ENZYME: 18.104.22.168 Help
hadA (gene name)
Transferring sulfur-containing groups;
4-methylpentanoyl-CoA + (R)-2-hydroxy-4-methylpentanoate = 4-methylpentanoate + (R)-2-hydroxy-4-methylpentanoyl-CoA [RN:
The enzyme, characterized from the bacterium Peptoclostridium difficile, participates in an L-leucine fermentation pathway. The reaction proceeds via formation of a covalent anhydride intermediate between a conserved aspartate residue and the acyl group of the CoA thioester substrate.
EC 22.214.171.124 created 2016
K20882 (R)-2-hydroxy-4-methylpentanoate CoA-transferase
PDF: CD630DERM_03950(hadA) » show all
Kim J, Darley D, Selmer T, Buckel W
Characterization of (R)-2-hydroxyisocaproate dehydrogenase and a family III coenzyme A transferase involved in reduction of L-leucine to isocaproate by Clostridium difficile.
ExplorEnz - The Enzyme Database: 126.96.36.199
ExPASy - ENZYME nomenclature database: 188.8.131.52
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