KEGG   ENZYME: 2.7.7.104
Entry
EC 2.7.7.104                Enzyme                                 
Name
2-hydroxyethylphosphonate cytidylyltransferase;
Fom1
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
CTP:2-hydroxyethylphosphonate cytidylyltransferase
Reaction(IUBMB)
2-hydroxyethylphosphonate + CTP = cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate [RN:R12498]
Reaction(KEGG)
R12498
Substrate
2-hydroxyethylphosphonate [CPD:C06451];
CTP [CPD:C00063]
Product
cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} [CPD:C22216];
diphosphate [CPD:C00013]
Comment
The enzyme, isolated from the bacterium Streptomyces wedmorensis, is involved in fosfomycin biosynthesis. The enzyme also is active as EC 5.4.2.9 phosphoenolpyruvate mutase.
History
EC 2.7.7.104 created 2020
Pathway
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
Orthology
K23999  phosphoenolpyruvate phosphomutase / 2-hydroxyethylphosphonate cytidylyltransferase
Genes
OSGBST96_06905
MPRFJ8N69_05410(aepX)
PHNPAEH1_00300
MEUACJ67_08960
AZOazo2698(pepM)
AOAdqs_2833
HCPHCN_1062
HCBHCBAA847_0912
HWIA0Z60_07480(aepX)
CHYOCHH_1593
CHWA2J15_004815(aepX)
CINFCINF_1344
AFCAFAEC_0069 AFAEC_0075
ANTArnit_2943
NSANitsa_1412
DAKDaAHT2_1860
DALDalk_1323
ECOGFIV45_08000(aepX)
CTCCTC_01698
CTETBN906_01840
CBJH04402_02796
CBECbei_4338
CBZCbs_4338
CBEILF65_04862
CSRCspa_c46190(ppm)
CSBCLSA_c08730(ppm)
CBUTATN24_05940
CARGRSJ17_12820
CDYF3K33_22185(aepX)
CCAAKQH81_02885(aepX)
RALRumal_1340
CLEClole_3577
RIXRO1_19910
HASHalsa_0038
SSGSelsp_0338
SELEADJ74_04700
SELOAXE86_05255
SELTBCS37_10905
LCGL3BBH23_02720
CQNG7Y29_04590
TESBW730_00185
SAIUJ4H86_04280(aepX)
NHYJQS43_02325(aepX)
SNASnas_5665
NAVJQS30_13655(aepX)
AYMYM304_30130
OLSOlsu_0594
ARPNIES39_A00310
TDETDE_1413
TBETrebr_0279
TAZTREAZ_2217
TPITREPR_2364
SCDSpica_1331
TPKJO40_09715
TPHGFUT81_06855(aepX)
TRIDYE50_04590(aepX)
TPAVHRQ91_06190(aepX)
SBUSpiBuddy_0272
SGPSpiGrapes_1560
BHCJFL75_01540(aepX)
FSUFisuc_0993
FSCFSU_1439
BTHBT_1720
BTHOBtheta7330_01295(pphA)
BFRBF1832 BF2578
BFSBF9343_1814(aepX)
BFGBF638R_1867
BUNBun01g_29040
BEGINE88_02862
BSTEK6V31_00385(aepX)
BDOEL88_10435
PCOILK433_14490(aepX)
DRCG0Q07_19260(aepX)
NLIG3M70_12635(aepX)
METBAW729_03845
TARTALC_00083
PSYTDSAG12_01622(ribL_1)
ARGQT11_C0001G0509
 » show all
Reference
1  [PMID:28727444]
  Authors
Cho SH, Kim SY, Tomita T, Shiraishi T, Park JS, Sato S, Kudo F, Eguchi T, Funa N, Nishiyama M, Kuzuyama T
  Title
Fosfomycin Biosynthesis via Transient Cytidylylation of 2-Hydroxyethylphosphonate by the Bifunctional Fom1 Enzyme.
  Journal
ACS Chem Biol 12:2209-2215 (2017)
DOI:10.1021/acschembio.7b00419
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.104
IUBMB Enzyme Nomenclature: 2.7.7.104
ExPASy - ENZYME nomenclature database: 2.7.7.104
BRENDA, the Enzyme Database: 2.7.7.104

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