076
Substrate
ATP [CPD:C00002];
phosphorylase b [CPD:C02308]
Product
ADP [CPD:C00008];
phosphorylase a [CPD:C02307]
Comment
Requires Ca2+ and calmodulin for activity. The enzyme phosphorylates a specific serine residue in each of the subunits of the dimeric phosphorylase b. For muscle phosphorylase but not liver phosphorylase, this is accompanied by a further dimerization to form a tetrameric phosphorylase. The enzyme couples muscle contraction with energy production via glycogenolysis---glycolysis by catalysing the Ca2+-dependent phosphorylation and activation of glycogen phosphorylase b [5]. The gamma subunit of the tetrameric enzyme is the catalytic subunit.
History
EC 2.7.11.19 created 1961 as EC 2.7.1.38, transferred 2005 to EC 2.7.11.19
Orthology
K00871  phosphorylase kinase gamma subunit
Genes
HSA5260(PHKG1) 5261(PHKG2)
PTR741602(PHKG2) 746486(PHKG1)
PPS100983464(PHKG2) 100986631(PHKG1)
GGO101125302(PHKG2)
PON100453698(PHKG1) 100455717(PHKG2)
NLE100588039(PHKG2) 100594015 115830981(PHKG1)
MCC100423096(PHKG2) 703091(PHKG1)
MCF102125953(PHKG1) 102128006(PHKG2)
CSAB103226033(PHKG1) 103231924(PHKG2)
CATY105571983(PHKG1) 105599267(PHKG2)
PANU101017842(PHKG2) 101023830(PHKG1)
TGE112613788(PHKG2) 112620149(PHKG1)
RRO104661547(PHKG2) 104675874(PHKG1)
RBB108526509(PHKG1) 108530886(PHKG2)
TFN117073532 117083595 117087666(PHKG2)
PTEH111525612(PHKG2) 111528016(PHKG1)
CJC100412760(PHKG2) 100414478(PHKG1)
SBQ101045885(PHKG2) 101048522(PHKG1)
CSYR103264376(PHKG2) 103272711(PHKG1)
MMUR105871018(PHKG1) 105871065(PHKG2)
LCAT123632666(PHKG1) 123632711(PHKG2)
OGA100942099(PHKG2) 100953265(PHKG1)
MMU18682(Phkg1) 68961(Phkg2)
MCAL110294811(Phkg1) 110298655(Phkg2)
MPAH110312993(Phkg1) 110337850(Phkg2)
RNO140671(Phkg2) 29353(Phkg1)
MCOC116068481(Phkg1) 116103020(Phkg2)
MUN110547989(Phkg2) 110560975(Phkg1)
CGE100750910(Phkg2) 100754334(Phkg1)
MAUA101828949(Phkg2) 101840125(Phkg1)
PLEU114693674(Phkg1) 114704378(Phkg2)
MORG121445879(Phkg1) 121458032(Phkg2)
AAMP119807018(Phkg2) 119825273(Phkg1)
NGI103726346(Phkg2) 103738953(Phkg1)
HGL101700591(Phkg2) 101707775(Phkg1)
CPOC100714336(Phkg2) 100732648(Phkg1)
CCAN109677759(Phkg1) 109682498(Phkg2)
DORD105982215(Phkg2) 105998474(Phkg1)
DSP122096289(Phkg2) 122114880(Phkg1)
NCAR124970212 124970758
OCU100009297(PHKG1) 100355661(PHKG2)
OPI101517824(PHKG2) 101520150(PHKG1)
TUP102476302(PHKG1) 102480103(PHKG2) 102498323
CFA489784(PHKG1) 607275(PHKG2)
VVP112929247(PHKG2) 112934117(PHKG1)
VLG121487929(PHKG2) 121487998(PHKG1)
AML100477667(PHKG1) 100478501(PHKG2)
UMR103657874(PHKG2) 103670188(PHKG1)
UAH113267697(PHKG2) 113267739(PHKG1)
UAR123784657(PHKG2) 123784697(PHKG1)
ELK111146405 111162228
LLV125090418 125090709
MPUF101673513(PHKG1) 101682961(PHKG2)
ORO101366392(PHKG1) 101373618(PHKG2)
EJU114214357(PHKG1) 114214412(PHKG2)
ZCA113933425(PHKG2) 113933683(PHKG1)
MLX117999543(PHKG1) 117999585(PHKG2)
