KEGG   ENZYME: 3.2.1.76
Entry
EC 3.2.1.76                 Enzyme                                 
Name
L-iduronidase;
alpha-L-iduronidase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
Sysname
glycosaminoglycan alpha-L-iduronohydrolase
Reaction(IUBMB)
Hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate
Reaction(KEGG)
(other) R07813(G) R07822(G)
History
EC 3.2.1.76 created 1972
Pathway
ec00531  Glycosaminoglycan degradation
ec01100  Metabolic pathways
Orthology
K01217  L-iduronidase
Genes
HSA3425(IDUA)
PTR461056(IDUA)
PPS100987172(IDUA)
GGO101130097(IDUA)
PON100458752(IDUA)
NLE100596160(IDUA)
MCC106998222(IDUA)
MCF102116889(IDUA)
CSAB103246507(IDUA)
CATY105585503(IDUA)
PANU101021298(IDUA)
TGE112625493(IDUA)
RRO104671724(IDUA)
RBB108524364(IDUA)
TFN117085018(IDUA)
PTEH111539046(IDUA)
CJC100896352(IDUA)
SBQ101048244(IDUA)
CSYR103257333(IDUA)
MMUR105881637(IDUA)
LCAT123622158(IDUA)
OGA100942976(IDUA)
MMU15932(Idua)
MCAL110294169(Idua)
MPAH110330560(Idua)
RNO360904(Idua)
MCOC116068105(Idua)
MUN110557444(Idua)
CGE100767663(Idua)
MAUA101830981(Idua)
PLEU114691844(Idua)
MORG121433559(Idua)
AAMP119821056(Idua)
NGI103741112(Idua)
HGL101725783(Idua)
CPOC100720499(Idua)
CCAN109698229(Idua)
DORD105991253(Idua)
DSP122102189(Idua)
NCAR124994072
OPI101527037(IDUA)
TUP102498980(IDUA)
CFA100505382(IDUA)
CLUD112653141(IDUA)
VVP112918586(IDUA)
VLG121489080(IDUA)
AML100483280(IDUA)
UMR103676887(IDUA)
UAH113245712(IDUA)
UAR123777820(IDUA)
ELK111148996
LLV125093445
MPUF101677077(IDUA)
ORO101385570(IDUA)
EJU114197782(IDUA)
ZCA113924252(IDUA)
MLX118010810(IDUA)
FCA101095896(IDUA)
PYU121039673(IDUA)
PBG122479151(IDUA)
PTG102960759(IDUA)
PPAD109259300(IDUA)
AJU106981830(IDUA)
HHV120222520(IDUA)
BTA511050(IDUA)
BIU109560709(IDUA)
BBUB102412202(IDUA)
CHX102188128(IDUA)
OAS101105916(IDUA)
ODA120861850(IDUA)
CCAD122428125(IDUA)
SSC110262029(IDUA)
CFR102508744(IDUA)
CBAI105072051(IDUA)
CDK105100850(IDUA)
VPC102543083(IDUA)
BACU103001116(IDUA)
LVE103070974(IDUA)
OOR101275978(IDUA)
DLE111164855(IDUA)
PCAD102983927(IDUA)
PSIU116754200(IDUA)
ECB100146682(IDUA)
EPZ103565375(IDUA)
EAI106825422(IDUA)
MMYO118665202(IDUA)
MNA107524122(IDUA)
PKL118707153(IDUA)
HAI109390938(IDUA)
DRO112316758(IDUA)
SHON118988001(IDUA)
AJM119035502(IDUA)
PDIC114489977(IDUA)
PHAS123815670(IDUA)
MMF118633460(IDUA)
RFQ117022205(IDUA)
PALE102878427(IDUA)
PGIG120582930(IDUA)
PVP105301866(IDUA)
RAY107517976(IDUA)
MJV108396952(IDUA)
TOD119260742(IDUA)
SARA101548072(IDUA)
TMU101342774
DNM101447531(IDUA)
MDO103095028(IDUA)
GAS123252488(IDUA)
SHR100921889(IDUA)
PCW110220974(IDUA)
OAA100083541(IDUA)
GGA427294(IDUA)
PCOC116239286(IDUA)
MGP100543278(IDUA)
CJO107306418(IDUA)
NMEL110389718(IDUA)
