KEGG   ENZYME: 2.7.2.17
Entry
EC 2.7.2.17                 Enzyme                                 
Name
[amino-group carrier protein]-L-2-aminoadipate 6-kinase;
lysZ (gene name);
[amino group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine 5-O-kinase;
[amino group carrier protein]-L-2-aminoadipate 6-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a carboxy group as acceptor
Sysname
[amino-group carrier protein]-C-terminal-[N-(1,4-dicarboxybutyl)-L-glutamine] 5-O-kinase
Reaction(IUBMB)
ATP + an [amino-group carrier protein]-C-terminal-[N-(1,4-dicarboxybutyl)-L-glutamine] = ADP + an [amino-group carrier protein]-C-terminal-{N-[1-carboxy-5-oxo-5-(phosphooxy)pentyl]-L-glutamine} [RN:R09776]
Reaction(KEGG)
R09776
Substrate
ATP [CPD:C00002];
[amino-group carrier protein]-C-terminal-[N-(1,4-dicarboxybutyl)-L-glutamine]
Product
ADP [CPD:C00008];
[amino-group carrier protein]-C-terminal-{N-[1-carboxy-5-oxo-5-(phosphooxy)pentyl]-L-glutamine}
Comment
The enzyme participates in an L-lysine biosynthetic pathway in certain species of bacteria and archaea.
History
EC 2.7.2.17 created 2020
Pathway
ec00300  Lysine biosynthesis
ec01100  Metabolic pathways
Orthology
K05828  [amino group carrier protein]-L-2-aminoadipate/L-glutamate 6-kinase
Genes
MSDMYSTI_01364
MFBMFUL124B02_07575
CCXCOCOR_02070(argB)
AVMJQX13_36420
GEKkuro4_23320
SGRSGR_3480
SFASfla_0119
STRPF750_6905
SFISFUL_3352
SCZABE83_19100
SCXAS200_22015
SRWTUE45_06898(argB_2)
SPAVSpa2297_32270
STRTA8713_31075
SALWCP975_34090
SLAUSLA_3043
SALJSMD11_6706(lysZ)
STIRDDW44_16555
SNKCP967_01840 CP967_15195
SFICEIZ62_06080
SSPODDQ41_08065
SCAVCVT27_15450
SCYGS1361_31460(argB2)
SGJIAG43_00730
SDDD9753_06840
KABB7C62_16035
KITCFP65_3940
AGRAAGRA3207_003396
SESPBN6_56680
SSYIEKG83_30600
ACTRAsp14428_21580
PLKCIK06_18390(argB)
CAICaci_6305
RRSRoseRS_1062
RCARcas_3466
CAUCaur_1087
CHLChy400_1190
CAGCagg_1877
HAUHaur_3308
TROtrd_1516(argB)
STISthe_0218
ATMANT_12390(argB)
PSUBPelsub_P1478
LEKhrd7_27820
CAPCLDAP_41070(argB)
KBSEPA93_38770
THUGKNN16_06520
TTRTter_0320
PMETG4Y79_18405
DRADR_1420
DGEDgeo_0678
DDRDeide_10430
DMRDeima_1346
DGODGo_CA1379
DPDDeipe_2752
DSWQR90_03980
DCHSY84_15465
DABAUC44_08500
DPUSU48_07495
DEZDKM44_08260(argB)
DWUDVJ83_04430
DFCDFI_07545
DEINDAAJ005_04900
DGADEGR_13390
DPHEHF33_00305
DRBN0D28_08050
TRATrad_1399
TTHTT_C1541
TTJTTHA1903(TTHA1903)
TTSThthe16_1905
TTLTtJL18_1987
TSCTSC_c01940(argB2)
THCTCCBUS3UF1_21010
