KEGG   ENZYME: 3.1.1.118
Entry
EC 3.1.1.118                Enzyme                                 
Name
phospholipid sn-1 acylhydrolase;
phospholipase DDHD1;
phosphatidic acid-preferring phospholipase A1;
PA-PLA1;
DDHD1 (gene name)
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
phospholipid sn-1 acylhydrolase
Reaction(IUBMB)
(1) a 1-phosphatidyl-1D-myo-inositol + H2O = a 2-acyl-sn-glycero-3-phospho-1D-myo-inositol + a fatty acid [RN:R12795];
(2) a 1,2-diacyl-sn-glycerol 3-phosphate + H2O = a 2-acyl-sn-glycerol 3-phosphate + a fatty acid [RN:R12796]
Reaction(KEGG)
R12795 R12796
Substrate
1-phosphatidyl-1D-myo-inositol [CPD:C01194];
H2O [CPD:C00001];
1,2-diacyl-sn-glycerol 3-phosphate [CPD:C00416]
Product
2-acyl-sn-glycero-3-phospho-1D-myo-inositol [CPD:C22400];
fatty acid [CPD:C00162];
2-acyl-sn-glycerol 3-phosphate [CPD:C03974]
Comment
The human enzyme shows broad specificity, and has a preference for phosphatidate over other phospholipids. Unlike EC 3.1.1.32, phospholipase A1, it is also active against phosphatidylinositol. It is not active towards acyl groups linked at the sn-2 position.
History
EC 3.1.1.118 created 2021
Orthology
K13619  phospholipase DDHD1
Genes
HSA80821(DDHD1)
PTR452911(DDHD1)
PPS100994366(DDHD1)
GGO101125781(DDHD1)
PON100461176(DDHD1)
NLE100581601(DDHD1)
MCC694361(DDHD1)
MCF102129871(DDHD1)
CSAB103229003(DDHD1)
CATY105586632(DDHD1)
PANU101019175(DDHD1)
TGE112629287(DDHD1)
RRO104669158(DDHD1)
RBB108513691(DDHD1)
TFN117069632(DDHD1)
PTEH111555042(DDHD1)
CJC100397054(DDHD1)
SBQ101041656(DDHD1)
CSYR103264551(DDHD1)
MMUR105867682(DDHD1)
OGA100962172(DDHD1)
MMU114874(Ddhd1)
MCAL110309253(Ddhd1)
MPAH110325222(Ddhd1)
RNO305816(Ddhd1)
MCOC116085362(Ddhd1)
MUN110552221(Ddhd1)
CGE100761687(Ddhd1)
PLEU114696048(Ddhd1)
NGI103739232(Ddhd1)
HGL101712889(Ddhd1)
CPOC100731571(Ddhd1)
CCAN109691902(Ddhd1)
DORD105982652(Ddhd1)
DSP122106466(Ddhd1)
NCAR124976674
OCU100354460(DDHD1)
OPI101531341(DDHD1)
TUP102482597(DDHD1)
CFA480326(DDHD1)
VVP112921420(DDHD1)
VLG121493351(DDHD1)
AML100479340(DDHD1)
UMR103674519(DDHD1)
UAH113242366(DDHD1)
UAR123800621(DDHD1)
ELK111162360
LLV125104104
MPUF101683505(DDHD1)
ORO101383276(DDHD1)
EJU114207630(DDHD1)
ZCA113909084(DDHD1)
MLX118002376(DDHD1)
FCA101091376(DDHD1)
PYU121031778(DDHD1)
PBG122469106(DDHD1)
PTG102954241(DDHD1)
PPAD109268459(DDHD1)
AJU106981957(DDHD1)
HHV120237270(DDHD1)
BTA338047(DDHD1)
BOM102271817(DDHD1)
BIU109565171(DDHD1)
BBUB102399107(DDHD1)
CHX102187228(DDHD1)
OAS101112738(DDHD1)
ODA120852925(DDHD1)
CCAD122443658(DDHD1)
SSC100518289(DDHD1)
CFR102512617(DDHD1)
CBAI105074584(DDHD1)
CDK105091430(DDHD1)
VPC102531831(DDHD1)
BACU103010055(DDHD1)
LVE103071873(DDHD1)
OOR101279589(DDHD1)
DLE111173146(DDHD1)
PCAD102979025(DDHD1)
PSIU116749164(DDHD1)
ECB100055200(DDHD1)
EPZ103542202 103565046
EAI106826766(DDHD1)
MYB102249329(DDHD1)
MYD102770195(DDHD1)
MMYO118655502(DDHD1)
MLF102437616(DDHD1)
MNA107525877(DDHD1)
PKL118718030(DDHD1)
HAI109384226(DDHD1)
DRO112311209(DDHD1)
SHON118992408(DDHD1)
AJM119057000(DDHD1)
PDIC114491721(DDHD1)
PHAS123808201(DDHD1)
MMF118627137(DDHD1)
RFQ117023490(DDHD1)
PALE102882168(DDHD1)
PGIG120604415(DDHD1)
PVP105309246(DDHD1)
RAY107509545(DDHD1)
MJV108410249(DDHD1)
TOD119239101(DDHD1)
SARA101539647(DDHD1)
