KEGG   ENZYME: 3.1.3.75
Entry
EC 3.1.3.75                 Enzyme                                 
Name
phosphoethanolamine/phosphocholine phosphatase;
PHOSPHO1;
3X11A
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
phosphoethanolamine phosphohydrolase
Reaction(IUBMB)
(1) O-phosphoethanolamine + H2O = ethanolamine + phosphate [RN:R06870];
(2) phosphocholine + H2O = choline + phosphate [RN:R06871]
Reaction(KEGG)
R06870 R06871
Substrate
O-phosphoethanolamine [CPD:C00346];
H2O [CPD:C00001];
phosphocholine [CPD:C00588]
Product
ethanolamine [CPD:C00189];
phosphate [CPD:C00009];
choline [CPD:C00114]
Comment
Requires active site Mg2+ but also works, to a lesser extent, with Co2+ and Mn2+. The enzyme is highly specific for phosphoethanolamine and phosphocholine.
History
EC 3.1.3.75 created 2004
Pathway
ec00564  Glycerophospholipid metabolism
ec01100  Metabolic pathways
Orthology
K06124  phosphoethanolamine/phosphocholine phosphatase
Genes
HSA162466(PHOSPHO1)
PTR455200(PHOSPHO1)
PPS100995130(PHOSPHO1)
GGO101135403(PHOSPHO1)
PON100453832(PHOSPHO1)
NLE100595367(PHOSPHO1)
MCC698959(PHOSPHO1)
MCF102142920(PHOSPHO1)
MTHB126939881
CSAB103243637(PHOSPHO1)
CATY105579465(PHOSPHO1)
PANU101022896(PHOSPHO1)
TGE112609712(PHOSPHO1)
RRO104659770(PHOSPHO1)
RBB108516490(PHOSPHO1)
TFN117067185(PHOSPHO1)
PTEH111537547(PHOSPHO1)
CANG105524589(PHOSPHO1)
CJC100393769(PHOSPHO1)
SBQ101044528(PHOSPHO1)
CSYR103266008(PHOSPHO1)
MMUR105885086(PHOSPHO1)
LCAT123620746(PHOSPHO1)
PCOQ105825269(PHOSPHO1)
OGA100947010(PHOSPHO1)
MMU237928(Phospho1)
MCAL110305039(Phospho1)
MPAH110331695(Phospho1)
RNO287644(Phospho1)
MCOC116078181(Phospho1)
MUN110551190(Phospho1)
CGE100760987(Phospho1)
MAUA101826535(Phospho1)
PLEU114692918(Phospho1)
MORG121456480(Phospho1)
MFOT126510516
AAMP119812507(Phospho1)
NGI103738361(Phospho1)
HGL101721548(Phospho1)
CPOC100717176(Phospho1)
CCAN109691393(Phospho1)
DORD106003021(Phospho1)
DSP122102114(Phospho1)
NCAR124980047 124987104
OCU100344433
OPI101533353(PHOSPHO1)
TUP102493382(PHOSPHO1)
GVR103595069(PHOSPHO1)
CFA491069(PHOSPHO1)
CLUD112655069(PHOSPHO1)
VVP112917840(PHOSPHO1)
VLG121473394(PHOSPHO1)
AML100484341(PHOSPHO1)
UAH113265598(PHOSPHO1)
UAR123802845(PHOSPHO1)
ELK111151657
LLV125086928
MPUF101677146(PHOSPHO1)
ORO101386933(PHOSPHO1)
EJU114201151(PHOSPHO1)
ZCA113939473(PHOSPHO1)
MLX118024788(PHOSPHO1)
NSU110593037(PHOSPHO1)
LWW102734986(PHOSPHO1)
FCA101095209(PHOSPHO1)
PYU121044823(PHOSPHO1)
PBG122485400(PHOSPHO1)
LRUF124513258
PPAD109247328(PHOSPHO1)
AJU106985155(PHOSPHO1)
HHV120229111(PHOSPHO1)
BTA524639(PHOSPHO1)
BOM102281872(PHOSPHO1)
BIU109574069(PHOSPHO1)
BBUB102410417(PHOSPHO1)
BBIS104990597(PHOSPHO1)
CHX102190731(PHOSPHO1)
OAS101112333(PHOSPHO1)
ODA120867304(PHOSPHO1)
CCAD122443006(PHOSPHO1)
SSC100621753(PHOSPHO1) 102158609
CFR102520575(PHOSPHO1)
CBAI105073347(PHOSPHO1)
CDK105095768(PHOSPHO1)
VPC102543169(PHOSPHO1)
BACU103013714(PHOSPHO1)
LVE103077302(PHOSPHO1)
OOR101284285(PHOSPHO1)
DLE111166311(PHOSPHO1)
PCAD102979410(PHOSPHO1)
PSIU116745852(PHOSPHO1)
ECB100055957(PHOSPHO1)
EPZ103551066(PHOSPHO1)
EAI106826446(PHOSPHO1)
MYB102253386(PHOSPHO1) 102259030 102263881
MYD102775093(PHOSPHO1)
MMYO118671400(PHOSPHO1) 118675903
MLF102424890 102435555(PHOSPHO1)
MNA107539172(PHOSPHO1)
PKL118726302(PHOSPHO1)
HAI109380823(PHOSPHO1)
DRO112316483(PHOSPHO1)
SHON118978070(PHOSPHO1)
AJM119052610(PHOSPHO1) 119065478
PDIC114503102(PHOSPHO1)
