KEGG   ENZYME: 3.1.3.62
Entry
EC 3.1.3.62                 Enzyme                                 
Name
multiple inositol-polyphosphate phosphatase;
inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase;
inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase;
inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase;
inositol tetrakisphosphate phosphomonoesterase;
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase;
MIPP
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
1D-myo-inositol-hexakisphosphate 5-phosphohydrolase
Reaction(IUBMB)
myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate [RN:R07584]
Reaction(KEGG)
R07584 > R07583;
(other) R03434
Substrate
myo-inositol hexakisphosphate [CPD:C01204];
H2O [CPD:C00001]
Product
myo-inositol pentakisphosphate [CPD:C15991];
phosphate [CPD:C00009]
Comment
This enzyme exists in two isoforms. It also acts on Ins(1,3,4,5)P4 to yield Ins(1,4,5)P3.
History
EC 3.1.3.62 created 1992, modified 2002
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K03103  multiple inositol-polyphosphate phosphatase / 2,3-bisphosphoglycerate 3-phosphatase
Genes
HSA9562(MINPP1)
PTR450579(MINPP1)
PPS100980933(MINPP1)
GGO101144263(MINPP1)
PON100173135(MINPP1)
NLE100602225(MINPP1)
MCC704362(MINPP1)
MCF101925472(MINPP1)
MTHB126963333
CSAB103216204(MINPP1)
CATY105587179(MINPP1)
PANU101012993(MINPP1)
TGE112632020(MINPP1)
RRO104675164(MINPP1)
RBB108527546(MINPP1)
TFN117086018(MINPP1)
PTEH111551309(MINPP1)
CJC100391750(MINPP1)
CSYR103273216(MINPP1)
MMUR105870306(MINPP1)
LCAT123649767(MINPP1)
OGA100958011(MINPP1)
MMU17330(Minpp1)
MCAL110285877(Minpp1)
MPAH110323978(Minpp1)
RNO29688(Minpp1)
MCOC116095796 116103741(Minpp1)
MUN110562929(Minpp1)
CGE100766430(Minpp1)
MAUA101825526(Minpp1)
MORG121454556(Minpp1)
MFOT126511414
AAMP119808044(Minpp1)
NGI103738050(Minpp1)
HGL101711589(Minpp1)
CPOC100716660(Minpp1)
CCAN109681827(Minpp1)
DORD105986352(Minpp1)
DSP122115803(Minpp1)
NCAR124984525
OCU100350561 100358192(MINPP1)
OPI101524790(MINPP1)
TUP102484201(MINPP1)
CFA486462(MINPP1)
CLUD112656191(MINPP1)
VVP112931957(MINPP1)
VLG121475661(MINPP1)
AML100468979(MINPP1)
UMR103661917(MINPP1)
UAH113258980(MINPP1)
UAR123795554(MINPP1)
ELK111144977
LLV125084884
MPUF101692752(MINPP1)
ORO101367977(MINPP1)
EJU114210314(MINPP1)
ZCA113923617(MINPP1)
MLX118012967(MINPP1)
NSU110585960(MINPP1)
FCA101091150(MINPP1)
PYU121016563(MINPP1)
PBG122492666(MINPP1)
LRUF124518684
PTG102971475(MINPP1)
PPAD109255399(MINPP1)
AJU106980974(MINPP1)
HHV120235962(MINPP1)
BTA541067(MINPP1)
BOM102266889(MINPP1)
BIU109553098(MINPP1)
BBUB102403735(MINPP1)
CHX102187288(MINPP1)
OAS101118833(MINPP1)
ODA120873780(MINPP1)
CCAD122446201(MINPP1)
SSC100152243(MINPP1)
CFR102522901(MINPP1)
CBAI105081865(MINPP1)
CDK105088961(MINPP1)
VPC102530024(MINPP1)
BACU103015775(MINPP1)
LVE103073572(MINPP1)
OOR101278048(MINPP1)
DLE111172535(MINPP1)
PCAD102981370(MINPP1)
PSIU116741817(MINPP1)
ECB100062448(MINPP1)
EPZ103549844(MINPP1)
EAI106845893(MINPP1)
MYB102256717(MINPP1)
