KEGG   ENZYME: 3.4.21.46
Entry
EC 3.4.21.46                Enzyme                                 
Name
complement factor D;
C3 proactivator convertase;
properdin factor D esterase;
factor D;
factor D (complement)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Selective cleavage of Arg!Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor
Comment
A component of the alternative pathway of complement activation. This reaction is analogous to the activation of complement component C2 by complement subcomponent C_overbar_1s_. In peptidase family S1 (trypsin family)
History
EC 3.4.21.46 created 1981
Orthology
K01334  complement factor D
Genes
HSA1675(CFD)
PON100936423(CFD)
NLE100599422(CFD)
MCC721138(CFD)
MCF102136571(CFD)
MTHB126942983
CSAB103233571(CFD)
CATY105591689(CFD)
TGE112612318(CFD)
RRO104671463(CFD)
TFN117075456(CFD)
PTEH111534786(CFD)
CJC100389630(CFD)
SBQ101030841(CFD)
MMUR105860755(CFD)
LCAT123632771(CFD)
OGA100960466(CFD)
MMU11537(Cfd)
MCAL110303909(Cfd)
MPAH110326960(Cfd)
RNO54249(Cfd)
MCOC116076101(Cfd)
MUN110551364(Cfd)
CGE100763302(Cfd)
MAUA121136815(Cfd)
PLEU114684101(Cfd)
MORG121459661(Cfd)
MFOT126489244
AAMP119802884(Cfd)
NGI103737401(Cfd)
HGL106007830(Cfd)
CPOC100724693(Cfd)
CCAN109693669(Cfd)
DSP122122752(Cfd)
NCAR124968607
OPI101525706
TUP106734227(CFD)
CFA485095(CFD)
CLUD112666161(CFD)
VVP112935509(CFD)
VLG121494247(CFD)
AML100483447(CFD) 117800215
UAH113242706(CFD)
UAR123794054(CFD)
ELK111161686
LLV125087404
MPUF101678869(CFD)
ORO101380360(CFD)
EJU114226342(CFD)
ZCA113917886(CFD)
MLX118005033(CFD)
NSU110593928(CFD)
FCA101093500(CFD)
PYU121021311(CFD)
PBG122486624(CFD)
LRUF124527664
PPAD109257710(CFD)
AJU113596379
HHV120242412(CFD)
BTA505647(CFD)
BOM102275200(CFD)
BBUB102411586(CFD)
CHX102173560(CFD)
OAS101115705(CFD)
ODA120863726(CFD)
SSC396877(CFD)
CFR102507253(CFD)
CBAI105078119(CFD)
CDK105106574(CFD)
VPC102525040(CFD)
LVE103086658(CFD)
OOR101272668(CFD)
DLE111170499(CFD)
PCAD102995550(CFD)
PSIU116750930(CFD)
ECB111774154(CFD)
EAI106834238(CFD)
MYD102756294(CFD)
MMYO118659139(CFD)
MLF102427276(CFD)
MNA107538545(CFD)
PKL118711775(CFD)
HAI109390585(CFD)
SHON118984388(CFD)
AJM119044597(CFD)
MMF118615470(CFD)
RFQ117038399(CFD)
PALE102897797(CFD)
PGIG120583677(CFD)
RAY107500957(CFD)
MJV108395527(CFD)
TOD119240492(CFD)
SARA101553713(CFD)
LAV100672291(CFD)
TMU101356637
GAS123254000
SHR100928352(CFD)
PCW110196242(CFD)
OAA791100(CFD)
GGA100857593(CFD)
PCOC116235815(CFD)
MGP100541228(CFD)
CJO107325464(CFD)
NMEL110388819(CFD)
APLA113845674
AFUL116499209(CFD)
TGU100224290
LSR110475732
SCAN103822039
PMOA120513444
OTC121341721
PRUF121361872(CFD)
GFR102036496(CFD)
FAB101807799(CFD)
PHI102114080
PMAJ107215597
CCAE111940403
CCW104697052(CFD)
CBRC103622133(CFD)
ETL114066373(CFD)
ZAB102069032(CFD)
ACHL103809276(CFD)
FPG101921526(CFD)
FCH102048162(CFD)
CLV106145861(CFD)
NNI104016308(CFD)