FCA101081184(PHKG1) 101092572(PHKG2)
PYU121017789(PHKG1) 121022214(PHKG2)
PBG122471390(PHKG1) 122471437(PHKG2)
PTG102958678(PHKG2) 102965580(PHKG1)
PPAD109250661(PHKG1) 109258973(PHKG2)
AJU106972855(PHKG1) 106979102(PHKG2)
HHV120235665(PHKG1) 120242267(PHKG2)
BTA512670(PHKG2) 540682(PHKG1)
BOM102266225(PHKG1) 102279229(PHKG2)
BIU109578248(PHKG1) 109578294(PHKG2)
BBUB102408486(PHKG2) 102414182(PHKG1)
CHX100861337(PHKG2) 102185139(PHKG1)
OAS100217403(PHKG2) 101109323(PHKG1)
ODA120876938(PHKG2) 120877899(PHKG1)
CCAD122432793(PHKG1) 122433072(PHKG2)
SSC100310801(PHKG2) 397548(PHKG1)
CFR102509900(PHKG1) 102517940(PHKG2)
CBAI105082757(PHKG1) 105082793(PHKG2)
CDK105089705(PHKG1) 105102728(PHKG2)
VPC102526926(PHKG2) 102535063(PHKG1)
BACU103011969(PHKG1) 103020540(PHKG2)
LVE103069260(PHKG1) 103082932(PHKG2)
OOR101270202(PHKG1) 101281573(PHKG2)
DLE111182088(PHKG1) 111182126(PHKG2)
PCAD102978084(PHKG2) 102982207(PHKG1)
PSIU116739983(PHKG1) 116740362(PHKG2)
ECB100061404(PHKG1) 100065274(PHKG2)
EPZ103547228(PHKG2) 103566047(PHKG1)
EAI106831860(PHKG1) 106831907(PHKG2)
MYB102249201(PHKG2) 102254502(PHKG1)
MYD102751284(PHKG2) 102760309(PHKG1)
MMYO118655777(PHKG2) 118656819(PHKG1)
MLF102423171(PHKG1) 102441572(PHKG2)
MNA107524377(PHKG1) 107542003(PHKG2)
PKL118702918(PHKG1) 118704829
HAI109374179(PHKG2) 109376279(PHKG1)
DRO112304780(PHKG2) 112314866(PHKG1)
SHON118976256(PHKG1) 118997397
AJM119041148(PHKG2) 119055031(PHKG1)
PDIC114493851(PHKG2) 114505420(PHKG1)
PHAS123806334(PHKG1) 123825658
MMF118641943(PHKG1) 118642446(PHKG2)
RFQ117019729(PHKG2) 117024807(PHKG1)
PALE102879938(PHKG1) 102882222(PHKG2)
PGIG120591810(PHKG1) 120620078(PHKG2)
PVP105296734(PHKG1) 105304523(PHKG2)
RAY107503972(PHKG2) 107507449(PHKG1)
MJV108385379(PHKG2) 108405955(PHKG1)
TOD119241473(PHKG1) 119241726(PHKG2)
SARA101543506(PHKG2) 101553368(PHKG1)
LAV100660711(PHKG2) 100663820(PHKG1)
TMU101347179 101351533
DNM101427602(PHKG2) 101435143(PHKG1)
MDO100012992(PHKG2) 100013442(PHKG1)
GAS123233610(PHKG2) 123244550(PHKG1)
SHR100920220(PHKG1) 100927663(PHKG2)
PCW110221270(PHKG1) 110223219(PHKG2)
OAA100088260(PHKG1) 100093441(PHKG2)
GGA417543(PHKG1)
PCOC116228111(PHKG1)
MGP100546214(PHKG1)
CJO107322445(PHKG1)
NMEL110407838(PHKG1)
APLA101793068(PHKG1)
ACYG106041427(PHKG1)
AFUL116497307(PHKG1)
TGU100221300(PHKG1)
LSR110482022(PHKG1)
SCAN103820093(PHKG1)
PMOA120507819(PHKG1)
OTC121345767(PHKG1)
PRUF121361655(PHKG1)
GFR102038175(PHKG1)
FAB101811164(PHKG1)
PHI102104524(PHKG1)
PMAJ107212749(PHKG1)
CCAE111937725(PHKG1)
CCW104691086(PHKG1)
ETL114060505(PHKG1)
ZAB102075324(PHKG1)
FPG101920077(PHKG1)
FCH102054686(PHKG1)
CLV102085380(PHKG1)
EGZ104131918(PHKG1)
NNI104016101(PHKG1)
PLET104614147(PHKG1)
ACUN113487119(PHKG1)
TALA104359193(PHKG1)
PADL103925605(PHKG1)
ACHC115347122(PHKG1)
AROW112978577(PHKG1)
NPD112945399(PHKG1)
DNE112987390(PHKG1)
ASN102372756(PHKG1) 102380957(PHKG2)
