KEGG   ENZYME: 3.4.13.20
Entry
EC 3.4.13.20                Enzyme                                 
Name
beta-Ala-His dipeptidase;
serum carnosinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidases
Reaction(IUBMB)
Preferential hydrolysis of the beta-Ala!His dipeptide (carnosine), and also anserine, Xaa!His dipeptides and other dipeptides including homocarnosine [RN:R01166 R03288]
Reaction(KEGG)
R01166 R03288 > R01992
Comment
Present in the serum of humans and higher primates, but not in the serum of other mammals. Activated by Cd2+ and citrate. Belongs in peptidase family M20.
History
EC 3.4.13.20 created 1992
Pathway
ec00330  Arginine and proline metabolism
ec00340  Histidine metabolism
ec00410  beta-Alanine metabolism
ec01100  Metabolic pathways
Orthology
K05604  beta-Ala-His dipeptidase
Genes
HSA84735(CNDP1)
PTR455474(CNDP1)
GGO101127378(CNDP1)
PON100172721(CNDP1)
NLE100583488(CNDP1)
MCC114675569 695195(CNDP1)
MCF102131452(CNDP1)
CSAB103244082(CNDP1)
CATY105596474(CNDP1)
PANU101015924(CNDP1)
TGE112611596(CNDP1)
RRO104656992(CNDP1)
RBB108525057(CNDP1)
TFN117062418(CNDP1)
PTEH111550667(CNDP1)
CJC100395623(CNDP1)
SBQ101048509(CNDP1)
CSYR103276518(CNDP1)
MMUR105865691(CNDP1)
LCAT123621855(CNDP1)
OGA100942379(CNDP1)
MMU338403(Cndp1)
MCAL110284617(Cndp1)
MPAH110333472(Cndp1)
RNO307212(Cndp1)
MCOC116087758(Cndp1)
MUN110555520(Cndp1)
CGE100761203(Cndp1)
MAUA101843727(Cndp1)
PLEU114696268(Cndp1)
MORG121440120(Cndp1)
AAMP119814477(Cndp1)
NGI103748140(Cndp1)
HGL101707301(Cndp1)
CPOC100729620(Cndp1)
CCAN109681064(Cndp1)
DORD105993016(Cndp1)
DSP122119467(Cndp1)
NCAR124965748
OCU100345937(CNDP1)
OPI101520559(CNDP1)
TUP102489508(CNDP1)
CFA476165(CNDP1)
CLUD112643958(CNDP1)
VVP112919334(CNDP1)
VLG121482003(CNDP1)
AML100467604(CNDP1)
UMR103658416(CNDP1)
UAH113253529(CNDP1)
UAR123787479(CNDP1)
ELK111154244
LLV125082265
MPUF101693266(CNDP1)
ORO101378722(CNDP1)
EJU114208805(CNDP1)
ZCA113912534(CNDP1)
MLX118004601(CNDP1)
FCA101099503(CNDP1)
PYU121032788(CNDP1)
PBG122470869(CNDP1)
PTG102964440(CNDP1)
PPAD109251775(CNDP1)
AJU106982253(CNDP1)
HHV120234524(CNDP1)
BTA614200(CNDP1)
BOM102267168(CNDP1)
BIU109578014(CNDP1)
BBUB102402300(CNDP1)
CHX102180002(CNDP1)
OAS101110987(CNDP1)
ODA120880845(CNDP1)
CCAD122425636(CNDP1)
SSC100516053(CNDP1)
CFR102512299(CNDP1)
CBAI105082224(CNDP1)
CDK105105074(CNDP1)
VPC102545337(CNDP1)
BACU103016948(CNDP1)
LVE103084929(CNDP1)
OOR101281356(CNDP1)
DLE111167305(CNDP1)
PCAD102991690(CNDP1)
PSIU116765104(CNDP1)
ECB100061728(CNDP1)
EPZ103544994 103561746
EAI106832860(CNDP1)
MYB102242328(CNDP1)
MYD102767022(CNDP1)
MMYO118663607(CNDP1)
MLF102441425(CNDP1)
MNA107537575(CNDP1)
PKL118707691(CNDP1)
HAI109383171(CNDP1)
DRO112322841(CNDP1)
SHON118979685(CNDP1)
AJM119049620(CNDP1)
PDIC114506599 114506601
PHAS123826383(CNDP1)
MMF118619295(CNDP1)
