KEGG   ENZYME: 3.4.18.1
Entry
EC 3.4.18.1                 Enzyme                                 
Name
cathepsin X;
cathepsin B2;
cysteine-type carboxypeptidase;
cathepsin IV;
cathepsin Z;
acid carboxypeptidase;
lysosomal carboxypeptidase B
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine-type carboxypeptidases
Reaction(IUBMB)
Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity
Comment
Cathepsin X is a lysosomal cysteine peptidase of family C1 (papain family). The pH optimum is dependent on the substrate and is 5.0 for the carboxypeptidase activity. Unstable above pH 7.0. Compound E-64, leupeptin and antipain are inhibitors, but not cystatin C. Cathepsin X is ubiquitously distributed in mammalian tissues. The propeptide is extremely short (38 amino acid residues) and the proenzyme is catalytically active. Human gene locus: 20q13.
History
EC 3.4.18.1 created 1981, modified 2000
Orthology
K08568  cathepsin X
Genes
HSA1522(CTSZ)
PTR736240(CTSZ)
PPS100978982(CTSZ)
GGO101135556(CTSZ)
PON100445547(CTSZ)
NLE100605843(CTSZ)
MCC694157(CTSZ)
MCF102118566(CTSZ)
MTHB126929368
CSAB103243445(CTSZ)
CATY105585314(CTSZ)
PANU101006441(CTSZ)
TGE112632359(CTSZ)
RRO104663800(CTSZ)
RBB108541622(CTSZ)
TFN117069005(CTSZ)
PTEH111555632(CTSZ)
CJC100409242(CTSZ)
SBQ101044087(CTSZ)
CSYR103270011(CTSZ)
MMUR105874515(CTSZ)
LCAT123622322(CTSZ)
OGA100941345(CTSZ)
MMU64138(Ctsz)
MCAL110310623(Ctsz)
MPAH110318622(Ctsz)
RNO252929(Ctsz)
MCOC116091501(Ctsz)
MUN110556816(Ctsz)
CGE100689392(Ctsz)
MAUA101836619(Ctsz)
PLEU114682019(Ctsz)
MORG121440870(Ctsz)
MFOT126508021
AAMP119814226(Ctsz)
NGI103741460(Ctsz)
HGL101720244(Ctsz)
CPOC100732992(Ctsz)
CCAN109692783(Ctsz)
DORD105991617(Ctsz)
DSP122124613(Ctsz)
NCAR124976901
OCU100101623(CTSZ)
OPI101526318(CTSZ)
TUP102500911(CTSZ)
CFA611983(CTSZ)
CLUD112674191(CTSZ)
VVP112932215(CTSZ)
VLG121478076(CTSZ)
AML100473166(CTSZ)
UMR103670963(CTSZ)
UAH113258770(CTSZ)
UAR123803292(CTSZ)
ELK111141946
LLV125108691
MPUF101685427(CTSZ)
ORO101365974(CTSZ)
EJU114197916(CTSZ)
ZCA113937568(CTSZ)
MLX118024013(CTSZ)
NSU110569884(CTSZ)
FCA101087983(CTSZ)
PYU121019952(CTSZ)
PBG122467216(CTSZ)
LRUF124503118
PTG102956771(CTSZ)
PPAD109253464(CTSZ)
AJU106969919(CTSZ)
HHV120234857(CTSZ)
BTA404187(CTSZ)
BOM102265582(CTSZ)
BIU109567290(CTSZ)
BBUB102412544(CTSZ)
CHX102175417(CTSZ)
OAS101101911(CTSZ)
ODA120869382(CTSZ)
CCAD122448259(CTSZ)
SSC100141405(CTSZ)
CFR102515641(CTSZ)
CBAI105071799(CTSZ)
CDK105095690(CTSZ)
VPC102533875(CTSZ)
BACU103013660(CTSZ)
LVE103085943(CTSZ)
OOR101287339(CTSZ)
DLE111186744(CTSZ)
PCAD102993000(CTSZ)
PSIU116740042(CTSZ)
ECB100056600(CTSZ)
EPZ103565404(CTSZ)
EAI106825078(CTSZ)
MYB102242643(CTSZ)
MYD102770003(CTSZ)
MMYO118662996(CTSZ)
MLF102418099(CTSZ)
MNA107529626(CTSZ)
PKL118708736(CTSZ)
HAI109380091(CTSZ)
DRO112304016(CTSZ)
SHON118996544(CTSZ)
AJM119055312(CTSZ)
PDIC114506467(CTSZ)
PHAS123814773(CTSZ)
MMF118618330(CTSZ)
RFQ117015827(CTSZ)
PALE102884357(CTSZ)
