KEGG   ENZYME: 3.4.24.18
Entry
EC 3.4.24.18                Enzyme                                 
Name
meprin A;
endopeptidase-2;
meprin-a;
meprin;
N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase;
PABA-peptide hydrolase;
PPH
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues
Comment
A membrane-bound metalloendopeptidase of rat and mouse kidney and intestinal brush borders, and salivary ducts. Differences from neprilysin (EC 3.4.24.11) (astacin family). Formerly included in EC 3.4.24.11
History
EC 3.4.24.18 created 1992
Orthology
K01395  meprin A
Genes
HSA4224(MEP1A)
PTR462745(MEP1A)
PPS100993933(MEP1A)
GGO101124221(MEP1A)
PON100456833(MEP1A)
NLE100602114(MEP1A)
MCC704781(MEP1A)
MCF102141031(MEP1A)
MTHB126952678
CSAB103221409(MEP1A)
CATY105590778(MEP1A)
PANU101011175(MEP1A)
TGE112622750(MEP1A)
RRO104656801(MEP1A)
RBB108512427(MEP1A)
TFN117087318(MEP1A)
PTEH111543189(MEP1A)
CJC100385555(MEP1A)
SBQ101050703(MEP1A)
CSYR103260810(MEP1A)
MMUR105860253(MEP1A)
LCAT123632920(MEP1A)
OGA100963726(MEP1A)
MMU17287(Mep1a)
MCAL110283838(Mep1a)
MPAH110335843(Mep1a)
RNO25684(Mep1a)
MCOC116074787(Mep1a)
MUN110552106(Mep1a)
CGE100771501(Mep1a)
MAUA101822749(Mep1a)
PLEU114705400(Mep1a)
MORG121451029(Mep1a)
MFOT126486845
AAMP119823876(Mep1a)
NGI103744884(Mep1a)
HGL101716131(Mep1a)
CPOC100732219(Mep1a)
CCAN109698380(Mep1a)
DORD105987757(Mep1a)
DSP122101537(Mep1a)
NCAR124989508
OCU100348747(MEP1A)
OPI101535860(MEP1A)
TUP102476731(MEP1A)
CFA481826(MEP1A)
CLUD112641692(MEP1A)
VVP112914219(MEP1A)
VLG121491445(MEP1A)
AML100467739(MEP1A)
UMR103664139(MEP1A)
UAH113261230(MEP1A)
UAR123797334(MEP1A)
ELK111147822
LLV125103093
MPUF101673518(MEP1A)
ORO101380422(MEP1A)
EJU114204628(MEP1A)
ZCA113927100(MEP1A)
MLX118000823(MEP1A)
NSU110582144(MEP1A)
FCA101101056(MEP1A)
PYU121029545(MEP1A)
PBG122490459(MEP1A)
LRUF124528849
PTG102969174(MEP1A)
PPAD109271709(MEP1A)
AJU106973949(MEP1A)
HHV120231196(MEP1A)
BTA513936(MEP1A)
BOM102270268(MEP1A)
BIU109576819(MEP1A)
BBUB102401068(MEP1A)
CHX102184856(MEP1A)
OAS101116774(MEP1A) 114109544
ODA120870047(MEP1A)
CCAD122429580(MEP1A)
SSC100154136(MEP1A)
CFR102520791(MEP1A)
CBAI105083844(MEP1A)
CDK105101209(MEP1A)
VPC102529829(MEP1A)
BACU103017419(MEP1A)
LVE103087996(MEP1A)
OOR101277573(MEP1A)
DLE111178626(MEP1A)
PCAD102981811(MEP1A)
PSIU116762282(MEP1A)
ECB100068383(MEP1A)
EPZ103566247(MEP1A)
EAI106828780(MEP1A)
MYB102251668(MEP1A)
MYD102754774(MEP1A)
MMYO118660361(MEP1A)
MLF102433498(MEP1A)
MNA107536851(MEP1A)
PKL118705173(MEP1A)
HAI109396009(MEP1A)
DRO112302481(MEP1A)
SHON118993585(MEP1A)
AJM119047220(MEP1A)
PDIC114495523(MEP1A)
PHAS123822043(MEP1A)
MMF118621385(MEP1A)
RFQ117015283(MEP1A)
PALE102894555(MEP1A)
PGIG120595953(MEP1A)
PVP105288518(MEP1A)
RAY107517793(MEP1A)
MJV108409968(MEP1A)
TOD119253325(MEP1A)
SARA101552537(MEP1A)
LAV100657109(MEP1A)
TMU101348614
DNM101413879(MEP1A)
MDO100014629(MEP1A)
GAS123245980(MEP1A)
SHR100920569(MEP1A)
PCW110213551(MEP1A)
OAA100080933(MEP1A)
GGA422060(MEP1A)
PCOC116236329(MEP1A)
MGP100550277(MEP1A)
CJO107312462(MEP1A)
NMEL110396031(MEP1A)
APLA101798272 101798463
ACYG106038157 106038159
