KEGG   ENZYME: 3.1.1.105
Entry
EC 3.1.1.105                Enzyme                                 

Name
3-O-acetylpapaveroxine carboxylesterase;
CXE1 (gene name)
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
3-O-acetylpapaveroxine acetatehydrolase
Reaction(IUBMB)
3-O-acetylpapaveroxine + H2O = narcotine hemiacetal + acetate [RN:R12347]
Reaction(KEGG)
R12347;
(other) R11693 R11694
Substrate
3-O-acetylpapaveroxine [CPD:C21591];
H2O [CPD:C00001]
Product
narcotine hemiacetal [CPD:C20297];
acetate [CPD:C00033]
Comment
The enzyme, characterized from the plant Papaver somniferum (opium poppy), participates in the biosynthesis of the isoquinoline alkaloid noscapine.
History
EC 3.1.1.105 created 2019
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K22097  3-O-acetylpapaveroxine carboxylesterase
Genes
PSOM: 113322812 113323289
Reference
1  [PMID:25485687]
  Authors
Dang TT, Chen X, Facchini PJ
  Title
Acetylation serves as a protective group in noscapine biosynthesis in opium poppy.
  Journal
Nat Chem Biol 11:104-6 (2015)
DOI:10.1038/nchembio.1717
Reference
2  [PMID:29723437]
  Authors
Park MR, Chen X, Lang DE, Ng KKS, Facchini PJ
  Title
Heterodimeric O-methyltransferases involved in the biosynthesis of noscapine in opium poppy.
  Journal
Plant J 95:252-267 (2018)
DOI:10.1111/tpj.13947
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.105
IUBMB Enzyme Nomenclature: 3.1.1.105
ExPASy - ENZYME nomenclature database: 3.1.1.105
BRENDA, the Enzyme Database: 3.1.1.105

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