KEGG   ENZYME: 3.2.1.197
Entry
EC 3.2.1.197                Enzyme                                 
Name
beta-1,2-mannosidase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
Sysname
beta-1,2-D-mannoside mannohydrolase
Reaction(IUBMB)
beta-D-mannopyranosyl-(1->2)-beta-D-mannopyranosyl-(1->2)-D-mannopyranose + H2O = beta-D-mannopyranosyl-(1->2)-D-mannopyranose + alpha-D-mannopyranose [RN:R11544]
Reaction(KEGG)
R11544
Substrate
beta-D-mannopyranosyl-(1->2)-beta-D-mannopyranosyl-(1->2)-D-mannopyranose [CPD:C21454];
H2O [CPD:C00001]
Product
beta-D-mannopyranosyl-(1->2)-D-mannopyranose [CPD:C21336];
alpha-D-mannopyranose [CPD:C00936]
Comment
The enzyme, characterized from multiple bacterial species, catalyses the hydrolysis of terminal, non-reducing D-mannose residues from beta-1,2-mannotriose and beta-1,2-mannobiose. The mechanism involves anomeric inversion, resulting in the release of alpha-D-mannopyranose. Activity with beta-1,2-mannotriose or higher oligosaccharides is higher than that with beta-1,2-mannobiose.
History
EC 3.2.1.197 created 2016
Orthology
K21065  beta-1,2-mannosidase
Genes
CAKCaul_5274
SPAIFPZ24_15095
SARIH5J25_15640
PMSKNP414_03490
PMQPM3016_1378
PMWB2K_07040
PLYCGXP70_21885
TMRTmar_1533
THEFE1B22_11255
THEPDYI95_007675
SDXC4B68_17345
LEIFHF024_07910
LSEF1C12_10730
MIMAKG07_12235
MIXAB663_000749
MICRBMW26_16950
MRNK8F61_02010
FRNF1C15_06880
BCVBcav_2271
BFABfae_04900
BRXBH708_03160
BRVCFK39_10515
BRZCFK38_00195
BRRC1N80_00765
BKIM4486_15525
BRHANLU66_00600
BHHBra3105_12440
TEHGKE56_04465
HALTIM660_06775
RHALLQF10_12880
MIKFOE78_02265
MICGGJV80_09435
NPSKRR39_23745
SACGFDZ84_33085
ATLAthai_51240
CAICaci_5767
BSCABBSC_0973
BEUBE0216_09775
FGIOP10G_4571
PHMPSMK_15170
MCADPan265_13500
ABAAcid345_0916
ACAACP_0702
ACMAciX9_3592
TSAAciPR4_4005
TRSTerro_0837
TALBFTW19_09990
ABASACPOL_0357
EDAGWR55_17895
EDGH7846_05525
ADINH7849_05105
SUSAcid_4608
PFERIRI77_12455
BTHBT_3780 BT_4094
BTHOBtheta7330_00213 Btheta7330_04130 Btheta7330_04506
BXYBXY_31780 BXY_48370
BOABovatus_02994 Bovatus_03907 Bovatus_04344
BCELBcellWH2_02647
BCAEA4V03_00905 A4V03_17495
BISDXK01_004125
BFEK6V30_03355 K6V30_07380 K6V30_08880
BNOK8P02_03930
PSACPSM36_1078
PROJKDN43_09410 KDN43_13445
PDIBDI_3141
PARCCI960_21960
PMERINE87_02059
PJOLK449_00190
ASENNQ519_05420
DRCG0Q07_17235
MCOSGM418_08360
CPICpin_6158
CBAECOR50_03215
CHITFW415_15625
CHIHGWR21_10565
CFILMYF79_26535
CHFKTO58_22020
NKONiako_1662
NSONIASO_16785
NIAA8C56_19890
FLASY85_19465
FGGFSB75_06065
ARBA9P82_10265
ARKD6B99_07660
AGIFSB73_10385
ARACE0W69_000090
ATEEK9M52_10785
PGINFRZ67_04795
PGOFSB84_10220
LACSH4075_01605
FLCKJS93_15540
FLVKJS94_01635
HHYHalhy_2351
PGSCPT03_16470
PEKFFJ24_020360
PROEH9L23_21415
PEXIZT61_02260
PMUOLOK61_09105
SHGSph21_4796
SPHNBV902_14695
SMIZ4412673_02100
SPDRG6053_14035
SDJNCTC13534_03034
STHANCTC11429_01489
SMUII6J00_03310 I6J00_17920
SSIYJVX97_18795
MUPA0256_16760
MUCMuYL_0039
MGOTMgSA37_03900
MUHHYN43_010370
MGINFRZ54_22630
MGKFSB76_17655
MRUBDEO27_010495
MGOSDIU38_010975
MGIKGO620_002360
MDJLLH06_11940
OLIFKG96_21805
CAMUCA2015_3661
ALMAO498_07455
MDAIPZ59_04480
SLISlin_3919
SRDSD10_20120
SPIRCWM47_22390
SPIKEXU85_25500
PSEZHME7025_02135
AANHG9X63_07555
ALENG9X62_07550
CHRWKA713_16235
RHOZGXP67_27410
DFEDfer_3176
DSNHWI92_14995
DYCNFI80_21590
RSIRunsl_2228
RUNDR864_20065
RUPDTQ70_19295
EOLEmtol_2662
FIBA6C57_04200
MAQALAG90_17265
HYEAM218_15635
HYZAXW84_01505
HNVDDQ68_17335
HYJFHG12_02105
ADDHUW48_24935
ASWUHUW51_08075
CHKD4L85_07830
GRLLPB144_11785
GFLGRFL_1111
GRSC7S20_03760
RBIRB2501_13184
ZPRZPR_0445
FBCFB2170_14743
MARTBTR34_02150
MARBCJ263_16555
MRSMurru_1532
MLTVC82_1561
SYISB49_02230
AUEC5O00_11460
MUREQY75_04415
ASAGFGM00_05115
KPFIX53_05415
MPGTheba_1903
MINFMESINF_1199
THVADU37_CDS02900
 » show all
Reference
1  [PMID:26286752]
  Authors
Cuskin F, Basle A, Ladeveze S, Day AM, Gilbert HJ, Davies GJ, Potocki-Veronese G, Lowe EC
  Title
The GH130 Family of Mannoside Phosphorylases Contains Glycoside Hydrolases That Target beta-1,2-Mannosidic Linkages in Candida Mannan.
  Journal
J Biol Chem 290:25023-33 (2015)
DOI:10.1074/jbc.M115.681460
  Sequence
[bth:BT_3780]
Reference
2  [PMID:26476324]
  Authors
Nihira T, Chiku K, Suzuki E, Nishimoto M, Fushinobu S, Kitaoka M, Ohtsubo K, Nakai H
  Title
An inverting beta-1,2-mannosidase belonging to glycoside hydrolase family 130 from Dyadobacter fermentans.
  Journal
FEBS Lett 589:3604-10 (2015)
DOI:10.1016/j.febslet.2015.10.008
  Sequence
[dfe:Dfer_3176]
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.197
IUBMB Enzyme Nomenclature: 3.2.1.197
ExPASy - ENZYME nomenclature database: 3.2.1.197
BRENDA, the Enzyme Database: 3.2.1.197

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