TOSTheos_1931
TAQTO73_0100
TPARAV541_01270
TBCA0O31_00868
TANTKNN15_05140
MRBMrub_2721
MREK649_08930
MSVMesil_0435
MTAIMtai_v1c23200
OPROcepr_1796
MHDMarky_0666
UAMUABAM_02296
SCORJ3U87_02890
TAITaci_0449
TLITlie_1471
AMOAnamo_0988
CPORBED41_13060
MROMROS_0162
CABYCabys_3151
PFUPF1684
PFIPFC_10185
PHOPH1718(PH1718)
PABPAB0292(argB)
PYNPNA2_0327
PYSPy04_1634
TKOTK0276
THSTES1_0509
THVADU37_CDS10070
TCHCHITON_1977
THEIK1720_00625
HDLHALDL1_01645
HHBHhub_3650(argB)
HNOLT974_00090
HLULT972_14170
HJEHacjB3_00980
HALHHTSR_0666(argB)
HHSRHSR6_0692(argB)
HSUHLASF_2139(argB)
HSFHLASA_2173(argB)
SALRFQU85_04725
HALREFA46_005460
HAADMW046_06595
HALXM0R89_05935
HAXZM0R88_06120
SALIL593_07895
SAIMK0C01_05785
HARAAArcS_3063(argB)
HMArrnAC2676(argB2)
HHIHAH_3081(argB2)
HHNHISP_15685
HABSG26_07780
HTABVU17_14995
HALJG9465_02495
HSINKDQ40_13805
NPHNP_5262A(argB)
NMONmlp_1241(argB)
NHOHWV23_08500
NSALHWV07_10865
HUTHuta_1500
HTIHTIA_1541
HALAHrd1104_12285
HMUHmuk_0774
HALZE5139_07055
HALLLC1Hm_3290(argB)
HAZPGBQ70_07050
HALIBV210_07085
HSNDV733_03385
HDSHSR122_1703(argB)
HRRHZS55_04385
HPELHZS54_04335
HLTI7X12_08375
HARCHARCEL1_01515(argB)
HDOMUK72_02355
SSAIN0B31_18440
HWAHQ_3716A(argB)
HWCHqrw_4131(argB)
HVOHVO_0044(argB)
HMEHFX_0044(argB)
HGIABY42_00210
HALEG3A49_00600
HLSKU306_04860
HBOHbor_01750
HAQDU484_03075
HAJDU500_03515
HAERDU502_01260
HRAEI982_12715
HLMDV707_00750
HALMFCF25_06935
HLAHlac_2614
HALPDOS48_13125
HALBEKH57_10845
HEZZEO776_15105
HALQHrr1229_007365
HSSJ7656_01815
HSAIHPS36_07350
HAZZKI388_13090
SRUBC2R22_20790
HAEhalTADL_1875
HALNB4589_001585
HALGHUG10_12785
HALUHUG12_02030
HMPK6T50_10105
HREK6T36_09870
HRMK6T25_06290
HACBHbl1158_01735
HDFAArcSl_0041(argB)
HAHHalar_1204
HTUHtur_0326
HDABB347_12540
HSALJMJ58_07545
HLOJ0X27_11120
HAKZJ0X25_08125
NMGNmag_1759(argB)
HXAHalxa_1380
NATNJ7G_0261
NPENatpe_3684
NVRFEJ81_17595
NPLFGF80_16420
NAYHYG81_11430
HALYHYG82_14945
HJTDVR14_08500
NGENatgr_1614
HRUHalru_0401
NOUNatoc_0150
HLRHALLA_05500
HLCCHINAEXTREME04205
NAJB1756_08240
NAGAArcMg_3556
NANAArc1_3500
NBGDV706_07700
NASGCU68_04995
SAWLNGM29_05195
PTOPTO1471
FACFACI_IFERC01G1525
FAIFAD_0506(lysZ)
CDIVCPM_0547
APEAPE_1461.1(lysZ)
ACJACAM_0920(lysZ)
IHOIgni_0621
IISEYM_06110
IPCIPA_02000
IAGIgag_1755
PFMPyrfu_0386
PDLPyrde_1834
STOSTK_01940(argB_lysZ)
SOHD1869_00445
SSOSSO0156(argB)
SOLSsol_1134
SSOASULA_1170
SSOLSULB_1171
SSOFSULC_1169
SSHIJ5U23_00108
SCASSACC_00690
SAISaci_0751