RFQ117011739(CNDP1)
PALE102890418(CNDP1)
PGIG120583410(CNDP1)
PVP105296966(CNDP1)
RAY107512645(CNDP1)
MJV108409039(CNDP1)
TOD119243737(CNDP1)
SARA101537805(CNDP1)
LAV100657615(CNDP1)
TMU101356417
DNM101419660(CNDP1)
MDO100619431(CNDP1)
GAS123231803(CNDP1)
SHR100922964(CNDP1)
PCW110215824(CNDP1)
OAA100076860(CNDP1)
GGA421012(CNDP1)
PCOC116226248(CNDP1)
MGP100541194(CNDP1)
CJO107309982(CNDP1)
NMEL110394441(CNDP1)
APLA101791863(CNDP1)
ACYG106035949(CNDP1)
AFUL116486255(CNDP1)
TGU100232073
LSR110470903(CNDP1)
SCAN103815755(CNDP1)
PMOA120503051(CNDP1)
OTC121337781(CNDP1)
PRUF121362906(CNDP1)
GFR102040432(CNDP1)
FAB101819344(CNDP1)
PHI102111429(CNDP1)
PMAJ107200306(CNDP1)
CCAE111925250(CNDP1)
CCW104685799(CNDP1)
CBRC103623610(CNDP1)
ETL114057532(CNDP1)
ZAB102061545(CNDP1)
FPG101915873(CNDP1)
FCH102045939(CNDP1)
CLV102095516
EGZ104128655(CNDP1)
NNI104018184(CNDP1)
PLET104617497(CNDP1)
PCRI104038420(CNDP1)
ACUN113476758(CNDP1)
TALA104365361(CNDP1)
PADL103924881(CNDP1)
ACHC115340732(CNDP1)
HALD104314544(CNDP1)
CCRI104154684(CNDP1)
CSTI104559417(CNDP1)
EHS104502793(CNDP1)
FGA104083911(CNDP1)
GSTE104259881(CNDP1)
LDI104352901(CNDP1)
MNB103768953(CNDP1)
AAM106482719(CNDP1)
AROW112965374(CNDP1)
NPD112947652(CNDP1)
DNE112983541(CNDP1)
ASN102367881(CNDP1)
AMJ106737110(CNDP1)
CPOO109316708(CNDP1)
GGN109302670(CNDP1)
PSS102445657
CMY102938002(CNDP1)
CPIC101937111
TST117873297(CNDP1)
CABI116819721(CNDP1) 116839990
MRV120399587
ACS100554161(cndp1)
PVT110083379(CNDP1)
SUND121927603
PMUR107291693(CNDP1)
TSR106550218
PGUT117672588(CNDP1)
VKO123021584
PMUA114600793 114600796
ZVI118089897 118090242
GJA107115115(CNDP1)
STOW125439529
XLA398917(cndp1.L)
XTR100135225(cndp1)
NPR108799252
RTEM120940816
BBUF121001433
BGAR122937900(CNDP1)
IPU108261199(cndp1)
AMEX103026681
EEE113574437
SASA100196692(cndp1)
OTW112247755
OMY110485118
ONE115140919
SALP111964936 112068906
SNH120047676
ELS105019194
SFM108940582
PKI111844178 111844287
AANG118225539(cndp2)
PSPA121313319 121314853
ARUT117399795 117435786
SOY115888585
CSET123313278
AGB108912082
PPYR116177011
 » show all
Reference
1  [PMID:7116644]
  Authors
Lenney JF, George RP, Weiss AM, Kucera CM, Chan PW, Rinzler GS
  Title
Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium.
  Journal
Clin Chim Acta 123:221-31 (1982)
DOI:10.1016/0009-8981(82)90166-8
  Sequence
[hsa:84735]
Reference
2  [PMID:1903095]
  Authors
Jackson MC, Kucera CM, Lenney JF.
  Title
Purification and properties of human serum carnosinase.
  Journal
Clin Chim Acta 196:193-205 (1991)
DOI:10.1016/0009-8981(91)90073-L
Other DBs
ExplorEnz - The Enzyme Database: 3.4.13.20
IUBMB Enzyme Nomenclature: 3.4.13.20
ExPASy - ENZYME nomenclature database: 3.4.13.20
BRENDA, the Enzyme Database: 3.4.13.20
CAS: 525589-43-9

DBGET integrated database retrieval system