KEGG   ENZYME: 2.7.7.50
Entry
EC 2.7.7.50                 Enzyme                                 
Name
mRNA guanylyltransferase;
RNGTT (gene name);
CEG1 (gene name);
mRNA capping enzyme;
messenger RNA guanylyltransferase;
Protein lambda2
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
GTP:mRNA guanylyltransferase
Reaction(IUBMB)
GTP + a 5'-diphospho-[mRNA] = diphosphate + a 5'-(5'-triphosphoguanosine)-[mRNA] [RN:R03828]
Reaction(KEGG)
R03828
Substrate
GTP [CPD:C00044];
5'-diphospho-[mRNA] [CPD:C02100]
Product
diphosphate [CPD:C00013];
5'-(5'-triphosphoguanosine)-[mRNA] [CPD:C02031]
Comment
The human enzyme is a multi domain protein that also has the activity of EC 3.6.1.74, mRNA 5'-phosphatase.
History
EC 2.7.7.50 created 1981, modified 2021
Orthology
K00987  mRNA guanylyltransferase
K13917  mRNA-capping enzyme
K21243  Alphabaculovirus DNA-dependent RNA polymerase subunit LEF-4
K25310  Rotavirus protein VP3
Genes
HSA8732(RNGTT)
PTR462878(RNGTT)
PPS100993736(RNGTT)
GGO101136858(RNGTT)
PON100439097(RNGTT)
NLE100588336(RNGTT)
MCC702334(RNGTT)
MCF102125723(RNGTT)
CSAB103240079(RNGTT)
CATY105588991(RNGTT)
PANU101001398(RNGTT)
TGE112623302(RNGTT)
RRO104657908(RNGTT)
RBB108532637(RNGTT)
TFN117097068(RNGTT)
PTEH111538067(RNGTT)
CJC100394937(RNGTT)
SBQ101049020(RNGTT)
CSYR103266422(RNGTT)
MMUR105863602(RNGTT)
OGA100957352(RNGTT)
MMU24018(Rngtt)
MCAL110292288(Rngtt)
MPAH110338665(Rngtt)
RNO313131(Rngtt)
MCOC116087980(Rngtt)
MUN110547371(Rngtt)
CGE100770876(Rngtt) 100773893
MAUA101838881(Rngtt)
PLEU114681721 114695435(Rngtt)
MORG121458403(Rngtt)
NGI103733076(Rngtt)
HGL101697192(Rngtt)
CPOC100732003(Rngtt)
DORD105998216(Rngtt)
DSP122107745(Rngtt)
NCAR124988525
OCU100340242(RNGTT)
OPI101535862 101536652(RNGTT)
TUP102495064(RNGTT)
CFA481914(RNGTT)
VVP112908388(RNGTT)
VLG121500237(RNGTT)
AML100483690(RNGTT)
UMR103659864(RNGTT)
UAH113264837(RNGTT)
UAR123798568(RNGTT)
ELK111158833
LLV125102458
MPUF101690994(RNGTT)
ORO101370328(RNGTT)
EJU114213060(RNGTT)
ZCA113927436(RNGTT)
MLX118001301(RNGTT)
FCA101096893(RNGTT)
PYU121029764(RNGTT)
PBG122489749(RNGTT)
PTG102959264(RNGTT)
PPAD109263391(RNGTT)
AJU106972542(RNGTT)
HHV120231871(RNGTT)
BTA511408(RNGTT)
BOM102269511(RNGTT)
BBUB102408950(RNGTT)
CHX102177341(RNGTT)
OAS101111376(RNGTT)
ODA120862736(RNGTT)
CCAD122422548(RNGTT)
SSC100520874(RNGTT)
CFR102516343(RNGTT)
CBAI105064127(RNGTT)
CDK105095541(RNGTT)
VPC102537528(RNGTT)
BACU103013048(RNGTT)
OOR101288281(RNGTT)
DLE111163638(RNGTT)