PHAS123817085(PHOSPHO1)
MMF118633773(PHOSPHO1)
RFQ117013105(PHOSPHO1)
PALE102882188(PHOSPHO1)
PGIG120611273(PHOSPHO1)
PVP105307235(PHOSPHO1)
RAY107517611(PHOSPHO1)
MJV108391067(PHOSPHO1)
TOD119231557(PHOSPHO1)
SARA101551481(PHOSPHO1)
LAV100674633(PHOSPHO1)
TMU101359892
ETF101652524(PHOSPHO1) 101662514
DNM101419311(PHOSPHO1)
MDO100021539(PHOSPHO1)
GAS123247750(PHOSPHO1)
SHR111720963(PHOSPHO1)
PCW110215702(PHOSPHO1)
OAA100087239(PHOSPHO1)
GGA395650(PHOSPHO1)
PCOC116233737(PHOSPHO1)
MGP100547041(PHOSPHO1)
CJO107325092(PHOSPHO1)
NMEL110388629(PHOSPHO1)
APLA101795093(PHOSPHO1)
ACYG106048340(PHOSPHO1)
AFUL116498506(PHOSPHO1)
TGU115490703(PHOSPHO1)
LSR110474784(PHOSPHO1)
SCAN103825423(PHOSPHO1)
OTC121347618(PHOSPHO1)
PRUF121352429(PHOSPHO1)
FAB101808298(PHOSPHO1)
PHI102101486(PHOSPHO1)
PMAJ107198660(PHOSPHO1)
CCW120411207(PHOSPHO1)
CBRC103619892(PHOSPHO1)
ETL114070120(PHOSPHO1)
ACHL103802514(PHOSPHO1)
FPG101914984(PHOSPHO1)
FCH102056152(PHOSPHO1)
CLV102086540(PHOSPHO1)
EGZ104131237(PHOSPHO1)
NNI104012239(PHOSPHO1)
PLET104628746(PHOSPHO1)
PCRI104027730(PHOSPHO1)
PCAO104049683(PHOSPHO1)
ACUN113489178(PHOSPHO1)
TALA104360182(PHOSPHO1)
PADL103915194(PHOSPHO1)
AFOR103905950(PHOSPHO1)
ACHC115344570(PHOSPHO1)
HALD104321157
HLE104842857(PHOSPHO1)
AGEN126038335
GCL127026517
CCRI104158834(PHOSPHO1)
CSTI104554365(PHOSPHO1)
EHS104505542(PHOSPHO1)
CMAC104486037(PHOSPHO1)
MUI104535851(PHOSPHO1)
FGA104082554(PHOSPHO1)
GSTE104258964(PHOSPHO1)
LDI104349247(PHOSPHO1)
MNB103772313(PHOSPHO1)
OHA104328520(PHOSPHO1)
DPUB104299920(PHOSPHO1)
PGUU104472457(PHOSPHO1)
ACAR104520229(PHOSPHO1)
CPEA104391096(PHOSPHO1)
AVIT104270653(PHOSPHO1)
CVF104292780(PHOSPHO1)
CUCA104068262(PHOSPHO1)
TEO104378659(PHOSPHO1)
BRHI104489166(PHOSPHO1)
AAM106495963(PHOSPHO1)
AROW112968996(PHOSPHO1)
NPD112960270(PHOSPHO1)
TGT104576613(PHOSPHO1)
DNE112987174(PHOSPHO1)
SCAM104144334(PHOSPHO1)
ASN102371816(PHOSPHO1)
AMJ102576418(PHOSPHO1)
CPOO109318926(PHOSPHO1)
GGN109302121(PHOSPHO1)
PSS102447415(PHOSPHO1)
CMY102936439(PHOSPHO1)
CPIC101942754(PHOSPHO1)
TST117869156(PHOSPHO1)
CABI116831458(PHOSPHO1)
MRV120392168(PHOSPHO1)
ACS100563935(phospho1)
PVT110090872(PHOSPHO1)
SUND121934078(PHOSPHO1)
PBI103055208(PHOSPHO1)
PMUR107282586(PHOSPHO1)
CTIG120303511(PHOSPHO1)
TSR106556048(PHOSPHO1)
PGUT117664536(PHOSPHO1)
VKO123030558(PHOSPHO1)
PMUA114581859(PHOSPHO1)
ZVI118095841(PHOSPHO1)
GJA107108721(PHOSPHO1)
STOW125444528(PHOSPHO1)
XLA108700823(phospho1.L) 108702531(phospho1.S)
XTR100492656(phospho1)
NPR108784014(PHOSPHO1)
RTEM120919557(PHOSPHO1)
BBUF121003866(PHOSPHO1)
BGAR122941199(PHOSPHO1)
DRE100002812(phospho1)
SRX107745765 107755127
SANH107661127 107689057
SGH107576079 107579193
CCAR109057067 109104610
CAUA113043795 113046893
PPRM120490274(phospho1)
MAMB125279121(phospho1)
IPU108261429 108273983(phospho1)
PHYP113527960 113535146
SMEO124388544 124397099(phospho1)
TFD113638008(phospho1) 113662539
AMEX103030183(phospho1) 103036134
EEE113580216(phospho1) 113589801
TRU101070337 101076946(phospho1)
TNGGSTEN00019396G001
LCO104926289(phospho1) 104930975
NCC104949136 104967613
CGOB115012881(phospho1) 115024187
ELY117260115 117268461(phospho1)
EFO125880015(phospho1) 125880873
PLEP121956975(phospho1) 121964601
SLUC116061189 116063891(phospho1)
ECRA117936825 117958448(phospho1)
ESP116671194 116702870
PFLV114547701 114570072(phospho1)
GAT120819233 120828454(phospho1)
PPUG119213148 119220418(phospho1)
