KEGG   ENZYME: 3.1.3.57
Entry
EC 3.1.3.57                 Enzyme                                 

Name
inositol-1,4-bisphosphate 1-phosphatase;
inositol-polyphosphate 1-phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase
Reaction(IUBMB)
1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate [RN:R03393]
Reaction(KEGG)
R03393;
(other) R03427
Substrate
1D-myo-inositol 1,4-bisphosphate [CPD:C01220];
H2O [CPD:C00001]
Product
1D-myo-inositol 4-phosphate [CPD:C03546];
phosphate [CPD:C00009]
Comment
The enzyme acts on inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate (forming inositol 3,4-bisphosphate) with similar Vmax values for both substrates, but with a five-times higher affinity for the bisphosphate. Does not act on inositol 1-phosphate, inositol 1,4,5-trisphosphate or inositol 1,3,4,5-tetrakisphosphate.
History
EC 3.1.3.57 created 1989, modified 2002
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K01107  inositol polyphosphate 1-phosphatase
K15422  3'(2'), 5'-bisphosphate nucleotidase / inositol polyphosphate 1-phosphatase
Genes
HSA: 3628(INPP1)
PTR: 460106(INPP1)
PPS: 100967835(INPP1)
GGO: 101129850(INPP1)
PON: 100461697(INPP1)
NLE: 100592468(INPP1)
MCC: 703301(INPP1)
MCF: 102129084 102144664(INPP1)
CSAB: 103217521(INPP1)
CATY: 105579951(INPP1)
PANU: 101000049(INPP1)
RRO: 104675276(INPP1)
RBB: 108523275 108527575(INPP1)
TFN: 117094721(INPP1)
PTEH: 111546263(INPP1)
CJC: 100399314(INPP1)
SBQ: 101034382(INPP1)
MMUR: 105877899(INPP1)
MMU: 16329(Inpp1)
MCAL: 110297363(Inpp1)
MPAH: 110322195(Inpp1)
RNO: 316376(Inpp1)
MCOC: 116088401(Inpp1)
MUN: 110555832(Inpp1)
CGE: 100755639
PLEU: 114705100(Inpp1)
NGI: 103736162(Inpp1)
HGL: 101724306(Inpp1)
OCU: 100357992(INPP1)
OPI: 101526202(INPP1)
TUP: 102481098(INPP1)
CFA: 478842(INPP1)
VVP: 112922928(INPP1)
VLG: 121480554(INPP1)
AML: 100473008(INPP1)
UMR: 103659679(INPP1)
UAH: 113250658(INPP1)
ORO: 101376858(INPP1)
ELK: 111140882
MPUF: 101681848(INPP1)
EJU: 114223619(INPP1)
MLX: 118012214(INPP1)
FCA: 101082081(INPP1)
PYU: 121030826(INPP1)
PBG: 122481570(INPP1)
PTG: 102951036(INPP1)
PPAD: 109274528(INPP1)
AJU: 106979728(INPP1)
HHV: 120233471(INPP1)
BTA: 281869(INPP1)
BOM: 102276134(INPP1)
BIU: 109565484(INPP1)
BBUB: 102416046(INPP1)
CHX: 102176832(INPP1)
OAS: 101110908(INPP1)
ODA: 120854041(INPP1)
CCAD: 122453921(INPP1)
SSC: 100514878(INPP1)
CFR: 102520689(INPP1)
CBAI: 105072928(INPP1)
CDK: 105099189(INPP1)
BACU: 103020750(INPP1)
LVE: 103071146(INPP1)
OOR: 101271125(INPP1)
DLE: 111171662(INPP1)
PCAD: 102982005(INPP1)
ECB: 100054603(INPP1)
EPZ: 103548647(INPP1)
EAI: 106828805(INPP1)
MYB: 102245840(INPP1)
MYD: 102766936(INPP1)
MMYO: 118661461(INPP1)
MNA: 107539777(INPP1)
PKL: 118710626(INPP1)
HAI: 109372960(INPP1)
DRO: 112308010(INPP1)
SHON: 118985305(INPP1)
AJM: 119062127(INPP1)
MMF: 118625103(INPP1)
PALE: 102885459(INPP1)
PGIG: 120587469(INPP1)
RAY: 107511589(INPP1)
MJV: 108402009(INPP1)
TOD: 119256036(INPP1)
LAV: 100668984(INPP1)
TMU: 101352306
MDO: 100028793(INPP1)
SHR: 100914455(INPP1)
PCW: 110213313(INPP1)
OAA: 103169187(INPP1)