PGIG120603887(CTSZ)
PVP105296094(CTSZ)
RAY107500086(CTSZ)
MJV108406175(CTSZ)
TOD119237005(CTSZ)
SARA101546246(CTSZ)
LAV100655776(CTSZ)
TMU101347887
DNM101436442(CTSZ)
MDO100027054(CTSZ)
GAS123237156(CTSZ)
SHR100927306(CTSZ)
PCW110205154(CTSZ)
OAA100080444(CTSZ)
GGA419311(CTSZ)
PCOC116227940(CTSZ)
MGP100550055(CTSZ)
CJO107323052(CTSZ)
NMEL110408306(CTSZ)
APLA101804246(CTSZ)
ACYG106040695(CTSZ)
AFUL116495575(CTSZ)
TGU100225523(CTSZ)
LSR110483614(CTSZ)
SCAN103818879(CTSZ)
PMOA120507088(CTSZ)
OTC121342977(CTSZ)
PRUF121359538(CTSZ)
GFR102041571(CTSZ)
FAB101818266(CTSZ)
PHI102103433(CTSZ)
PMAJ107213248(CTSZ)
CCAE111938177(CTSZ)
CCW104687808(CTSZ)
CBRC103617976(CTSZ)
ETL114056210(CTSZ)
ZAB102064931(CTSZ)
ACHL103797669(CTSZ)
FPG101921980(CTSZ)
FCH102059599(CTSZ)
CLV102084569(CTSZ)
EGZ104130672(CTSZ)
NNI104009598(CTSZ)
PLET104628096(CTSZ)
PCRI104035583(CTSZ)
PCAO104053474(CTSZ)
ACUN113487623(CTSZ)
TALA104357128(CTSZ)
PADL103919374(CTSZ)
AFOR103895219(CTSZ)
ACHC115338811(CTSZ)
HALD104320740(CTSZ)
CCRI104156732(CTSZ)
CSTI104551545(CTSZ)
EHS104504341(CTSZ)
CMAC104481431(CTSZ)
MUI104539135(CTSZ)
FGA104070928(CTSZ)
GSTE104256963(CTSZ)
LDI104341186(CTSZ)
MNB103781972(CTSZ)
OHA104328872(CTSZ)
NNT104400473(CTSZ)
DPUB104302676(CTSZ)
PGUU104459389(CTSZ)
ACAR104519116(CTSZ)
AVIT104268545(CTSZ)
CVF104294041(CTSZ)
CUCA104067665(CTSZ)
AAM106492788(CTSZ)
AROW112972591(CTSZ)
NPD112949780(CTSZ)
TGT104571470(CTSZ)
DNE112986165(CTSZ)
SCAM104141820(CTSZ)
ASN102384346(CTSZ)
AMJ102561646(CTSZ)
CPOO109318706(CTSZ)
GGN109292636(CTSZ)
PSS102447291(CTSZ)
CMY102934401(CTSZ)
CPIC101938312(CTSZ)
TST117885662(CTSZ)
CABI116826100(CTSZ)
MRV120380404(CTSZ)
ACS100559158 100559357 100559555 100559751 100564288 103281402
PVT110084725 110084731(CTSZ)
SUND121928250 121928643 121928644 121928645 121928915 121930087
PBI103065322(CTSZ) 103065568
PMUR107294709 107295542
CTIG120317704 120317705
PGUT117674884 117674885
VKO123036415 123036416 123036417
PMUA114599688 114599690
ZVI118088371 118088574
GJA107111924(CTSZ) 107111931
STOW125433696 125433928
XLA432187(ctsz.L) 494800(ctsz.S)
XTR100127597(ctsz)
NPR108802340(CTSZ)
RTEM120918214(CTSZ)
BBUF121004181(CTSZ)
BGAR122941529(CTSZ)
DRE100333521 450022(ctsz)
SRX107708086 107729770 107750940
SANH107666025 107685845 107687928 107696163
SGH107554162 107554171 107575226 107596856
CCAR109052067 109058538 109091588
CAUA113045276 113050267 113105100
PPRM120460983 120493951(ctsz)
MAMB125251387 125273561(ctsz)
IPU108272968(ctsz) 108280169
PHYP113533381 113545887(ctsz)
SMEO124388375(ctsz) 124403175
TFD113634461(ctsz) 113645145
AMEX103033117 103034761(ctsz) 103034982
EEE113577871(ctsz)
TRU101077965(ctsz)
TNGGSTEN00013610G001 GSTEN00024460G001
LCO104919412 104936415 104937245(ctsz)
NCC104948760 104954748(ctsz)
CGOB115008545(ctsz) 115022593
ELY117257189(ctsz) 117261012 117271606
EFO125888752(ctsz) 125894748 125902617
PLEP121948083 121951695 121957150(ctsz)
SLUC116045840 116066470(ctsz)
