KEGG   ENZYME: 3.1.4.43
Entry
EC 3.1.4.43                 Enzyme                                 
Name
glycerophosphoinositol inositolphosphodiesterase;
1,2-cyclic-inositol-phosphate phosphodiesterase;
D-myo-inositol 1:2-cyclic phosphate 2-phosphohydrolase;
D-inositol 1,2-cyclic phosphate 2-phosphohydrolase;
D-myo-inositol 1,2-cyclic phosphate 2-phosphohydrolase;
1-D-myo-inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase;
inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
Sysname
1-(sn-glycero-3-phospho)-1D-myo-inositol inositolphosphohydrolase
Reaction(IUBMB)
1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O = glycerol + 1D-myo-inositol 1-phosphate [RN:R03331]
Reaction(KEGG)
R03331;
(other) R03333
Substrate
1-(sn-glycero-3-phospho)-1D-myo-inositol [CPD:C01225];
H2O [CPD:C00001]
Product
glycerol [CPD:C00116];
1D-myo-inositol 1-phosphate [CPD:C01177]
Comment
This enzyme also hydrolyses Ins(cyclic1,2)P to Ins-1-P
History
EC 3.1.4.43 created 1984, (EC 3.1.4.36 created 1976, incorporated 2002), modified 2002
Orthology
K01124  glycerophosphoinositol inositolphosphodiesterase
Genes
HSA54857(GDPD2)
PTR465687(GDPD2)
PPS100969535(GDPD2)
GGO101125597(GDPD2)
PON100446576(GDPD2)
NLE100582979(GDPD2)
MCC695687(GDPD2)
MCF102136065(GDPD2)
CSAB103232133(GDPD2)
CATY105586132(GDPD2)
PANU101002823(GDPD2)
TGE112615625(GDPD2)
RRO104678788(GDPD2)
RBB108539315(GDPD2)
TFN117077616(GDPD2)
PTEH111536117(GDPD2)
CJC100412949(GDPD2)
SBQ101038113(GDPD2)
CSYR103261388(GDPD2)
MMUR105855328(GDPD2)
OGA100954786(GDPD2)
MMU71584(Gdpd2)
MCAL110286954(Gdpd2)
MPAH110313610(Gdpd2)
RNO302421(Gdpd2)
MCOC116093783(Gdpd2)
MUN110542516(Gdpd2)
CGE100771225(Gdpd2)
MAUA101837360(Gdpd2)
PLEU114703179(Gdpd2)
MORG121443316 121444963
NGI103743163(Gdpd2)
HGL101706272(Gdpd2)
CPOC100732849(Gdpd2)
CCAN109680749(Gdpd2)
DORD105997262(Gdpd2)
DSP122120678(Gdpd2)
NCAR124972329
OCU100346403(GDPD2)
OPI101525704(GDPD2)
TUP102484003(GDPD2)
CFA480951(GDPD2)
VVP112907588(GDPD2)
VLG121483508(GDPD2)
AML100477309(GDPD2)
UMR103682623(GDPD2)
UAH113245592(GDPD2)
UAR123786188(GDPD2)
ELK111161024
LLV125091348
MPUF101674035(GDPD2)
ORO101376595(GDPD2)
EJU114200108(GDPD2)
ZCA113930860(GDPD2)
MLX118026009(GDPD2)
FCA101088650(GDPD2)
PYU121025245(GDPD2)
PBG122476906(GDPD2)
PTG102967871(GDPD2)
PPAD109254601(GDPD2)
AJU106982398(GDPD2)
HHV120246034(GDPD2)
BTA514673(GDPD2)
BOM102272674(GDPD2)
BIU109555339(GDPD2)
BBUB102395386(GDPD2)
CHX102173824(GDPD2)
OAS101101866(GDPD2)
ODA120882018(GDPD2)
CCAD122434860(GDPD2)