PCAD102995880(RNGTT)
PSIU116763608(RNGTT)
ECB100065700(RNGTT)
EPZ103549521(RNGTT)
EAI106826688(RNGTT)
MYB102249374(RNGTT)
MYD102770454(RNGTT)
MMYO118659810(RNGTT)
MLF102432858(RNGTT)
MNA107533435(RNGTT)
PKL118705103(RNGTT)
DRO112296942(RNGTT)
SHON118982278(RNGTT)
AJM119038679(RNGTT)
PDIC114494299(RNGTT)
PHAS123822009(RNGTT)
MMF118621042(RNGTT)
RFQ117020572(RNGTT)
PALE102887732(RNGTT)
PGIG120594956(RNGTT)
PVP105296983(RNGTT)
RAY107508669(RNGTT)
TOD119252683(RNGTT)
SARA101543017(RNGTT)
LAV100671236(RNGTT)
DNM101442726(RNGTT)
MDO100025582(RNGTT)
GAS123247489(RNGTT)
SHR100921795(RNGTT)
PCW110192035(RNGTT)
OAA100082839(RNGTT)
GGA421819(RNGTT)
PCOC116240660(RNGTT)
MGP100541550(RNGTT)
CJO107311978(RNGTT)
NMEL110395836(RNGTT)
ACYG106035397(RNGTT)
AFUL116487622(RNGTT)
TGU100232080(RNGTT)
LSR110478776(RNGTT)
SCAN103819287(RNGTT)
PMOA120511792(RNGTT)
OTC121340035(RNGTT)
PRUF121360529(RNGTT)
GFR102031604(RNGTT)
FAB101811251(RNGTT)
PHI102104686(RNGTT)
PMAJ107201707(RNGTT)
CCAE111925738 111925739
CCW104694262(RNGTT)
ETL114063766(RNGTT)
ZAB102069057(RNGTT)
FPG101910294(RNGTT)
FCH102049627(RNGTT)
CLV102089917
EGZ104135255(RNGTT)
NNI104021950(RNGTT)
ACUN113478600(RNGTT)
TALA104364707(RNGTT)
PADL103924648(RNGTT)
ACHC115335617(RNGTT)
AAM106489707(RNGTT)
AROW112974970(RNGTT)
NPD112946564(RNGTT)
DNE112979324(RNGTT)
ASN102376947(RNGTT)
AMJ102570226(RNGTT)
CPOO109311853(RNGTT)
GGN109299876(RNGTT)
PSS102453098(RNGTT)
CMY102935462(RNGTT)
CPIC101947951(RNGTT)
TST117875114(RNGTT)
CABI116818018
MRV120400375(RNGTT)
ACS100560223(rngtt)
PVT110076717(RNGTT)
SUND121921496(RNGTT)
PBI103048279(RNGTT)
PMUR107296765(RNGTT)
PGUT117660756(RNGTT)
VKO123022255(RNGTT)
PMUA114593943(RNGTT)
ZVI118082264(RNGTT)
GJA107115389(RNGTT)
STOW125431640(RNGTT)
XLA399383(rngtt.S)
XTR407900(rngtt)
NPR108785315(RNGTT)
RTEM120937106(RNGTT)
BBUF120998180(RNGTT)
BGAR122935055(RNGTT)
DRE405803(rngtt)
SRX107731501 107742988(rngtt)
SANH107660510 107680298(rngtt)
SGH107554925
CAUA113037664 113063493
PPRM120474125(rngtt)
MAMB125277738(rngtt)
IPU108256101(rngtt)
PHYP113529038(rngtt)
SMEO124401189(rngtt)
TFD113662347(rngtt)
EEE113590000(rngtt)
TRU101079531(rngtt)
TNGGSTEN00030419G001
LCO104936194(rngtt)
CGOB115028774(rngtt)
ELY117270900(rngtt)
PLEP121955307(rngtt)
SLUC116066138(rngtt)
ECRA117961477(rngtt)
PFLV114573592(rngtt)
GAT120808521(rngtt)
PPUG119194746(rngtt)
MSAM119909597(rngtt)
CUD121520906(rngtt)
ALAT119012706(rngtt)
MZE101470505(rngtt)
ONL100693252(rngtt)
OAU116312742(rngtt)
OLA101173353(rngtt)