SACNSacN8_03650
SACRSacRon12I_03635
SACSSUSAZ_03365
SISLS215_2148
SIAM1425_1983
SIMM1627_2061
SIDM164_1989
SIYYG5714_2106
SINYN1551_0812
SIILD85_2244
SIHSiH_1927
SIRSiRe_1854
SICSiL_1836
SULABFU36_05155
SULEGFS03_10860
SULOGFS33_02675
SULLEWF20_01885
MSEMsed_0165
MEMJMJ1HA_0244
MCNMcup_1908
MHKDFR87_05985
MPRUDFR88_05815
MTENGWK48_06265
MJNMjAS7_0748
AHOAhos_0884
AMANB6F84_08270
ABRIDFR85_06575
ASULDFR86_07285
AAMBD1866_12315
ACIHHS5_22590
SACDHS1genome_0845
SAZOD1868_01590
CSTYKN1_18160
STEPIC006_1903
PAIPAE2882
PISPisl_0277
PCLPcal_0372
PASPars_0967
PYRP186_1635
POGPogu_1379
TNETneu_1836
PYWPYWP30_01975
CMACmaq_1300
TTNTTX_0121(lysZ_argB)
TUZTUZN_1286
VDIVdis_0202
VMOVMUT_1540
VSOVsou_14200
NMRNmar_1290
NIRNSED_07160
NKRNKOR_07280
NIDNPIRD3C_0834(argB)
NINNADRNF5_0666(argB)
NIWNisw_07280
NCLC5F47_06950(argB)
NOXC5F49_06960(argB)
NUEC5F50_09715(argB)
NIPNsoK4_01585
NCTNMSP_0398(argB)
NICDSQ20_07915
CSYCENSYa_1204
NGANgar_c29950(argB)
NVNNVIE_1688(argB)
NEVNTE_00735
TAANMY3_02223(argB)
NFNNFRAN_2985(lysZ)
NCVNCAV_1250(lysZ)
CSUCSUB_C1304
NBVT478_1045(argB)
TAHSU86_009070
NIUDSQ19_03215
NDVNDEV_1625(argB)
CCAINAS2_0268
KCRKcr_0810
BARBAOA66_0021(argB)
 » show all
Reference
1  [PMID:10613839]
  Authors
Nishida H, Nishiyama M, Kobashi N, Kosuge T, Hoshino T, Yamane H.
  Title
A prokaryotic gene cluster involved in synthesis of lysine through the amino adipate pathway: a key to the evolution of amino acid biosynthesis.
  Journal
Genome Res 9:1175-83 (1999)
DOI:10.1101/gr.9.12.1175
Reference
2  [PMID:19620981]
  Authors
Horie A, Tomita T, Saiki A, Kono H, Taka H, Mineki R, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M
  Title
Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus.
  Journal
Nat Chem Biol 5:673-9 (2009)
DOI:10.1038/nchembio.198
  Sequence
[tth:TT_C1541]
Reference
3  [PMID:23434852]
  Authors
Ouchi T, Tomita T, Horie A, Yoshida A, Takahashi K, Nishida H, Lassak K, Taka H, Mineki R, Fujimura T, Kosono S, Nishiyama C, Masui R, Kuramitsu S, Albers SV, Kuzuyama T, Nishiyama M
  Title
Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.
  Journal
Nat Chem Biol 9:277-83 (2013)
DOI:10.1038/nchembio.1200
  Sequence
[sai:Saci_0751]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.2.17
IUBMB Enzyme Nomenclature: 2.7.2.17
ExPASy - ENZYME nomenclature database: 2.7.2.17
BRENDA, the Enzyme Database: 2.7.2.17

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