ECRA117942891(ctsz)
ESP116679808 116687242 116698858
PFLV114553806(ctsz) 114565417
GAT120816042 120835333(ctsz)
PPUG119208848 119230125(ctsz)
MSAM119885934(ctsz) 119901806
CUD121506978(ctsz) 121515880 121519556
ALAT119006897 119011314 119021232(ctsz)
MZE101465864 106675089(ctsz) 106675090
ONL100696456 100708870(ctsz)
OAU116313367 116329886(ctsz)
OLA101156316(ctsz) 101171361
OML112144898(ctsz) 112152409
XMA102230901 102232031 102236501(ctsz)
XCO114136290(ctsz) 114138823 114147224
XHE116710933(ctsz) 116714705 116721327
PRET103465303(ctsz) 103471866 103479906
PFOR103137306 103144284(ctsz) 103146313
PLAI106941242 106954715(ctsz) 106963207
PMEI106928165(ctsz) 106929094 106930956
GAF122834095(ctsz) 122836712 122841540
CVG107089173 107095424 107103116
CTUL119787897 119795571(ctsz) 119798938
GMU124856150(ctsz) 124870136
NFU107382187 107383534 107385676(ctsz)
KMR108232812 108235675(ctsz) 108236644
ALIM106513222(ctsz) 106520731 106520732 106525878 106533483
NWH119412610(ctsz)
AOCE111579743(ctsz)
MCEP125007148(ctsz) 125008233 125010117
CSEM103386030(ctsz) 103390711 103396679
POV109629142(ctsz) 109640431 109643907
SSEN122767800(ctsz) 122770918 122778629
HHIP117761194(ctsz) 117769239 117777657
HSP118105306(ctsz) 118112367 118118260
LCF108884246 108898914 108901531
SDU111221495(ctsz) 111231108 111232597
SLAL111644680 111648001 111658373 111667853(ctsz)
XGL120784917 120798493 120807202(ctsz)
HCQ109522377(ctsz) 109524165 109526244
BPEC110153692 110171270(ctsz) 110174895
MALB109955289 109956083(ctsz) 109972033
BSPL114844807 114856045(ctsz) 114865051
SASA106565426(CATZ) 106569716 106583261(CATZ)
STRU115150442 115157612 115207978
OTW112216098 112241541 112254734
OMY100136231(cathy) 110510807 110528245(ctsz)
OGO124002606 124009860 124031150
ONE115119876 115141247 115143058
SALP111965338 111970224
SNH120055686 120062241 120065246
CCLU121534515 121575139 121577815
ELS105016941(ctsz) 105030515
SFM108928420(ctsz) 108930071
PKI111835251(ctsz)
AANG118210990 118232826
LOC102686170(ctsz)
PSPA121307803 121319452(ctsz)
ARUT117423512 117432598
LCM102354050(CTSZ)
CMK103171603(ctsz)
RTP109923996 109937610
BFO118417697
BBEL109483239
SPU115918298 580617 583170
APLC110974742 110981365
SKO102804623
CELCELE_F32B5.8(cpz-1) CELE_M04G12.2(cpz-2)
CBRCBG_04105(Cbr-cpz-1) CBG_06727(Cbr-cpz-2)
BMYBM_BM3754(Bma-cpz-1)
LOALOAG_07418
NAINECAME_02023 NECAME_06826
TSPTsp_10493
HROHELRODRAFT_88168
LGILOTGIDRAFT_122453 LOTGIDRAFT_163452 LOTGIDRAFT_163455 LOTGIDRAFT_233463
PCAN112576650
BGT106059222 106068293
GAE121388260 121389018
HRF124112862 124112863 124139827
HRJ124257257 124265042 124266292 124284146
CRG105327153
MYI110453406
PMAX117337774
MMER123549029
OBI106881834
OSN115212941
LAK106156390
NVE5508584 5508589
EPA110236948 110236973
ATEN116298646
ADF107348434
AMIL114964139
PDAM113681648
SPIS111329960
DGT114516372
XEN124443567 124443568 124443949
HMG100208353 100213044
AQU100632176 100632979 100634212 100638168
