KEGG   ENZYME: 2.7.7.82
Entry
EC 2.7.7.82                 Enzyme                                 
Name
CMP-N,N'-diacetyllegionaminic acid synthase;
CMP-N,N'-diacetyllegionaminic acid synthetase;
neuA (gene name);
legF (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
CTP:N,N'-diacetyllegionaminate cytidylyltransferase
Reaction(IUBMB)
CTP + N,N'-diacetyllegionaminate = CMP-N,N'-diacetyllegionaminate + diphosphate [RN:R10182]
Reaction(KEGG)
R10182
Substrate
CTP [CPD:C00063];
N,N'-diacetyllegionaminate [CPD:C20418]
Product
CMP-N,N'-diacetyllegionaminate [CPD:C20419];
diphosphate [CPD:C00013]
Comment
Isolated from the bacteria Legionella pneumophila and Campylobacter jejuni. Involved in biosynthesis of legionaminic acid, a sialic acid-like derivative that is incorporated into virulence-associated cell surface glycoconjugates which may include lipopolysaccharide (LPS), capsular polysaccharide, pili and flagella.
History
EC 2.7.7.82 created 2012
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K18431  CMP-N,N'-diacetyllegionaminic acid synthase
Genes
CITZE4Z61_12365
LEFLJPFL01_2718
SRLSOD_c14550(ptmB)
SQUE4343_08210
SOFNCTC11214_05338(neuA)
PPARA8F97_19530
VPHVPUCM_0206
VCAM892_09465
VOWA9237_07125
VAFD1115_16670
VNLD3H41_01120
VAQFIV01_00050(neuA1)
PMAICF386_03190
PMEDE3Z27_08385
PVKEPZ47_08515
PXAKSS93_10455
MLQASQ50_04370
MARJMARI_04490(neuA)
PSYCDABAL43B_0735(neuA)
ABZABZJ_00083
ABDABTW07_0089
ABABBJAB0715_00100
ABAJBJAB0868_00099
ATNFM020_15590
SBTSbal678_3131
SBKSHEWBE_0693(siaB)
SLITJQC75_12060
ILOIL0518(siaB)
ILIK734_02595 K734_02775
COZA3Q34_06155
COVEKO29_16880
PIAPI2015_0476
PRRAT705_09930
AMKAMBLS11_04845
ASPAOR13_2478
ASQAVL57_11065
AAWAVL56_10205
ALEAV939_10085
ALZAV940_09855
PMESFX988_03696
PAEWKIH87_01875
FESHER31_10800
MVSMVIS_3783(siaB)
MMAAFR932_21270
LPNlpg0751(neuA)
LPHLPV_0877(neuA)
LPOLPO_0832(neuA)
LPULPE509_02460
LPMLP6_0731(neuA)
LPFlpl0788(neuA)
LPPlpp0817(neuA)
LPCLPC_2541(neuA)
LPAlpa_01159(neuA)
LPElp12_0761
LFALFA_0803
LCDclem_09295(neuA_1) clem_09325(neuA_2) clem_09390(neuA_3) clem_09460(neuA_4)
LWASAMEA4504053_1065(neuA)
MDNJT25_014965
MDHAYM39_17530
MKOMKLM6_3560
METLU737_04555
MOZMoryE10_08870
FPHFphi_1170
FPIBF30_1414
FPXKU46_144
FHACDV26_09110
FRCKX01_1743
TCXTcr_1455
HTREPV75_07790
HMARHVMH_1501(neuA)
TAOTHIAE_07300
THIOAYJ59_06125
THIGFE785_07400
TSETHMIRHAS_08980(neuA)
BLEPAL038_07835
TEETel_05530
THIMKFB96_06495
HAZA9404_06805
GAIIMCC3135_21680(neuA_1) IMCC3135_22670(neuA_2)
HAHEENC22_08715 ENC22_10840
MMEMarme_0611
AAJBOQ57_08300
AEMCK911_04480
ARVC7N77_17325
SLIMSCL_1208
TBNTBH_C0743
THOSP60_02300 SP60_02365
CHRIDK842_11440
CHRBDK843_16885
CRZD1345_23645
PRBX636_09640
CARIFNU76_04770
PIGEGT29_04930
POSDT070_03515
POOF7R28_05925
CBXCenrod_0010(neuA)
MIUABE85_17590
JAJEKL02_02190
HHTF506_01245
