KEGG   ENZYME: 2.7.11.21
Entry
EC 2.7.11.21                Enzyme                                 
Name
polo kinase;
Cdc5;
Cdc5p;
Plk;
PLK;
Plk1;
Plo1;
POLO kinase;
polo serine-threonine kinase;
polo-like kinase;
polo-like kinase 1;
serine/threonine-specific Drosophila kinase polo;
STK21
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
Sysname
ATP:protein phosphotransferase (spindle-pole-dependent)
Reaction(IUBMB)
ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Reaction(KEGG)
R00162
Substrate
ATP [CPD:C00002];
protein [CPD:C00017]
Product
ADP [CPD:C00008];
phosphoprotein [CPD:C00562]
Comment
The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein [2].
History
EC 2.7.11.21 created 2005 (EC 2.7.1.37 part-incorporated 2005)
Orthology
K06631  polo-like kinase 1
K06660  cell cycle serine/threonine-protein kinase CDC5/MSD2
K08861  polo-like kinase 2
K08862  polo-like kinase 3
K08863  polo-like kinase 4
Genes
HSA10733(PLK4) 10769(PLK2) 1263(PLK3) 5347(PLK1)
PTR453991(PLK1) 456546(PLK3) 461480(PLK4) 461861(PLK2)
PPS100968426(PLK2) 100973032(PLK3) 100985260(PLK4) 100992499(PLK1)
GGO101132540(PLK2) 101142495(PLK1) 101143772(PLK3) 101145407(PLK4)
PON100174060(PLK2) 100294540(PLK4) 100433480(PLK3) 100437332(PLK1)
NLE100585156(PLK2) 100596287(PLK1) 100599818(PLK4) 100603047(PLK3)
MCC697686(PLK1) 704071(PLK3) 708835(PLK2) 710233(PLK4)
MCF101865340(PLK1) 101866828(PLK4) 102130926(PLK3) 102131018(PLK2)
CSAB103221820(PLK2) 103224928(PLK3) 103229799(PLK1) 103236240(PLK4)
CATY105576721(PLK2) 105586109(PLK1) 105587425(PLK4) 105594606(PLK3)
PANU101004903(PLK2) 101009200(PLK1) 101010952(PLK4) 101020739(PLK3)
TGE112614583(PLK1) 112625432(PLK4) 112625780(PLK2) 112629933(PLK3)
RRO104658253(PLK1) 104665120(PLK2) 104669059(PLK3) 104682373(PLK4)
RBB108517680 108531000(PLK2) 108535666(PLK3) 108538812(PLK1) 108544387(PLK4)
TFN117065155(PLK2) 117085894(PLK4) 117087490(PLK1) 117092692(PLK3)
PTEH111524210(PLK1) 111541619(PLK2) 111546253(PLK4) 111548812(PLK3)
CJC100393070(PLK3) 100395177(PLK4) 100409054(PLK1) 100409089(PLK2)
SBQ101032499(PLK2) 101032516(PLK4) 101034044(PLK3) 101038450(PLK1)
CSYR103252406(PLK4) 103254566(PLK2) 103257863(PLK1) 103270130(PLK3)
MMUR105877267(PLK2) 105877449(PLK3) 105879722(PLK1) 105885822(PLK4)
LCAT123632488(PLK1) 123634221(PLK3) 123638581(PLK4) 123648480(PLK2)
OGA100941632(PLK3) 100942948(PLK1) 100946857(PLK4) 100955488(PLK2)
MMU12795(Plk3) 18817(Plk1) 20620(Plk2) 20873(Plk4)
MCAL110290810(Plk4) 110292294(Plk3) 110298205(Plk1) 110307780(Plk2)
MPAH110319327(Plk1) 110319840(Plk4) 110323044(Plk3) 110328753(Plk2)
RNO25515(Plk1) 310344(Plk4) 58936(Plk3) 83722(Plk2)
MCOC116083574(Plk2) 116095130(Plk4) 116096490(Plk3) 116102914(Plk1)
MUN110546553(Plk3) 110550653(Plk1) 110555355(Plk2) 110558171(Plk4)
CGE100753472(Plk2) 100760676(Plk1) 100762491(Plk3) 100774595(Plk4)
MAUA101823159(Plk2) 101829484(Plk1) 101832013(Plk4) 101834719(Plk3)
PLEU114688632 114688873 114692205(Plk1) 114700602 114703520(Plk2) 114709376(Plk3) 114710768(Plk4)
MORG121448029(Plk3) 121452834(Plk4) 121455975(Plk2) 121457826(Plk1)
AAMP119809556(Plk2) 119815249(Plk1) 119816900(Plk3) 119826195(Plk4)
NGI103726217(Plk4) 103733921(Plk2) 103746591(Plk3) 103746931(Plk1)
HGL101702778(Plk3) 101716837(Plk2) 101721399(Plk1) 101723384(Plk4)
CPOC100716866(Plk1) 100720147(Plk2) 100722765(Plk3) 100723956(Plk4)
CCAN109681418(Plk4) 109696460(Plk2) 109699641(Plk1) 109702194(Plk3)
DORD105981819(Plk1) 105986072(Plk3) 105992384(Plk2) 105999760(Plk4)
DSP122106086(Plk3) 122110937 122111999(Plk4) 122116188(Plk1) 122117262(Plk2)
NCAR124970412 124978982 124987460 124994502
OCU100338079(PLK4) 100349159(PLK3) 100351005(PLK2) 100356287(PLK1)
OPI101520959(PLK3) 101522960(PLK1) 101528157(PLK4) 101529855(PLK2)