GGA: 107049248(INPP1)
PCOC: 116235214(INPP1)
MGP: 104916077(INPP1)
CJO: 107325828(INPP1)
NMEL: 110391102(INPP1)
LSR: 110482129(INPP1)
OTC: 121338760(INPP1)
PRUF: 121357165(INPP1)
PHI: 102109751(INPP1)
ETL: 114070097(INPP1)
FPG: 101914982(INPP1)
CLV: 102088663(INPP1)
NPD: 112954222(INPP1)
ASN: 102386296(INPP1)
AMJ: 102571874(INPP1)
PSS: 102452926
CMY: 102940917(INPP1) 102947691
CPIC: 101953281(INPP1)
TST: 117884990(INPP1) 117888676
CABI: 116815202(INPP1) 116827757
ACS: 100556887(inpp1)
PVT: 110074857(INPP1)
PBI: 103053524(INPP1)
PMUR: 107293737(INPP1) 107300809
TSR: 106548583(INPP1)
PGUT: 117662749(INPP1)
PMUA: 114592953(INPP1)
ZVI: 118078820(INPP1)
GJA: 107120900(INPP1)
XLA: 398838(inpp1.L)
XTR: 100144649(inpp1)
NPR: 108786717 108786723(INPP1)
DRE: 555899(si:ch211-160o17.2)
SANH: 107683640
SGH: 107557551(inpp1) 107562242
CCAR: 109077394(inpp1) 109104896
IPU: 108255283(inpp1)
PHYP: 113537788(inpp1)
AMEX: 103037924(inpp1)
EEE: 113588699(inpp1)
TRU: 101068265(inpp1)
NCC: 104954761(inpp1)
CGOB: 115008160(inpp1)
ELY: 117256325(inpp1)
PLEP: 121950029(inpp1)
SLUC: 116066658(inpp1)
ECRA: 117944008(inpp1)
PFLV: 114553800(inpp1)
GAT: 120835252(inpp1)
PPUG: 119193950(inpp1)
MSAM: 119886042(inpp1)
CUD: 121528912(inpp1)
MZE: 101464380(inpp1)
ONL: 100692058(inpp1)
OAU: 116329894(inpp1)
OLA: 101154772(inpp1)
OML: 112145722(inpp1)
XMA: 102216503(inpp1)
XCO: 114135867(inpp1)
XHE: 116711137(inpp1)
PRET: 103465287(inpp1)
CVG: 107083317(inpp1)
CTUL: 119791830(inpp1)
NFU: 107385611(inpp1)
KMR: 108235670(inpp1)
ALIM: 106513286(inpp1)
AOCE: 111579734(inpp1)
CSEM: 103386015(inpp1)
POV: 109629125(inpp1)
LCF: 108898919(inpp1)
SDU: 111221493(inpp1)
SLAL: 111667781(inpp1)
XGL: 120807198(inpp1)
HCQ: 109522370(inpp1)
BPEC: 110171309(inpp1)
MALB: 109956047(inpp1)
SASA: 100306749(inpp) 106583335
OTW: 112215856(inpp1)
ELS: 105017082(inpp1)
SFM: 108918545 108927928(inpp1)
PKI: 111842935(inpp1) 111854764
AANG: 118211820(inpp1)
LOC: 102690388
LCM: 102349777(INPP1)
CMK: 103176536(inpp1)
RTP: 109933224(inpp1)
BFO: 118423791
BBEL: 109472076
CIN: 100182945
SCLV: 120332331
SPU: 584178
APLC: 110973571
SKO: 100373112
DME: Dmel_CG3028(Ipp)
DER: 6553381
DSE: 6606457
DSI: Dsimw501_GD18939(Dsim_GD18939)
DAN: 6499025
DSR: 110186462
DPE: 6588323
DMN: 108154941
DWI: 6649474
DGR: 6568376
DAZ: 108609143
DNV: 115563516
DHE: 111602750
DVI: 6629641
CCAT: 101448467
BOD: 106625225
MDE: 101888480
SCAC: 106083385
LCQ: 111684799
ACOZ: 120953248
AARA: 120905831
AAG: 110674709
AME: 107963968
ACER: 108002365
BIM: 100748881
BBIF: 117210778
BVK: 117231168
BVAN: 117166507
BTER: 100650852
CCAL: 108627285
OBB: 114873942
MGEN: 117225229
NMEA: 116425469
CGIG: 122397406
SOC: 105201853
MPHA: 105830074
AEC: 105151247
ACEP: 105619421
PBAR: 105430157
VEM: 105565095
HST: 105190691
DQU: 106749393
CFO: 105257301
FEX: 115233830
LHU: 105678194
PGC: 109863506
OBO: 105274709
PCF: 106784339
PFUC: 122521473
NVI: 100122810
CSOL: 105368207
TPRE: 106654473
MDL: 103579536
FAS: 105273126
DAM: 107035449
CCIN: 107264550
TCA: 656805
DPA: 109539053
ATD: 109601500
