KEGG   ENZYME: 3.1.1.111
Entry
EC 3.1.1.111                Enzyme                                 
Name
phosphatidylserine sn-1 acylhydrolase;
phosphatidylserine-specific phospholipase A1;
PS-PLA1;
PLA1A (gene name)
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
3-sn-phosphatidyl-L-serine sn-1 acylhydrolase
Reaction(IUBMB)
(1) a phosphatidylserine + H2O = a 2-acyl-1-lyso-phosphatidylserine + a fatty acid [RN:R04034];
(2) a 1-acyl-2-lyso-phosphatidylserine + H2O = glycerophosphoserine + a fatty acid [RN:R12537]
Reaction(KEGG)
R04034 R12537
Substrate
phosphatidylserine [CPD:C02737];
H2O [CPD:C00001];
1-acyl-2-lyso-phosphatidylserine [CPD:C18125]
Product
2-acyl-1-lyso-phosphatidylserine [CPD:C05974];
fatty acid [CPD:C00162];
glycerophosphoserine [CPD:C22237]
Comment
The enzyme, which has been described from mammals, is specific for phosphatidylserine and 2-lysophosphatidylserine, and does not act on phosphatidylcholine, phosphatidylethanolamine, phosphatidic acid or phosphatidylinositol.
History
EC 3.1.1.111 created 2019
Pathway
ec00564  Glycerophospholipid metabolism
Orthology
K13618  phosphatidylserine sn-1 acylhydrolase
Genes
HSA51365(PLA1A)
PTR470894(PLA1A)
PPS100969100(PLA1A)
GGO101150916(PLA1A)
PON100171726(PLA1A)
NLE100602828(PLA1A)
MCC712705(PLA1A)
MCF102138086(PLA1A)
CSAB103228224(PLA1A)
CATY105589731(PLA1A)
PANU101021807(PLA1A)
TGE112618618(PLA1A)
RRO104657620(PLA1A)
RBB108541869(PLA1A)
TFN117083465(PLA1A)
PTEH111543826(PLA1A)
CJC100391282(PLA1A)
SBQ101053883(PLA1A)
CSYR103258392
MMUR105879921(PLA1A)
OGA100963538(PLA1A)
MMU85031(Pla1a)
MCAL110311435(Pla1a)
MPAH110329906(Pla1a)
RNO85311(Pla1a)
MCOC116085898(Pla1a)
MUN110555393(Pla1a)
CGE100759743(Pla1a)
PLEU114701486(Pla1a)
NGI103741942(Pla1a)
HGL101703405(Pla1a)
CPOC100719689(Pla1a)
CCAN109694535(Pla1a)
DORD105987860(Pla1a)
DSP122099218(Pla1a)
OCU100343827(PLA1A)
OPI101527277(PLA1A)
TUP102473695(PLA1A)
CFA100686158(PLA1A)
VVP112913464(PLA1A)
VLG121484433(PLA1A)
AML100483166(PLA1A)
UMR103678789(PLA1A)
UAH113251915(PLA1A)
UAR123784028(PLA1A)
ELK111150672
LLV125097796
MPUF101671018(PLA1A)
ORO101363818(PLA1A)
EJU114214775(PLA1A)
ZCA113916411(PLA1A)
MLX118007062(PLA1A)
FCA101101581(ADPRH)
PYU121036276
PBG122491474
PTG102963545
PPAD109266435
AJU106968281
HHV120242898(PLA1A)
BTA515900(PLA1A)
BOM102276590(PLA1A)
BIU109577314(PLA1A)
BBUB102403763(PLA1A)
CHX102168941(PLA1A)
OAS101106480(PLA1A)
ODA120871224(PLA1A)
CCAD122445582(PLA1A)
SSC100154368(PLA1A)
CFR102503620(PLA1A)
CBAI105081593(PLA1A)
CDK105090326(PLA1A)
VPC102538870(PLA1A)
BACU103001838(PLA1A)
LVE103086697(PLA1A)