OML112158300(rngtt)
XMA102225982(rngtt)
XCO114158778(rngtt)
XHE116734325(rngtt)
PRET103457371(rngtt)
PFOR103133411(rngtt)
PLAI106962886(rngtt)
PMEI106911250(rngtt)
GAF122825435(rngtt)
CVG107105147(rngtt)
CTUL119771567(rngtt)
GMU124882252(rngtt)
NFU107377729(rngtt)
KMR108233334(rngtt)
ALIM106525679(rngtt)
NWH119418315(rngtt)
CSEM103381224(rngtt)
SSEN122784009(rngtt)
HHIP117758441(rngtt)
HSP118099331(rngtt)
LCF108873496(rngtt)
SDU111239258(rngtt)
SLAL111661520(rngtt)
XGL120789264(rngtt)
HCQ109508037(rngtt)
BPEC110173038(rngtt)
MALB109962341(rngtt)
BSPL114849883(rngtt)
SASA100380472(rngtt)
OTW112217500(rngtt)
OMY110522104(rngtt)
OGO123994915(rngtt)
ONE115139593(rngtt)
SALP111972809(rngtt)
SNH120019650(rngtt)
ELS105017860(rngtt)
SFM108929338(rngtt)
PKI111843049(rngtt)
AANG118230509(rngtt)
LOC102693195(rngtt)
PSPA121317600(rngtt)
ARUT117411619(rngtt)
LCM102363178(RNGTT)
CMK103186202(rngtt)
RTP109911996(rngtt)
BFO118404722
BBEL109465799
SCLV120337899
SPU577418
DMEDmel_CG1810(mRNA-cap)
DER6550097
DSE6618519
DSIDsimw501_GD15855(Dsim_GD15855)
DYADyak_GE16118
DAN6498788
DSR110180624
DPODpse_GA14791
DPE6599294
DMN108155312
DWI6648910
DGR6565059
DMODmoj_GI15976
DAZ108619342
DNV108656840
DHE111596546
DVI6631663
CCAT101454832
BOD106616714
MDE101893695
SCAC106087451
LSQ119607078
HIS119658043
AGAAgaP_AGAP005142
ACOZ120952170
AARA120898157
ASTE118511535
AAG5575290
AALB109431612
CQUCpipJ_CPIJ018510
CPII120425624
CNS116347166 116351382
BCOO119070255 119076789
AME414001
ACER107995092
ALAB122718246
BBIF117207087
BVK117237346
BVAN117160926
BPYO122572696
CCAL108622917
OBB114878850
MGEN117229853
NMEA116428246
CGIG122404724
PFUC122526774
VPS122636961
NVI100113955 100118034
TPRE106649390
CGLO123273181
FAS105269236
DAM107040204
AGIF122852653 122855234 122855508 122855563
CCIN107272598
TCA660879
SOY115879688
CSET123312076
AGB108908923
LDC111513901
APLN108740019
PPYR116172284
OTU111424689
MSEX115456279
BANY112053878
PPOT106099499
PXU106127656
PRAP110994202
SLIU111352536
OFU114350316
API100169498 100169584
HHAL106691572
NLU120350672
PHUPhum_PHUM149080
FOC113217495
TPAL117639158
ZNE110830940
CSEC111869117
DMK116919835 116934547 116936452 123468033 123470576
PVM113804004
PJA122251329
PCHN125047836
HAME121879502
PCLA123746587
PTRU123503527
HAZT108675378
EAF111706330
LSM121118386
PPOI119095886 119095888
DSV119450721
RSAN119383714
RMP119170759
VDE111250669
VJA111261602
DPTE113799883
DFR124495188
SDM118185145
CELCELE_C03D6.3(cel-1)
CBRCBG_03700(Cbr-cel-1) CBG_03761