TUP102486453(PLK2) 102488961(PLK4) 102494746(PLK1) 102500186(PLK3)
CFA475380(PLK3) 476087(PLK4) 478063(PLK2) 489971(PLK1)
CLUD112640234(PLK1) 112642595(PLK3) 112642776(PLK4) 112660168(PLK2)
VVP112908097(PLK2) 112908293(PLK1) 112914964(PLK3) 112931626(PLK4)
VLG121481545(PLK3) 121486144(PLK1) 121493395(PLK4) 121498023(PLK2)
AML100464587(PLK4) 100475589(PLK3) 100478763(PLK1) 100478979(PLK2)
UMR103663888(PLK2) 103668898(PLK1) 103670899(PLK3) 103671142(PLK4)
UAH113254757(PLK3) 113255313(PLK2) 113255653(PLK4) 113267582(PLK1)
UAR123778828(PLK1) 123790174(PLK2) 123793294(PLK4) 123793776(PLK3)
ELK111143112 111154602 111156928 111162240
LLV125090174 125093373 125098534 125099862
MPUF101672560(PLK3) 101674418(PLK1) 101686803(PLK2) 101687962(PLK4)
ORO101365658(PLK4) 101381651(PLK1) 101382255(PLK2) 101384788(PLK3)
EJU114198766(PLK1) 114208213(PLK4) 114220981(PLK2) 114224239(PLK3)
ZCA113918410 113924653(PLK4) 113927573(PLK3) 113929767(PLK2) 113933549(PLK1)
MLX117999124(PLK1) 118016807(PLK2) 118019500(PLK3) 118022332(PLK4)
FCA101086791(PLK4) 101088599(PLK3) 101092083(PLK2) 101098508(PLK1)
PYU121015634(PLK2) 121019375(PLK1) 121027020(PLK3) 121029875(PLK4)
PBG122471549(PLK1) 122476283(PLK4) 122480411(PLK3) 122489207(PLK2)
PTG102953697(PLK1) 102960020(PLK3) 102965486(PLK2) 102970464(PLK4)
PPAD109246356(PLK2) 109249053(PLK4) 109254819(PLK3) 109255556(PLK1)
AJU106970176(PLK3) 106970495(PLK1) 106974531(PLK4) 106976401(PLK2)
HHV120233285(PLK1) 120236050(PLK3) 120239508(PLK2) 120248078(PLK4)
BTA504282(PLK3) 514405(PLK4) 538238(PLK1) 539449(PLK2)
BOM102266414(PLK2) 102272163(PLK1) 102273124(PLK3) 102287935(PLK4)
BIU109556375(PLK3) 109571424(PLK4) 109574968(PLK2) 109578571(PLK1)
BBUB102405333(PLK4) 102407714(PLK1) 102408271(PLK3) 102414266(PLK2)
CHX102171678(PLK1) 102175787(PLK4) 102183106(PLK2) 106501977(PLK3)
OAS101105713(PLK1) 101109760(PLK3) 101110619(PLK2) 101121970(PLK4)
ODA120856216(PLK3) 120868434 120870947(PLK4) 120876160(PLK1) 120879536(PLK2)
CCAD122437064(PLK3) 122452900(PLK4) 122454444(PLK2)
SSC100517044(PLK4) 396953(PLK1) 397250(PLK3) 397251(PLK2)
CFR102506528(PLK3) 102510290(PLK2) 102512097(PLK1) 102523992(PLK4)
CBAI105061948(PLK3) 105067101(PLK4) 105073670(PLK1) 105077792(PLK2)
CDK105084720(PLK2) 105087060(PLK4) 105090883 105094832(PLK1)
VPC102525910(PLK1) 102528483(PLK3) 102539769(PLK4) 102539826(PLK2)
BACU103006088(PLK2) 103011702(PLK4) 103012253(PLK1) 103018493(PLK3)
LVE103069213(PLK4) 103070984(PLK3) 103075989(PLK2) 103090008(PLK1)
OOR101269319(PLK2) 101276504(PLK1) 101278695(PLK4) 101282052(PLK3)
DLE111165894(PLK4) 111175730(PLK3) 111182235(PLK1) 111186501(PLK2)
PCAD102974840(PLK1) 102990542(PLK3) 102992160(PLK4) 102992172(PLK2)
PSIU116738730(PLK3) 116740000(PLK1) 116751813(PLK2) 116754053(PLK4)
ECB100051484(PLK2) 100063593(PLK4) 100065793(PLK3) 100068388(PLK1)
EPZ103548309(PLK3) 103560878(PLK2) 103562657(PLK1) 103562823(PLK4)
EAI106822748(PLK3) 106829891(PLK4) 106843377(PLK2) 106845827(PLK1)
MYB102239886(PLK3) 102256839(PLK4) 102258931(PLK2) 102260682(PLK1)
MYD102752290(PLK3) 102758132(PLK1) 102764634(PLK2) 102769993(PLK4)
MMYO118652533 118656115(PLK2) 118656343(PLK1) 118658157(PLK4) 118676346(PLK3)
MLF102436810(PLK4) 102441801(PLK1) 102442906(PLK3) 102443080(PLK2)
MNA107526760(PLK3) 107527144(PLK2) 107529804(PLK4) 107544743(PLK1)
PKL118703378(PLK2) 118710888(PLK4) 118723727(PLK3) 118731590(PLK1)
HAI109383334(PLK3) 109385693(PLK2) 109386529(PLK1) 109394661(PLK4)
DRO112304766(PLK1) 112312557(PLK4) 112314601(PLK3) 112315263(PLK2)
SHON118981679(PLK2) 118995475(PLK4) 119003336(PLK3) 119003965(PLK1)
AJM119037662(PLK4) 119039852(PLK2) 119052332(PLK3) 119059249(PLK1)
PDIC114497777(PLK2) 114497838(PLK3) 114503973(PLK4) 114504052(PLK1)
PHAS123813827(PLK4) 123819557(PLK2) 123825417(PLK1) 123832161(PLK3)
