KEGG   ENZYME: 2.7.7.48
Entry
EC 2.7.7.48                 Enzyme                                 

Name
RNA-directed RNA polymerase;
RNA nucleotidyltransferase (RNA-directed);
RNA nucleotidyltransferase (RNA-directed);
RNA-dependent ribonucleate nucleotidyltransferase;
3D polymerase;
PB1 proteins;
PB2 proteins;
phage f2 replicase;
polymerase L;
Q-beta replicase;
phage f2 replicase;
ribonucleic acid replicase;
ribonucleic acid-dependent ribonucleate nucleotidyltransferase;
ribonucleic acid-dependent ribonucleic acid polymerase;
ribonucleic replicase;
ribonucleic synthetase;
RNA replicase;
RNA synthetase;
RNA transcriptase;
RNA-dependent ribonucleate nucleotidyltransferase;
RDRP;
RNA-dependent RNA polymerase;
RNA-dependent RNA replicase;
transcriptase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Reaction(IUBMB)
nucleoside triphosphate + RNAn = diphosphate + RNAn+1 [RN:R00444]
Reaction(KEGG)
Substrate
nucleoside triphosphate [CPD:C00201];
RNAn [CPD:C00046]
Product
diphosphate [CPD:C00013];
RNAn+1 [CPD:C00046]
Comment
Catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. See also EC 2.7.7.6 DNA-directed RNA polymerase.
History
EC 2.7.7.48 created 1981, modified 1982
Orthology
K00985  Enterovirus RNA-directed RNA polymerase
K11699  RNA-dependent RNA polymerase
K19376  Paramyxoviridae RNA-directed RNA polymerase L
K19389  Influenza virus RNA-directed RNA polymerase catalytic subunit
K21316  Rhabdoviridae RNA-directed RNA polymerase
K21924  Orthobornavirus RNA-directed RNA polymerase
K22472  HCV RNA-dependent RNA polymerase
K25021  SARS coronavirus RNA-directed RNA polymerase
K25303  Mammarenavirus RNA-dependent RNA polymerase L
K25309  Rotavirus RNA-directed RNA polymerase
K25311  Coltivirus RNA-directed RNA polymerase
K25323  Norovirus RNA-directed RNA polymerase
K25332  Flavivirus RNA-directed RNA polymerase NS5
K25333  Ebolavirus RNA-dependent RNA polymerase L
K25336  Marburgvirus RNA-dependent RNA polymerase L
K25345  Orthobunyavirus RNA-dependent RNA polymerase L
K25347  Orthonairovirus RNA-dependent RNA polymerase L
Genes
BFO: 118420943 118427356 118428502 118428503 118429714
BBEL: 109481876 109482478 109482591 109483270 109486421
SKO: 100373859
EAF: 111701756
ISC: IscW_ISCW001005 IscW_ISCW002744 IscW_ISCW004502 IscW_ISCW008904 IscW_ISCW008905 IscW_ISCW009270 IscW_ISCW018089
DSV: 119432954 119433454 119433620 119433862 119435580 119437001 119439287 119439367 119439400 119439416 119439527 119444391 119463244
RSAN: 119372084 119392810 119398745 119399513 119404543 119404960 119405282 119405482
RMP: 119177102 119177164 119179084 119179556 119181112 119181122 119181398 119185871 119187896
VDE: 111244709 111249053 111252784
VJA: 111259205 111262788 111263600 111267812
CBR: CBG04006
TSP: Tsp_01517
LAK: 106181258
LJA: Lj0g3v0080799.1(Lj0g3v0080799.1) Lj1g3v1911730.1(Lj1g3v1911730.1) Lj2g3v0855300.1(Lj2g3v0855300.1) Lj2g3v0855300.2(Lj2g3v0855300.2) Lj2g3v0855300.3(Lj2g3v0855300.3) Lj2g3v1069050.1(Lj2g3v1069050.1) Lj2g3v1069050.2(Lj2g3v1069050.2) Lj4g3v1535110.1(Lj4g3v1535110.1)
DOSA: Os01t0197900-01(Os01g0197900) Os01t0198000-01(Os01g0198000) Os01t0527600-01(Os01g0527600) Os04t0465700-01(Os04g0465700)
MNG: MNEG_1492
NCR: NCU02178(sad-1)
NTE: NEUTE1DRAFT149305(NEUTE1DRAFT_149305)
MGR: MGG_02748
SSCK: SPSK_02932
NHE: NECHADRAFT_91974(RDR2103)
MAW: MAC_00872
MAJ: MAA_07362
CMT: CCM_03262
MBE: MBM_00675
ANI: AN4790.2
ANG: ANI_1_2480094(An11g09540)
PBN: PADG_11586(PADG_03312)
ABE: ARB_07328
TVE: TRV_04770
PTE: PTT_17559
ZTR: MYCGRDRAFT_51407(RDR2402)
SPO: SPAC6F12.09(rdp1)
CNE: CNG01230
CNB: CNBG3560
ABP: AGABI1DRAFT127795(AGABI1DRAFT_127795) AGABI1DRAFT56570(AGABI1DRAFT_56570) AGABI1DRAFT56593(AGABI1DRAFT_56593) AGABI1DRAFT66661(AGABI1DRAFT_66661) AGABI1DRAFT72859(AGABI1DRAFT_72859)
ABV: AGABI2DRAFT117230(AGABI2DRAFT_117230) AGABI2DRAFT205003(AGABI2DRAFT_205003) AGABI2DRAFT205025(AGABI2DRAFT_205025) AGABI2DRAFT214572(AGABI2DRAFT_214572) AGABI2DRAFT220313(AGABI2DRAFT_220313)
DFA: DFA_00541(rrpB)
EHI: EHI_139420(171.t00022)
SMIN: v1.2.028223.t1(symbB.v1.2.028223.t1)
 » show all
Reference
1
  Authors
August, J.T., Cooper, S., Shapiro, L. and Zinder, N.D.
  Title
RNA phage induced RNA polymerase.
  Journal
Cold Spring Harbour Symp Quant Biol 28:95-97 (1963)
Reference
2  [PMID:14082356]
  Authors
HARUNA I, NOZU K, OHTAKA Y, SPIEGELMAN S
  Title
AN RNA "REPLICASE" INDUCED BY AND SELECTIVE FOR A VIRAL RNA: ISOLATION AND PROPERTIES.
  Journal
Proc Natl Acad Sci U S A 50:905-11 (1963)
DOI:10.1073/pnas.50.5.905
Reference
3  [PMID:13999778]
  Authors
WEISSMANN C, SIMON L, OCHOA S
  Title
Induction by an RNA phage of an enzyme catalyzing incorporation of ribonucleotides into ribonucleic acid.
  Journal
Proc Natl Acad Sci U S A 49:407-14 (1963)
DOI:10.1073/pnas.49.3.407
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.48
IUBMB Enzyme Nomenclature: 2.7.7.48
ExPASy - ENZYME nomenclature database: 2.7.7.48
BRENDA, the Enzyme Database: 2.7.7.48
CAS: 9026-28-2

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