KEGG   ENZYME: 3.1.3.62
Entry
EC 3.1.3.62                 Enzyme                                 

Name
multiple inositol-polyphosphate phosphatase;
inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase;
inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase;
inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase;
inositol tetrakisphosphate phosphomonoesterase;
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase;
MIPP
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
1D-myo-inositol-hexakisphosphate 5-phosphohydrolase
Reaction(IUBMB)
myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate [RN:R07584]
Reaction(KEGG)
R07584 > R07583;
(other) R03434
Substrate
myo-inositol hexakisphosphate [CPD:C01204];
H2O [CPD:C00001]
Product
myo-inositol pentakisphosphate [CPD:C15991];
phosphate [CPD:C00009]
Comment
This enzyme exists in two isoforms. It also acts on Ins(1,3,4,5)P4 to yield Ins(1,4,5)P3.
History
EC 3.1.3.62 created 1992, modified 2002
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K03103  multiple inositol-polyphosphate phosphatase / 2,3-bisphosphoglycerate 3-phosphatase
Genes
HSA: 9562(MINPP1)
PTR: 450579(MINPP1)
PPS: 100980933(MINPP1)
GGO: 101144263(MINPP1)
PON: 100173135(MINPP1)
NLE: 100602225(MINPP1)
MCC: 704362(MINPP1)
MCF: 101925472(MINPP1)
CSAB: 103216204(MINPP1)
CATY: 105587179(MINPP1)
PANU: 101012993(MINPP1)
RRO: 104675164(MINPP1)
RBB: 108527546(MINPP1)
TFN: 117086018(MINPP1)
PTEH: 111551309(MINPP1)
CJC: 100391750(MINPP1)
MMUR: 105870306(MINPP1)
MMU: 17330(Minpp1)
MCAL: 110285877(Minpp1)
MPAH: 110323978(Minpp1)
RNO: 29688(Minpp1)
MCOC: 116095796 116103741(Minpp1)
MUN: 110562929(Minpp1)
CGE: 100766430(Minpp1)
NGI: 103738050(Minpp1)
HGL: 101711589(Minpp1)
CCAN: 109681827(Minpp1)
OCU: 100350561 100358192(MINPP1)
OPI: 101524790(MINPP1)
TUP: 102484201(MINPP1)
CFA: 486462(MINPP1)
VVP: 112931957(MINPP1)
VLG: 121475661(MINPP1)
AML: 100468979(MINPP1)
UMR: 103661917(MINPP1)
UAH: 113258980(MINPP1)
ORO: 101367977(MINPP1)
ELK: 111144977
MPUF: 101692752(MINPP1)
EJU: 114210314(MINPP1)
MLX: 118012967(MINPP1)
FCA: 101091150(MINPP1)
PYU: 121016563(MINPP1)
PBG: 122492666(MINPP1)
PTG: 102971475(MINPP1)
PPAD: 109255399(MINPP1)
AJU: 106980974(MINPP1)
HHV: 120235962(MINPP1)
BTA: 541067(MINPP1)
BOM: 102266889(MINPP1)
BIU: 109553098(MINPP1)
BBUB: 102403735(MINPP1)
CHX: 102187288(MINPP1)
OAS: 101118833(MINPP1)
ODA: 120873780(MINPP1)
CCAD: 122446201(MINPP1)
SSC: 100152243(MINPP1)
CFR: 102522901(MINPP1)
CBAI: 105081865(MINPP1)
CDK: 105088961(MINPP1)
BACU: 103015775(MINPP1)
LVE: 103073572(MINPP1)
OOR: 101278048(MINPP1)
DLE: 111172535(MINPP1)
PCAD: 102981370(MINPP1)
ECB: 100062448(MINPP1)
EPZ: 103549844(MINPP1)
EAI: 106845893(MINPP1)
MYB: 102256717(MINPP1)
MYD: 102754386(MINPP1)
MMYO: 118670003(MINPP1)
MNA: 107543261(MINPP1)
PKL: 118719255(MINPP1)
HAI: 109387537(MINPP1)
DRO: 112307316(MINPP1)
SHON: 118987934(MINPP1)
AJM: 119057723(MINPP1)
MMF: 118632317(MINPP1)
PALE: 102882782(MINPP1)
PGIG: 120609362(MINPP1)
RAY: 107501766(MINPP1)
MJV: 108404755(MINPP1)
TOD: 119233710(MINPP1)
LAV: 100661711(MINPP1)
TMU: 101353457
MDO: 100022488(MINPP1)
GAS: 123236541(MINPP1) 123247903
SHR: 100924973(MINPP1)
PCW: 110199940(MINPP1)
OAA: 100681694(MINPP1)
GGA: 395356(MINPP1)
PCOC: 116234765(MINPP1)
MGP: 100540797(MINPP1)
CJO: 107315617(MINPP1)
NMEL: 110390504(MINPP1)
APLA: 101798501(MINPP1)
ACYG: 106030215(MINPP1)
TGU: 100225117(MINPP1)
LSR: 110474022(MINPP1)
SCAN: 103814225(MINPP1)
PMOA: 120499702(MINPP1)
OTC: 121336132(MINPP1)
PRUF: 121356682(MINPP1)
GFR: 102040581(MINPP1)
FAB: 101807959(MINPP1)
PHI: 102106327(MINPP1)
PMAJ: 107207068(MINPP1)
CCAE: 111931623(MINPP1)
CCW: 104695103(MINPP1)
ETL: 114069298(MINPP1)
FPG: 101912524(MINPP1)
FCH: 102050541(MINPP1)
CLV: 102099022(MINPP1)
EGZ: 104125133(MINPP1)