MMF118616157(PLK4) 118626439(PLK3) 118642575(PLK2) 118642717(PLK1)
RFQ117019716(PLK1) 117025312(PLK2) 117027639(PLK3) 117038564(PLK4)
PALE102886992(PLK3) 102895334(PLK1) 102897781(PLK4) 102898481(PLK2)
PGIG120584536(PLK1) 120608201(PLK2) 120616244(PLK4) 120619741(PLK3)
PVP105293466(PLK4) 105297114(PLK3) 105299354(PLK2) 105301680(PLK1)
RAY107499392(PLK3) 107503315(PLK2) 107512497(PLK4) 107516089(PLK1)
MJV108383431(PLK1) 108389963(PLK3) 108394763(PLK2) 108396045(PLK4)
TOD119233699(PLK4) 119236492(PLK3) 119241821(PLK1) 119260858(PLK2)
SARA101547393(PLK1) 101553771(PLK4) 101554661(PLK2) 101556038(PLK3)
LAV100659650(PLK3) 100671267(PLK2) 100674614(PLK4) 100675411(PLK1)
TMU101349926 101355672 101355876 101355942
DNM101415451(PLK4) 101421042(PLK1) 101423602(PLK3) 101430218(PLK2)
MDO100010836(PLK4) 100024987(PLK3) 100027403(PLK1) 100032162(PLK2)
GAS123231080(PLK1) 123231469(PLK2) 123243731(PLK3) 123251181(PLK4)
SHR100914691(PLK2) 100917173(PLK3) 100928146(PLK4) 100930498(PLK1)
PCW110202459(PLK1) 110202754(PLK2) 110209263(PLK3) 110209833(PLK4)
OAA100073533(PLK1) 100075832(PLK2) 100085938(PLK4) 100091573(PLK3)
GGA416575(PLK1) 422497(PLK4) 424586(PLK3) 427150(PLK2)
PCOC116234013(PLK3) 116236682(PLK2) 116237566(PLK1) 116238000(PLK4)
MGP100539569(PLK1) 100545840(PLK3) 100548694(PLK4) 100551083(PLK2)
CJO107306024(PLK2) 107313205(PLK4) 107317517(PLK3) 107320693(PLK1)
NMEL110390070(PLK2) 110397673(PLK4) 110402612(PLK3) 110405608(PLK1)
APLA101795651 101797863(PLK3) 101799170(PLK4) 101800116(PLK1)
ACYG106032963(PLK3) 106035657(PLK2) 106042423(PLK4) 106046017(PLK1)
AFUL116489299(PLK4) 116491989(PLK3) 116495259(PLK1) 116500932(PLK2)
TGU100221236(PLK3) 100221581(PLK1) 100231503(PLK2) 100231569(PLK4)
LSR110467658(PLK3) 110472561(PLK2) 110476542(PLK4) 110479539(PLK1)
SCAN103815166(PLK3) 103817797(PLK1) 103821045(PLK2) 103821440(PLK4)
PMOA120501840(PLK4) 120502451(PLK2) 120503370(PLK3) 120512967(PLK1)
OTC121334687(PLK1) 121339862(PLK4) 121341295(PLK2) 121345014(PLK3)
PRUF121355445(PLK2) 121361500(PLK4) 121362021(PLK3) 121365837(PLK1)
GFR102034868(PLK4) 102035739(PLK2) 102037104(PLK3) 102042745(PLK1)
FAB101806039(PLK4) 101808952(PLK2) 101813168(PLK3) 101821878(PLK1)
PHI102099886(PLK4) 102103579(PLK2) 102106048(PLK1) 102108445(PLK3)
PMAJ107198442(PLK2) 107203124(PLK4) 107208500(PLK3) 107210991(PLK1)
CCAE111929085(PLK4) 111933127(PLK3) 111936205(PLK1) 111941346(PLK2)
CCW104684984(PLK1) 104686683(PLK2) 104693717(PLK4) 104695255(PLK3)
CBRC103615511(PLK1) 103617456(PLK4) 103621984(PLK3) 103623789(PLK2)
ETL114055125(PLK2) 114061457(PLK1) 114061919(PLK3) 114065544(PLK4)
ZAB102062139(PLK1) 102065842(PLK2) 102069338(PLK4) 102071391(PLK3)
FPG101913858(PLK2) 101914988(PLK3) 101921429(PLK1) 101923128(PLK4)
FCH102046673(PLK1) 102048461(PLK2) 102049980(PLK3) 102059128(PLK4)
CLV102089372(PLK1) 102090340(PLK3) 102093496(PLK4) 102096899(PLK2)
EGZ104126293(PLK3) 104134547(PLK1) 104134686(PLK2) 104135662(PLK4)
NNI104011955(PLK2) 104015281(PLK1) 104015554(PLK3) 104015972(PLK4)
PLET104614365(PLK2) 104616288 104623054(PLK1) 104626810(PLK4)
PCRI104025047(PLK1) 104029318(PLK4) 104030774(PLK2) 104038006(PLK3)
ACUN113479555(PLK4) 113483064(PLK3) 113485917(PLK1) 113489880(PLK2)
TALA104355624(PLK2) 104367254 104369409(PLK3) 104369483(PLK4) 122153983
PADL103913915(PLK1) 103918312(PLK3) 103919419(PLK2) 103926145(PLK4)
ACHC115335880(PLK1) 115337172(PLK2) 115349628(PLK3) 115351905(PLK4)
HALD104315793(PLK1) 104317233(PLK2) 104321070(PLK4) 104322106
CCRI104155256(PLK2) 104155649(PLK1) 104163997(PLK3) 104169541(PLK4)
CSTI104555694(PLK4) 104557147(PLK2) 104558260(PLK3) 104563869(PLK1)
EHS104514290(PLK1) 104515962(PLK3) 104516254(PLK4) 104516853(PLK2)
CMAC104473636(PLK3) 104478324(PLK2) 104485315(PLK1) 104487707(PLK4)