MSAM119892928(phospho1) 119916387
CUD121503437(phospho1) 121528873
ALAT119009267 119013895(phospho1)
MZE101469983 101470712(phospho1)
ONL100708331 100710388(phospho1)
OAU116329803 116330982(phospho1)
OLA101155150 101167458
OML112145853(phospho1) 112154155
XMA102220236(phospho1) 102227979
XCO114152272 114159552(phospho1)
XHE116726738 116735289(phospho1)
PRET103469363(phospho1) 103481271
PFOR103142150(phospho1) 103153392
PLAI106948325 106961835(phospho1)
PMEI106907681 106925795(phospho1)
GAF122822549(phospho1) 122823649
CVG107084754(phospho1) 107099757
CTUL119783019(phospho1) 119792210
GMU124863068 124864505 124874619
NFU107378570(phospho1) 107387866
KMR108243759(phospho1) 108249903
ALIM106516971 106527682(phospho1)
NWH119421887(phospho1) 119423658
AOCE111567303 111567379(phospho1)
MCEP124997638(phospho1) 125022291
CSEM103381457 103393135(phospho1)
POV109627102 109634063(phospho1)
SSEN122759032 122784710(phospho1)
HHIP117752949 117767050(phospho1)
HSP118100268 118122948(phospho1)
LCF108872764 108898750
SDU111217605(phospho1) 111220061
SLAL111657148 111658418
XGL120794197 120805836(phospho1)
HCQ109519339(phospho1) 109524043
BPEC110154152 110161755(phospho1)
MALB109954835 109963084
BSPL114846363 114860536(phospho1)
SASA100195269(phop1) 106579160 106607258
STRU115160667 115171074 115197547
OTW112223761 112225966 112258623(phospho1)
OMY110485158 110491668 110538152
OGO124000605 124016138 124048412
ONE115104098 115106628 115110245
SALP111978385 111981137 111981248
SNH120034516 120035472 120046287
CCLU121569510 121569613 123486289
ELS105013313(phospho1) 105030554
SFM108919065 108941591
PKI111856024 111856092
AANG118216665(phospho1) 118221039
LOC102698302(phospho1)
PSPA121302043(phospho1)
ARUT117433339 117434619
PSEX120517967(phospho1)
LCM102365260(PHOSPHO1)
CMK103183818
RTP109926898
AGIF122859035
OSA4324704
DOSAOs01t0720400-01(Os01g0720400)
OBR102716824
BDI100828291
ATS109783536
TDC119268984 119276970 119276971 119276972 119281514 119281515
TAES123062040 123065663 123065665 123065667 123070764 123074743 123074744 123074745
TUA125548607 125548609 125548611
LPER127321474 127321488 127321840 127321842 127329529 127343628 127343629
SBI8069806
ZMA100191227 100284789
SITA101772309
SVS117856988
PVIR120676003 120707864
PHAI112892401
 » show all
Reference
1  [PMID:9990301]
  Authors
Houston B, Seawright E, Jefferies D, Hoogland E, Lester D, Whitehead C, Farquharson C.
  Title
Identification and cloning of a novel phosphatase expressed at high levels in differentiating growth plate chondrocytes.
  Journal
Biochim Biophys Acta 1448:500-6 (1999)
DOI:10.1016/S0167-4889(98)00153-0
  Sequence
[gga:395650]
Reference
2  [PMID:14983068]
  Authors
Stewart AJ, Schmid R, Blindauer CA, Paisey SJ, Farquharson C.
  Title
Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the haloacid dehalogenase superfamily.
  Journal
Protein Eng 16:889-95 (2003)
DOI:10.1093/protein/gzg126
  Sequence
[hsa:162466]
Reference
3  [PMID:15175005]
  Authors
Roberts SJ, Stewart AJ, Sadler PJ, Farquharson C
  Title
Human PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities.
  Journal
Biochem J 382:59-65 (2004)
DOI:10.1042/BJ20040511
  Sequence
[hsa:162466]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.75
IUBMB Enzyme Nomenclature: 3.1.3.75
ExPASy - ENZYME nomenclature database: 3.1.3.75
BRENDA, the Enzyme Database: 3.1.3.75

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