MYD102754386(MINPP1)
MMYO118670003(MINPP1)
MLF102429829(MINPP1)
MNA107543261(MINPP1)
PKL118719255(MINPP1)
HAI109387537(MINPP1)
DRO112307316(MINPP1)
SHON118987934(MINPP1)
AJM119057723(MINPP1)
PDIC114496574(MINPP1)
PHAS123828944(MINPP1)
MMF118632317(MINPP1)
RFQ117036242(MINPP1)
PALE102882782(MINPP1)
PGIG120609362(MINPP1)
PVP105293116(MINPP1)
RAY107501766(MINPP1)
MJV108404755(MINPP1)
TOD119233710(MINPP1)
SARA101559306(MINPP1)
LAV100661711(MINPP1)
TMU101353457
DNM101440877(MINPP1)
MDO100022488(MINPP1)
GAS123236541(MINPP1) 123247903
SHR100924973(MINPP1)
PCW110199940(MINPP1)
OAA100681694(MINPP1)
GGA395356(MINPP1)
PCOC116234765(MINPP1)
MGP100540797(MINPP1)
CJO107315617(MINPP1)
NMEL110390504(MINPP1)
APLA101798501(MINPP1)
ACYG106030215(MINPP1)
AFUL116491268(MINPP1)
TGU100225117(MINPP1)
LSR110474022(MINPP1)
SCAN103814225(MINPP1)
PMOA120499702(MINPP1)
OTC121336132(MINPP1)
PRUF121356682(MINPP1)
GFR102040581(MINPP1)
FAB101807959(MINPP1)
PHI102106327(MINPP1)
PMAJ107207068(MINPP1)
CCAE111931623(MINPP1)
CCW104695103(MINPP1)
CBRC103615275(MINPP1)
ETL114069298(MINPP1)
ZAB102065076(MINPP1)
ACHL103800832(MINPP1)
FPG101912524(MINPP1)
FCH102050541(MINPP1)
CLV102099022(MINPP1)
EGZ104125133(MINPP1)
NNI104013518(MINPP1)
PLET104628481(MINPP1)
PCRI104033387(MINPP1)
ACUN113481831(MINPP1)
TALA104358323(MINPP1)
PADL103924285(MINPP1)
AFOR103895507(MINPP1)
ACHC115348302(MINPP1)
CCRI104155464(MINPP1)
CSTI104558867(MINPP1)
EHS104515371(MINPP1)
CMAC104486342(MINPP1)
FGA104069559(MINPP1)
GSTE104250653(MINPP1)
LDI104346404(MINPP1)
OHA104330396(MINPP1)
NNT104399502(MINPP1)
DPUB104302462(MINPP1)
PGUU104457958(MINPP1)
CVF104283484(MINPP1)
AAM106489037(MINPP1)
AROW112973345(MINPP1)
NPD112948436(MINPP1)
TGT104573663(MINPP1)
DNE112981621(MINPP1)
PSS102458605(MINPP1)
CMY102941827(MINPP1)
CPIC101932598(MINPP1)
TST117879812(MINPP1)
CABI116818985(MINPP1)
MRV120369205(MINPP1)
ACS100555619(minpp1)
PVT110083113(MINPP1) 110083124
SUND121925894(MINPP1)
PBI103064022(MINPP1)
PMUR107285106(MINPP1)
CTIG120311923(MINPP1)
TSR106551602(MINPP1)
PGUT117670640(MINPP1)
VKO123018463(MINPP1)
PMUA114597276(MINPP1)
ZVI118096383(MINPP1)
GJA107120017(MINPP1)
STOW125437903(MINPP1)
XLA108696047(minpp1.L) 108697356(minpp1.S)
XTR100493648(minpp1)
NPR108794027(MINPP1)
RTEM120947076(MINPP1)
BBUF121004675(MINPP1)
BGAR122941566 122942097
DRE394075(minpp1b) 561891(minpp1a)
SRX107715961 107753454 107753455
SANH107669175 107689803
SGH107553544 107553810 107583552
CCAR109055567 109108025 109108028
CAUA113093185 113111787(minpp1) 113117123
PPRM120467148(minpp1a) 120490840(minpp1b)
MAMB125255748(minpp1b) 125268754(minpp1a)
IPU108269684(minpp1a) 108273659(minpp1b)
PHYP113527108(minpp1) 113547731
SMEO124388365(minpp1b) 124390225
TFD113637213(minpp1b) 113662050
AMEX103024240(minpp1) 103025372 103047786
EEE113579496(minpp1) 113591888
TRU101067675 115251774
TNGGSTEN00006046G001 GSTEN00016383G001 GSTEN00016384G001
LCO104927472 104929794 104936552
NCC104956666(minpp1)
CGOB115020288 115020406
ELY117247140 117247817 117248088
