KEGG   ENZYME: 3.4.21.36
Entry
EC 3.4.21.36                Enzyme                                 
Name
pancreatic elastase;
pancreatopeptidase E;
pancreatic elastase I;
elastase;
elaszym;
serine elastase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Hydrolysis of proteins, including elastin. Preferential cleavage: Ala!
Comment
Formed by activation of proelastase from mammalian pancreas by trypsin. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.11
History
EC 3.4.21.36 created 1981 (EC 3.4.4.7 created 1961, transferred 1972 to EC 3.4.21.11 created 1972, part incorporated 1984)
Orthology
K01326  pancreatic elastase I
Genes
HSA1990(CELA1)
PTR740437(CELA1)
PPS100976646(CELA1)
GGO101143430(CELA1)
PON100450522(CELA1)
NLE100582065(CELA1)
MCC695507(CELA1)
MCF102139348(CELA1)
MTHB126931069
CSAB103238322(CELA1)
CATY105580335(CELA1)
PANU101017405(CELA1)
TGE112634318(CELA1)
RRO104670677(CELA1)
RBB108521573(CELA1)
TFN117090111(CELA1)
PTEH111541989(CELA1)
CJC100390402(CELA1)
SBQ101036476(CELA1)
CSYR103259496(CELA1)
MMUR105871431(CELA1)
LCAT123640362(CELA1)
OGA100952933(CELA1)
MMU109901(Cela1)
MCAL110310384(Cela1)
MPAH110334999(Cela1)
RNO24331(Cela1)
MCOC116082165(Cela1)
MUN110562116(Cela1)
CGE100750829(Cela1)
MAUA101837660
PLEU114696589(Cela1)
MORG121441508(Cela1)
MFOT126488771
AAMP119823569(Cela1)
NGI103739592(Cela1)
HGL101715061(Cela1)
CPOC100717214(Cela1)
CCAN109685226(Cela1)
DORD105987421(Cela1)
DSP122098353(Cela1)
NCAR124983609
OCU100348556(CELA1)
OPI101528047(CELA1)
TUP102501966(CELA1)
CFA403515(CELA1)
CLUD112667257(CELA1)
VVP112921148(CELA1)
VLG121480381(CELA1)
AML100477910(CELA1)
UMR103675492(CELA1)
UAH113257608(CELA1)
UAR123794568(CELA1)
ELK111157854
LLV125106471
MPUF101681795(CELA1)
ORO101378556(CELA1)
EJU114225754(CELA1)
ZCA113921656(CELA1)
MLX118009014(CELA1)
NSU110593557(CELA1)
FCA494217(CELA1)
PYU121038565(CELA1)
PBG122473405(CELA1)
LRUF124501411
PTG102970463(CELA1)
HHV120237869(CELA1)
BTA281139(CELA1)
BOM102265097(CELA1)
BIU109559087(CELA1)
BBUB102398695(CELA1)
CHX102187460(CELA1)
OAS101114258(CELA1)
ODA120858230(CELA1)
CCAD122427330(CELA1)
SSC396766(CELA1)
CFR102517832(CELA1)
CBAI105076244(CELA1)
CDK105107155(CELA1)
VPC102527457(CELA1)
BACU103016249(CELA1)
LVE103073295(CELA1)
OOR101276770(CELA1)
DLE111173681(CELA1)
PCAD102974342(CELA1)
PSIU116760273(CELA1)
ECB100052672(CELA1)
EPZ103545629(CELA1)
EAI106835230(CELA1)
MYB102247948(CELA1)
MYD102768502(CELA1)
MMYO118651592(CELA1)
MLF102425049(CELA1)
MNA107528159(CELA1)
PKL118729955(CELA1)
HAI109371421(CELA1)
DRO112318498(CELA1)
SHON118976499(CELA1)
AJM119043253(CELA1)
PDIC114513590(CELA1)
PHAS123812399(CELA1)
MMF118624215(CELA1)
RFQ117028478(CELA1)
PALE102894029(CELA1)
PGIG120602185(CELA1)
PVP105307020(CELA1)
RAY107509814(CELA1)
MJV108401690(CELA1)
TOD119247933(CELA1)
SARA101540175(CELA1)
LAV100676855(CELA1)
TMU101357926
DNM101414606(CELA1)
GAS123249383(CELA1)
SHR100934635(CELA1)
PCW110194049(CELA1)
GGA425200(CELA1)
PCOC116235256(CELA1)
MGP100543650(CELA1)
CJO107325771(CELA1)
NMEL110389208(CELA1)
APLA101796072(CELA1)
ACYG106048709(CELA1)
AFUL116499837(CELA1)
TGU100221837 115491516
LSR110477839(CELA1) 110481815
SCAN103825509(CELA1)
PMOA120500616
OTC121343207(CELA1)
PRUF121355270(CELA1)
FAB101814575(CELA1)
PHI102106901 102107083 102110430
PMAJ107199081(CELA1) 107215653
CCAE111940565
CCW104686505
CBRC103611939(CELA1) 103623983
ACHL103799780
FPG101916345(CELA1) 101922556
FCH102047421(CELA1)