LAV100677441(DDHD1)
TMU101355157
DNM101421583(DDHD1)
MDO100011027(DDHD1)
GAS123237678(DDHD1)
SHR100915122(DDHD1)
PCW110199852(DDHD1)
OAA100085148(DDHD1)
GGA423592(DDHD1)
PCOC116234610(DDHD1)
MGP100544026(DDHD1)
CJO107315511(DDHD1)
NMEL110401123(DDHD1)
APLA101791297(DDHD1)
ACYG106044026(DDHD1)
AFUL116489717(DDHD1)
TGU100219046(DDHD1)
LSR110474757(DDHD1)
SCAN103826841(DDHD1)
PMOA120500696(DDHD1)
OTC121338903(DDHD1)
PRUF121348704(DDHD1)
GFR102045342(DDHD1)
FAB101813293(DDHD1)
PHI102102892(DDHD1)
PMAJ107206080(DDHD1)
CCAE111929660(DDHD1)
CCW104695910(DDHD1)
ETL114068790(DDHD1)
ZAB102070745(DDHD1)
FPG101914478(DDHD1)
FCH102053112(DDHD1)
CLV102083502(DDHD1)
EGZ104122999(DDHD1)
NNI104019476(DDHD1)
ACUN113480827(DDHD1)
TALA104357881(DDHD1)
PADL103916003(DDHD1)
ACHC115335214(DDHD1)
AAM106485072
AROW112961230(DDHD1)
NPD112957773(DDHD1)
DNE112988542(DDHD1)
ASN102385359(DDHD1)
AMJ102577034(DDHD1)
CPOO109324575(DDHD1)
GGN109305248(DDHD1)
PSS102445213(DDHD1)
CMY102935388(DDHD1)
CPIC101953595(DDHD1)
TST117876177(DDHD1)
CABI116827382(DDHD1)
MRV120404415(DDHD1)
ACS100561471(ddhd1)
PVT110088778(DDHD1)
SUND121927959(DDHD1)
PBI103055357(DDHD1)
PMUR107289085(DDHD1)
TSR106548975(DDHD1)
PGUT117675059(DDHD1)
VKO123026489(DDHD1)
PMUA114585447(DDHD1)
ZVI118097760(DDHD1)
GJA107114080(DDHD1)
STOW125427085(DDHD1)
XLA100158329(ddhd1.L) 495273(ddhd1.S)
XTR100493824(ddhd1)
NPR108788627(DDHD1)
BBUF120981780(DDHD1)
BGAR122921608 122921731
DRE562868(ddhd1a) 570320(ddhd1b)
SRX107712414 107723264 107740295 107752719(ddhd1)
SANH107664821 107668131 107687830 107702228
SGH107549504 107565218 107577847 107582105 107589766
CCAR109048861 109074462 109078930 109107056 109108350
CAUA113060419 113062984 113116949 113121125 113121183
PPRM120479070 120493910(ddhd1b)
MAMB125268290(ddhd1a) 125279023(ddhd1b)
IPU108257669(ddhd1b) 108269913(ddhd1a)
PHYP113524833 113538576
SMEO124377096(ddhd1b) 124390038(ddhd1a)
TFD113647913(ddhd1b) 113659505(ddhd1a)
AMEX103023862 103030578(ddhd1)
EEE113571722 113572646
TRU101077693(ddhd1)
TNGGSTEN00031995G001
LCO104922405 104938520(ddhd1)
NCC104949736 104965147
CGOB115003711 115027276
ELY117252670(ddhd1b) 117267077(ddhd1a)
PLEP121953199(ddhd1a) 121955482
SLUC116053505(ddhd1b) 116057589(ddhd1a)
ECRA117935661(ddhd1a) 117961483(ddhd1b)
PFLV114546810 114573014(ddhd1)
GAT120808396(ddhd1b) 120832866(ddhd1a)
PPUG119195053(ddhd1b) 119227451(ddhd1a)
MSAM119909179(ddhd1b) 119910508(ddhd1a)
CUD121520894(ddhd1b) 121526264(ddhd1a)
MZE101468746(ddhd1) 101479185
ONL100699782(ddhd1) 100710483
OAU116321745(ddhd1b) 116326096(ddhd1a)
OLA101163939 101171796
OML112143675(ddhd1a) 112157645(ddhd1b)
XMA102223187(ddhd1)
XCO114134187(ddhd1)
XHE116708986(ddhd1)
PRET103458755(ddhd1)
PFOR103154895(ddhd1)
PLAI106953911(ddhd1)
PMEI106906481(ddhd1)
GAF122846257(ddhd1a)
CVG107096911(ddhd1)
CTUL119775031(ddhd1a)
GMU124855400(ddhd1a)
NFU107392165(ddhd1)
KMR108236473(ddhd1a)
ALIM106518438(ddhd1)
NWH119427673(ddhd1a)
AOCE111573281 111574124(ddhd1)
CSEM103378824 103380600(ddhd1)
POV109632300 109636490
SSEN122782832(ddhd1a) 122783827(ddhd1b)
HHIP117755575(ddhd1a) 117758624(ddhd1b)
LCF108875010 108901771(ddhd1)
SDU111225838 111239269
SLAL111651011 111667903
XGL120788681(ddhd1b) 120795654(ddhd1a)
HCQ109516696 109517422
BPEC110156397(ddhd1)