APLA101792515(IDUA)
ACYG106040440(IDUA)
AFUL116500649(IDUA)
TGU100231378(IDUA)
LSR110480219(IDUA)
SCAN103821276(IDUA)
PMOA120509450(IDUA)
OTC121331475(IDUA)
PRUF121355383(IDUA)
GFR102032557(IDUA)
PHI102109268(IDUA)
PMAJ107216336(IDUA)
CCW120411475(IDUA)
CBRC103616391(IDUA)
ETL114066321(IDUA)
ZAB102067782(IDUA)
FPG101912371(IDUA)
FCH102060219(IDUA)
CLV102089844(IDUA)
EGZ104126428(IDUA)
NNI104017564(IDUA)
PLET104626199(IDUA)
PCRI104034527(IDUA)
ACUN113490029(IDUA)
TALA104364768(IDUA)
PADL103923229(IDUA)
ACHC115336568(IDUA)
HALD104325464(IDUA)
CCRI104169477(IDUA)
CSTI104562518(IDUA)
EHS104503687(IDUA)
CMAC104474032(IDUA)
FGA104079274(IDUA)
GSTE104261765(IDUA)
LDI104350879(IDUA)
MNB103770325(IDUA)
OHA104333548(IDUA)
AAM106482506(IDUA)
AROW112972057(IDUA)
NPD112956407(IDUA)
DNE112982318(IDUA)
ASN102368509(IDUA)
AMJ102565029(IDUA)
CPOO109323410(IDUA)
GGN109297424(IDUA)
PSS102456511(IDUA)
CMY102935517(IDUA)
CPIC101949799(IDUA)
TST117879513(IDUA)
CABI116823765(IDUA)
MRV120407788(IDUA)
ACS100560915(idua)
PVT110086254(IDUA)
SUND121923576(IDUA)
PBI103061358(IDUA)
PMUR107291845(IDUA)
TSR106549595 106549904(IDUA)
PGUT117661663(IDUA)
VKO123030240(IDUA)
PMUA114587673(IDUA)
ZVI118097657(IDUA)
GJA107117238
STOW125436655(IDUA)
XLA446866(idua.L)
XTR100488103(idua)
NPR108788188(IDUA)
RTEM120913975(IDUA)
BBUF120989740(IDUA)
BGAR122945413(IDUA)
DRE567720(idua)
SRX107725121(idua) 107750302
SANH107667438(idua)
SGH107572256
CCAR109088490(idua)
CAUA113067964(idua)
PPRM120469924(idua)
MAMB125267270(idua)
IPU108255637(idua)
PHYP113528161(idua)
SMEO124380735(idua)
TFD113656751(idua)
AMEX103032337(idua)
EEE113589884(idua)
TRU101070380(idua)
TNGGSTEN00034903G001
LCO104939129(idua)
NCC104955545(idua)
CGOB115012953(idua)
ELY117253037(idua)
EFO125890999(idua)
PLEP121944645(idua)
SLUC116050618(idua)
ECRA117945160(idua)
PFLV114555667(idua)
GAT120830478(idua)
PPUG119225185(idua)
MSAM119891721(idua)
CUD121509474(idua)
ALAT119019933(idua)
MZE101477966(idua)
ONL100706743(idua)
OAU116323344(idua)
OLA101168340(idua)
OML112148925(idua)
XMA102227056(idua)
XCO114154579(idua)
XHE116729803(idua)
PRET103469719(idua)
PFOR103141354(idua)
PLAI106944617(idua)
PMEI106929226(idua)
GAF122827759(idua)
CVG107084656(idua)
CTUL119782288(idua)
GMU124877701(idua)
NFU107393559(idua)
KMR108234892(idua)
ALIM106529500(idua)
AOCE111569438(idua)
MCEP125012738(idua)
CSEM103398091(idua)
POV109633675(idua)
SSEN122769732(idua)
HHIP117768074(idua)
HSP118115441(idua)
LCF108878648(idua)
SDU111228761(idua)
SLAL111645089(idua)
XGL120805641(idua)
HCQ109511648(idua)
BPEC110163382(idua)
MALB109954941(idua)
BSPL114861787(idua)
SASA106580451(idua)
OTW112262726(idua)
OMY110536216(idua)
OGO124036455(idua)
ONE115140211(idua)