AFUL116487511 116487512
TGU100223713(MEP1A)
LSR110470255(MEP1A)
SCAN103821016(MEP1A)
PMOA120508211(MEP1A)
OTC121344314(MEP1A)
PRUF121360751(MEP1A)
GFR102034827(MEP1A)
FAB101810044(MEP1A)
PHI102112290(MEP1A)
PMAJ107201583(MEP1A)
CCAE111927425(MEP1A)
CCW104685391(MEP1A)
CBRC103622815(MEP1A)
ETL114065052(MEP1A)
ZAB102073181(MEP1A)
ACHL103803106(MEP1A)
FPG101917590 101917757(MEP1A)
FCH102054284 102054455
CLV102093522(MEP1A)
EGZ104126993 104127013
NNI104014738 104014739
PLET104618385 104618386
PCRI104025808(MEP1A) 104031659
PCAO104045507 104045508
ACUN113478324 113478900
TALA104357816(MEP1A) 104357817
PADL103913199 103913259
AFOR103906919 103906920
ACHC115351123 115351125
HALD104316775(MEP1A) 104316848
CCRI104157934(MEP1A) 104157936
CSTI104556867
EHS104505665 104516896(MEP1A)
CMAC104483995(MEP1A) 104483996
MUI104534644 104535040
FGA104069347(MEP1A) 104072506
GSTE104254630
LDI104344452(MEP1A) 104344453
MNB103782621(MEP1A)
OHA104332418(MEP1A)
NNT104410190(MEP1A)
DPUB104304549(MEP1A)
PGUU104464109(MEP1A)
ACAR104523934(MEP1A) 104523936
AVIT104275704(MEP1A) 104275705
CVF104286733(MEP1A)
CUCA104057112 104057122
AAM106495190 106495197(MEP1A)
AROW112962882(MEP1A)
NPD112952103(MEP1A)
DNE112979529(MEP1A)
SCAM104139675(MEP1A)
ASN102387802 102388049(MEP1A)
AMJ102561580(MEP1A) 102561804
CPOO109311473(MEP1A) 109312050
GGN109300292(MEP1A)
PSS102462010(MEP1A)
CMY102929325(MEP1A)
CPIC101931408(MEP1A)
TST117875538(MEP1A)
CABI116823203(MEP1A)
MRV120401189(MEP1A)
ACS100554603 100554797
PVT110069777 110083218
SUND121918910 121937214
PBI103066442
PMUR107284262 107284263(MEP1A)
CTIG120300341 120300424(MEP1A)
TSR106545749(MEP1A)
PGUT117671091 117671096(MEP1A)
VKO123030856 123030857(MEP1A)
PMUA114593472(MEP1A)
ZVI118082801(MEP1A)
GJA107114141
STOW125438315 125438323
XLA100037179(mep1a.L) 447263
XTR548484(mep1a)
NPR108796542(MEP1A)
RTEM120936248(MEP1A)
BBUF120999920(MEP1A)
BGAR122935759(MEP1A)
DRE553530(mep1a.1) 565535(mep1a.2)
SRX107719099
SANH107696095 107696105
SGH107601466 107601486
CCAR109067933
CAUA113062851 113062853
PPRM120493673(mep1a.1) 120494034(mep1a.2)
MAMB125278247(mep1a.1) 125278249(mep1a.2)
AMEX103024428 103025272 103025777
EEE113581055 113581056
TRU101076916 115253063
TNGGSTEN00035505G001
LCO104939906 104939907
NCC104957453(mep1a)
CGOB115003558 115028856
ELY117270313(mep1a.2) 117270507(mep1a.1)
EFO125897369(mep1a.2) 125897374(mep1a.1)
PLEP121955203(mep1a.1) 121955454(mep1a.2)
SLUC116047013(mep1a.1) 116047020(mep1a.2)
ECRA117961258(mep1a.2) 117961261(mep1a.1)
ESP116706500 116706501
PFLV114573580
GAT120807796(mep1a.1) 120808432(mep1a.2)
PPUG119194859(mep1a.2) 119194864(mep1a.1)
MSAM119908447(mep1a.1) 119909505(mep1a.2)
CUD121520978(mep1a.2) 121521687(mep1a.1)
ALAT119013001
ONL100712081 100712349
OAU116315447(mep1a.1) 116325156(mep1a.2)
OLA101160615 101173759
OML112157791(mep1a.2) 112158539(mep1a.1)
XMA102231460 102231722
XCO114158431 114158432
XHE116733828 116733829
PRET103457752 103457753
PFOR103148799 103148801
PLAI106944984 106944985
PMEI106907790 106907796
GAF122825399(mep1a.1) 122825401(mep1a.2)
CVG107100249 107100257
CTUL119772550(mep1a.2) 119772552