FGA104069164 104069966(PLK2) 104074295(PLK4) 104081516(PLK1)
GSTE104251109(PLK2) 104255518(PLK3) 104257463(PLK4) 104261456(PLK1)
LDI104344030(PLK4) 104348886(PLK3) 104354264(PLK2)
MNB103770030(PLK4) 103770792(PLK3) 103777099(PLK2)
OHA104337713(PLK2) 104339495(PLK3) 104339559(PLK1) 104339588(PLK4)
AAM106486200(PLK1) 106492025(PLK4) 106500310(PLK3)
AROW112969862(PLK4) 112971260(PLK2) 112975034(PLK1) 112976011(PLK3)
NPD112943710(PLK3) 112945578(PLK2) 112958161(PLK4) 112959937(PLK1)
DNE112985400(PLK1) 112985789(PLK3) 112987604(PLK4) 112995776(PLK2)
ASN102370156(PLK1) 102375098(PLK3) 102380732(PLK2) 102387484(PLK4)
AMJ102559194(PLK2) 102560421(PLK3) 102561861(PLK1) 102561880(PLK4)
CPOO109307402(PLK3) 109307936(PLK2) 109309323(PLK4) 109314790(PLK1)
GGN109286736(PLK3) 109294290(PLK1) 109297799(PLK2) 109301144(PLK4)
PSS102446825(PLK1) 102452285(PLK3) 102453466(PLK2) 102462374(PLK4)
CMY102930864(PLK3) 102931153(PLK1) 102938667(PLK2) 102943709(PLK4)
CPIC101932718(PLK3) 101932834(PLK4) 101943364(PLK1) 101952802(PLK2)
TST117877747(PLK4) 117879236(PLK2) 117881979(PLK3) 117884413(PLK1)
CABI116816751(PLK1) 116832549(PLK3) 116834728(PLK2) 116839821(PLK4)
MRV120370924(PLK3) 120373278(PLK1) 120407073(PLK4) 120408653(PLK2)
ACS100553693(plk2) 100557501(plk4) 100558384(plk1) 100559459(plk3)
PVT110072845(PLK4) 110073767(PLK3) 110084996(PLK1) 110088668(PLK2)
SUND121923157(PLK2) 121928314(PLK3) 121931049(PLK4) 121937470(PLK1)
PBI103054081(PLK2) 103059922(PLK1) 103062899(PLK4) 103065204(PLK3)
PMUR107283415(PLK3) 107286728(PLK2) 107290572(PLK4) 107299263 107299990
TSR106545382(PLK3) 106546233(PLK4) 106550331(PLK2) 106553451(PLK1)
PGUT117654677(PLK4) 117664149(PLK3) 117667328(PLK1) 117679206(PLK2)
VKO123022740(PLK4) 123029174(PLK3) 123031555(PLK2) 123034877(PLK1)
PMUA114584349 114584489 114599075(PLK3) 114604394(PLK4) 114606563(PLK2)
ZVI118077236(PLK2) 118083756(PLK4) 118088637(PLK3) 118093263(PLK1)
GJA107109642(PLK4) 107119475(PLK3) 107121669(PLK2) 107126199(PLK1)
STOW125430612(PLK1) 125433892(PLK3) 125436869(PLK2) 125440298(PLK4)
XLA100381164(plk3.S) 100505422(plk3.L) 108701628(plk1.L) 108706689(plk4.S) 379122(plk2.L) 379315(plk2.S) 380481(plk1.S) 398770(plk4.L)
XTR100038180(plk4) 100125189(plk2) 407937(plk1) 448451(plk3)
NPR108790309(PLK2) 108790758(PLK1) 108794845(PLK4) 108801812(PLK3)
RTEM120918865(PLK4) 120928593(PLK2) 120943311(PLK1)
BBUF120979421(PLK3) 120991720(PLK4) 120992367(PLK2) 121007775(PLK1)
BGAR122922798(PLK4) 122924766(PLK2) 122943743(PLK3) 122944942 122944958
DRE100148413(plk2a) 280649(plk1) 334202(plk3) 368390(plk4) 565576(plk2b)
SRX107706772 107709193 107710915 107718857 107722069 107722962 107725406(plk1) 107726922 107732588 107743863
SANH107653495 107657898 107658359 107664465 107678927 107692656(plk1) 107700579 107702528 107703461 107704164
SGH107550293(plk2) 107557223 107561682 107563563 107564476(plk1) 107586821 107588929 107590713 107599807 107602251
CCAR109061199 109062389 109062942 109072007 109078959 109086066 109086784 109086785 109094533
CAUA113037796 113044527 113045432 113054723 113060548 113069854 113093854 113107083 113110189 113117112 113119136
PPRM120463622(plk1) 120465103(plk3) 120475697(plk4) 120482019(plk2b) 120482518(plk2a)
MAMB125250476(plk3) 125262525(plk2a) 125268971(plk4) 125272726(plk1) 125279245(plk2b)
IPU108258666(plk1) 108265524(plk2b) 108268125(plk3) 108269474(plk4) 108277216(plk2a)
PHYP113534877(plk2) 113535688(plk1) 113538595(plk4) 113540416(plk3) 113544888
SMEO124378011(plk1) 124387937(plk3) 124389843(plk4) 124393956(plk2a) 124400484(plk2b)
TFD113634325(plk3) 113634330(plk2b) 113638487(plk2a) 113640456(plk1) 113659457(plk4)
AMEX103024965(plk3) 103027010 103032271(plk4) 103034005(plk1) 103036971
EEE113578224(plk3) 113580062 113580908(plk1) 113583314(plk4) 113584568
