KEGG   ENZYME: 3.2.1.144
Entry
EC 3.2.1.144                Enzyme                                 

Name
3-deoxyoctulosonase;
alpha-Kdo-ase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
Sysname
3-deoxyoctulosonyl-lipopolysaccharide hydrolase
Reaction(IUBMB)
3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide [RN:R06054]
Reaction(KEGG)
R06054;
(other) R12219
Substrate
3-deoxyoctulosonyl-lipopolysaccharide [CPD:C06744];
H2O [CPD:C00001]
Product
3-deoxyoctulosonic acid [CPD:C01187];
lipopolysaccharide [CPD:C00338]
Comment
Releases Kdo (alpha- and beta-linked 3-deoxy-D-manno-octulosonic acid) from different lipopolysaccharides, including Re-LPS from Escherichia coli and Salmonella, Rd-LPS from S. minnesota, and de-O-acyl-re-LPS. 4-Methylumbelliferyl-alpha-Kdo (alpha-Kdo-OMec) is also a substrate.
History
EC 3.2.1.144 created 2000
Pathway
ec00540  Lipopolysaccharide biosynthesis
ec01100  Metabolic pathways
Orthology
K23082  3-deoxy-D-manno-octulosonic acid-hydrolase
Genes
HPY: HP_0579
HEO: C694_02985
HPJ: jhp_0526
HPA: HPAG1_0558
HPS: HPSH_03980
HHP: HPSH112_04135
HHQ: HPSH169_02980
HHR: HPSH417_02780
HPG: HPG27_538
HPP: HPP12_0585
HPL: HPB8_775
HPZ: HPKB_0765
HPD: KHP_0739
HEY: MWE_0938
HPYR: K747_06965
HPYI: K750_05175
HPYU: K751_03515
HPYM: K749_01605
HEB: U063_0884
HEZ: U064_0888
HAC: Hac_1433
HCE: HCW_06240
HCM: HCD_01360
 » show all
Reference
1  [PMID:9334217]
  Authors
Li YT, Wang LX, Pavlova NV, Li SC, Lee YC.
  Title
alpha-KDOase activity in oyster and synthesis of alpha- and beta-4-methylumbelliferyl ketosides of 3-deoxy-D-manno-octulosonic acid.
  Journal
J Biol Chem 272:26419-24 (1997)
DOI:10.1074/jbc.272.42.26419
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.144
IUBMB Enzyme Nomenclature: 3.2.1.144
ExPASy - ENZYME nomenclature database: 3.2.1.144
BRENDA, the Enzyme Database: 3.2.1.144
CAS: 199128-67-1

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