GMU124881634(mep1a.1) 124882132(mep1a.2)
NFU107378236 107378237
KMR108245453(mep1a.1) 108245473(mep1a.2)
ALIM106526863 106526880
AOCE111567862 111567866
MCEP124999050(mep1a.1) 124999555(mep1a.2)
CSEM103398578 103398579
POV109632399 109632403
SSEN122783724(mep1a.1) 122784416(mep1a.2)
HHIP117758021(mep1a.2) 117758022(mep1a.1)
HSP118099549
LCF108895818 108895821(mep1a.2)
SDU111238040 111238062
SLAL111661366 111661541
XGL120788600(mep1a.2) 120789033(mep1a.1)
BPEC110154737 110154746
MALB109969813 109969814
SASA106571460 106571463 106571464
STRU115174713 115174714 115174715
OTW112250368(mep1a.2) 112250371 112250372
OMY110529669(mep1a.2) 110529672 110529673
OGO123990813(mep1a.2) 123990815 123990816
ONE115107815 115107817 115107818
SALP112068748 112068749 112068756
SNH120023976 120023977(mep1a.2) 120024576(mep1a.1)
CCLU121552375(mep1a.2) 121552377 121552378
ELS105017592 105017593 105017596 106024753
SFM108920369 108920377 108921075
PKI111856769 111856794
AANG118229714(mep1a.1) 118230345(mep1a.2)
LOC102697599(mep1a) 102697789
PSPA121315365 121317737(mep1a.2)
ARUT117403264(mep1a.1) 117410973(mep1a.2)
LCM102363508(MEP1A)
RTP109918882(mep1a)
CIN100177122 100181769
SCLV120326559 120334903 120338139 120338485
PJA122267005
PCHN125028033 125040260
PPOI119097914
PTEP107438087 122268366
CRG105327079
MYI110452156
PMAX117316630
MMER123539866
OBI106872749 106872756
OSN115217516 115232594
LAK106181764 106181780 106181782
EPA110232879
 » show all
Reference
1  [PMID:7041888]
  Authors
Beynon RJ, Shannon JD, Bond JS.
  Title
Purification and characterization of a metallo-endoproteinase from mouse kidney.
  Journal
Biochem J 199:591-8 (1981)
DOI:10.1042/bj1990591
Reference
2  [PMID:3105525]
  Authors
Butler PE, McKay MJ, Bond JS.
  Title
Characterization of meprin, a membrane-bound metalloendopeptidase from mouse kidney.
  Journal
Biochem J 241:229-35 (1987)
DOI:10.1042/bj2410229
Reference
3  [PMID:2461706]
  Authors
Stephenson SL, Kenny AJ.
  Title
The metabolism of neuropeptides. Hydrolysis of peptides by the phosphoramidon-insensitive rat kidney enzyme 'endopeptidase-2' and by rat microvillar membranes.
  Journal
Biochem J 255:45-51 (1988)
DOI:10.1042/bj2550045
Reference
4  [PMID:3261961]
  Authors
Sterchi EE, Naim HY, Lentze MJ, Hauri HP, Fransen JA.
  Title
N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase: a metalloendopeptidase of the human intestinal microvillus membrane which degrades biologically active peptides.
  Journal
Arch Biochem Biophys 265:105-18 (1988)
DOI:10.1016/0003-9861(88)90376-1
Reference
5  [PMID:2690825]
  Authors
Barnes K, Ingram J, Kenny AJ.
  Title
Proteins of the kidney microvillar membrane. Structural and immunochemical properties of rat endopeptidase-2 and its immunohistochemical localization in tissues of rat and mouse.
  Journal
Biochem J 264:335-46 (1989)
DOI:10.1042/bj2640335
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.18
IUBMB Enzyme Nomenclature: 3.4.24.18
ExPASy - ENZYME nomenclature database: 3.4.24.18
BRENDA, the Enzyme Database: 3.4.24.18
CAS: 148938-24-3

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