AMJ102572090(PHKG2) 102574725(PHKG1)
CPOO109317058(PHKG1)
GGN109293440(PHKG1)
PSS102445349(PHKG2) 102455436(PHKG1)
CMY102934958(PHKG2) 102939493(PHKG1)
CPIC101932837(PHKG1) 101949847(PHKG2)
TST117867504(PHKG1) 117876272(PHKG2)
CABI116815071(PHKG2) 116821327(PHKG1)
MRV120387084(PHKG1) 120403179(PHKG2)
ACS100557980(phkg2)
PVT110084500(PHKG1) 110090073(PHKG2)
SUND121916974(PHKG1) 121934241(PHKG2)
PBI103061914(PHKG2) 103065315(PHKG1)
PMUR107287056(PHKG1) 107300286
TSR106552842(PHKG2)
PGUT117666808(PHKG2) 117667539(PHKG1)
VKO123032249(PHKG2) 123036661(PHKG1)
PMUA114583711(PHKG2) 114585912(PHKG1)
ZVI118094673(PHKG2) 118097034(PHKG1)
GJA107111216(PHKG2) 107112491(PHKG1)
STOW125444796(PHKG2) 125445464(PHKG1)
XLA108708334(phkg1.L) 373780(phkg1.S) 496328(phkg2.L)
XTR448255(phkg1) 779740(phkg2)
NPR108799187(PHKG1) 108803931(PHKG2)
RTEM120926616(PHKG1) 120942880(PHKG2)
BBUF120995534(PHKG1) 121008526(PHKG2)
BGAR122932805(PHKG1) 122945299(PHKG2)
DRE393937(phkg2) 554046(phkg1b) 565379(phkg1a)
SRX107715340 107730984 107743765 107747678 107754103 107756070
SANH107655811 107669401 107675026 107677094 107677866 107699969
SGH107563781 107566018 107567175 107567581 107574034
CCAR109069376 109069379 109097561 109097759
CAUA113063635 113074328 113079985 113098387 113111475(phkg2) 113115331
PPRM120464696(phkg1a) 120474564(phkg2) 120494635(phkg1b)
MAMB125248481(phkg1a) 125252630(phkg1b) 125255993(phkg2)
IPU108273676(phkg2) 108280550(phkg1a)
PHYP113527058(phkg2) 113541799 113543328(phkg1)
SMEO124388593(phkg2) 124402848(phkg1a)
TFD113638930(phkg2) 113652847(phkg1a)
AMEX103023937 103041098(phkg2) 103046290
EEE113573644(phkg1) 113583965(phkg2) 113584646
TRU101077385(phkg2) 101080204(phkg1)
TNGGSTEN00024080G001 GSTEN00035702G001
LCO104923220(phkg2) 104936522(phkg1)
NCC104946331(phkg2) 104964917
CGOB115017640(phkg1) 115025091(phkg2)
ELY117246647(phkg2) 117260119(phkg1a)
PLEP121943338 121959332(phkg2)
SLUC116044288(phkg2) 116047992(phkg1a)
ECRA117937148(phkg2) 117942209(phkg1a)
PFLV114548023(phkg2) 114549461(phkg1)
GAT120819044(phkg2) 120835316
PPUG119213401(phkg2) 119221840(phkg1a)
MSAM119882387 119915987(phkg2)
CUD121523885 121528945(phkg2)
ALAT119009517(phkg2) 119030366(phkg1a)
MZE101469795(phkg1) 101485765(phkg2)
ONL100694651(phkg1) 100694837(phkg2)
OAU116316002 116319882(phkg2)
OLA101165598(phkg2) 101167060(phkg1)
OML112149621 112154320(phkg2)
XMA102229601(phkg2) 102233585(phkg1)
XCO114133398(phkg1) 114157788(phkg2)
XHE116708153(phkg1) 116727743(phkg2)
PRET103474557(phkg1) 103481060(phkg2)
PFOR103155081 103155198(phkg1)
PLAI106942046 106957239(phkg1)
PMEI106907820 106927278(phkg1)
GAF122822788(phkg2) 122833177
CVG107088313(phkg1) 107089513
CTUL119782813 119793720(phkg2)
GMU124875028(phkg2) 124884141
NFU107380364(phkg1) 107388054 107388073(phkg2)
KMR108237211(phkg2) 108246020(phkg1a)
ALIM106515467(phkg1) 106517365
NWH119410594(phkg1a) 119423417(phkg2)