TRU101066743(plk3) 101069402(plk2) 101072492(plk1) 101075724(plk4)
TNGGSTEN00015731G001 GSTEN00028387G001 GSTEN00032246G001 GSTEN00032641G001
LCO104921165(plk1) 104922952(plk2) 104936706(plk3) 109142667(plk4)
NCC104941883(plk4) 104943728(plk1) 104953311(plk3) 104966846(plk2)
CGOB115014029(plk2) 115015796(plk1) 115022885(plk3) 115027169(plk4)
ELY117251883(plk2b) 117254781(plk1) 117267011(plk4) 117272304(plk3)
EFO125886396(plk1) 125889842(plk2b) 125900462(plk4) 125902087(plk3)
PLEP121942648(plk1) 121944753(plk2b) 121951134(plk3) 121953502(plk4)
SLUC116035500(plk4) 116042997(plk1) 116046120(plk3) 116056758(plk2b)
ECRA117936026(plk4) 117945271(plk2b) 117954304(plk3) 117961332(plk1)
PFLV114546720(plk4) 114555305(plk2) 114565094(plk3) 114568232(plk1)
GAT120815898(plk3) 120825557(plk1) 120831063(plk2b) 120832913(plk4)
PPUG119209629(plk3) 119217929(plk1) 119225563(plk2b) 119227173(plk4)
MSAM119891313(plk2b) 119898697(plk1) 119902124(plk3) 119910029(plk4)
CUD121509139(plk1) 121510365(plk2b) 121520072(plk3) 121526352(plk4)
ALAT119004413(plk4) 119010752(plk3) 119020031(plk2b) 119027927(plk1)
MZE101467664(plk1) 101468743(plk4) 101475303(plk3) 101476510(plk2)
ONL100698165(plk4) 100698269(plk1) 100698581(plk2) 100709304(plk3)
OAU116323531(plk1) 116328866(plk2b) 116332842(plk3) 116334768(plk4)
OLA101155385(plk3) 101161450(plk4) 101166557(plk2) 101170155(plk1)
OML112137374(plk1) 112147646(plk3) 112148185(plk2b) 112149235(plk4)
XMA102216895(plk3) 102218913(plk1) 102229409(plk4) 102235107(plk2)
XCO114133930(plk4) 114143902(plk1) 114146922(plk3) 114154687(plk2)
XHE116709403(plk4) 116720741(plk1) 116721510(plk3) 116729876(plk2)
PRET103458927(plk4) 103462043(plk1) 103470174(plk2) 103479620(plk3)
PFOR103135431(plk2) 103148307(plk3) 103154787(plk4) 103156475(plk1)
PLAI106945486(plk2) 106948979(plk3) 106956968(plk4) 106961976(plk1)
PMEI106908268(plk1) 106916956(plk2) 106925694(plk3) 106928495(plk4)
GAF122828138(plk2b) 122829014(plk1) 122840960(plk3) 122846633(plk4)
CVG107083776(plk3) 107098129(plk2) 107099106(plk4) 107099337(plk1)
CTUL119771437(plk4) 119781123(plk2b) 119783691(plk1) 119786150(plk3)
GMU124855131(plk4) 124867824(plk1) 124870211(plk3) 124877274(plk2b)
NFU107383991(plk3) 107389935(plk1) 107392333(plk4) 107394073(plk2)
KMR108233407(plk4) 108239684(plk3) 108243614(plk1) 108244824(plk2b)
ALIM106513736(plk2) 106521169(plk4) 106522726(plk1) 106534803
NWH119413924(plk2b) 119415118(plk3) 119422973(plk1) 119427548(plk4)
AOCE111566256(plk1) 111568077(plk3) 111578908(plk4) 111588629(plk2)
MCEP125004766(plk1) 125011220(plk3) 125012929(plk2b) 125023569(plk4)
CSEM103377189(plk4) 103383451(plk1) 103396050(plk3) 103398298(plk2)
POV109628079(plk4) 109639337(plk2) 109644828(plk3) 109646908(plk1)
SSEN122770159(plk2b) 122771702(plk1) 122776524(plk3) 122782660(plk4)
HHIP117755877(plk4) 117767980(plk2b) 117770384(plk1) 117778212(plk3)
HSP118098020(plk1) 118115017(plk2b) 118116458(plk4) 118117575(plk3)
LCF108878162(plk2) 108883487(plk3) 108892537(plk4) 108894767(plk1)
SDU111216631(plk1) 111225418(plk4) 111229128(plk3) 111230829(plk2)
SLAL111645168(plk2) 111654440(plk3) 111659816(plk4) 111672930(plk1)
XGL120795005(plk4) 120799271(plk3) 120800890(plk1) 120805586(plk2b)
HCQ109511272(plk1) 109516027(plk4) 109516852(plk3) 109520647(plk2)
BPEC110153514(plk1) 110155269(plk4) 110157564(plk3) 110167009(plk2)
MALB109955063(plk4) 109956657(plk2) 109957683(plk3) 109973323(plk1)
BSPL114844811(plk3) 114848328(plk4) 114855984(plk1) 114862738(plk2b)
SASA100195918(plk2) 106569079 106580403 106585026 106590979 106592455(plk1) 106597351 106599391 106610996
OTW112220000 112226947(plk3) 112241904(plk1) 112248580 112256743 112260461 112262795(plk2b)