LGILOTGIDRAFT_213204
BGT106051004
GAE121377111
HRF124148416
HRJ124258779
CRG105322687
PMAX117316469
OSN115223445
NVE5511796
ATEN116300710
XEN124439938 124449714
HMG100205625
ATHAT3G09100 AT5G01290 AT5G28210
ALY9307003 9320779
CRB17881235 17890698
CSAT104708977 104734174 104745076 104749285 104764607 104768335
EUSEUTSA_v10000074mg EUTSA_v10020216mg
BRP103855428 103870561 117131528 117131533
BNA106427351 106433828 111215797
BOE106295759 106336393
RSZ108846505 108846508 108860069
THJ104816222 104823280 104827039
CPAP110814241
CIT102609768
CICCICLE_v10011182mg
PVY116134565
MINC123192666 123201994
TCC18597604
GRA105761849 105786527
GHI107898847 107899038 107905646 107941706 107958035
GAB108467315 108473646
DZI111294014 111312022
EGR104426395
GMX100776633 100803597
GSJ114395445 114415507
PVUPHAVU_010G008200g
VRA106753467
VAR108322542
VUN114166056
CCAJ109788592 109815064
APRC113848903 113860645
MTRMTR_4g014920 MTR_7g066810
CAM101496087 101515090
LJALj0g3v0256839.2(Lj0g3v0256839.2) Lj3g3v1603870.2(Lj3g3v1603870.2)
ADU107475134
AIP107625682
AHF112727906 112749454
LANG109339089 109340917
FVE101311588
RCN112193240
PPER18775434
PMUM103338253
PAVI110757331
PDUL117631546
MDM103433569 103450536
PXB103949448 103959590
ZJU107430745
MNT21402718 21402720
CSV101209960
CMO103491007
BHJ120073197
MCHA111019426
CMAX111466182 111478187
CMOS111438145 111453716
CPEP111803494
RCU8262595
JCU105646640
HBR110661792 110667973
MESC110620874 110622631
POP18100001
PEU105121971
PALZ118037561 118037563 118048390
JRE109000805 109004210
QSU111987380 112005893 112006691 112027729 112036124
QLO115954106 115976991
TWL119995268 120013062
VVI100256199
VRI117920000
SLY101258480
SPEN107031176
SOT102584702
CANN107847477
NTA107818261
NSY104248191
NTO104100989
NAU109229421
INI109158896 109181493
SIND105161563
OEU111373839
HAN110918265 110936015
ECAD122593609 122608141
LSV111884062
CCAV112507049
DCR108196097 108199385
CSIN114267699 114287661 114319874
BVG104908854
SOE110804970
CQI110719040 110738468
NNU104597018
MING122090070
TSS122660064 122662197
PSOM113303508
OSA4350086 4351709
DOSAOs12t0193200-01(Os12g0193200)
OBR102700564 102702516
BDI100825234 100840366
ATS109749722 109782048
TDC119286366 119295370 119353000 119362063
TAES123043384 123051254 123086552 123091397 123096366 123187213
TUA125530610 125535356
SBI8071691
ZMA100193119 103646942
SITA101755911
SVS117866810
PVIR120644093 120685815
PHAI112902508
PDA103705692 103715187
EGU105048839 105049618
MUS103992112