SSC100516309(GDPD2)
CFR102513549(GDPD2)
CBAI105083696(GDPD2)
CDK105087975(GDPD2)
VPC102529108(GDPD2)
BACU103013177(GDPD2)
LVE103091359(GDPD2)
OOR101289657(GDPD2)
DLE111167777(GDPD2)
PCAD102978987(GDPD2)
PSIU116747377(GDPD2)
ECB100055691(GDPD2)
EPZ103544986(GDPD2)
EAI106827113(GDPD2)
MYB102238745(GDPD2)
MYD102760571(GDPD2)
MMYO118654483(GDPD2)
MLF102417970(GDPD2)
MNA107532876(GDPD2)
PKL118704114(GDPD2)
HAI109385582(GDPD2)
DRO112300077(GDPD2)
SHON118996725(GDPD2)
AJM119040217(GDPD2)
PDIC114505016(GDPD2)
PHAS123824306(GDPD2)
MMF118636249(GDPD2)
RFQ117020552(GDPD2)
PALE102886565(GDPD2)
PGIG120585409(GDPD2)
PVP105299611(GDPD2)
RAY107503837(GDPD2)
MJV108403636(GDPD2)
TOD119246100(GDPD2)
SARA101550095(GDPD2)
LAV100665406(GDPD2)
TMU101356229
DNM101447384(GDPD2)
MDO100014029(GDPD2)
GAS123253998(GDPD2)
SHR100932224(GDPD2)
PCW110201085(GDPD2)
OAA114812948(GDPD2)
GGA422217(GDPD2)
PCOC116229608(GDPD2)
MGP100544970(GDPD2)
CJO107312626(GDPD2)
NMEL110403328(GDPD2)
APLA101792816(GDPD2)
ACYG106037473(GDPD2)
AFUL116494445(GDPD2)
TGU100231010(GDPD2)
LSR110472672(GDPD2)
PMOA120506202(GDPD2)
OTC121331832(GDPD2)
PRUF121363145(GDPD2)
GFR102031707(GDPD2)
FAB101814282(GDPD2)
PHI102100679(GDPD2)
PMAJ107204083(GDPD2)
CCAE111942692(GDPD2)
CCW104691662(GDPD2)
ETL114067446(GDPD2)
ZAB102068205(GDPD2)
FPG101922487(GDPD2)
FCH102051523(GDPD2)
CLV102095560(GDPD2)
EGZ104124264(GDPD2)
NNI104012895(GDPD2)
ACUN113480044(GDPD2)
TALA104362601(GDPD2)
PADL103923351(GDPD2)
ACHC115333854(GDPD2)
AAM106496634(GDPD2)
AROW112966326(GDPD2)
NPD112948676(GDPD2)
DNE112989767(GDPD2)
ASN102381477(GDPD2)
AMJ102574797(GDPD2)
CPOO109310975(GDPD2)
GGN109300569(GDPD2)
CMY102941248(GDPD2)
CPIC101950361(GDPD2)
TST117883116(GDPD2)
CABI116834986(GDPD2)
MRV120371999(GDPD2)
ACS100566715(gdpd2)
PVT110080167(GDPD2)
SUND121937044(GDPD2)
PBI103063018(GDPD2)
PMUR107303215(GDPD2)
PGUT117679612(GDPD2)
VKO123034975(GDPD2)
PMUA114589141(GDPD2)
ZVI118083745(GDPD2)
GJA107108520(GDPD2)
STOW125442955(GDPD2)
XLA108698333(gdpd2.L)
XTR100038173(gdpd2)
NPR108800179(GDPD2)
RTEM120921948(GDPD2)
BBUF120977396(GDPD2)
BGAR122919646(GDPD2)
DRE563198(gdpd2)
SRX107744531(gdpd2) 107752000
SANH107658123(gdpd2) 107664355
SGH107550770(gdpd2) 107560350
CCAR109060314 109102259 109111173
CAUA113057760 113058034 113113941
PPRM120474408(gdpd2)
MAMB125259132(gdpd2)
IPU108268889(gdpd2)
PHYP113529405(gdpd2)
SMEO124386502(gdpd2)
TFD113636095(gdpd2)
AMEX103040773(gdpd2)
EEE113582678(gdpd2)
TRU101070529(gdpd2)
TNGGSTEN00031233G001
