KEGG   ENZYME: 3.4.21.109
Entry
EC 3.4.21.109               Enzyme                                 

Name
matriptase;
serine protease 14;
membrane-type serine protease 1;
MT-SP1;
prostamin;
serine protease TADG-15;
tumor-associated differentially-expressed gene 15 protein;
ST14;
breast cancer 80 kDa protease;
epithin;
serine endopeptidase SNC19
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position
Comment
This trypsin-like integral-membrane serine peptidase has been implicated in breast cancer invasion and metastasis [1,2]. The enzyme can activate hepatocyte growth factor/scattering factor (HGF/SF) by cleavage of the two-chain form at an Arg residue to give active alpha- and beta-HGF, but It does not activate plasminogen, which shares high homology with HGF [1]. The enzyme can also activate urokinase plasminogen activator (uPA), which initiates the matrix-degrading peptidase cascade [1,2]. Belongs in peptidase family S1A.
History
EC 3.4.21.109 created 2006
Orthology
K08670  suppressor of tumorigenicity protein 14
Genes
HSA: 6768(ST14)
PTR: 100188950(ST14)
PPS: 100969412(ST14)
GGO: 101128044(ST14)
PON: 100448596(ST14)
NLE: 100583520(ST14)
MCC: 718848(ST14)
MCF: 102117178(ST14)
CSAB: 103248837(ST14)
CATY: 105582655(ST14)
PANU: 101008090(ST14)
RRO: 104656766(ST14)
RBB: 108529077(ST14)
TFN: 117079938(ST14)
PTEH: 111522103(ST14)
CJC: 100411816(ST14)
SBQ: 101030484(ST14)
MMUR: 105881596(ST14)
MMU: 19143(St14)
MCAL: 110302026(St14)
MPAH: 110327886(St14)
RNO: 114093(St14)
MCOC: 116073150(St14)
MUN: 110552588(St14)
CGE: 100755225(St14)
PLEU: 114684412(St14)
NGI: 103749253(St14)
HGL: 101697952(St14)
CCAN: 109688547(St14)
OCU: 100101609(ST14)
OPI: 101524819(ST14)
TUP: 102486454(ST14)
CFA: 489278(ST14)
VVP: 112920252(ST14)
VLG: 121500680(ST14)
AML: 100466959(ST14)
UMR: 103660745(ST14)
UAH: 113259860(ST14)
ORO: 101372817(ST14)
ELK: 111153753
MPUF: 101673806(ST14)
EJU: 114222358(ST14)
MLX: 118013509(ST14)
FCA: 101095767(ST14)
PYU: 121035642(ST14)
PBG: 122483151(ST14)
PTG: 102953519(ST14)
PPAD: 109250316(ST14)
AJU: 106970577(ST14)
HHV: 120237111(ST14)
BTA: 767617(ST14)
BOM: 102277353(ST14)
BIU: 109554629(ST14)
BBUB: 102401731(ST14)
CHX: 102187300(ST14)
OAS: 101119684(ST14)
ODA: 120874467(ST14)
CCAD: 122431288(ST14)
SSC: 100517843(ST14)
CFR: 102503998(ST14)
CBAI: 105071252(ST14)
CDK: 105094280(ST14)
BACU: 102997802(ST14)
LVE: 103071841(ST14)
OOR: 101274463(ST14)
DLE: 111165489(ST14)
PCAD: 102992773(ST14)
ECB: 100072676(ST14)
EPZ: 103550003(ST14)
EAI: 106842158(ST14)
MYB: 102241616(ST14)
MYD: 102771965(ST14)
MMYO: 118678254(ST14)
MNA: 107530512(ST14)
HAI: 109392376(ST14)
DRO: 112301895(ST14)
SHON: 118981433(ST14)
AJM: 119041077(ST14)
MMF: 118639968(ST14)
PALE: 102887302(ST14)
PGIG: 120615649(ST14)
RAY: 107506290(ST14)
MJV: 108391268(ST14)
TOD: 119239960(ST14)
LAV: 100654624(ST14)
TMU: 101354762
MDO: 100021603(ST14)
SHR: 100930600(ST14)
PCW: 110192573(ST14)
OAA: 100075025(ST14)
GGA: 419731(ST14)
PCOC: 116233066(ST14)
MGP: 100547194(ST14)