NNI104019207(CELA1) 104021776
PLET104623491
PCRI104029719
PCAO104039511
ACUN113491005(CELA1)
TALA104362533 116962754(CELA1)
PADL103926268(CELA1)
AFOR103896182 103906277(CELA1)
ACHC115339281 115350932(CELA1)
HALD104315431(CELA1) 104325027
CCRI104165414(CELA1) 104167619
CSTI104555973
EHS104505048 104507676(CELA1)
CMAC104481329
MUI104544685 104548512(CELA1)
GSTE104254078 104254860
LDI104351171
MNB103776141(CELA1) 103777738 103777739
OHA104336180(CELA1)
NNT104413213(CELA1)
DPUB104302131 104302322
ACAR104524145(CELA1) 104532936
AVIT104272591(CELA1)
CVF104284142(CELA1) 104291266
CUCA104059898(CELA1)
AAM106484943(CELA1) 106490266
AROW112972125(CELA1) 112978271
NPD112952274(CELA1)
TGT104574908(CELA1)
DNE112981555 112991461(CELA1)
SCAM104148805
ASN102373062
AMJ102576128
CPOO109321009
GGN109291075
PSS102448958 102454481(CELA1) 102463241
CMY119564313 119564316
CPIC101952427(CELA1)
TST117873949 117888768(CELA1)
CABI116828524(CELA1)
MRV120390814(CELA1) 120398331
ACS100567701(cela1)
PVT110074414(CELA1)
SUND121922753(CELA1)
PBI103057004(CELA1)
PGUT117663091(CELA1)
VKO123029820(CELA1)
GJA107107390 107122101(CELA1)
XLA108707551(cela1.3.L) 108718720 379467(cela1.1.L) 398300(cela1.2.L) 444358(cela1.4.L) 447166(cela1.1.S) 734670(cela1.5.L)
XTR100135144(cela1.6) 100170431(cela1.1) 496972(cela1.5) 496993(cela1.2) 595061(cela1.4)
NPR108799131 108799132 108799135 108799136
RTEM120929415 120929416 120929417 120929418
BBUF120993948 120993949 120993950 120993951 120993952 120993953 120996160 120996161 120996162
BGAR122931373 122931374 122931375 122931376 122931377 122931378 122931379 122931439 122931440 122932370 122932499
DRE100334908 100535584(cela1.2) 445032(cela1.3) 445282(cela1.6) 574008(cela1.4)
SRX107721235 107727187
SANH107694262(cela1) 107698556
SGH107566436 107570146
CCAR109064316 109064772(cela1) 109095828
CAUA113039478 113040710 113040754 113076267 113083500 113092165
PPRM120474270 120474286(cela1.6)
MAMB125263462 125263464 125263465 125263467 125263469
IPU108255297
PHYP113537786
SMEO124402006
TFD113639119(cela1.6)
AMEX103039974 103040289 103040969
EEE113580603(cela1) 113590533
TRU101061139 101078582 115246798
TNGGSTEN00033842G001 GSTEN00033843G001
LCO104922033 104922034 104922035
NCC104958759 104964279
CGOB115007747 115008133
ELY117256300 117257532 117257533
EFO125887960 125887970 125889526
PLEP121949361 121950040 121956806
SLUC116051564 116051565
ECRA117943472 117943473
ESP116687750 116687751
PFLV114554111 114554298
GAT120835835 120835837
PPUG119229690 119229691
MSAM119886402 119886403 119886405
CUD121507047 121507175 121527331 121527664 121528438
ALAT119008969 119021248 119021932 119021933
MZE101480566 101480856 112434834
ONL100695248 100711148
OAU116326855 116326856
OLA101155843 101156080 101156319
OML112145106 112145107 112145108
XMA102222248 102227665 111605784 111605785
XCO114136090 114136175
XHE116709845
PRET103464657(cela1) 103464856
PFOR103150137 103155732
PLAI106952143 106957078
PMEI106923337 106926983
GAF122833708 122834557
CVG107096176 107102979 107103436 107103448
CTUL119788659 119793546 119797900 119797982
GMU124856859 124856987 124857003
NFU107385386 107385387
KMR108231507 108231669 108231670
ALIM106517591 106517653
NWH119411858 119412794
AOCE111576043 111576044 111576047
MCEP125006425 125006426 125006427 125006428
CSEM103386708 103386709 103386721
POV109635616 109635618
SSEN122765813 122767731 122767747
HHIP117761344
HSP118104644 118104742 118104854