OOR101281354(PLA1A)
DLE111175837(PLA1A)
PCAD102974952
PSIU116752550(PLA1A)
ECB100070985(PLA1A)
EPZ103547419(PLA1A)
EAI106823716(PLA1A)
MYB102246152(PLA1A)
MYD102754480(PLA1A)
MMYO118676172(PLA1A)
MLF102426606(PLA1A)
MNA107527216(PLA1A)
PKL118724328(PLA1A)
HAI109388443(PLA1A)
DRO112320477(PLA1A)
SHON118986587(PLA1A)
AJM119059197(PLA1A)
PDIC114490593(PLA1A)
PHAS123826858(PLA1A)
MMF118617149(PLA1A)
RFQ117037702(PLA1A)
PALE102893952(PLA1A)
PGIG120586660(PLA1A)
PVP105301770(PLA1A)
RAY107508367(PLA1A)
MJV108392241(PLA1A)
TOD119258114(PLA1A)
SARA101539420(PLA1A)
LAV100660582(PLA1A)
TMU101349358
DNM101421864(PLA1A)
MDO100016392(PLA1A)
GAS123242377(PLA1A)
SHR100920035(PLA1A)
PCW110208069(PLA1A)
OAA103166923
GGA770199(PLA1A)
PCOC116242311(PLA1A)
MGP100546329(PLA1A)
CJO107319756(PLA1A)
NMEL110399255(PLA1A)
APLA101801340(PLA1A)
ACYG106037445(PLA1A)
AFUL116498732(PLA1A)
TGU100227537(PLA1A)
LSR110480796(PLA1A)
SCAN103827111(PLA1A)
PMOA120506422(PLA1A)
OTC121339315(PLA1A)
PRUF121351607(PLA1A)
GFR102036635(PLA1A)
FAB101809029(PLA1A)
PHI102106179(PLA1A)
PMAJ107207715(PLA1A)
CCAE111943176(PLA1A)
CCW104687044(PLA1A)
ETL114055107(PLA1A)
ZAB102068266(PLA1A)
FPG101918777(PLA1A)
FCH102059780(PLA1A)
CLV102092015(PLA1A)
EGZ104126506(PLA1A)
NNI104008632(PLA1A)
ACUN113481271(PLA1A)
TALA104365474(PLA1A)
PADL103921381(PLA1A)
ACHC115343540(PLA1A)
AAM106490603(PLA1A)
AROW112965949(PLA1A)
NPD112956905(PLA1A)
DNE112985095(PLA1A)
ASN102368651(PLA1A)
AMJ102572073(PLA1A)
CPOO109319217(PLA1A)
GGN109304692(PLA1A)
PSS102452674(PLA1A)
CMY102944751(PLA1A)
CPIC101933691(PLA1A)
TST117886700(PLA1A)
CABI116836356(PLA1A)
MRV120408550(PLA1A)
ACS100563242(pla1a)
PVT110076962(PLA1A)
SUND121923700(PLA1A)
PBI103054600(PLA1A)
PMUR107286096(PLA1A)
TSR106549750(PLA1A)
PGUT117661888(PLA1A)
PMUA114587721(PLA1A)
ZVI118097767(PLA1A)
GJA107109383(PLA1A)
XLA108707384(pla1a.L)
XTR100490448(pla1a)
NPR108803036(PLA1A)
RTEM120928107(PLA1A)
BBUF120994334(PLA1A)
DRE334017(pla1a)
SRX107712265 107724500
SANH107668900
SGH107569279 107597373
CAUA113053400 113108556 113108797
IPU108266535(pla1a)
PHYP113526077(pla1a)
SMEO124379311(pla1a)
AMEX103024914 103031962(pla1a)
EEE113587743(pla1a)
TRU101069655(pla1a)
TNGGSTEN00029151G001
LCO104921487(pla1a)
NCC104951595(pla1a)
CGOB115026138(pla1a)
ELY117251322(pla1a)
PLEP121948884(pla1a)
SLUC116059434(pla1a)
ECRA117952731(pla1a)
PFLV114564576(pla1a)
GAT120834343(pla1a)
PPUG119229129(pla1a)
MSAM119904485(pla1a)
CUD121522343(pla1a)
MZE101486002(pla1a)
ONL100695169(pla1a)
OAU116332561(pla1a)
OLA101169888(pla1a)
OML112138009(pla1a)
XMA102232463(pla1a)
XCO114147929(pla1a)