TINTint_2653
THITHI_3182
NEUNE1569(neuA1)
NETNeut_1548
NSTNstercoris_01519
NMUNmul_A0410
NLCEBAPG3_000885
METRBSY238_2006
SLACSKTS_36100(neuA)
ACOMCEW83_19910
HHQHPSH169_04325
HHRHPSH417_04095
HPUHPCU_04475
HPTHPSAT_02535
HEPHPPN120_04175
HEUHPPN135_04155
HPYKHPAKL86_02825
HACHac_1269(neuA)
HMSHMU06140(siaB)
HFEHFELIS_02740(siaB)
HBIHBZC1_02550
HCEHCW_07295
HCMHCD_01685
HCPHCN_1207 HCN_1208 HCN_1209 HCN_1214
HCBHCBAA847_0752 HCBAA847_0757 HCBAA847_0758 HCBAA847_0759
HBLXJ32_10875
HADCDV25_02410
HETBBW65_04550
HCLNCTC13205_00836(siaB)
SULGFJR48_00810
SPALFM071_00620
SMASHUE87_09335
SULRB649_08520
CJECj1331(ptmB)
CJBBN148_1331(ptmB)
CJJCJJ81176_1161
CJUC8J_1333
CJNICDCCJ07001_1101
CJICJSA_1267(ptmB)
CJSCJS3_1425
CJPA911_06470
CJEJN564_02275
CJEUN565_02365
CJENN755_02425
CJEIN135_01419
CJERH730_07610
CJYQZ67_01222(neuA) QZ67_01467(legF_2)
CJQUC78_1274(legF_2)
CJLPJ17_05855 PJ17_07040 PJ17_07460
CJWPJ18_05665 PJ18_06840
CJRCJE1520(ptmB)
CJDJJD26997_0378(ptmB)
CJZM635_01415 M635_02350
CJXBN867_13160
CCOCCC13826_2299(legF)
CCOCCCON33237_1634(legF)
CLACLA_1229(legF)
CLLCONCH_0311
CCOLBN865_08050c BN865_09870c
CCCG157_01710 G157_02165
CCQN149_1294(legF)
CCFYSQ_02195
CCYYSS_06180 YSS_07220 YSS_07635
CCOIYSU_02230
CCOFVC76_06680(legF_2)
CCOOATE51_00902(legF_2)
CAJCIG1485E_0045 CIG1485E_0047(legF)
CISCINS_1190(legF) CINS_1203(neuA)
CVOCVOL_1210(legF)
CSMCSUB8521_1413(legF)
CSFCSUB8523_1513(legF)
CHVCHELV3228_1651(legF)
CLXCLAN_1245(legF)
CAVICAV_1245(legF)
CAMZCVIC12175_0318(legF)
CAMYCSUIS_1332(legF)
COJCORN_1302
CUXCUP3940_0188(legF) CUP3940_0882(neuA)
CBLACBLAS_1484(neuA)
CARMCARM_1260(legF)
CMUCCMCT_0190(legF)
CNVCNZW441b_0378(legF)
SBASulba_1894
ABTABED_0623
ABLA7H1H_1746
ATPATR_1810
ACIBACBT_0323
ACREACRYA_0155
ALANALANTH_0846
AELLAELL_2678
ACLOACLO_2502
ARCABLL_0815
ALKALEK_0983
AMYTAMYT_0901
APAIAPAC_2449
HBVABIV_2485
GSBGSUB_14700
GSUBKP001_18470 KP001_19695
GPLM1B72_02000 M1B72_03385
PACEA6070_09810
PEFA7E78_05545
DEUDBW_1496
DFLDFE_2596 DFE_2600 DFE_2854
DHYDESAM_21178
DAFDesaf_0644
DPIBN4_12686
PSELGM415_02260 GM415_04205
DSFUWK_02448 UWK_03118
DTOTOL2_C35410(neuA)
DMMdnm_097120
BBAEFRD01_15930
NAFGQ61_06870
PMOBHG718_03805
RBSRHODOSMS8_01664(legF)
SIXBSY16_2621
EMXFKV68_30735
RELREMIM1_CH00778
REIIE4771_CH00806
RLGRleg_0443
RRGJ3P73_04770
RHTNT26_3158
BJAblr5996(ptmB)
BRCBCCGELA001_25440 BCCGELA001_25505
BRADBF49_5664
BOTCIT37_24310 CIT37_24405
BRQCIT40_21835 CIT40_21930
BGQX265_13765
BSYMCIT39_21125 CIT39_21220
BDGLPJ38_31940
BSEIKMZ68_19020
RPBRPB_1536
RPERPE_4239
NWINwi_2397
MCHMchl_3990
RHZRHPLAN_50180
DEIC4375_03860
DEAFPZ08_13195
BVRBVIR_1973
BLAGBLTE_00370
MHEYH2LOC_005775
PSINCAK95_17660
RBMTEF_17260
BSBBresu_3265
RLIRLO149_c044220
OTMOSB_23460(legF)
OCTFTO60_12850
OCDFHY55_17140
RCPRCAP_rcc02967
RBLB6K69_05230
PTPRCA23_c02120