SALP111957624(idua)
SNH120063249(idua)
CCLU121530625(idua)
ELS105029445(idua)
SFM108938055(idua)
PKI111856526(idua)
AANG118206864(idua)
LOC102687879(idua)
PSPA121317644(idua)
ARUT117409492(idua)
LCM102360004(IDUA)
CMK103187950(idua)
RTP109924360 109927841
BFO118412356
BBEL109466677
CIN100183172
SCLV120341109
SPU115924180 592184
APLC110982461
SKO102805060
DMEDmel_CG6201(CG6201)
DER6543228
DSE6612122
DSIDsimw501_GD22194(Dsim_GD22194)
DYADyak_GE13010
DAN6497057
DSR110183163
DPO4817324
DPE6589728
DMN108161628
DWI6651785
DGR6561574
DMODmoj_GI14757
DAZ108610286
DNV115563151
DHE111602469
DVI6627912
CCAT101461980
BOD106614995
MDE101901034
SCAC106095576
LCQ111676858
LSQ119603134
HIS119654735
AGAAgaP_AGAP010549
ACOZ120957692
AARA120902926
ASTE118506061
AAG5564727
AALB109412913 109418687
CQUCpipJ_CPIJ014499
CPII120420388
CNS116345333
BCOO119078732
TCA661752
ATD109599887
AGB108906514
NVL108557457
PPYR116167558
CLEC106672237
HHAL106686041 112210041
NLU111049694
PHUPhum_PHUM353480
FOC113213394
TPAL117641078
ZNE110837697
CSEC111869873
PVM113809236
PJA122247605
PCHN125044141
HAME121858388
PCLA123750857
PTRU123517906 123517907
PPOI119111294
ISCIscW_ISCW005222
DSV119460871
RSAN119382959
RMP119176668
CSCU111635221
PTEP107455475
SDM118179418 118181453
LGILOTGIDRAFT_128432
BGT106079208
GAE121384379
HRF124114669 124143040 124143041
HRJ124259609 124262708 124262709
PMAX117344443
MMER123547093
OBI106881522
OSN115229948
LAK106158068
NVE5516889
EPA110241641
ATEN116286222
ADF107353250
PDAM113679881
SPIS111321885
MBRMONBRDRAFT_23268
REPIE4803_PD00055
REIIE4771_PE00054
RLEpRL100282
RLBRLEG3_01365
RLURLEG12_05110
RGARGR602_PC02345
RHNAMJ98_PB00065
RPHAAMC79_PA00072
RHXAMK02_PB00064
RHKKim5_PD00055
REZAMJ99_PA00065
RIIFFM53_035345
RHIDFFM81_022755
RBQJ2J99_24580
RLNJ0663_28490
RRGJ3P73_32030
 » show all
Reference
1  [PMID:4993544]
  Authors
Matalon R, Cifonelli JA, Dorfman A.
  Title
L-iduronidase in cultured human fibroblasts and liver.
  Journal
Biochem Biophys Res Commun 42:340-5 (1971)
DOI:10.1016/0006-291X(71)90108-2
Reference
2  [PMID:30407]
  Authors
Rome LH, Garvin AJ, Neufeld EF.
  Title
Human kidney alpha-L-iduronidase: purification and characterization.
  Journal
Arch Biochem Biophys 189:344-53 (1978)
DOI:10.1016/0003-9861(78)90221-7
Reference
3
  Authors
Srivastava, R.M., Hudson, N., Seymour, F.R. and Weissman, B.
  Title
Preparation of (aryl alpha-L-idopyranosid)uronic acids.
  Journal
Carbohydr Res 60:315-326 (1978)
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.76
IUBMB Enzyme Nomenclature: 3.2.1.76
ExPASy - ENZYME nomenclature database: 3.2.1.76
BRENDA, the Enzyme Database: 3.2.1.76
CAS: 9073-56-7

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