EFO125880663 125903274
PLEP121954582 121954583
SLUC116055165 116059242(minpp1b)
ECRA117960050 117960051
ESP116705333 116705334
PFLV114548504 114571973 114572560
GAT120819649 120820469(minpp1a)
PPUG119213180 119213978(minpp1a)
MSAM119915874 119917535 119917536
CUD121510753 121510956
ALAT119010299(minpp1b) 119033234 119033235 119033236
MZE101465653 101465958 101471718 112429926
ONL100698642 100698911 100700292
OAU116324417(minpp1b) 116333778 116333786
OLA101172268 101174333
OML112162089(minpp1a) 118597846(minpp1b)
XMA102232727 102232990 102236183
XCO114138464 114138465 114150596
XHE116713683 116713684 116726578
PRET103476795 103476796 103482126(minpp1)
PFOR103129792(minpp1) 103132329 103133525 103133527
PLAI106943405 106947670 106947671 106963906(minpp1)
PMEI106912844 106913188 106929123 106929124
GAF122822905(minpp1b) 122842976(minpp1a)
CVG107088974 107092394 107102079(minpp1)
CTUL119790840 119790872(minpp1a) 119792861(minpp1b)
GMU124859643 124859644 124874602(minpp1b)
NFU107376031 107387490(minpp1)
KMR108242898 108251380(minpp1b)
ALIM106513483 106528196(minpp1)
NWH119412970 119423887(minpp1b)
AOCE111585457 111588570 111588571
MCEP125018821 125019222 125022570 125022886
CSEM103382249(minpp1) 103387684 103387687
POV109632753
SSEN122759393(minpp1b) 122781461(minpp1a)
HHIP117753044(minpp1b) 117775612 117775613
HSP118101114(minpp1b) 118118836 118118837
LCF108891493 108891621 108897275 108897293
SDU111219960 111235163 111235387
SLAL111646461 111650504 111655112 111670039 111670083
XGL120794537(minpp1b) 120796379(minpp1a)
HCQ109526516 109528786
BPEC110157067 110157245 110166055
MALB109962120 109969682
BSPL114845582(minpp1b) 114870403
SASA106577007 106578953 106589393
STRU115157096 115193758 115201169
OTW112223438 112224280 112253031
OMY110491372 110498981 110528965
OGO124040037 124041254 124048157(minpp1b)
ONE115106353(minpp1) 115135101 115144055
SALP111951788 111967782 111977848
SNH120017653 120029830 120046135(minpp1b)
CCLU121533143 121547339 121553185
ELS105006245(minpp1) 105010648
SFM108939677(minpp1)
PKI111853700(minpp1)
AANG118218022 118221659(minpp1b)
LOC102685596(minpp1)
PSPA121325690(minpp1b)
ARUT117415668 117418274
LCM102349601(MINPP1) 102355063
CMK103180855(minpp1b)
RTP109911866(minpp1)
BFO118412093
BBEL109481336
CIN100185018 100186130
SCLV120330955 120339681 120348202
SPU100891283 115921721
APLC110973933 110977508
SKO100376334 102806176
DMEDmel_CG4123(Mipp1) Dmel_CG4317(Mipp2)
DER6544522 6551318
DSE6605972 6612312
DSIDsimw501_GD12462(Dsim_GD12462) Dsimw501_GD16214(Dsim_GD16214)
DYADyak_GE16484 Dyak_GE22212
DAN6493392
DSR110182076 110187148
DPO4811883 4814522
DPE6599274 6599768
DMN108151665 108158639
DWI6639228 6653080
DGR6558734 6566000
DMODmoj_GI16368 Dmoj_GI16858
DAZ108612744 108618745
DNV108652406
DHE111596480
DVI116650601 6623806 6623986 6633637
CCAT101453201 101462872
BOD106623122 106627044
RZE108363777
MDE101897926 101898124
SCAC106087349
LCQ111677469 111678520
HIS119650083 119650193 119658431
AGAAgaP_AGAP003555 AgaP_AGAP006962