AGB: 108911859
LDC: 111516841
NVL: 108570021
APLN: 108740125
PPYR: 116163408
OTU: 111422312
BMOR: 101745603
BMAN: 114243639
BANY: 112052762
PMAC: 106718335
PPOT: 106103542
PXU: 106115803
PRAP: 110996506
ZCE: 119838413
HAW: 110374210
TNL: 113500690
PXY: 105392571
DNX: 107164159
AGS: 114119547
RMD: 113560581
BTAB: 109033272
DCI: 113469124
CLEC: 106669705
HHAL: 106691324
NLU: 111043305
FOC: 113209055
ZNE: 110831304
CSEC: 111864479
FCD: 110861442
PVM: 113813437
HAME: 121854309
HAZT: 108683083
EAF: 111701600
DSV: 119442164
RSAN: 119387764
VDE: 111245697
VJA: 111269204
DPTE: 113792231
CSCU: 111624569
PTEP: 107439288
SDM: 118196035
PCAN: 112563815
BGT: 106072619
GAE: 121382210
CRG: 105347500
MYI: 110465129
PMAX: 117344194
OBI: 106872453
OSN: 115216816
NVE: 5507017
ATEN: 116300482
ADF: 107348893
AMIL: 114953045
PDAM: 113675931
SPIS: 111341176
CPAP: 110816127
CIT: 102627477
PVY: 116140353
TCC: 18611884
VRA: 106766815
VAR: 108347870
VUN: 114175827
CCAJ: 109812821
APRC: 113857669
CAM: 101512228
LJA: Lj4g3v0231940.1(Lj4g3v0231940.1) Lj4g3v0231940.2(Lj4g3v0231940.2)
ADU: 107481633
AIP: 107631494
LANG: 109362951
FVE: 101292053
RCN: 112189693
PPER: 18779780
PMUM: 103327119
PAVI: 110751194
PDUL: 117625973
MDM: 114826767
MNT: 21403578
CSV: 101204881
CMO: 103485286
BHJ: 120072626
MCHA: 111005385
CMAX: 111478099
CMOS: 111453114
CPEP: 111803461
RCU: 107261021
JCU: 105632756
HBR: 110644282
MESC: 110628194
JRE: 108996258
QSU: 112009029
QLO: 115963512
TWL: 120002309
VVI: 100244767
VRI: 117912858
SLY: 101267407
SPEN: 107020572
SOT: 102601366
CANN: 107851478
NSY: 104246659
NTO: 104116454
NAU: 109225448
ITR: 116012753
SIND: 105178071
EGT: 105973236
HAN: 110878734
ECAD: 122589089
LSV: 111882493
CCAV: 112515300
DCR: 108204352
CSIN: 114310174
BVG: 104895417
SOE: 110800752
NNU: 104606715
MING: 122062507
NCOL: 116266866
DOSA: Os12t0183200-00(Os12g0183200) Os12t0183300-01(Os12g0183300)
BDI: 100844934
PDA: 103720532
EGU: 105051760
MUS: 103976059
DCT: 110111209
PEQ: 110039533
AOF: 109824316
ATR: 18436938
PPP: 112292558
MNG: MNEG_5969
APRO: F751_6258
DFA: DFA_01660
DLI: dnl_29360
PLM: Plim_3418
PEH: Spb1_00090(suhB_1)
MRI: Mal4_14500(hisN_1)
SACI: Sinac_5439
CABY: Cabys_4010
 » show all
Reference
1  [PMID:6309146]
  Authors
Berridge MJ, Dawson RM, Downes CP, Heslop JP, Irvine RF.
  Title
Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides.
  Journal
Biochem J 212:473-82 (1983)
DOI:10.1042/bj2120473
Reference
2  [PMID:3029066]
  Authors
Connolly TM, Bansal VS, Bross TE, Irvine RF, Majerus PW.
  Title
The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes.
  Journal
J Biol Chem 262:2146-9 (1987)
Reference
3  [PMID:2824473]
  Authors
Inhorn RC, Majerus PW.
  Title
Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+.
  Journal
J Biol Chem 262:15946-52 (1987)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.57
IUBMB Enzyme Nomenclature: 3.1.3.57
ExPASy - ENZYME nomenclature database: 3.1.3.57
BRENDA, the Enzyme Database: 3.1.3.57
CAS: 111070-17-8 111694-13-4

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