KEGG ENZYME: 3.1.6.1

ENZYME: 3.1.6.1

Entry

EC 3.1.6.1                  Enzyme

Name

arylsulfatase (type I);
sulfatase;
nitrocatechol sulfatase;
phenolsulfatase;
phenylsulfatase;
p-nitrophenyl sulfatase;
arylsulfohydrolase;
4-methylumbelliferyl sulfatase;
estrogen sulfatase;
type I sulfatase;
arylsulfatase

Class

Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases

Sysname

aryl-sulfate sulfohydrolase

Reaction(IUBMB)

an aryl sulfate + H2O = a phenol + sulfate [RN:R01243]

Reaction(KEGG)

R01243 > R03980;
(other) R04856 R06280(G)

Substrate

aryl sulfate [CPD:C00850];
H2O [CPD:C00001]

Product

phenol [CPD:C15584];
sulfate [CPD:C00059]

Comment

Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors. Arylsulfatases are type I enzymes, found in both prokaryotes and eukaryotes, with rather similar specificities. The key catalytic residue 3-oxo-L-alanine initiates the reaction through a nucleophilic attack on the sulfur atom in the substrate. This residue is generated by posttranslational modification of a conserved cysteine or serine residue by EC 1.8.3.7, formylglycine-generating enzyme, EC 1.1.98.7, serine-type anaerobic sulfatase-maturating enzyme, or EC 1.8.98.7, cysteine-type anaerobic sulfatase-maturating enzyme.

History

EC 3.1.6.1 created 1961, modified 2011, modified 2021

Pathway

ec00140

Steroid hormone biosynthesis

ec00600

Sphingolipid metabolism

ec01100

Metabolic pathways

Orthology

K01130

arylsulfatase

Genes

KLW:	DA718_20290

ETE:

ETEE_3380

EDW:	QY76_12995

EDL:	AAZ33_07220

GAI:	IMCC3135_09555

HHU:	AR456_01895

PCAF:

DSC91_007680

BBRO:

BAU06_00040 BAU06_05825

BOH:	AKI39_13145

ACHR:

C2U31_06605

AKA:	TKWG_21235

MESM:

EJ066_13465

RJG:	CCGE525_31715 CCGE525_31725

RHR:	CKA34_30115

RSUL:

N2599_13465

NGL:	RG1141_PA09260 RG1141_PA12920

NGG:	RG540_PA08240 RG540_PA13910

NEN:	NCHU2750_53620

BGZ:	XH91_30815

BARH:

WN72_43370

MOC:	BB934_10175

PHL:	KKY_3091 KKY_3092

MEY:	TM49_15780

MAAD:

AZF01_09150

MMED:

Mame_04823

MALG:

MALG_00822

PABY:

Ga0080574_TMP478 Ga0080574_TMP494

BOO:	E2K80_04590 E2K80_11615

PPAF:

I8N54_04630 I8N54_18025

CMAG:

CBW24_06020

FAP:	GR316_13240

PCAY:

FRD00_07775 FRD00_27270

BACA:

FAY30_21980 FAY30_26840

VIR:	X953_15095

VHL:	BME96_14445

VIL:	CFK37_08495

LEX:	Len3610_12770

MEKU:

HUW50_24170

BLEN:

NCTC4824_01157 NCTC4824_01489

SSD:	SPSINT_0710

SDT:

SPSE_1822

SDP:	NCTC12225_02043

SFQ:	C7J90_06785

SLLO:

ISP08_12545

PJD:	Pjdr2_3275

GYM:	GYMC10_3591

POD:	PODO_17545

PAEF:

R50345_17625 R50345_17630

PAEJ:

H70737_17455 H70737_17460

PIB:	BBD41_05085

PVO:	PVOR_18444

PLW:	D5F53_12285

PALB:

EJC50_09000

PBK:	Back11_15510 Back11_42790

PRZ:	GZH47_23540 GZH47_30135

PLYC:

GXP70_14480

PALO:

E6C60_0776 E6C60_0797 E6C60_3608

SPW:

SPCG_1785

SJJ:

SPJ_1708

SNV:	SPNINV200_16270

SNE:	SPN23F18200

SPV:

SPH_1924

SNM:	SP70585_1861

SNI:	INV104_15470

SPNG:

HMPREF1038_01772

SNP:

SPAP_1798

SNX:	SPNOXC15830

SNU:	SPNA45_00441

SPNU:

SPN034183_15850

SPNM:

SPN994038_15740

SPNO:

SPN994039_15750

SACO:

SAME_00562

LCS:

LCBD_0376

LCE:

LC2W_0372

LCW:	BN194_03810

LCB:	LCABL_03730

LCT:	BI355_0118

EFL:

EF62_2204

EFU:	HMPREF0351_12962

ESG:	EsVE80_00870

ECEC:

NCTC12421_00037

EDS:	PML78_07270

ADC:	FOC79_05975

JEM:	LZ578_10280

GAD:	K8O88_02400

CPE:

CPE0231

CPF:

CPF_0221

HHJ:	NQ487_28975

FSA:	C5Q98_04645

RUK:	A4V00_18535

CAPR:

EQM14_02105

PFAA:

MM59RIKEN_16380

BHAN:

CGC63_02880 CGC63_03295

CSH:	Closa_2327

SINT:

K5I26_04290

MFOR:

NQ534_12375

EHN:	H9Q80_11425

VGU:	HYG85_17990

VPY:	HZI73_07275 HZI73_07905 HZI73_08045 HZI73_08065 HZI73_10800 HZI73_14370

AARG:

Aargi30884_25930

ABSI:

A9CBEGH2_23250

LCG:	L3BBH23_22600

ERB:	A4V01_18005

CIU:	G4D55_14905

SALF:

SMD44_02010

SAST:

CD934_00820

SAOV:

G3H79_29075

MHOS:

CXR34_01585

MCHN:

HCR76_11955

AMAU:

DSM26151_12600

ARR:	ARUE_c16440

ARM:

ART_4143

ARE:	AL755_08370

ARW:	MB46_08130

APOA:

J0916_04670

AAU:

AAur_1732

PNV:	JMY29_08245

BCV:	Bcav_0304 Bcav_0569 Bcav_1300

BFA:	Bfae_06030 Bfae_28180

BRX:	BH708_10430 BH708_16095 BH708_16510 BH708_16895

BRV:	CFK39_11060

BGG:	CFK41_13840

BRZ:	CFK38_00615 CFK38_16445

BSAU:

DWV08_16075

BKI:	M4486_12950 M4486_17220

BRHA:

NLU66_17500

BHH:	Bra3105_13905

LMOI:

VV02_08325

HALT:

IM660_01935 IM660_02155 IM660_12510 IM660_13715 IM660_17030 IM660_17360 IM660_18100 IM660_19155

RHAL:

LQF10_06845 LQF10_16870

RSUA:

LQF12_10315

MIK:	FOE78_08600 FOE78_09660 FOE78_09710

MICG:

GJV80_01260

TES:	BW730_09190

TDF:	H9L22_01550

NOW:	GBF35_41150

PSEE:

FRP1_09870

PSEQ:

AD006_17430

PECQ:

AD017_25265

PHH:	AFB00_15765 AFB00_17025 AFB00_28850

VER:	HUT12_13375

AREP:

ID810_07800

CSTC:

LK434_01995 LK434_06575

RUFI:

K0V07_04670 K0V07_16095

RML:	FF011L_10200

AHEL:

Q31a_10040 Q31a_30530

LCRE:

Pla8534_23680 Pla8534_36380 Pla8534_56540(atsA_47) Pla8534_62320

AAGG:

ETAA8_66950

RLC:	K227x_25550

AMUC:

Pan181_48500

PND:	Pla175_12770(betC_4) Pla175_23510 Pla175_32370 Pla175_48660(betC_25)

PBS:	Plabr_1085

FMR:	Fuma_01030

GMR:	GmarT_19840

GIM:	F1728_04980 F1728_19830

GPN:	Pan110_19390 Pan110_44510

MRI:	Mal4_27360 Mal4_29420 Mal4_30210 Mal4_46690 Mal4_58780(betC_22)

SDYN:

Mal52_08690 Mal52_40630

PLON:

Pla110_05160

TSPH:

KIH39_01535

PHM:	PSMK_09670 PSMK_11570 PSMK_27950

MCAD:

Pan265_03490 Pan265_04460 Pan265_13720

PBU:	L21SP3_00903 L21SP3_01497

PBP:	STSP1_01495

PBAS:

SMSP2_00826 SMSP2_01427 SMSP2_02069

ALUS:

STSP2_02144

VBL:	L21SP4_02331

TAER:

GT409_04395 GT409_07575 GT409_07990 GT409_10360 GT409_13370 GT409_13400

LPRO:

PQO03_05570

TBE:	Trebr_2355

SBU:	SpiBuddy_0360

SASS:

MUG09_02450 MUG09_03425

BHC:	JFL75_01475 JFL75_14310 JFL75_20605

BHY:	BHWA1_00429

BHD:	BHYOB78_01035

BRM:

Bmur_0151

BIP:

Bint_1411

BHP:	BHAMNSH16_00780

EDA:	GWR55_15335

EDG:	H7846_14450

SUS:

Acid_7475

PFER:

IRI77_03680 IRI77_30330

FVA:	FV113G1_27040

FUL:	C4N20_10170

FMO:	C4N19_13235

STR:	Sterm_2100

BTH:

BT_1918

BTHO:

Btheta7330_01094

BFR:

BF0070

BFS:	BF9343_0080

BFG:	BF638R_0067

BFB:	VU15_21615

BCAC:

CGC64_09985

BNO:	K8P02_17955

BSAL:

K6V25_03855

BVU:

BVU_3788

BDO:	EL88_11875

BDH:	GV66_19545

PCOP:

I6J50_11325

DYS:	G7050_15260

PDI:

BDI_2610

PARC:

CI960_19260

PMER:

INE87_01848

PGOL:

K6V26_01490

PJO:	LK449_13010

PFAI:

NXY11_00860

RBC:	BN938_1433

MCOS:

GM418_29000

ARK:	D6B99_12925

AGD:	FRZ59_08675

FKA:	KM029_23770

AALG:

AREALGSMS7_03288

GAA:	HX109_09160

HRR:	HZS55_14555 HZS55_14595 HZS55_14625 HZS55_14630

HPEL:

HZS54_10725

HDO:	MUK72_15915

HALG:

HUG10_15510

HALV:

NGM15_03580

HLR:	HALLA_01810

SAWL:

NGM29_11665

» show all

Reference

1 [PMID:13363831]

Authors

DODGSON KS, SPENCER B, WILLIAMS K.

Title

Studies on sulphatases. 13. The hydrolysis of substituted phenyl sulphates by the arylsulphatase of Alcaligenes metalcaligenes.

Journal

Biochem J 64:216-21 (1956)
DOI:10.1042/bj0640216

Reference

2 [PMID:13843260]

Authors

WEBB EC, MORROW PF.

Title

The activation of an arysulphatase from ox liver by chloride and other anions.

Journal

Biochem J 73:7-15 (1959)
DOI:10.1042/bj0730007

Reference

3 [PMID:13744184]

Authors

ROY AB.

Title

The synthesis and hydrolysis of sulfate esters.

Journal

Adv Enzymol Relat Subj Biochem 22:205-35 (1960)
DOI:10.1002/9780470122679.ch5

Reference

4 [PMID:13772]

Authors

Roy AB.

Title

Sulphatases, lysosomes and disease.

Journal

Aust J Exp Biol Med Sci 54:111-35 (1976)
DOI:10.1038/icb.1976.13

Reference

5 [PMID:7628016]

Authors

Schmidt B, Selmer T, Ingendoh A, von Figura K.

Title

A novel amino acid modification in sulfatases that is defective in multiple sulfatase deficiency.

Journal

Cell 82:271-8 (1995)
DOI:10.1016/0092-8674(95)90314-3

Reference

6 [PMID:9748219]

Authors

Dierks T, Miech C, Hummerjohann J, Schmidt B, Kertesz MA, von Figura K

Title

Posttranslational formation of formylglycine in prokaryotic sulfatases by modification of either cysteine or serine.

Journal

J Biol Chem 273:25560-4 (1998)
DOI:10.1074/jbc.273.40.25560

Other DBs

ExplorEnz - The Enzyme Database:

3.1.6.1

IUBMB Enzyme Nomenclature:

3.1.6.1

ExPASy - ENZYME nomenclature database:

3.1.6.1

BRENDA, the Enzyme Database:

3.1.6.1

CAS:

9016-17-5

DBGET integrated database retrieval system