KEGG   ENZYME: 2.7.4.29
Entry
EC 2.7.4.29                 Enzyme                                 
Name
Kdo2-lipid A phosphotransferase;
lipid A undecaprenyl phosphotransferase;
LpxT;
YeiU
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor
Sysname
ditrans-octacis-undecaprenyl-diphosphate:alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid-A phosphotransferase
Reaction(IUBMB)
ditrans-octacis-undecaprenyl diphosphate + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A = ditrans-octacis-undecaprenyl phosphate + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate [RN:R11186]
Reaction(KEGG)
R11186
Substrate
ditrans,octacis-undecaprenyl diphosphate [CPD:C04574];
alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A [CPD:C06026]
Product
ditrans,octacis-undecaprenyl phosphate [CPD:C17556];
alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate [CPD:C21157]
Comment
An inner-membrane protein. The activity of the enzyme is regulated by PmrA. In vitro the enzyme can use diacylglycerol 3-diphosphate as the phosphate donor.
History
EC 2.7.4.29 created 2015
Pathway
ec00540  Lipopolysaccharide biosynthesis
Orthology
K19803  Kdo2-lipid A phosphotransferase
Genes
ECOb2174(lpxT)
ECJJW2162(yeiU)
ECDECDH10B_2332(yeiU)
EBWBWG_1950(lpxT)
ECOKECMDS42_1744(yeiU)
ECEZ3433
ECSECs_3066(lpxT)
ECFECH74115_3312
ETWECSP_3054(yeiU)
ELXCDCO157_2829
EOIECO111_2893(yeiU)
EOJECO26_3087(yeiU)
EOHECO103_2651(yeiU)
ECOOECRM13514_2938
ECOHECRM13516_2879
ESLO3K_08570
ESOO3O_17065
ESMO3M_08520
ECKEC55989_2428(yeiU)
ECGE2348C_2321(yeiU)
EOKG2583_2717(yeiU)
ELRECO55CA74_13440
ELHETEC_2311
ECWEcE24377A_2472
EUNUMNK88_2722
ECPECP_2215
ENAECNA114_2268
ECOSEC958_2512
ECVAPECO1_4380(yeiU)
ECOAAPECO78_14595
ECXEcHS_A2312
ECMEcSMS35_2323
ECYECSE_2443
ECRECIAI1_2256(yeiU)
ECQECED1_2624(yeiU)
EUMECUMN_2511(yeiU)
ECTECIAI39_2315(yeiU)
EOCCE10_2548(lpxT)
EBRECB_02104(yeiU)
EBLECD_02104(lpxT)
EBEB21_02063(lpxT)
EBDECBD_1483
ECIUTI89_C2451
EIHECOK1_2409
ECZECS88_2323(yeiU)
ECCc2711(yeiU)
ELOEC042_2407
ELNNRG857_11040
ESEECSF_2056
ECLEcolC_1473
EKOEKO11_1579
EKFKO11_11755(lpxT)
EABECABU_c25060(yeiU)
EDHEcDH1_1483
EDJECDH1ME8569_2111(yeiU)
ELUUM146_05920
ELWECW_m2376(lpxT)
ELLWFL_11625(lpxT)
ELCi14_2511(yeiU)
ELDi02_2511(yeiU)
ELPP12B_c2270
ELFLF82_3022(yeiU)
ECOLLY180_11365
ECOIECOPMV1_02335(yeiU)
ECOJP423_12225
EFEEFER_2263(yeiU)
EALEAKF1_ch3816c
EMAC1192_01025
ESZFEM44_01105(lpxT)
STYSTY2449
STTt0642
SEXSTBHUCCB_6860
SENTTY21A_03265
STMSTM2213(yeiU)
SEOSTM14_2735(yeiU)
SEVSTMMW_22441
SEYSL1344_2190(yeiU)
SEMSTMDT12_C22330
SEJSTMUK_2243(yeiU)
SEBSTM474_2306(yeiU)
SEFUMN798_2391
SETUSTU288_07450
SETCCFSAN001921_05720
SENRSTMDT2_21901