ACOZ120948682 120949246
AARA120896246 120897307
ASTE118503615 118514249
AAG5565995 5574784 5574905
AALB109412121 109417626 109428883 115253446
CQUCpipJ_CPIJ002955 CpipJ_CPIJ011248 CpipJ_CPIJ011249
CPII120413224 120413265 120415120
CNS116337592 116337751 116338168 116338169 116338289 116340520 116341371 116346521 116349789
BCOO119066106 119066471 119066771 119067361 119067792 119068066 119068517 119068753 119068984 119069450 119073531 119074259 119076080 119076377 119076755 119077331 119079221 119080036 119080041 119080281 119080726 119080921 119081320 119081587 119081942 119084219 119084478 119084976 119085326 119086031 119086035
AME100577002 100578307 409751 724619 725931
ACER107993843 107996991 108000632 108000687 108004425
ALAB122711095 122711193 122712667 122715545 122717551
BIM100743752 100745787 100747437
BBIF117206936 117209957 117209958
BVK117235966 117243022 117243023
BVAN117153836 117160862 117160863
BTER100645347 100646336 100650220
BPYO122566372 122575027 122575028
CCAL108626162 108626164 108626353
OBB114871235 114871236
MGEN117222325 117225998 117226092
NMEA116428953 116429027 116432183
CGIG122396778 122396824 122398582
SOC105194144 105194175 105194176 105203734
MPHA105834959 105836913 105836918 105836920
AEC105145333 105145334 105146329
ACEP105620717 105621739 105621741
PBAR105422817 105430728
VEM105556286 105562094 105565679
HST105184017 105186207
DQU106742854 106742884 106746364
CFO105252391 105257036
FEX115245494
LHU105673955 105676795
PGC109860814
OBO105279692 105279919 105284872
PCF106783586
PFUC122520664
VPS122636939
NVI100113577 100121717 100121734 100121754 107980464 107980665
CSOL105361412 105365340 105365831
TPRE106651102 106657786 106657787 106657876 106657927
MDL103569701 103579775
CGLO123259347 123265594
FAS105263001 105269723 105269728 105269729
DAM107037664 107037682 107043735
AGIF122851583 122856467 122857472 122857481
CCIN107269277 107273946
TCA657509 661691
DPA109544610 109546541
SOY115874332 115883021
ATD109599779 109603461
CSET123316551 123317012 123317396
AGB108912760
LDC111513135 111513138
NVL108563490 108568816
APLN108734578 108736076
PPYR116163406 116177892 116178173
OTU111426658 111426767
BMOR101737657 101738228 101738359 101739930 119628812
BMAN114244962 114247920 114248834 114249278 114249290
MSEX115441094 115441095 115442775 115447498 115454243
DPLKGM_206366 KGM_208133 KGM_215854 KGM_216080A KGM_216080B
BANY112043694 112043741 112053761 112056259 112056870 112056871 112057612 112057657
PMAC106709198 106714798 106714799 106717554 106720140
PPOT106105623 106105624 106107414 106107576 106109194
PXU106115517 106119189 106125473 106125474 106127035
PRAP110991595 110997965 111000138 111001263 111001264
ZCE119830899 119830900 119831186 119831470 119832352 119835294
HAW110372084 110372554 110375300 110375302 110377243 110377244 110379226
HZE124630362 124630455 124631478 124633526 124637417
TNL113491673 113495011 113498758 113502600 113502601 113502687 113505659