OMY110497860(plk4) 110505604 110508736(plk3) 110515273 110523192 110525781 110530313 110536158(plk2b) 118948701
OGO123989474 124002088(plk4) 124009721 124021791 124022872 124033271 124035231(plk2b) 124041866 124046499
ONE115103092 115111697 115114415 115118350 115138550 115140155 115146181
SALP111956832 111956843 111958003 111963319 111968684 111974994 112080852
SNH120020363 120023837 120026259 120030497 120055871 120060330 120063322(plk2b)
CCLU121535215 121539330 121544861 121557559 121573559 121580916(plk3) 121581992 121584947
ELS105014278 105015587(plk4) 105021744(plk2) 105022688 105029645(plk1)
SFM108920830(plk4) 108927406 108935291(plk3) 108937177 108938356(plk2)
PKI111836956 111839330(plk2) 111844198(plk4) 111845541(plk1) 111849137
AANG118212151 118220062(plk1) 118227644(plk4) 118230601(plk3) 118237180(plk2b)
LOC102682835(plk4) 102689064(plk3) 102689579(plk2) 102690553(plk1)
PSPA121300783 121300868 121316785 121325413 121327258 121330472 121330772 121331080
ARUT117399437 117403664 117408943 117416711 117418491(plk1) 117421007 117425156 117431392
LCM102348600(PLK1) 102349883(PLK4) 102355147(PLK3) 102363585(PLK5) 102364369(PLK2)
CMK103177812(plk2b) 103186623(plk1) 103190060(plk4)
RTP109910478(plk1) 109920893(plk4) 109932494(plk2)
BFO118407845 118420242 118428003
BBEL109462796 109464730 109477622 109479867 109485701
CIN100177145 100177586 100183083
SCLV120339201 120347284 120347718
SPU584420 587774 589028
APLC110976976 110981126 110985188
SKO100371198 100373314 100375057(PLK1) 102809763
DMEDmel_CG12306(polo) Dmel_CG7186(SAK)
DER6543822 6545229
DSE6616273 6616457
DSIDsimw501_GD12112(Dsim_GD12112) Dsimw501_GD14871(Dsim_GD14871)
DYADyak_GE19659 Dyak_GE22325
DAN6492926 6493575
DSR110184654 110190434
DPO4812761 4813961 6902946 6903594
DPE6588944 6593368 6595978 6603338
DMN108151376 108160313 108161410 108162552 117186200 117186202 117186383 117186404 117186417 117186419 117186420 117186421 117186715 117186829 117186830 117186831 117188114 117193429 117193811 117194001 117194048 117195266 117195289 117195290 117195291 117195292
DWI6638839 6642935
DGR6556999 6558478
DMODmoj_GI11323 Dmoj_GI13469
DAZ108612345 108612879
DNV108650228 108650551
DHE111592326 111605730
DVI6622842 6624728
CCAT101455785 101460240
BOD106616891 106620663
MDE101893106 101895764
SCAC106092888 106096181
LCQ111680103 111680220
LSQ119600247 119607916
HIS119650429
AGAAgaP_AGAP004239 AgaP_AGAP012499
ACOZ120951230 120960096
AARA120893390 120895956
ASTE118506386 118510929
AAG5571876 5577816
AALB109429192 109623259
CQUCpipJ_CPIJ004252 CpipJ_CPIJ006236
CPII120421500 120427345
CNS116346000 116349104 116349783
BCOO119074908 119081287
AME413261 550739 726051
ACER107998635 107999607 108002938
ALAB122717610 122717940 122719237
BIM100741609 100744392 100745573
BBIF117206619 117211044 117212722
BVK117231316 117236835 117240055
BVAN117156539 117157659 117161316
BTER100645092 100648842 100651238
BPYO122572885 122577639 122577746
CCAL108623026 108631225 108632358
OBB114874957 114876362 114879203
MGEN117229704
NMEA116427861 116428296 116432355
CGIG122397744 122402526 122404402
SOC105195156 105195386 105197894
MPHA105830341 105833075 105835863
AEC105147565 105148341 105153306
ACEP105623226 105625390 105626318
PBAR105426410 105427344 105429329
VEM105566607 105567455 105568864
HST105182847 105186763 105188527
DQU106740673 106740832 106751944
CFO105249967 105250345 105251234
FEX115233064 115233671 115243140
LHU105676765 105679107 105679900
PGC109855054 109855515 109857078
OBO105276880 105284265 105287695
PCF106790868 106790885 106791109
PFUC122514274 122518593 122523874
VPS122631858 122635012 122637246
NVI100115256(Plk4) 100120719
CSOL105359294 105360901 105363566
TPRE106649000 106649771 106657844
MDL103572052 103575130 103575550
CGLO123261930 123267648 123268492