DCT110110603
PEQ110021775
AOF109832843
ATR18436476
SMOSELMODRAFT_100916
PPP112283864
CRECHLRE_08g376700v5 CHLRE_33g758897v5
CSLCOCSUDRAFT_34803
CVRCHLNCDRAFT_24090
APROF751_1379
OLUOSTLU_36207
OTAOT_ostta02g05080
BPGBathy14g02310
MISMICPUN_112642
MPPMICPUCDRAFT_1330
CMECYME_CMA035C
SCEYGL130W(CEG1)
SEUBDI49_1844
SPAOSPAR_G01180
AGOAGOS_AFL107W
ERCEcym_2188
KLAKLLA0_B02200g
KMXKLMA_40549(CEG1)
LTHKLTH0H03850g
VPOKpol_228p3
ZROZYRO0E07150g
CGRCAGL0I09570g
NCSNCAS_0D04100(NCAS0D04100)
NDINDAI_0I00830(NDAI0I00830)
TPFTPHA_0E02770(TPHA0E02770)
TBLTBLA_0A02070(TBLA0A02070)
TDLTDEL_0E05370(TDEL0E05370)
TGBHG536_0E05470
KAFKAFR_0K02360(KAFR0K02360)
KNGKNAG_0F01900(KNAG0F01900)
ZMKHG535_0B00970
PPAPAS_chr2-1_0216
DHADEHA2D03322g
PICPICST_34053(CEG1)
PGUPGUG_01540
SPAASPAPADRAFT_53905
LELLELG_05654
CALCAALFM_C405760WA(CGT1)
CTPCTRG_03836
COTCORT_0B00700
CDUCD36_45420(CGT1)
CTENCANTEDRAFT_114096
YLIYALI0E02904g
CLUCLUG_02318
CLUSA9F13_22g00792
CAURCJI97_004578
SLBAWJ20_1325(CEG1)
PKZC5L36_0C01940
BNNFOA43_002033
BBRXBRETT_003980
OPAHPODL_01362
SLUDSCDLUD_001115
NCRNCU06260
NTENEUTE1DRAFT81441(NEUTE1DRAFT_81441)
SMPSMAC_00077
PANPODANSg4788
TTTTHITE_2118870
MTMMYCTH_2305148
MGRMGG_12831
PPEIPpBr36_06054
TMNUCRPA7_86
SSCKSPSK_07590
FGRFGSG_06951
FPUFPSE_04773
FVRFVEG_08243
FOXFOXG_01865
NHENECHADRAFT_68506
TRETRIREDRAFT_54450
TRRM419DRAFT_125929
MAWMAC_03147
MAJMAA_05816
CMTCCM_02636
VALVDBG_06692
VDAVDAG_05749
CFJCFIO01_10277
CHIGCH63R_02262
SAPOSAPIO_CDS7700
ELAUCREL1_2088
PFYPFICI_03431
SSLSS1G_13698
BFUBCIN_13g00390(Bcceg1)
MBEMBM_04493
PSCOLY89DRAFT_581241
GLZGLAREA_09870
ANIAN7473.2
AFMAFUA_2G05780
ACTACLA_068560
NFINFIA_082500
AORAO090001000697
ANGANI_1_1966024(An02g14240)
AFVAFLA_012831
ALUCAKAW2_11196S(CEG1)
ACHEACHE_80301A(CEG1)
APUUAPUU_80575S(CEG1)
PCSPc22g09050
PDPPDIP_86740
TMFPMAA_071310
TRGTRUGW13939_06295
CIMCIMG_00792
CPWCPC735_055110
UREUREG_00757
PBLPAAG_02227
PBNPADG_05365
ABEARB_04899
TVETRV_05912
AJEHCAG_07297
BGHBDBG_08042
PNOSNOG_13749
PTEPTT_12153
BZECOCCADRAFT_23109
BSCCOCSADRAFT_327773
BORCOCMIDRAFT_96941
AALTCC77DRAFT_1015767
ZTRMYCGRDRAFT_70544
PFJMYCFIDRAFT_210703
FFUCLAFUR5_05400
BCOMBAUCODRAFT_382033
NPAUCRNP2_3709
TMLGSTUM_00010206001
SPOSPBC2F12.08c(ceg1)
CNECNB01130
CNBCNBB4580
CNGCNAG_03610
CGICGB_B6560C
TMSTREMEDRAFT_62350
TASAA1Q1_05416
PPLPOSPLDRAFT_134948 POSPLDRAFT_134950
TVSTRAVEDRAFT_164684
DSQDICSQDRAFT_132239
PCOPHACADRAFT_120236
SHSSTEHIDRAFT_128866
HIRHETIRDRAFT_438535
PSQPUNSTDRAFT_104687