MALB109952524 109968021 109970951
SASA106571651 106601609 106608167 106611105
OTW112217915 112250487 112261631(ddhd1a)
OMY110497763(ddhd1a) 110504214 110521086 110529783(ddhd1b)
OGO123990921 123995365 124002015(ddhd1a) 124046940
ONE115107921 115123971 115138816 115146087
SALP111954261 111962988 111968587 111972742
SNH120019156 120024144 120060391(ddhd1a)
ELS105015524 105017575
SFM108919407(ddhd1) 108924025
PKI111859960(ddhd1)
AANG118231899(ddhd1a)
LOC102682572(ddhd1)
PSPA121324419 121329923
ARUT117421737 117422437 117973977
LCM102352890(DDHD1)
CMK103175247(ddhd1b)
RTP109919087(ddhd1)
BFO118427130
BBEL109470135
CIN100180467
SCLV120326450
SPU578370
APLC110981920
SKO100377407
AME724115
ACER107994848
ALAB122712710
BIM100742668
BBIF117213607
BVK117234301
BVAN117166224
BTER100643199
BPYO122568696
CCAL108623811
OBB114874639
MGEN117221152
NMEA116431731
CGIG122404698
SOC105201122
MPHA105836852
AEC105147258
ACEP105625039
PBAR105423097
VEM105557271
HST105183032
DQU106749730
CFO105249675
FEX115237467
LHU105674232
PGC109853918
OBO105277799
PCF106790640
PFUC122513434
VPS122637115
NVI100680179
CSOL105367628
TPRE106652317
MDL103568712
CGLO123258812
FAS105271153
DAM107048197
AGIF122847338
CCIN107263759
API100570693 103309374 107882143
DNX107165359
AGS114131494
RMD113549223
BTAB109030559
DCI103513864
CLEC106662488
HHAL106690420
NLU111059161
PHUPhum_PHUM366090
FOC113209304
ZNE110840404
CSEC111863223
FCD110843358
PVM113805417 113816131
PJA122254288
PCHN125024597
HAME121871172
PCLA123764520
PTRU123503874
HAZT108671547
EAF111712430
LSM121115374
CELCELE_M03A1.6(ipla-1)
CBRCBG_11786 CBG_13444(Cbr-ipla-1)
BMYBM_BM5072(Bma-ipla-1)
LOALOAG_17210
NAINECAME_11091
LGILOTGIDRAFT_133288
PCAN112570093
BGT106075981
GAE121371612
HRF124118361
HRJ124289797
CRG105326251
MYI110467238
PMAX117323428
MMER123534323
OBI106876756
OSN115218077
LAK106175188
SMMSmp_141150 Smp_210300
OVIT265_03979 T265_09016
EGLEGR_00152 EGR_09695
NVE5512722
EPA110249081
ATEN116295478
ADF107350406
AMIL114977148
PDAM113671503
SPIS111334534
DGT114531681
XEN124452750
HMG101234320
AQU100640606
CMECYME_CMP267C
ADLAURDEDRAFT_182151
UMAUMAG_02255
MLRMELLADRAFT_88499
DPPDICPUDRAFT_50997
DFADFA_10293
TANTA16640
TPVTP01_1157
TOTTOT_010001100
BBOBBOV_IV011470(23.m06387)
BMICBMR1_02g02600
CPVcgd2_1280
CHOChro.20140
PIFPITG_18070
PSOJPHYSODRAFT_554083
GTTGUITHDRAFT_109533
 » show all
Reference
1  [PMID:20359546]
  Authors
Yamashita A, Kumazawa T, Koga H, Suzuki N, Oka S, Sugiura T.
  Title
Generation of lysophosphatidylinositol by DDHD domain containing 1 (DDHD1): Possible involvement of phospholipase D/phosphatidic acid in the activation of DDHD1.
  Journal
Biochim Biophys Acta 1801:711-20 (2010)
DOI:10.1016/j.bbalip.2010.03.012
Reference
2  [PMID:24599962]
  Authors
Baba T, Kashiwagi Y, Arimitsu N, Kogure T, Edo A, Maruyama T, Nakao K, Nakanishi H, Kinoshita M, Frohman MA, Yamamoto A, Tani K.
  Title
Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics.
  Journal
J Biol Chem 289:11497-11511 (2014)
DOI:10.1074/jbc.M113.531921
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.118
IUBMB Enzyme Nomenclature: 3.1.1.118
ExPASy - ENZYME nomenclature database: 3.1.1.118
BRENDA, the Enzyme Database: 3.1.1.118

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