SLIU111349369 111349370 111349441 111352131 111359778 111365025
OFU114360328 114365389 114365391 114365395 114365913
PXY105388809 105388970 105391162 105391173 105397880
CFEL113387886 113387898
API100162014 100162318 100167959
DNX107164027 107169391 107171485
AGS114127287 114127288 114127882 114127971 114128085 114128882
RMD113548047 113548990 113553445 113555936 113560731
BTAB109037275 109044018
DCI103513143 103517490
CLEC106666202 106668318 106672500
HHAL106678595 106686055 106690856
NLU111044094 111051619 111052563 111063101 111064176
PHUPhum_PHUM354750 Phum_PHUM429190
FOC113204107 113206001 113208122 113213497 113216061
TPAL117646120 117651807 117654150 117654279
ZNE110827468 110830259 110830260 110830261 110830262
CSEC111861778 111861779 111861780 111861781 111871908
FCD110848801 110861553
DPXDAPPUDRAFT_248902 DAPPUDRAFT_301637 DAPPUDRAFT_301638 DAPPUDRAFT_64728
DMK116923826 116927303 116932007 116932008
PVM113802440 113806211 113810059 113812806 113829191 113829192 113830466
PJA122243751 122244318 122246093 122247291 122259189 122261397 122262740
PCHN125024540 125029084 125035975 125043727 125044336
HAME121855797 121865065
PCLA123761652 123766526
PTRU123504102 123517350
HAZT108672377 108679549
EAF111697543 111709965
LSM121122830 121123186
PPOI119114274 119114287 119114299
ISCIscW_ISCW003591
DSV119453325
RSAN119400147 119400209
RMP119179372 119179394
VDE111246308 111246728
VJA111270065 111270552
TUT107370859 107370866
DPTE113799142
DFR124498849
PTEP107449113 107449118 107451713
SDM118185378
HROHELRODRAFT_111769 HELRODRAFT_161517 HELRODRAFT_181703 HELRODRAFT_181715 HELRODRAFT_182785
LGILOTGIDRAFT_110384
PCAN112557841
BGT106058145
GAE121379899
HRF124132194
HRJ124286736
CRG105336484
MYI110441115 110441361 110441363 110456990 110466319
PMAX117321782 117321789 117328784 117339815
MMER123562723 123563158 123563879 123565003 123565004
OBI106879508
OSN115225400
LAK106153933 106159043 106165742 106170756 106178973
SMMSmp_179560
SHXMS3_00011054(MINPP1_1)
OVIT265_01827
EGLEGR_04276
NVE5509134 5520830
EPA110238865 110239560 110252103 110252104
ATEN116291378 116294896
ADF107341978 107346610 107354584
AMIL114954844 114956440 114958553
PDAM113669245 113683131 113687070
SPIS111323000 111330545 111346582
DGT114522237 114523690 114528286 114536854
XEN124443002 124445451
HMG100198610 100214113 105846401
AQU109582726
ATHAT1G09870
ALY9328594
CRB17896695
CSAT104739589 104755195 104768195
EUSEUTSA_v10002208mg EUTSA_v10007485mg
BRP103843331 103871767
BNA106346235 106401658 106416383 106419789
BOE106295822 106312044
RSZ108833857 108858409 108859120 108859135
THJ104810121 104824338
CPAP110819153
CIT102615443
CICCICLE_v10031326mg
PVY116106184
MINC123228123 123230356
TCC18585803
GRA105773694 105779472
GHI107900553 107955204 121230723
GAB108484036
DZI111298017
EGR104455913
GMX100812135(PAP02) 100815749
GSJ114395304 114412326
PVUPHAVU_006G048800g
VRA106776102
VAR108343523
VUN114188689
CCAJ109809735
APRC113849463
MTR11415895
CAM101507608
LJALj0g3v0197689.1(Lj0g3v0197689.1) Lj0g3v0197689.2(Lj0g3v0197689.2)