FAS105265449 105269809 105273614
DAM107036167 107038832 107041699
AGIF122848737 122853013 122857642
LHT122503827 122509029
CCIN107264373 107266934 107273614
TCA660822(polo) 663303
DPA109536032 109541525
SOY115884116 115890645
ATD109599911 109604358
CSET123312468 123315559
AGB108903585 108911086
LDC111514808 111517736
NVL108565775 108567985
APLN108732849 108733002
PPYR116159906 116163240 116172275 116172305
OTU111427799 111428468
BMOR101737015 101740671
BMAN114242124 114250344
MSEX115447005 115449070
DPLKGM_206060
BANY112052822 112052917
PMAC106712452 106720334
PPOT106109326 106110994
PXU106117461 106123641 106128520 106128754
PRAP110992700 110997850
ZCE119829925 119835124
HAW110369932 110371560
HZE124631301 124639263
TNL113492842 113506998
SLIU111351905 111352806 111360980
OFU114355689 114362875
PXY105384810 105390690 105392819
API100168105 100168700 100571755
DNX107164321 107173372
AGS114122059 114127137 114131580
RMD113551612 113553222 113556878
BTAB109034815 109043875
DCI103521467 113465355
CLEC106666218 106669672
HHAL106680606 106685142
NLU111045553 111051407 111055226 111061119
PHUPhum_PHUM087560 Phum_PHUM252390 Phum_PHUM611910
FOC113209917 113212603
TPAL117639967 117648662
ZNE110830084 110831259 110839445
CSEC111862822 111864705 111868005
FCD110850780 110861805 110862094
DPXDAPPUDRAFT_237171 DAPPUDRAFT_301125 DAPPUDRAFT_302355 DAPPUDRAFT_309099 DAPPUDRAFT_309383
DMK116921243 116924837 116928738 116932577
PVM113805011 113805901 113821461 113827645
PJA122248201 122258850 122262262
PCHN125027416 125034570 125041868
HAME121870700 121874694 121880030 121880090
PCLA123745603 123773466 123773765
PTRU123508145 123508307 123519864
HAZT108672971 108673105 108675394
EAF111697925 111703977 111705379
LSM121116145 121127538 121131953
PPOI119091546 119092513 119112816
DSV119433212 119433927 119450220
RSAN119383270 119385883 119385885 119404721 119404968
RMP119169509 119169523 119170457 119181257 119181289
VDE111249353 111252403 111252413
VJA111262146 111270729 111271598
TUT107366765
DPTE113790754 113793946 113795273
DFR124490563 124491883 124496666
CSCU111619716 111623038 111629017 111637140 111640532
PTEP107443667 107450227
SDM118183940 118186915 118199633 118200802
CELCELE_C14B9.4(plk-1) CELE_F55G1.8(plk-3) CELE_F59E12.2(zyg-1) CELE_Y71F9B.7(plk-2)
CBRCBG_02462(Cbr-zyg-1) CBG_04120(Cbr-plk-2) CBG_09233(Cbr-plk-1)
BMYBM_BM7046(Bm7046) BM_BM8857(Bm8857)
LOALOAG_00597 LOAG_08113 LOAG_17495
NAINECAME_09217 NECAME_11948 NECAME_13476
TSPTsp_02561
HROHELRODRAFT_112284 HELRODRAFT_185535 HELRODRAFT_187844 HELRODRAFT_64399 HELRODRAFT_69616
LGILOTGIDRAFT_111267 LOTGIDRAFT_112005 LOTGIDRAFT_157318 LOTGIDRAFT_157319 LOTGIDRAFT_176322 LOTGIDRAFT_223730 LOTGIDRAFT_230563 LOTGIDRAFT_231306
PCAN112558606 112559577 112560024 112560388 112573623
BGT106060920 106061949 106068934 106074446
GAE121375608 121375877 121380961
HRF124146036 124146262
HRJ124262039 124262937 124272820 124284865
CRG105326368 105340555 105341494
MYI110442904 110445780 110466099
PMAX117325404 117329471 117335616
MMER123525405 123536396 123558416
OBI106874129 106875068 106880620
OSN115215835 115220525
LAK106151762 106156762 106169017 106170668 106179484
SMMSmp_009600 Smp_079410
OVIT265_04511 T265_07542 T265_09928
EGLEGR_01044 EGR_08557
NVE5504879 5506045 5509390
EPA110240168
ATEN116293643 116298531 116302074
ADF107345140
AMIL114954501 114966121
PDAM113666440 113680010 113680258
SPIS111326806 111331734 111337339
DGT114521586 114523265 114526321
XEN124437932 124445851 124452649
HMG100199862 100205568 100206873
TADTRIADDRAFT_50801
AQU100641743 109588157
PXB103942415
OLUOSTLU_30992
OTAOT_ostta04g00680
BPGBathy18g00680
MISMICPUN_85283
MPPMICPUCDRAFT_23784
CMECYME_CME146C
GSLGasu_43360
CCPCHC_T00008772001
SCEYMR001C(CDC5)
SEUBDI49_4089