ADLAURDEDRAFT_145190
FMEFOMMEDRAFT_104172
GTRGLOTRDRAFT_72544
MRRMoror_853
MOREE1B28_009001
CCICC1G_01010
SCMSCHCODRAFT_38732
ABPAGABI1DRAFT52628(AGABI1DRAFT_52628)
ABVAGABI2DRAFT148425(AGABI2DRAFT_148425)
PCUBJR316_0003853
CPUTCONPUDRAFT_97447
SLASERLADRAFT_475657
WSEWALSEDRAFT_46256
WICJ056_003667
UMAUMAG_04881
PFPPFL1_04278
MGLMGL_3457 MGL_4188
MRTMRET_0836
PGRPGTG_00459
MLRMELLADRAFT_45847
ECUECU09_0400
EINEint_090400
EHEEHEL_090390
EROEROM_090400
DDIDDB_G0289199
DPPDICPUDRAFT_50749
EHIEHI_035610(17.t00048)
EDIEDI_019080
PFAPF3D7_1414600
PFDPFDG_02336
PFHPFHG_04031
PREIPRSY57_1413900
PGABPGSY75_1414600
PYOPY17X_1030500
PCBPCHAS_102890
PBEPBANKA_1028100
PVVPVVCY_1003340
PKNPKNH_1343500
PVXPVX_085720
PCYPCYB_134210
TANTA12700
TPVTP02_0352
TOTTOT_020001004
BEQBEWA_020780
BBOBBOV_III006110(17.m07541)
BMICBMR1_03g02270
BBIGBBBOND_0308240
CPVcgd6_2380
CHOChro.60277
TGOTGME49_305320
TETTTHERM_00760200
PTMGSPATT00012039001
PIFPITG_08375
EHXEMIHUDRAFT_106724 EMIHUDRAFT_107852 EMIHUDRAFT_117749
TVATVAG_187730
GLAGL50803_0017308
 » show all
Reference
1  [PMID:1058472]
  Authors
Ensinger MJ, Martin SA, Paoletti E, Moss B.
  Title
Modification of the 5'-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus.
  Journal
Proc Natl Acad Sci U S A 72:2525-9 (1975)
DOI:10.1073/pnas.72.7.2525
Reference
2  [PMID:629955]
  Authors
Groner Y, Gilboa E, Aviv H.
  Title
Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates.
  Journal
Biochemistry 17:977-82 (1978)
DOI:10.1021/bi00599a005
Reference
3  [PMID:3029058]
  Authors
Itoh N, Yamada H, Kaziro Y, Mizumoto K.
  Title
Messenger RNA guanylyltransferase from Saccharomyces cerevisiae. Large scale purification, subunit functions, and subcellular localization.
  Journal
J Biol Chem 262:1989-95 (1987)
  Sequence
[sce:YGL130W]
Reference
4  [PMID:1194287]
  Authors
Martin SA, Moss B.
  Title
Modification of RNA by mRNA guanylyltransferase and mRNA (guanine-7-)methyltransferase from vaccinia virions.
  Journal
J Biol Chem 250:9330-5 (1975)
Reference
5  [PMID:1194286]
  Authors
Martin SA, Paoletti E, Moss B.
  Title
Purification of mRNA guanylyltransferase and mRNA (guanine-7-) methyltransferase from vaccinia virions.
  Journal
J Biol Chem 250:9322-9 (1975)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.50
IUBMB Enzyme Nomenclature: 2.7.7.50
ExPASy - ENZYME nomenclature database: 2.7.7.50
BRENDA, the Enzyme Database: 2.7.7.50
CAS: 56941-23-2

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