SENDDT104_22721
SENICY43_11890
SEENSE451236_17265
SPTSPA0638(yeiU)
SEKSSPA0599
SPQSPAB_00791
SEISPC_1487
SECSCH_2229(yeiU)
SEHSeHA_C2450
SHBSU5_02807
SENHCFSAN002069_20770
SEEHSEEH1578_20340
SEESNSL254_A2407
SENNSN31241_33280
SEWSeSA_A2453
SEASeAg_B2362
SENSQ786_10980
SEDSeD_A2564
SEGSG2251(yeiU)
SETSEN2206(yeiU)
SENAAU38_11150
SENOAU37_11160
SENVAU39_11160
SENQAU40_12495
SENLIY59_11460
SENJCFSAN001992_00295
SEECCFSAN002050_18065
SEEBSEEB0189_008450
SENBBN855_23060(yeiU)
SENEIA1_11070
SENCSEET0819_18245
SESSARI_00674
SBGSBG_2028
SBZA464_2344
SBVN643_09885
SALZEOS98_07895
SFLSF2261
SFXS2390
SFVSFV_2252
SFESFxv_2495
SFNSFy_3209
SFSSFyv_3286
SFTNCTC1_02484(yeiU)
SSNSSON_2230
SBOSBO_2150
SBCSbBS512_E0784
SDYSDY_0905
SDZAsd1617_01140
SHQA0259_14695
ENCECL_03493
ENLA3UG_15695
ECLGEC036_30480
ECLEECNIH2_15670
ECLNECNIH4_07515
ECLIECNIH5_14615
ECLXLI66_15015
ECLYLI62_16515
ECLZLI64_14450
ECLOENC_39960
EHMAB284_10405
EXFBFV63_14835
ECLAECNIH3_14710
ECLCECR091_14645
EAUDI57_04055
EKBBFV64_15285
ENOECENHK_15140
EECEcWSU1_03086(yeiU)
ELGBH714_11485
ECANCWI88_07245
ERNBFV67_14730
ECLSLI67_016280
ECHGFY206_16785
ESHC1N69_15525
ENTEnt638_2770
EASEntas_2941
ENRH650_06640
ENXNI40_015185
ENFAKI40_1640
LNICWR52_19900
EBGFAI37_13965
ENDA4308_19810
ENZG0034_15755
ENSHWQ15_00525
ENKLOC22_03140
EHUD5067_0007595
EMORL6Y89_14830
ENBELK40_15545
ESAESA_01063
CSKES15_1310
CSZCSSP291_05060
CSJCSK29544_02390
CCONAFK62_13015
CDMAFK67_13645
CSIP262_01912
CMJAFK66_006380
CUIAFK65_13360
CMWAFK63_04975
CTUCTU_28400(yeiU)
KPNKPN_02607(yeiU)
KPUKP1_3836(yeiU)
KPMKPHS_36730
KPPA79E_1496
KPHKPNIH24_10285
KPZKPNIH27_17545
KPVKPNIH29_18320
KPWKPNIH30_18550
KPYKPNIH31_17485
KPGKPNIH32_18880
KPCKPNIH10_17925
KPQKPR0928_17945
KPTVK055_4914
KPOKPN2242_16105
KPRKPR_1483(yeiU)
KPJN559_1646
KPID364_13285
KPAKPNJ1_01746
KPSKPNJ2_01714
KPXPMK1_00094(yeiU)
KPBFH42_09155
KPNEKU54_008045
KPNULI86_08055
KPNKBN49_3824(yeiU)
KVAKvar_1453
KPEKPK_1555
KPKA593_02855
KVDKR75_00510
KVQSP68_07010
KOXKOX_25850
KOEA225_4072
KOYJ415_11715
KOMHR38_23985
KMIVW41_15320
KOKKONIH1_20145
KOCAB185_16135
KQUAVR78_22305
EAEEAE_24065
EARCCG29063
KQVB8P98_08745
KLLBJF97_20030
KLWDA718_08865
KARLGL98_07745
KGRJJJ10_08570
KPASLUW96_26615
RORRORB6_01470
RONTE10_19890
RPLNB1209_07680
RAODSD31_07870
RTGNCTC13098_02095(yeiU)
REEelectrica_01534(yeiU)
CROROD_23051
CKOCKO_00606
CBRAA6J81_00085
CWECO701_06995
CYOCD187_08190
CPOTFOB25_19305
CFQC2U38_16415
CSEDJY391_08005
CAMAF384_11675
CAFAL524_11205
CIFAL515_15375
CFARCI104_17000
CIRC2U53_26850
CIEAN232_12905
CPARCUC49_11415
CTELGBC03_13485
CITZE4Z61_01825
CARSE1B03_17860
EBTEBL_c13410(yeiU)
CNTJT31_19790
CEMLH23_21300
CENLH86_19895
