KEGG   ENZYME: 3.1.1.110
Entry
EC 3.1.1.110                Enzyme                                 

Name
xylono-1,5-lactonase;
xylC (gene name);
D-xylono-1,5-lactone lactonase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
D-xylono-1,5-lactone lactonohydrolase
Reaction(IUBMB)
D-xylono-1,5-lactone + H2O = D-xylonate [RN:R02427]
Reaction(KEGG)
R02427
Substrate
D-xylono-1,5-lactone [CPD:C02266];
H2O [CPD:C00001]
Product
D-xylonate [CPD:C00502]
Comment
The enzyme, found in bacteria, participates in the degradation of D-xylose. cf. EC 3.1.1.68, xylono-1,4-lactonase.
History
EC 3.1.1.110 created 2019
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K14274  xylono-1,5-lactonase
Genes
PDJ: D0907_16170
ALR: DS731_20350
APEL: CA267_011000
LAL: AT746_16735
SALK: FBQ74_03155
SAGA: M5M_11590
MTHD: A3224_13600
MAGA: Mag101_00660
CSA: Csal_0453 Csal_1727
HCAM: I4484_06145
RPI: Rpic_4078
BGU: KS03_3045
BXE: Bxe_C1362
BXB: DR64_8448
AAV: Aave_2259
AAA: Acav_2881
HPSE: HPF_09080(araB2)
MXA: MXAN_3250
MOR: MOC_1680
MCG: GL4_0247
CCR: CC_0820
CCS: CCNA_00863(xylC)
CAK: Caul_4002
CSE: Cseg_3555
PZU: PHZ_c2467(gnl)
TSV: DSM104635_01758(araB_1) DSM104635_03103(araB_2)
SAL: Sala_0747
STAX: MC45_10355
SPHI: TS85_11215
SSAN: NX02_17665
SINB: SIDU_07860
SPMI: K663_01025
SPHB: EP837_02111(araB)
SPHT: K426_04615
BLAS: BSY18_1344
AAY: WYH_02214(araB)
ADO: A6F68_00103(araB_1)
ERF: FIU90_14250(araB)
GOX: GOX1793
GOH: B932_0278
GDI: GDI2179
GDJ: Gdia_0398
GXY: GLX_25580
GXL: H845_501
KSC: CD178_00518(araB)
ACU: Atc_2721
 » show all
Reference
1  [PMID:22709678]
  Authors
Toivari M, Nygard Y, Kumpula EP, Vehkomaki ML, Bencina M, Valkonen M, Maaheimo H, Andberg M, Koivula A, Ruohonen L, Penttila M, Wiebe MG
  Title
Metabolic engineering of Saccharomyces cerevisiae for bioconversion of D-xylose to D-xylonate.
  Journal
Metab Eng 14:427-36 (2012)
DOI:10.1016/j.ymben.2012.03.002
  Sequence
[ccr:CC_0820]
Reference
2  [PMID:25073011]
  Authors
Nygard Y, Maaheimo H, Mojzita D, Toivari M, Wiebe M, Resnekov O, Gustavo Pesce C, Ruohonen L, Penttila M
  Title
Single cell and in vivo analyses elucidate the effect of xylC lactonase during production of D-xylonate in Saccharomyces cerevisiae.
  Journal
Metab Eng 25:238-47 (2014)
DOI:10.1016/j.ymben.2014.07.005
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.110
IUBMB Enzyme Nomenclature: 3.1.1.110
ExPASy - ENZYME nomenclature database: 3.1.1.110
BRENDA, the Enzyme Database: 3.1.1.110

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