AOCE111564740(phkg1) 111584911(phkg2)
CSEM103378132(phkg1) 103381724(phkg2)
POV109627136(phkg2) 109629980(phkg1)
SSEN122759311(phkg2) 122760604
HHIP117753024(phkg2) 117773232(phkg1a)
HSP118100551(phkg2) 118105810(phkg1a)
LCF108886377(phkg1) 108886752(phkg2)
SDU111219834(phkg2) 111228039(phkg1)
SLAL111650931(phkg1) 111658612(phkg2)
XGL120791493 120794168(phkg2)
HCQ109525437(phkg1) 109530189(phkg2)
BPEC110154096 110159624(phkg2)
MALB109960264(phkg1) 109963558(phkg2)
BSPL114845723(phkg2) 114868105(phkg1a)
SASA100195216(phkg2) 106581056 106612828
OTW112223679(phkg2) 112265471(phkg1a)
OMY110491588(phkg2) 110507716(phkg1a)
OGO123992778(phkg1a) 124048338(phkg2)
ONE115106549 115136794(phkg1)
SALP111956767 111977401 111982583
SNH120018218 120028957 120046243(phkg2)
ELS105021305 105030287(phkg1)
SFM108922452(phkg1)
PKI111847182(phkg1)
AANG118220570(phkg2) 118235967
LOC102695754(phkg1)
PSPA121306827(phkg2) 121308581(phkg1b)
ARUT117429493 117430719 117967194(phkg2)
LCM102345800(PHKG1) 102362563
CMK103188445
RTP109917579 109938585
BFO118426605
BBEL109466676
CIN100182979
SCLV120346799
SPU582497
APLC110980692
SKO102804634
DMEDmel_CG1830(PhKgamma)
DER6551326
DSE6619897
DSIDsimw501_GD17041(Dsim_GD17041)
DYADyak_GE15660
DAN6503515
DSR110184224
DPODpse_GA14880
DPE6600411
DMN108153016
DWI6641221
DGR6566254
DMODmoj_GI16230
DAZ108618638
DNV108656298
DHE111605130
DVI6634800
CCAT101455500
BOD106619549
MDE101900257
SCAC106082103
LCQ111686460
LSQ119606995
HIS119656302
AGAAgaP_AGAP002647
ACOZ120952908
AARA120908442
ASTE118504952
AAG5578562
AALB109418342 115253710
CQUCpipJ_CPIJ014338 CpipJ_CPIJ014339
CPII120420459
CNS116349901
BCOO119074758
AME107964213 550645
ACER107994806
ALAB122715414
BIM100745483 105682157
BBIF117213926
BVK117237598
BVAN117157564
BTER100644069
BPYO122572599
CCAL108628393
OBB114878897 114878899
MGEN117227035
NMEA116429195
CGIG122400146
SOC105203941
MPHA105838151
AEC105144123
PBAR105434370
VEM105560950
HST105183521
DQU106749081
CFO105255564
FEX115246089
LHU105667336
PGC109856378
OBO105280515
PCF106790636
PFUC122513387
VPS122637122
NVI100117602
CSOL105365361
TPRE106659158
MDL103571859
CGLO123271665
FAS105263642
DAM107043954
AGIF122852244
CCIN107268633
TCA655530
DPA109543742
SOY115881572
ATD109600150
CSET123319992
AGB108913185
LDC111502690
NVL108565553
APLN108743885 112903987
PPYR116162573
OTU111417464
BMOR101743489
BMAN114240512
MSEX115446834
DPLKGM_212724
BANY112049934
PMAC106707485 106709848
PPOT106109289
PXU106117943
PRAP110998330
ZCE119836322
HAW110380614
TNL113503033
SLIU111360141
OFU114364767
PXY105380550
API100168501
DNX107163272
AGS114120380
RMD113549900
BTAB109036818
DCI103524519
CLEC106665838
HHAL106679629
NLU111045286
PHUPhum_PHUM607620
FOC113205730
TPAL117643052
ZNE110830693
FCD110853985
DPXDAPPUDRAFT_303518
DMK116931076
PVM113815105
PJA122252910
PCHN125042074
HAME121853966
PCLA123773457
PTRU123520633
HAZT108672972
EAF111697010