CLAPNCTC11466_01379(yeiU)
PGELG71_12360
KSAC813_23450
KORAWR26_08390
KRDA3780_15595
KCOBWI95_20710
KOTEH164_07455
KPSEIP581_15245
KOBHF650_15870
KIENCTC12125_00477(yeiU)
KASKATP_14750(lpxT)
KLUK7B04_21625
LAXAPT61_07155
LEIC2U54_20435
LEHC3F35_19300
LEEDVA44_07345
LERGNG29_15455
LEAGNG26_15295
LPNUKQ929_06340
LAZA8A57_14390
LEFLJPFL01_2839
LEWDAI21_12240
BUFD8682_23070
BAGEBADSM9389_13380
BFTMNO13_07340
SYMK6K13_08100
METYMRY16398_16840(lpxT)
AHNNCTC12129_01666(yeiU)
ASUBNLZ15_14640
YREHEC60_10430
SGOEA8O29_007440
KINAB182_07285
PDZHHA33_10365
IZHFEM41_21980
PSGCG163CM_04390(lpxT)
SCOLKFZ77_13245
PVJLMA04_19275
EBFD782_1451
EBCC2U52_17830
EBUCUC76_23385
PSTSE05_23980
YPEYPO1276
YPKy2907
YPHYPC_2918(yeiU)
YPAYPA_0994
YPNYPN_2700
YPMYP_1313(pgpB4)
YPPYPDSF_2418
YPGYpAngola_A1502
YPZYPZ3_1169
YPTA1122_20285
YPDYPD4_1130
YPXYPD8_1015
YPWCH59_565(yeiU)
YPJCH55_1269(yeiU)
YPVBZ15_2276(yeiU)
YPLCH46_3851(yeiU)
YPSYPTB1310
YPOBZ17_1211(yeiU)
YPIYpsIP31758_2706
YPYYPK_2783
YPBYPTS_1402
YPQDJ40_919(yeiU)
YPUBZ21_584(yeiU)
YPRBZ20_671(yeiU)
YPCBZ23_916(yeiU)
YPFBZ19_717
YENYE1434
YEPYE105_C2681
YEYY11_03091
YELLC20_03593
YEWCH47_852(yeiU)
YETCH48_215(yeiU)
YEFFORC2_1471
YEEYE5303_12821
YSIBF17_15530
YALAT01_1063(yeiU)
YINCH53_256(yeiU)
YROCH64_1130
YRUBD65_782(yeiU)
YRBUGYR_04200
YAKACZ76_16040
YMADA391_14865
YHID5F51_05590
YCAF0T03_08065
YMOHRD69_18420
YASN0H69_10725
YKIHRD70_12140
SMARSM39_2809(lpxT)
SMACSMDB11_2572(lpxT)
SMWSMWW4_v1c33400(lpxT)
SPESpro_3242
SRRSerAS9_3383
SRLSOD_c31560(yeiU)
SRYM621_17190
SPLYQ5A_017135(lpxT)
SRSSerAS12_3384
SRASerAS13_3386
SMAFD781_2993
SLQM495_16590
SERFL085_11970
SERSSERRSCBI_16130
SFWWN53_25100
SFGAV650_20745
SRZAXX16_2083
SERASer39006_016285
SERQCWC46_16285
SERMCLM71_15930
SQUE4343_24580
SFJSAMEA4384070_3355(yeiU)
SOFNCTC11214_03478(yeiU)
SSURATE40_013225
SURIJ0X03_07315
SRHZFO014_18360
SENPKHA73_16235
SNEMNLX84_16665
RAHRahaq_1326
RACEJHW33_01135
RAQRahaq2_1403
RAAQ7S_06385
ROXBV494_01995
RVCJ9880_14450
GQUAWC35_03735
EAMEGXP68_07050
RBADH2866_01085
RCBO1V66_02815
ECAECA2734
PATREV46_13360
PATOGZ59_18260
PCTPC1_1647
PCCPCC21_016520
PCVBCS7_08240
PWAPecwa_1918
PPARA8F97_09245
PECW5S_1865
PWSA7983_16845
PPOABJK05_03265
PBRAB5S52_13475
PPUJE2566_08870
PARII2D83_09095
PAQUDMB82_0008530
PVZOA04_26310(lpxT)
PPAVLOZ86_13100
PQUIG609_007870
PPOOLW347_08610
PCACOI450_07175
DDDDda3937_03831(yeiU)
DSOA4U42_18150
CEDLH89_03205
DFNCVE23_09600
DDADd703_2334
BGJAWC36_09615
BNGEH206_13340
BIZHC231_08830
LBQCKQ53_15630
LPOPI6N93_09530
SGLSG0953
SODSant_1409(lpxT)
SLIGGTU79_18765
EAMEAMY_2308(yeiU)
EAYEAM_2226
ETAETA_12710
EPYEpC_13330
EPREPYR_01421(yeiU)
EBIEbC_30080
ERJEJP617_33640
EGEEM595_2451(yeiU)