DONBSK21_04525
LVSLOKVESSMR4R_02195(legF)
TAWEI545_04020
BOOE2K80_11645
PSEBEOK75_02965
PAEDG5B38_19515
PAMOBAR1_08375
RBZB9057_08970 B9057_15025
FAQG5B39_16625
CBOTATE48_13360
SALSala_1578 Sala_1581
SLANGV829_10175
ERKCD351_01760
ALIAZOLI_p60076 AZOLI_p60140(neuA)
AZZDEW08_29930 DEW08_30030
RCERC1_3768(neuA)
MGYMGMSRv2__3413(ptmB)
MGRYMSR1_31150(neuA)
MAGXXM1_0964
MAGNWV31_13100
THAIIT893_15770
MAGQMGMAQ_3695 MGMAQ_3718
MGMMmc1_0559
PELSAR11G3_00107
APMHIMB5_00011120
ECOGFIV45_02400
BBABd1686(neuA)
BSTOC0V70_01595
SBFJCM31447_25320 JCM31447_25510
BPUMBW16_10400
BPUSUP12_09695
BXIBK049_17435
BALTCFN77_10220
BSAFBSL056_10675
BACWQR42_09650
OCNCUC15_16540
ANMGFC28_3020
ANLGFC29_2415
LYSLBYS11_03265
LYBC3943_04100
LYZDCE79_02920
LPAKGDS87_03430
LMACI6G82_14980
LYCFH508_0003275
LCAPICJ70_21060
TAIDKS242_13215
FPNABE65_018200
APAKAP3564_07765
POFGS400_17635
BVJI5776_04785
PPYPPE_04402
PTAHPL003_04500
PDUPDUR_25205
PPEOABE82_23150
PAIHASL14_14795
PALBEJC50_01620
PRZGZH47_18515
PLYCGXP70_28080
PTRIKDC22_30460
PALOE6C60_3855
CCHLFPL14_11265
TUMCBW65_04520
TABCIG75_02450
EFFskT53_28690
SIVSSIL_3274
SOBCSE16_03035
SPOSDV702_01120
PAEKD3873_03375
EFCEFAU004_01366
EFAUEFAU085_00965
EFUHMPREF0351_10922(neuA)
AUIAPT62_03120
CARCNY10_945
CNONT01CX_1783
CBLCLK_2102
CBBCLD_1850
CBNCbC4_0995 CbC4_1116
CBMCBF_2765
CKLCKL_2466(neuA)
CKRCKR_2180
CCBClocel_2195
CEUA7L45_12115
CTAEBGI42_06500
CFMBJL90_06980 BJL90_21210
CCHVBTM20_03700
CGASJ1C67_15985
CMAHC1I91_08390
HHWNCTC503_01055(neuA_1)
CALEFDN13_00885
CTHCthe_2639
CTXClo1313_0228
CCLClocl_4178
HSCHVS_09970(legF)
CAPREQM14_03330
BPBbpr_I0432(neuA1)
CLEClole_3570
ARFAR1Y2_2888
PXVFXF36_03370
ANRAna3638_07750 Ana3638_07860
LBWC3V36_05600
CSTCLOST_0369(neuA)
PSORRSJ16_13970
TEBT8CH_0145
DDLDesdi_3205
DMTDESME_12770
DORDesor_0346
FWADCMF_13700
AACXDEACI_3995
AWOAwo_c24820(neuA)
CBARPATL70BA_2647
THEPDYI95_003440
CTHMCFE_2504
TITThit_0484
MTHOMOTHE_c07020(neuA)
MTHZMOTHA_c07960(neuA)
COBCOB47_0923
CCHAELD05_07930
TXYThexy_1873
TSHTsac_2665
HPKHprae_0329
HALSD7D81_05085 D7D81_17920
AFTBBF96_11105
SPOAEQM13_03515
SELOAXE86_07145
MANAMAMMFC1_02390(neuA)
TURAT726_03470
LPILLIP_2374
MSEDE3O41_11640
HUWFPZ11_09620
ARTHC3B78_15465
ARIUM93_07615
MICKB1A86_00002525
RDNHMPREF0733_11424
RTERIDM49_08865
RAMAIDM48_08705
RKRI6G21_06730
NAEBHE16_04890
DNIHX89_10670
DAYFV141_09820
TEHGKE56_00605
PHWG7075_09745
NROK8W59_19490
ACTOC3V41_10125
PLANA1s21148_00255
NHIB1s21160_05765
SYGsync_0182(neuA-2)
DSLDacsa_0260 Dacsa_2196
SYWSYNW0444
PMBA9601_13421
PMHP9215_14631
PRCEW14_1450
GENGM3709_1255
CWACwatDRAFT_1938
MPROBJP34_15945 BJP34_26760 BJP34_35260
NOPNos7524_1916
NSPBMF81_04461(legF)
SCSSta7437_2603
OBGVerru16b_02057(neuA)
BVOPan97_06830(neuA)
RLCK227x_18860(neuA)
GMRGmarT_17210(neuA)
GIMF1728_06175
GPNPan110_17040(neuA)