LCO104923477(gdpd2)
NCC104958393(gdpd2)
CGOB115015175(gdpd2)
ELY117261247(gdpd2)
PLEP121947661 121947770 121948467
SLUC116052340(gdpd2)
ECRA117951769(gdpd2)
PFLV114562368(gdpd2)
GAT120818121(gdpd2)
PPUG119210503(gdpd2)
MSAM119889173(gdpd2)
CUD121516641(gdpd2)
MZE101481713
ONL100706815(gdpd2)
OAU116323526(gdpd2)
OLA101168550(gdpd2)
OML112142577(gdpd2)
XMA102230452
XCO114139550
XHE116714470
PRET103471626(gdpd2)
PFOR103140130(gdpd2)
PLAI106940877(gdpd2)
PMEI106926642(gdpd2)
GAF122836824(gdpd2)
CVG107092566(gdpd2)
CTUL119795758(gdpd2)
GMU124860986(gdpd2)
NFU107378587(gdpd2)
KMR108231120(gdpd2)
ALIM106515379
NWH119408678(gdpd2)
AOCE111579648(gdpd2)
CSEM103390757(gdpd2)
POV109632286(gdpd2)
SSEN122778928(gdpd2)
HHIP117769511(gdpd2)
HSP118112630(gdpd2)
LCF108872608(gdpd2)
SDU111232775(gdpd2)
SLAL111666338(gdpd2)
XGL120785761(gdpd2)
HCQ109516566(gdpd2)
BPEC110158919(gdpd2)
MALB109953061(gdpd2)
BSPL114863922(gdpd2)
SASA106604731 106611742
OTW112220887(gdpd2) 112256194
OMY110488768 110504963
OGO123994070(gdpd2) 124011473
ONE115129420 115130644(gdpd2)
SALP111965676 111967449
SNH120047464(gdpd2) 120061963
ELS105029530(gdpd2)
SFM108922931(gdpd2)
PKI111835039(gdpd2)
AANG118222833(gdpd2)
LOC107077912(gdpd2)
PSPA121295874(gdpd2) 121318847
ARUT117411955 117430758
LCM102357097(GDPD2)
TGOTGME49_263270
 » show all
Reference
1  [PMID:192216]
  Authors
Dawson RM, Hemington N.
  Title
A phosphodiesterase in rat kidney cortex that hydrolyses glycerylphosphorylinositol.
  Journal
Biochem J 162:241-5 (1977)
DOI:10.1042/bj1620241
Reference
2  [PMID:4342209]
  Authors
Dawson RM, Clarke N.
  Title
D-myoinositol 1:2-cyclic phosphate 2-phosphohydrolase.
  Journal
Biochem J 127:113-8 (1972)
DOI:10.1042/bj1270113
Reference
3  [PMID:4353088]
  Authors
Dawson RM, Clarke NG.
  Title
A comparison of D-inositol 1:2-cyclic phosphate 2-phosphohydrolase with other phosphodiesterases of kidney.
  Journal
Biochem J 134:59-67 (1973)
DOI:10.1042/bj1340059
Reference
4  [PMID:1845995]
  Authors
Ross TS, Majerus PW.
  Title
Inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase. Substrate specificity and regulation of activity by phospholipids, metal ion chelators, and inositol 2-phosphate.
  Journal
J Biol Chem 266:851-6 (1991)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.43
IUBMB Enzyme Nomenclature: 3.1.4.43
ExPASy - ENZYME nomenclature database: 3.1.4.43
BRENDA, the Enzyme Database: 3.1.4.43
CAS: 9076-91-9 72414-13-2

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