LSM121114117 121119945
PPOI119112076 119112204
ISCIscW_ISCW015509
DSV119446828
RSAN119389346
RMP119183669
VJA111259722
TUT107369709
DPTE113791735
DFR124493425
CSCU111622314 111622331
PTEP107439334
SDM118205337
CELCELE_Y50D7A.3(Y50D7A.3)
CBRCBG_15711
BMYBM_BM6708(Bm6708)
LOALOAG_17265 LOAG_17266
NAINECAME_03497
TSPTsp_00128
HROHELRODRAFT_185431 HELRODRAFT_82909
LGILOTGIDRAFT_209139
PCAN112561347
BGT106056379 106060923 106070907
GAE121368874
HRF124133390 124137517
HRJ124289263
CRG105317472
MYI110462867
PMAX117332829
MMER123534419 123534848
OBI106871486
OSN115213407
LAK106157129 106172511
SMMSmp_098840
SHXMS3_0014654
OVIT265_09098
EGLEGR_05948
NVE5516534
EPA110233083
ATEN116297762
ADF107344746
AMIL114960188
PDAM113665510
SPIS111344824
DGT114523818 114524037
XEN124434835
HMG100207615
AQU100641898
PTMGSPATT00035369001 GSPATT00035512001 GSPATT00036542001
PTIPHATRDRAFT_14702
PIFPITG_02565
PCUPC_RS05430
 » show all
Reference
1  [PMID:13315361]
  Authors
KREBS EG, FISCHER EH.
  Title
The phosphorylase b to a converting enzyme of rabbit skeletal muscle.
  Journal
Biochim Biophys Acta 20:150-7 (1956)
DOI:10.1016/0006-3002(56)90273-6
Reference
2  [PMID:13538949]
  Authors
KREBS EG, KENT AB, FISCHER EH.
  Title
The muscle phosphorylase b kinase reaction.
  Journal
J Biol Chem 231:73-83 (1958)
Reference
3  [PMID:13315351]
  Authors
RALL TW, WOSILAIT WD, SUTHERLAND EW.
  Title
The interconversion of phosphorylase a and phosphorylase b from dog heart muscle.
  Journal
Biochim Biophys Acta 20:69-76 (1956)
DOI:10.1016/0006-3002(56)90264-5
Reference
4  [PMID:4029141]
  Authors
Nikolaropoulos S, Sotiroudis TG.
  Title
Phosphorylase kinase from chicken gizzard. Partial purification and characterization.
  Journal
Eur J Biochem 151:467-73 (1985)
DOI:10.1111/j.1432-1033.1985.tb09125.x
Reference
5  [PMID:1931956]
  Authors
Farrar YJ, Carlson GM.
  Title
Kinetic characterization of the calmodulin-activated catalytic subunit of phosphorylase kinase.
  Journal
Biochemistry 30:10274-9 (1991)
DOI:10.1021/bi00106a027
Reference
6  [PMID:7673209]
  Authors
Dasgupta M, Blumenthal DK.
  Title
Characterization of the regulatory domain of the gamma-subunit of phosphorylase kinase. The two noncontiguous calmodulin-binding subdomains are also autoinhibitory.
  Journal
J Biol Chem 270:22283-9 (1995)
DOI:10.1074/jbc.270.38.22283
  Sequence
[ocu:100009297]
Reference
7  [PMID:9362479]
  Authors
Lowe ED, Noble ME, Skamnaki VT, Oikonomakos NG, Owen DJ, Johnson LN
  Title
The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition.
  Journal
EMBO J 16:6646-58 (1997)
DOI:10.1093/emboj/16.22.6646
  Sequence
[ocu:100009297]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.19
IUBMB Enzyme Nomenclature: 2.7.11.19
ExPASy - ENZYME nomenclature database: 2.7.11.19
BRENDA, the Enzyme Database: 2.7.11.19
CAS: 9001-88-1

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