NNI: 104013518(MINPP1)
ACUN: 113481831(MINPP1)
PADL: 103924285(MINPP1)
AAM: 106489037(MINPP1)
AROW: 112973345(MINPP1)
NPD: 112948436(MINPP1)
DNE: 112981621(MINPP1)
PSS: 102458605(MINPP1)
CMY: 102941827(MINPP1)
CPIC: 101932598(MINPP1)
TST: 117879812(MINPP1)
CABI: 116818985(MINPP1)
ACS: 100555619(minpp1)
PVT: 110083113(MINPP1) 110083124
PBI: 103064022(MINPP1)
PMUR: 107285106(MINPP1)
TSR: 106551602(MINPP1)
PGUT: 117670640(MINPP1)
VKO: 123018463(MINPP1)
PMUA: 114597276(MINPP1)
ZVI: 118096383(MINPP1)
GJA: 107120017(MINPP1)
XLA: 108696047(minpp1.L) 108697356(minpp1.S)
XTR: 100493648(minpp1)
NPR: 108794027(MINPP1)
DRE: 394075(minpp1b) 561891(minpp1a)
IPU: 108269684 108273659(minpp1)
PHYP: 113527108(minpp1) 113547731
EEE: 113579496(minpp1) 113591888
NCC: 104956666(minpp1)
SLUC: 116055165 116059242(minpp1b)
GAT: 120819649 120820469(minpp1a)
PPUG: 119213180 119213978(minpp1a)
OML: 112162089(minpp1a) 118597846(minpp1b)
CTUL: 119790840 119790872(minpp1a) 119792861(minpp1b)
NFU: 107376031 107387490(minpp1)
KMR: 108242898 108251380(minpp1b)
ALIM: 106513483 106528196(minpp1)
POV: 109632753
XGL: 120794537(minpp1b) 120796379(minpp1a)
ELS: 105006245(minpp1) 105010648
SFM: 108939677(minpp1)
PKI: 111853700(minpp1)
AANG: 118218022 118221659(minpp1b)
LOC: 102685596(minpp1)
PSPA: 121325690(minpp1b)
LCM: 102349601(MINPP1) 102355063
CMK: 103180855(minpp1b)
RTP: 109911866(minpp1)
BFO: 118412093
BBEL: 109481336
DME: Dmel_CG4123(Mipp1) Dmel_CG4317(Mipp2)
DSI: Dsimw501_GD12462(Dsim_GD12462) Dsimw501_GD16214(Dsim_GD16214)
DAN: 6493392
DNV: 108652406
DHE: 111596480
SCAC: 106087349
FEX: 115245494
PGC: 109860814
PCF: 106783586
PFUC: 122520664
AGB: 108912760
DSV: 119453325
DPTE: 113799142
SDM: 118185378
PCAN: 112557841
BGT: 106058145
GAE: 121379899
CRG: 105336484
OBI: 106879508
OSN: 115225400
EGL: EGR_04276
AQU: 109582726
ATH: AT1G09870
ALY: 9328594
CRB: 17896695
CPAP: 110819153
CIT: 102615443
PVY: 116106184
TCC: 18585803
GAB: 108484036
DZI: 111298017
EGR: 104455913
GMX: 100812135(PAP02) 100815749
VRA: 106776102
VAR: 108343523
VUN: 114188689
CCAJ: 109809735
APRC: 113849463
CAM: 101507608
LJA: Lj0g3v0197689.1(Lj0g3v0197689.1) Lj0g3v0197689.2(Lj0g3v0197689.2)
ADU: 107471196
FVE: 101314222
RCN: 112179772
PPER: 18785898
PMUM: 103332825
PAVI: 110749720
PDUL: 117619714
MDM: 103417780
PXB: 103937111
ZJU: 107413891
MNT: 21390348
BHJ: 120081561
MCHA: 111015966
RCU: 8272082
PALZ: 118055917
JRE: 108983886
QLO: 115955878
CANN: 107871120
INI: 109154998
ITR: 116019989
SIND: 105160857
OEU: 111390935
EGT: 105977634
HAN: 110872695
ECAD: 122605897
CCAV: 112524542
DCR: 108210743
BVG: 104905971
SOE: 110781869
NNU: 104597681
NCOL: 116263272
OSA: 4334577
DOSA: Os03t0818100-01(Os03g0818100)
OBR: 102712072
BDI: 100831816
ATS: 109744068
SBI: 8057380
ZMA: 100282868
SITA: 101772807
PHAI: 112875216
PDA: 103708852
EGU: 105033642
MUS: 103984406
DCT: 110101297
PEQ: 110029458
MNG: MNEG_3694
DFA: DFA_01730
EHI: EHI_059910(101.t00003)
FLN: FLA_2532
 » show all
Reference
1  [PMID:2786415]
  Authors
Cullen PJ, Irvine RF, Drobak BK, Dawson AP.
  Title
Inositol 1,3,4,5-tetrakisphosphate causes release of Ca2+ from permeabilized mouse lymphoma L1210 cells by its conversion into inositol 1,4,5-trisphosphate.
  Journal
Biochem J 259:931-3 (1989)
DOI:10.1042/bj2590931
Reference
2  [PMID:9359836]
  Authors
Craxton A, Caffrey JJ, Burkhart W, Safrany ST, Shears SB.
  Title
Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase.
  Journal
Biochem J 328 ( Pt 1):75-81 (1997)
DOI:10.1042/bj3280075
  Sequence
[rno:29688]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.62
IUBMB Enzyme Nomenclature: 3.1.3.62
ExPASy - ENZYME nomenclature database: 3.1.3.62
BRENDA, the Enzyme Database: 3.1.3.62
CAS: 116958-30-6

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