ADU107471196
AIP107622818 107623366
AHF112716382 112782484 112783531
LANG109328031 109343632
FVE101314222
RCN112179772
PPER18785898
PMUM103332825
PAVI110749720
PDUL117619714
MDM103417780
PXB103937111
ZJU107413891
MNT21390348
CSV101205760 101205988 101206233 101216505 101221482
CMO103495130 103495131
BHJ120081561
MCHA111015966
CMAX111477244 111491066
CMOS111447082 111458625
CPEP111802997 111810208
RCU8272082
HBR110635352 110645553
MESC110619520 110624810
POP7462092 7464624
PEU105109357 105133543
PALZ118055917
JRE108983886
QSU112013110 112026680
QLO115955878
TWL120004053 120014063
VVI100248519 100253622
VRI117928149 117928150
SLY101244492 101260052
SPEN107020361 107021472
SOT102580208 102582317
SSTN125868245 125874746
CANN107871120
NTA107789799 107801145 107809225 107832535
NSY104226627 104245686
NTO104088880 104088886
NAU109223383 109232259
INI109154998
ITR116019989
SIND105160857
OEU111390935
EGT105977634
SSPL121744254 121761912
HAN110872695
ECAD122605897
LSV111878897 111896846
CCAV112524542
DCR108210743
CSIN114269771 114292464
BVG104905971
SOE110781869
CQI110699325 110733482
NNU104597681
MING122061146 122087726
TSS122640041 122671689
PSOM113308609 113329213 113338931 113340562
NCOL116263272
OSA4334577
DOSAOs03t0818100-01(Os03g0818100)
OBR102712072
BDI100831816
ATS109744068
TDC119303786 119312485
TAES100037593 100038341 123113959
SBI8057380
ZMA100282868
SITA101772807
SVS117838547
PVIR120649296 120678951 120689464
PHAI112875216
PDA103708852
EGU105033642
MUS103984406
DCT110101297
PEQ110029458
AOF109830085 109842764 109842875 109843642
ATR18425245 18433376
SMOSELMODRAFT_181288 SELMODRAFT_182070
PPP112276329 112285927
CRECHLRE_13g568550v5 CHLRE_13g568600v5
VCNVOLCADRAFT_104207
MNGMNEG_3694
DDIDDB_G0285339(mipp1) DDB_G0286993
DPPDICPUDRAFT_54584 DICPUDRAFT_7448
DFADFA_01730
EHIEHI_059910(101.t00003)
EDIEDI_223820
EIVEIN_095610
ACANACA1_205990
PIFPITG_02776 PITG_02783
PSOJPHYSODRAFT_472758 PHYSODRAFT_475094
SPARSPRG_00684 SPRG_01084
GTTGUITHDRAFT_108721
FPPFPB0191_00112
ARBA9P82_11410
ARKD6B99_11900
ARACE0W69_013465
FLNFLA_2532
PEPAQ505_13810
PROEH9L23_11835
MGKFSB76_06585
MMABHQ865_18070
MGIKGO620_015850
FLMMY04_3832
 » show all
Reference
1  [PMID:2786415]
  Authors
Cullen PJ, Irvine RF, Drobak BK, Dawson AP.
  Title
Inositol 1,3,4,5-tetrakisphosphate causes release of Ca2+ from permeabilized mouse lymphoma L1210 cells by its conversion into inositol 1,4,5-trisphosphate.
  Journal
Biochem J 259:931-3 (1989)
DOI:10.1042/bj2590931
Reference
2  [PMID:9359836]
  Authors
Craxton A, Caffrey JJ, Burkhart W, Safrany ST, Shears SB.
  Title
Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase.
  Journal
Biochem J 328 ( Pt 1):75-81 (1997)
DOI:10.1042/bj3280075
  Sequence
[rno:29688]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.62
IUBMB Enzyme Nomenclature: 3.1.3.62
ExPASy - ENZYME nomenclature database: 3.1.3.62
BRENDA, the Enzyme Database: 3.1.3.62
CAS: 116958-30-6

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