KEGG   ENZYME: 2.7.7.74
Entry
EC 2.7.7.74                 Enzyme                                 
Name
1L-myo-inositol 1-phosphate cytidylyltransferase;
CTP:inositol-1-phosphate cytidylyltransferase (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS));
IPCT (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS));
L-myo-inositol-1-phosphate cytidylyltransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
CTP:1L-myo-inositol 1-phosphate cytidylyltransferase
Reaction(IUBMB)
CTP + 1L-myo-inositol 1-phosphate = diphosphate + CDP-1L-myo-inositol [RN:R09669]
Reaction(KEGG)
R09669
Substrate
CTP [CPD:C00063];
1L-myo-inositol 1-phosphate [CPD:C04006]
Product
diphosphate [CPD:C00013];
CDP-1L-myo-inositol [CPD:C19794]
Comment
In many organisms this activity is catalysed by a bifunctional enzyme. The cytidylyltransferase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 (CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase) is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments.
History
EC 2.7.7.74 created 2011
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K07281  1L-myo-inositol 1-phosphate cytidylyltransferase
K23992  1L-myo-inositol 1-phosphate cytidylyltransferase / CDP-L-myo-inositol myo-inositolphosphotransferase
Genes
MTHDA3224_07290
ENMEBS_0412
DBKDGMP_08060
CCROCMC5_034520 CMC5_075830
PAUUE8A73_025990
DAODesac_2272
SFUSfum_2920
BSEDDN745_05540 DN745_10835
PCAYFRD00_02815 FRD00_21750
NARSaro_0100 Saro_0102
NOTC7W88_05615
NORFA702_11445 FA702_11455
NGFFRF71_04960
NOGGKE62_14325
STAXMC45_06680
SNJA7E77_02155
SMYBJP26_11175
SKRBRX40_00985
SPLMBXU08_09805
SPLKAV944_05835
SPHCCVN68_10510
SPHFDM480_12980
SPAPH3Z74_16915 H3Z74_19210
SARIH5J25_13030
SPHJBSL82_01690
SMICSmB9_25610
SPHSETR14_18250
SANDH3309_10530
ERYCP97_03755 CP97_03775
PORLBG023_11492 BG023_11496
PHZCHX26_13940 CHX26_13960
GBEGbCGDNIH1_0237
GBHGbCGDNIH2_0237
GBCGbCGDNIH3_0237
GBSGbCGDNIH4_0237
GDIGDI0629(hasC)
GDJGdia_1377
LCKHN018_00880
NAOY958_26660
ECOGFIV45_08015 FIV45_13855
CTHUHUR95_02260
NTRB0W44_00905
TMRTmar_0126
THEFE1B22_04180
THEPDYI95_000435
TPZTph_c20790
KMEH0A61_00158(spsI)
ATLAthai_19700
RXYRxyl_1212
TBHTbon_07190
TTRTter_0472
SSMSpirs_4227
ADINH7849_05720
RMRRmar_1196
RMGRhom172_1617
NOBCW736_12840
CACICLOAM0421
AAEaq_1367(spsI)
PMXPERMA_1921
TTKTST_0884
TMMTmari_1425
TMITHEMA_07220
TMWTHMA_1449
TMQTHMB_1449
TMXTHMC_1449
TPTTpet_1374
TNPTnap_1392
TRQTRQ2_1312
TNACTN_1074
THQT2812B_07090
THZCELL2_07150
THRTRQ7_06825
CABYCabys_1832
NDENIDE0736
NMVNITMOv2_0605
NIONITINOP_0313
NJANSJP_1717
TIDThein_0126
TAVG4V39_06760
TMAIFVE67_04000
NLIG3M70_02610 G3M70_02615
MOXDAMO_2608
MIFMetin_0454
MIGMetig_1787
METFCFE53_00410
AFUAF_0263
AFGAFULGI_00002550
APOArcpr_0766
AVEArcve_1159 Arcve_2013
ASTAsulf_00859
FPLFerp_0148 Ferp_0859
GACGACE_2065
GAHGAH_01161
PFUPF1058
PFIPFC_04525
PHOPH1219(PH1219)
PABPAB2433
PYNPNA2_1704
PYAPYCH_00120
PYSPy04_1010
PYCTQ32_04290
TKOTK2279
TONTON_1248
TGATGAM_1853
TSITSIB_1010
TBATERMP_01130
THEGQS_09430
THATAM4_5
THMCL1_1475
TLTOCC_08385
THSTES1_1181
TNUBD01_1626
TEUTEU_00190
TCHCHITON_0904
TPEPA0127_03970
TGGA3K92_01915
TCEA3L02_05685
TBSA3L01_06850
THHCDI07_06820
TSLA3L11_01110
TTDA3L14_09240
TPRFA3L09_03245
TRLA3L10_06295
TPAFA3L08_00135
THYA3L12_02080
TCQTIRI35C_1679
THEIK1720_08170
PPACPAP_05835
APEAPE_1514.1
ACJACAM_0951
IAGIgag_0487
HBUHbut_0150
PFMPyrfu_0046
PDLPyrde_0746
TPETpen_1250
THBN186_00105
THELIG193_09070
KCRKcr_0184
BARCAOA65_0707
 » show all
Reference
1  [PMID:17526717]
  Authors
Rodrigues MV, Borges N, Henriques M, Lamosa P, Ventura R, Fernandes C, Empadinhas N, Maycock C, da Costa MS, Santos H
  Title
Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles.
  Journal
J Bacteriol 189:5405-12 (2007)
DOI:10.1128/JB.00465-07
  Sequence
[aae:aq_1367] [afu:AF_0263] [pfu:PF1058][rxy:Rxyl_1212] [tko:TK2279]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.74
IUBMB Enzyme Nomenclature: 2.7.7.74
ExPASy - ENZYME nomenclature database: 2.7.7.74
BRENDA, the Enzyme Database: 2.7.7.74

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