TALA116961660(CFD)
AFOR103899332(CFD)
ACHC115349111(CFD)
CUCA104067745(CFD)
AAM106484250(CFD)
AROW112965646(CFD)
NPD112946823
DNE112988069(CFD)
ASN102381206
AMJ102567707(CFD)
CPOO109312290(CFD)
GGN109294926
PSS112545587
CMY102931053 114022442
CPIC101935732
TST117868803
CABI116827447 116827718
MRV120391700
PVT110072602(CFD)
SUND121916385 121918355
PBI103066225
PMUR107282291(CFD)
CTIG120304317
TSR106542872
PGUT117677459(CFD)
VKO123035384(CFD)
PMUA114588305(CFD)
ZVI118086494(CFD)
GJA107120759(CFD)
STOW125433984(CFD)
XLA494791(cfd.L)
XTR394945(cfd)
NPR108798700
RTEM120910362
BBUF120989435
BGAR122930786
DRE553553(cfd)
SRX107733667
SANH107666376 107695014
SGH107556907
CCAR109071492 109071498
CAUA113057061 113112848
PPRM120479299(cfd)
MAMB125276571(cfd)
IPU100862744(cfd)
PHYP113544922
SMEO124401299(cfd)
TFD113639975(cfd)
AMEX103044529
EEE113579255
TRU101070023
TNGGSTEN00012908G001
LCO104926791
NCC104963116
CGOB115027348
ELY117266675(cfd)
EFO125900873(cfd)
PLEP121954070(cfd)
SLUC116036785(cfd)
ECRA117936166(cfd)
ESP116686939
PFLV114547394
GAT120832694(cfd)
PPUG119227597(cfd)
MSAM119910420(cfd)
CUD121526046(cfd)
ALAT119005139(cfd)
MZE101478226
ONL100692083
OAU116329030(cfd)
OLA100049308(olklklp)
OML112150046(cfd)
XMA102225583
XCO114134801
XHE116709474
PRET103458165
GAF122846140(cfd)
CVG107087104
CTUL119796215(cfd)
GMU124885048(cfd)
NFU107373416
KMR108250570(cfd)
ALIM106519943
NWH119427911(cfd)
AOCE111580112
MCEP125024194(cfd)
CSEM103383188
POV109640960
SSEN122782500(cfd)
HHIP117756454(cfd)
HSP118115936(cfd)
LCF108889155(cfd)
SDU111225539
SLAL111646789
XGL120795014(cfd)
HCQ109511554
BPEC110155605
MALB109962455
BSPL114848564(cfd)
SASA101448046
STRU115173057
OTW112265777(cfd)
OMY110514148(cfd)
OGO124025771 124029184
ONE115126409
SALP112075441
SNH120042389(cfd)
CCLU121556229(cfd) 121556989
ELS105015868
SFM108919827
PKI111860508
AANG118224646(cfd)
LOC102685416
PSPA121300830 121301136 121301521
ARUT117428810 117428860 117428987 117428988 117966210 117966232 117966331
BCOO119070104
FAS105267006
LDC111510533
BANY112055271
SLIU111349872
CLEC106662046
HHAL106689898
DMK116925602 116925603 116925605 116925681 116931363 116934608
PJA122244116
 » show all
Reference
1  [PMID:6918766]
  Authors
Reid KB, Johnson DM, Gagnon J, Phohaska R.
  Title
Preparation of human factor D of the alternative pathway of complement.
  Journal
Methods Enzymol 80 Pt C:134-43 (1981)
DOI:10.1016/s0076-6879(81)80013-4
Reference
2  [PMID:3052276]
  Authors
Muller-Eberhard HJ.
  Title
Molecular organization and function of the complement system.
  Journal
Annu Rev Biochem 57:321-47 (1988)
DOI:10.1146/annurev.bi.57.070188.001541
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.46
IUBMB Enzyme Nomenclature: 3.4.21.46
ExPASy - ENZYME nomenclature database: 3.4.21.46
BRENDA, the Enzyme Database: 3.4.21.46
CAS: 37213-56-2

DBGET integrated database retrieval system