PPP112282901
CRECHLRE_02g119900v5 CHLRE_12g498850v5 CHLRE_16g659750v5
VCNVOLCADRAFT_120530
MNGMNEG_3283 MNEG_8426
CSLCOCSUDRAFT_15830 COCSUDRAFT_28006 COCSUDRAFT_47921
CVRCHLNCDRAFT_35526
APROF751_5316 F751_5840
OLUOSTLU_39605
OTAOT_ostta01g04900
BPGBathy01g02970
MISMICPUN_100793 MICPUN_104906
MPPMICPUCDRAFT_66431
MBRMONBRDRAFT_34651 MONBRDRAFT_9815
SREPTSG_00265
DDIDDB_G0280187 DDB_G0283401(ctsZ)
DPPDICPUDRAFT_44383
DFADFA_10566 DFA_10571(ctsZ)
TETTTHERM_00102770 TTHERM_00102779 TTHERM_00564440 TTHERM_00823810
PTMGSPATT00017357001
SMINv1.2.007800.t1(symbB.v1.2.007800.t1)
PTIPHATRDRAFT_43432 PHATRDRAFT_4741 PHATRDRAFT_4936
FCYFRACYDRAFT_173237 FRACYDRAFT_194870 FRACYDRAFT_211859 FRACYDRAFT_222323 FRACYDRAFT_271180
TPSTHAPSDRAFT_263404 THAPSDRAFT_268564 THAPSDRAFT_38360
AAFAURANDRAFT_12990 AURANDRAFT_25936
PIFPITG_00245 PITG_00248 PITG_00395 PITG_02423
PSOJPHYSODRAFT_316167 PHYSODRAFT_353757 PHYSODRAFT_508417 PHYSODRAFT_561622
SPARSPRG_01087 SPRG_08809 SPRG_14903 SPRG_22117 SPRG_22119
EHXEMIHUDRAFT_437057 EMIHUDRAFT_44322 EMIHUDRAFT_44342 EMIHUDRAFT_446652
GTTGUITHDRAFT_101312
NGRNAEGRDRAFT_3364 NAEGRDRAFT_62623 NAEGRDRAFT_78125 NAEGRDRAFT_82224
TVATVAG_2v0817610
 » show all
Reference
1  [PMID:10504234]
  Authors
Nagler DK, Zhang R, Tam W, Sulea T, Purisima EO, Menard R
  Title
Human cathepsin X: A cysteine protease with unique carboxypeptidase activity.
  Journal
Biochemistry 38:12648-54 (1999)
DOI:10.1021/bi991371z
  Sequence
[hsa:1522]
Reference
2  [PMID:9738465]
  Authors
Nagler DK, Menard R
  Title
Human cathepsin X: a novel cysteine protease of the papain family with a very short proregion and unique insertions.
  Journal
FEBS Lett 434:135-9 (1998)
DOI:10.1016/S0014-5793(98)00964-8
  Sequence
[hsa:1522]
Reference
3  [PMID:9642240]
  Authors
Santamaria I, Velasco G, Pendas AM, Fueyo A, Lopez-Otin C.
  Title
Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location.
  Journal
J Biol Chem 273:16816-23 (1998)
DOI:10.1074/jbc.273.27.16816
  Sequence
[hsa:1522]
Reference
4  [PMID:577]
  Authors
McDonald JK, Ellis S.
  Title
On the substrate specificity of cathepsins B1 and B2 including a new fluorogenic substrate for cathepsin B1.
  Journal
Life Sci 17:1269-76 (1975)
DOI:10.1016/0024-3205(75)90137-X
Reference
5  [PMID:1122298]
  Authors
Otto K, Riesenkonig H.
  Title
Improved purification of cathepsin B1 and cathepsin B2.
  Journal
Biochim Biophys Acta 379:462-75 (1975)
DOI:10.1016/0005-2795(75)90153-1
Reference
6  [PMID:4429705]
  Authors
Ninjoor V, Taylor SL, Tappel AL.
  Title
Purification and characterization of rat liver lysosomal cathepsin B2.
  Journal
Biochim Biophys Acta 370:308-21 (1974)
DOI:10.1016/0005-2744(74)90055-2
Other DBs
ExplorEnz - The Enzyme Database: 3.4.18.1
IUBMB Enzyme Nomenclature: 3.4.18.1
ExPASy - ENZYME nomenclature database: 3.4.18.1
BRENDA, the Enzyme Database: 3.4.18.1
CAS: 37217-21-3

DBGET integrated database retrieval system