XHE116723047(pla1a)
PRET103477984(pla1a)
PFOR103152153(pla1a)
PLAI106939752(pla1a)
PMEI106917520(pla1a)
GAF122839769(pla1a)
CVG107087358(pla1a)
CTUL119774710(pla1a)
GMU124871928(pla1a)
NFU107389613(pla1a)
KMR108244184(pla1a)
ALIM106531919(pla1a)
NWH119419427(pla1a)
AOCE111570575(pla1a)
CSEM103391993(pla1a)
POV109637909(pla1a)
SSEN122785116(pla1a)
HHIP117754991(pla1a)
LCF108902471(pla1a)
SDU111218105(pla1a)
SLAL111652105(pla1a)
XGL120801207(pla1a)
HCQ109521818
BPEC110156183(pla1a)
MALB109951661(pla1a)
SASA100195006(pla1a) 106582073
OTW112225480 112240615
OMY110501669 110520409(pla1a)
OGO124044098 124046082
ONE115112170 115128659
SALP111959540 111978675
SNH120058418(pla1a) 120064076
ELS105016431(pla1a)
SFM108926931(pla1a)
PKI111856869(pla1a)
AANG118214478(pla1a)
LOC102685355
PSPA121320747(pla1a)
ARUT117405726(pla1a)
LCM102347723(PLA1A)
RTP109923493
CNS116337153 116344113 116344212
PBAR105433450
LHU105677452
OBO105277850
PPYR116161647
CSEC111875625
FCD110845572
HAME121863250
PCLA123772903
HAZT108671140
SDM118204417
 » show all
Reference
1  [PMID:8999922]
  Authors
Sato T, Aoki J, Nagai Y, Dohmae N, Takio K, Doi T, Arai H, Inoue K
  Title
Serine phospholipid-specific phospholipase A that is secreted from activated platelets. A new member of the lipase family.
  Journal
J Biol Chem 272:2192-8 (1997)
DOI:10.1074/jbc.272.4.2192
  Sequence
[rno:85311]
Reference
2  [PMID:10196188]
  Authors
Nagai Y, Aoki J, Sato T, Amano K, Matsuda Y, Arai H, Inoue K
  Title
An alternative splicing form of phosphatidylserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific lysophospholipase activity in humans.
  Journal
J Biol Chem 274:11053-9 (1999)
DOI:10.1074/jbc.274.16.11053
  Sequence
[hsa:51365]
Reference
3  [PMID:11395520]
  Authors
Hosono H, Aoki J, Nagai Y, Bandoh K, Ishida M, Taguchi R, Arai H, Inoue K
  Title
Phosphatidylserine-specific phospholipase A1 stimulates histamine release from rat peritoneal mast cells through production of 2-acyl-1-lysophosphatidylserine.
  Journal
J Biol Chem 276:29664-70 (2001)
DOI:10.1074/jbc.M104597200
  Sequence
[rno:85311]
Reference
4  [PMID:12069807]
  Authors
Aoki J, Nagai Y, Hosono H, Inoue K, Arai H
  Title
Structure and function of phosphatidylserine-specific phospholipase A1.
  Journal
Biochim Biophys Acta 1582:26-32 (2002)
DOI:10.1016/s1388-1981(02)00134-8
  Sequence
[hsa:51365]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.111
IUBMB Enzyme Nomenclature: 3.1.1.111
ExPASy - ENZYME nomenclature database: 3.1.1.111
BRENDA, the Enzyme Database: 3.1.1.111

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