LCF108902128 108902129
SDU111233576 111233577 111233578
SLAL111655087 111655090 111655102
XGL120783161 120807229 120807565
HCQ109521386 109521676
BPEC110173733 110173734 110173767 110173768 110173769 110173770
MALB109964907 109965486
BSPL114852896 114855614 114856315 114856326
SASA106566159 106566160
STRU115151166 115207303 115207304
OTW112221936 112221943
OMY110494786 110495200
OGO124004103
ONE115121299 115121300
SALP112072806
SNH120023990 120058115 120058127
CCLU121575742 121575773 121575774 121575775
ELS105008138 105028855 105028857 105028858 105028859 105028860 105028861 105028862 105028863 105028864 105028867 106024132 114828646 114828906 114828908 114832647
SFM108928375 108931181 114909327 114909328 114909329 114909331 114909338 114909339 114909340 114909341 114909342 114909343 114909344 114909358 114909359 114909363 114909364 114909761 114909764 114909765 114909766 114909768 114909769 114909770 114909771
PKI111835297
AANG118226326
LOC102682440 102682647 102685766 102686168 102686373 102694205(cela1) 102694966 102695168 102695359
PSPA121313742 121325216
ARUT117394884 117400728 117421297
LCM102347906 102349204 102353251(CELA1)
CMK103189977
RTP109925812
BFO118428236
BBEL109463813
SKO100375882
AARA120901253
ASTE118504872
CQUCpipJ_CPIJ014524 CpipJ_CPIJ016103
BCOO119071949
TPRE106649941 106654999
DAM107035816
AGIF122848403
TCA100141575 100141641(h103)
SOY115880183
ATD109606652 109608947
AGB108904599
APLN108736032 108743702
OTU111426720
MSEX115441484
PRAP110996588
OFU114359801
DPXDAPPUDRAFT_306115
DMK116931355
HAZT108667907
VDE111251367
VJA111272603
TUT107361579
DFR124489771
PCAN112563167 112563174 112563175
BGT106051298 106054788 106054789 106066913 106066935 106067232 106067241 106074660 106076928 106076930 106077861 106079069
HRF124116237 124119804 124125091 124143995 124146749 124149097
HRJ124253772 124264923 124271215 124287653
CRG105328721 105347894 105348528
MYI110460740
PMAX117328829 117333202
MMER123558383
OSN115224571
EPA110238475
ATEN116307996
ADF107331798 107339738
AMIL114965735
TADTRIADDRAFT_63088
 » show all
Reference
1
  Authors
Shotton, D.M.
  Title
Elastase.
  Journal
Methods Enzymol 19:113-140 (1970)
Reference
2  [PMID:6380580]
  Authors
Harper JW, Cook RR, Roberts CJ, McLaughlin BJ, Powers JC.
  Title
Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II. Bovine chymotrypsin A alpha, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates.
  Journal
Biochemistry 23:2995-3002 (1984)
DOI:10.1021/bi00308a023
Reference
3  [PMID:3646943]
  Authors
Kawashima I, Tani T, Shimoda K, Takiguchi Y.
  Title
Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas.
  Journal
DNA 6:163-72 (1987)
DOI:10.1089/dna.1987.6.163
Reference
4  [PMID:2909256]
  Authors
Bieth JG, Dirrig S, Jung ML, Boudier C, Papamichael E, Sakarellos C, Dimicoli JL.
  Title
Investigation of the active center of rat pancreatic elastase.
  Journal
Biochim Biophys Acta 994:64-74 (1989)
DOI:10.1016/0167-4838(89)90063-0
Reference
5  [PMID:2655701]
  Authors
Bode W, Meyer E Jr, Powers JC.
  Title
Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors.
  Journal
Biochemistry 28:1951-63 (1989)
DOI:10.1021/bi00431a001
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.36
IUBMB Enzyme Nomenclature: 3.4.21.36
ExPASy - ENZYME nomenclature database: 3.4.21.36
BRENDA, the Enzyme Database: 3.4.21.36
CAS: 9004-06-2

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