EPECI789_03645
ERWIGN242_06770
ERPLJN55_15595
PAMPANA_2567(yeiU)
PLFPANA5342_1509(yeiU)
PAJPAJ_1861(yeiU)
PAQPAGR_g1462
PVAPvag_2049(yeiU)
PAGGAL522_17140
PAOPat9b_2658
KLNLH22_09230
PANTPSNIH1_16315
PANPPSNIH2_04635
PAGCBEE12_00830
PSTWDSJ_16430
PALHB1H58_14020
PANSFCN45_12950
PEYEE896_06445
PDISD8B20_11415
PERLAC65_10300
PJIKTJ90_06220
PGZC2E15_14005
PCDC2E16_14125
MINTC7M51_02010(lpxT)
MTHIC7M52_00832(lpxT)
TCIA7K98_13420
TPTYNCTC11468_02449(yeiU_2)
KPIEN5580_05725
PLUplu2863
PLUMA4R40_14275
PAYPAU_01673
PAKHB0X70_14635
PLUICE143_14630
PMRPMI0832
PMIBBB2000_0948
PVLAOB99_06590
PVGCRN77_15175
PHAUPH4a_13455
PROTBTA34_05250
PCOLF1325_07110
PCIBF9282_06890
XBOXBJ1_2892(yeiU)
XBVXBW1_2520(yeiU)
XNEXNC1_3152(yeiU)
XNMXNC2_3030(yeiU)
XDOXDD1_2533(yeiU)
XPOXPG1_1286(yeiU)
XHOA9255_08155
XBUHGO23_08190
MMKMU9_2759
HAVAT03_07635
HPARAL518_17945
OPODSM2777_12920
LPVHYN51_15690
PFQQQ39_11830
PRAGEKN56_05455
LRINCTC12151_01317(yeiU)
CSACsal_0690
HELHELO_3273
HCOLOKO_03370(yeiU)
HALOBWR19_16360
HAFC8233_09785
HCAMI4484_17945
HSXHNO51_17905
HSVHNO53_18245
HTXEKK97_20165
ZPLZBT109_1836 ZBT109_1837
HAAA5892_17715
CMAIBFX80_15830
CAMHLCW13_01450
COBECLAM6_02880
KUSB9G99_09770 B9G99_09775
KMAB9H00_05065 B9H00_05070
KUYFY550_03130 FY550_03135
AHAAHA_3523
AHYAHML_18655
AHDAI20_01745
AHRV428_19395
AHPV429_19425
AHJV469_03880
AHHRY45_18105
AHIVU14_04075
AAJBOQ57_18400
ASAASA_0794
AEOO23A_p2806
AVRB565_0678
AVOAMS64_04910
AMEDB224_0509
ASRWL1483_3679
ADHCK627_22055
AEMCK911_13185
AEAC2U39_04120
ARVC7N77_07845
AESC2U30_10120
AELNCTC12917_03497(yeiU)
ASIMFE240_03925 FE240_09805
AALLI6G90_12270
AJDI6H43_14425
ASAAKXJ75_04045
OCEGU3_03480 GU3_03985
OCMCBP12_09165 CBP12_11925
OPFCBP31_06150 CBP31_09430
ZDFAN401_01035 AN401_16620
ORBIPMB12_07765
SEDSAAY24_17215
SRISELR_09950
PFACPFJ30894_00421(yeiU)
 » show all
Reference
1  [PMID:18047581]
  Authors
Touze T, Tran AX, Hankins JV, Mengin-Lecreulx D, Trent MS
  Title
Periplasmic phosphorylation of lipid A is linked to the synthesis of undecaprenyl phosphate.
  Journal
Mol Microbiol 67:264-77 (2008)
DOI:10.1111/j.1365-2958.2007.06044.x
  Sequence
[eco:b2174]
Reference
2  [PMID:20384697]
  Authors
Herrera CM, Hankins JV, Trent MS
  Title
Activation of PmrA inhibits LpxT-dependent phosphorylation of lipid A promoting resistance to antimicrobial peptides.
  Journal
Mol Microbiol 76:1444-60 (2010)
DOI:10.1111/j.1365-2958.2010.07150.x
  Sequence
[eco:b2174]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.4.29
IUBMB Enzyme Nomenclature: 2.7.4.29
ExPASy - ENZYME nomenclature database: 2.7.4.29
BRENDA, the Enzyme Database: 2.7.4.29

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