CJO: 107324168(ST14)
NMEL: 110387738(ST14)
APLA: 101797476(ST14)
ACYG: 106040585(ST14)
TGU: 100223474(ST14)
LSR: 110470973(ST14)
SCAN: 103822812(ST14)
PMOA: 120508441(ST14)
OTC: 121340830(ST14)
PRUF: 121360634(ST14)
GFR: 102045487(ST14)
FAB: 101807159(ST14)
PHI: 102099462(ST14)
PMAJ: 107214462(ST14)
CCAE: 111939399(ST14)
CCW: 104692158(ST14)
ETL: 114070128(ST14)
FPG: 101919145(ST14)
FCH: 102052997(ST14)
CLV: 102084734(ST14)
EGZ: 104129611(ST14)
NNI: 104016640(ST14)
ACUN: 113488432(ST14)
PADL: 103915698(ST14)
AAM: 106491009(ST14)
AROW: 112968918(ST14)
NPD: 112947261(ST14)
DNE: 112981570(ST14)
ASN: 102369849(ST14)
AMJ: 102566264(ST14)
CPOO: 109318007(ST14)
GGN: 109292110(ST14)
PSS: 102451977(ST14) 102460566
CMY: 102929499(ST14) 102933252
CPIC: 101933655(ST14)
TST: 117868632(ST14)
CABI: 116821753 116837763(ST14)
ACS: 100559139(st14)
PVT: 110078111(ST14) 110088643
PBI: 103048601 103048713(ST14)
PMUR: 107289310(ST14) 107290134
PGUT: 117668240(ST14)
PMUA: 114585352(ST14)
ZVI: 118085157 118096778(ST14)
GJA: 107114358(ST14)
XLA: 394363(st14.L) 494753(st14.S)
XTR: 448647(st14)
NPR: 108800339(ST14)
DRE: 557248(zmp:0000001114) 678603(st14a)
IPU: 108264634(st14) 108278113(ST14) 108278916
NCC: 104944245(st14) 104961400
ELY: 117258716 117259575(st14a) 117266415(zmp:0000001114)
PLEP: 121943201(st14a) 121946084(zmp:0000001114) 121947401
SLUC: 116041148(st14a) 116049333(zmp:0000001114) 116059191
ECRA: 117941342(st14a) 117946895(zmp:0000001114)
GAT: 120811115(zmp:0000001114) 120819859(st14a) 120829850
PPUG: 119197466(zmp:0000001114) 119221884(st14a) 119222841
MSAM: 119882371(st14a) 119898302(zmp:0000001114) 119906001
CUD: 121513359(zmp:0000001114) 121515285(st14a) 121517274
KMR: 108241995(zmp:0000001114) 108248801(st14a)
XGL: 120783768(zmp:0000001114) 120790196 120792473(st14a) 120803752
OTW: 112222738(zmp:0000001114) 112226793 112231264(st14b)
OMY: 110503277(st14a) 110510036(st14b) 110510471 110536557 110538136(zmp:0000001114)
AANG: 118208793(st14a) 118233057(zmp:0000001114) 118235964(st14b)
LOC: 102691172 102697193(st14)
PSPA: 121298948(zmp:0000001114) 121302857 121302859 121304205 121309541(st14a)
LCM: 102354865 102356973(ST14)
CMK: 103180258(st14a)
CSOL: 105362745
FOC: 113214510
HAZT: 108673492
DSV: 119433874
RMP: 119184226
SDM: 118195313
LAK: 106160037
 » show all
Reference
1  [PMID:10962009]
  Authors
Lee SL, Dickson RB, Lin CY.
  Title
Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease.
  Journal
J Biol Chem 275:36720-5 (2000)
DOI:10.1074/jbc.M007802200
Reference
2  [PMID:10373424]
  Authors
Lin CY, Anders J, Johnson M, Sang QA, Dickson RB.
  Title
Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity.
  Journal
J Biol Chem 274:18231-6 (1999)
DOI:10.1074/jbc.274.26.18231
  Sequence
[hsa:6768]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.109
IUBMB Enzyme Nomenclature: 3.4.21.109
ExPASy - ENZYME nomenclature database: 3.4.21.109
BRENDA, the Enzyme Database: 3.4.21.109
CAS: 241475-96-7

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