SPAOSPAR_M01260
AGOAGOS_ACL006W
ERCEcym_3035
KLAKLLA0_C06138g
KMXKLMA_10270(CDC5)
LTHKLTH0C10912g
VPOKpol_1023p26 Kpol_1037p20
ZROZYRO0C07480g
CGRCAGL0J11638g
NCSNCAS_0D02100(NCAS0D02100)
NDINDAI_0C02680(NDAI0C02680)
TPFTPHA_0F02430(TPHA0F02430) TPHA_0J00420(TPHA0J00420)
TBLTBLA_0B00490(TBLA0B00490)
TDLTDEL_0G04380(TDEL0G04380)
TGBHG536_0H04480
KAFKAFR_0A05090(KAFR0A05090) KAFR_0G02690(KAFR0G02690)
KNGKNAG_0E00850(KNAG0E00850) KNAG_0F02900(KNAG0F02900)
ZMKHG535_0G02830
PPAPAS_chr3_0243
DHADEHA2F09966g
PICPICST_68049(CDC5)
PGUPGUG_04276
SPAASPAPADRAFT_63966
LELLELG_01370
CALCAALFM_C100950CA(CDC5)
CTPCTRG_04398
COTCORT_0B11100
CDUCD36_00900
CTENCANTEDRAFT_121196
YLIYALI0D26015g
CLUCLUG_01461
CLUSA9F13_06g02750
CAURCJI97_003499
SLBAWJ20_4043(CDC5)
PKZC5L36_0C05810
BNNFOA43_002728
BBRXBRETT_002751
OPAHPODL_04492
SLUDSCDLUD_000932
TRRM419DRAFT_35417
TMLGSTUM_00008436001
SPOSPAC23C11.16(plo1)
CNECNK02500
CNBCNBK1050
CNGCNAG_01907
CGICGB_K1340C
TMSTREMEDRAFT_72015
TVSTRAVEDRAFT_172289
PCOPHACADRAFT_115710
HIRHETIRDRAFT_157315
PSQPUNSTDRAFT_103050
ADLAURDEDRAFT_91195
FMEFOMMEDRAFT_114502
GTRGLOTRDRAFT_80687
LBCLACBIDRAFT_309201
CCICC1G_07437
PCUBJR316_0008639
MRRMoror_12875
MOREE1B28_003206
SCMSCHCO_02569377(SCHCODRAFT_02569377)
SLASERLADRAFT_442577 SERLADRAFT_445649
PFPPFL1_05533
MLRMELLADRAFT_88965
ECUECU01_0630
EINEint_010510
EHEEHEL_010500
EROEROM_010420
NCENCER_100270
MBRMONBRDRAFT_39338
SREPTSG_07493 PTSG_09382
DDIDDB_G0274503(plk)
DPPDICPUDRAFT_98258
DFADFA_03393(plk)
EHIEHI_008410(114.t00009)
EDIEDI_061560
EIVEIN_491160
ACANACA1_274380
TETTTHERM_00191790 TTHERM_00470890 TTHERM_00992960 TTHERM_01076980 TTHERM_01443850
PTMGSPATT00000415001 GSPATT00006256001 GSPATT00009060001 GSPATT00009588001 GSPATT00018143001 GSPATT00022475001 GSPATT00025198001 GSPATT00026684001 GSPATT00028443001 GSPATT00029023001 GSPATT00031090001 GSPATT00032340001 GSPATT00034942001 GSPATT00036333001 GSPATT00039351001 PTMB.124
SMINv1.2.007788.t1(symbB.v1.2.007788.t1) v1.2.007788.t2(symbB.v1.2.007788.t2)
PTIPHATR_10628
TPSTHAPSDRAFT_33979
PIFPITG_02077 PITG_10092
PSOJPHYSODRAFT_311474 PHYSODRAFT_313705
SPARSPRG_00035
GTTGUITHDRAFT_64205 GUITHDRAFT_88322
TBRTb927.7.6310
TBGTbgDal_VII7280
TCR506513.160 508917.10
LMALMJF_17_0790
LIFLINJ_17_0770
LDOLDBPK_170770
LMILMXM_17_0790
LBZLBRM_17_0690
LPANLPMP_170660
NGRNAEGRDRAFT_53552 NAEGRDRAFT_63986
TVATVAG_003370 TVAG_039910 TVAG_069810 TVAG_088660 TVAG_107500 TVAG_432460 TVAG_496190
GLAGL50803_00104150
 » show all
Reference
1  [PMID:1660828]
  Authors
Llamazares S, Moreira A, Tavares A, Girdham C, Spruce BA, Gonzalez C, Karess RE, Glover DM, Sunkel CE.
  Title
polo encodes a protein kinase homolog required for mitosis in Drosophila.
  Journal
Genes Dev 5:2153-65 (1991)
DOI:10.1101/gad.5.12A.2153
  Sequence
Reference
2  [PMID:7790358]
  Authors
Golsteyn RM, Mundt KE, Fry AM, Nigg EA.
  Title
Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.
  Journal
J Cell Biol 129:1617-28 (1995)
DOI:10.1083/jcb.129.6.1617
Reference
3  [PMID:12186944]
  Authors
Mulvihill DP, Hyams JS.
  Title
Cytokinetic actomyosin ring formation and septation in fission yeast are dependent on the full recruitment of the polo-like kinase Plo1 to the spindle pole body and a functional spindle assembly checkpoint.
  Journal
J Cell Sci 115:3575-86 (2002)
DOI:10.1242/jcs.00031
Reference
4  [PMID:14654016]
  Authors
Ohkura H.
  Title
Phosphorylation: polo kinase joins an elite club.
  Journal
Curr Biol 13:R912-4 (2003)
DOI:10.1016/j.cub.2003.11.012
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.21
IUBMB Enzyme Nomenclature: 2.7.11.21
ExPASy - ENZYME nomenclature database: 2.7.11.21
BRENDA, the Enzyme Database: 2.7.11.21
CAS: 149433-93-2

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