KSTKSMBR1_2320(neuA)
PHMPSMK_03640
PCORKS4_35120(neuA)
TPEDTPE_0202
SLRL21SP2_3145
SCDSpica_0514
LILLA_1605(neuA)
LIELIF_A1292(neuA)
LICLIC_12177(neuA)
LSTLSS_16491
LAJA0128_07325 A0128_07405
LMAYDPV73_15940
LKMEFP84_18000
GMAAciX8_1507
FVAFV113G1_25400
FULC4N20_01270
FMOC4N19_03150
FGOC4N16_07640
FNFBSQ88_01800
BISDXK01_010795
BUNBun01g_24060(neuA)
BNOK8P02_14895
BDHGV66_21470
TFOBFO_1063
DUNFDZ78_09645
COPRCop2CBH44_22050(neuA)
ASXCDL62_03670
CHIHGWR21_21010
PGINFRZ67_17745
PGOFSB84_04805
FLSGLV81_12310
PEPAQ505_02070
PSTYBFS30_06865
PEJFYC62_11645
SDJNCTC13534_05277
SCNSolca_4310
MGOSDIU38_000405
OLIFKG96_05960
ALMAO498_13835
DFEDfer_3365
RSIRunsl_2327
RUNDR864_20415
RUPDTQ70_21565
FLIFleli_3536
PACTCA264_12425
NIBGU926_17070
ASWUHUW51_14180
FBTD770_00740
FUVJR347_14615
GFOGFO_0572(neuA)
GRLLPB144_06580
GFLGRFL_2398
GRSC7S20_00235
FINKQS_03405(neuA)
FMGHYN48_06650
FSEDI487_03485
COLAM608_07330
ZPRZPR_1113
FBCFB2170_05775
MARTBTR34_08485
MARBCJ263_08125
LVNBWR22_10520
MUTGVT53_17470
PTQP700755_001634
NDODDD_3551
NOBCW736_09225
NOJEJ995_10785
POMMED152_05670
POLABXQ17_03855 BXQ17_13945
POACW731_03480
PHALH9I45_03440
PPECH9W90_01225 H9W90_03860
PBATJL193_16070
PCEAJ3359_01885
WIJBWZ20_06335
TJETJEJU_1147
LULLPB138_01925
WFUAXE80_08440
FOPFNB79_09380
SALTAO058_07935
KOSKORDIASMS9_03605(neuA)
KANIMCC3317_05770(neuA)
AFLAFHG64_14690
ANPFK178_08450
ALTIALE3EI_0108
CJGNCTC13459_02718(neuA)
CANTNCTC13489_01538(neuA)
FTEFluta_2180
BBAUAEM51_03760
PROCPtc2401_00369(neuA)
TTKTST_1476(neuA)
DTPJZK55_12430 JZK55_12510 JZK55_23620
NDENIDE3000(neuA)
TAVG4V39_08740
NLIG3M70_11120
PRFPeribacterA2_0950
MIBUY43_C0001G0714
CGWUR58_C0001G0067(neuA)
MMQMmarC5_0507
MMAKMMKA1_03780
MSJMSSAC_2014
MSWMSSIT_2303
MBUMbur_1585
MENDL6E24_13060
MFOMetfor_1312
HABOJRZ79_04065
SAIMK0C01_02725
HALJG9465_17995
HMUHmuk_1467
HALZE5139_10485
HAZPGBQ70_10480
HLSKU306_12650
HALQHrr1229_001175
HSAIHPS36_03935
HAEhalTADL_2402
MAXMMALV_05366
NINNADRNF5_2152(neuA)
NICDSQ20_00895
TAHSU86_007060
AGWQT03_C0001G0652
 » show all
Reference
1  [PMID:18275154]
  Authors
Glaze PA, Watson DC, Young NM, Tanner ME
  Title
Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacetylbacillosamine in Legionella pneumophila.
  Journal
Biochemistry 47:3272-82 (2008)
DOI:10.1021/bi702364s
  Sequence
[lpn:lpg0751]
Reference
2  [PMID:19282391]
  Authors
Schoenhofen IC, Vinogradov E, Whitfield DM, Brisson JR, Logan SM
  Title
The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors.
  Journal
Glycobiology 19:715-25 (2009)
DOI:10.1093/glycob/cwp039
  Sequence
[cje:Cj1331]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.82
IUBMB Enzyme Nomenclature: 2.7.7.82
ExPASy - ENZYME nomenclature database: 2.7.7.82
BRENDA, the Enzyme Database: 2.7.7.82

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