KEGG   ENZYME: 3.5.1.101
Entry
EC 3.5.1.101                Enzyme                                 
Name
L-proline amide hydrolase;
S-stereoselective piperazine-2-tert-butylcarboxamide hydrolase;
LaaA;
L-amino acid amidase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
(S)-piperidine-2-carboxamide amidohydrolase
Reaction(IUBMB)
(1) (S)-piperidine-2-carboxamide + H2O = (S)-piperidine-2-carboxylate + NH3 [RN:R09680];
(2) L-prolinamide + H2O = L-proline + NH3 [RN:R09650]
Reaction(KEGG)
R09650 R09680;
(other) R09649
Substrate
(S)-piperidine-2-carboxamide [CPD:C19809];
H2O [CPD:C00001];
L-prolinamide [CPD:C19781]
Product
(S)-piperidine-2-carboxylate;
NH3 [CPD:C00014];
L-proline [CPD:C00148]
History
EC 3.5.1.101 created 2009
Orthology
K18457  L-proline amide hydrolase
Genes
ENRH650_21365
ENFAKI40_3759
KOXKOX_25325
KOEA225_3919
KOYJ415_12255
KOMHR38_23405
KOKKONIH1_19640
KOCAB185_16635
KLLBJF97_19530
KLWDA718_09620
KGRJJJ10_09110
RTGNCTC13098_04863(laaA_1)
REEelectrica_01634(laaA)
KSAC813_25130
KORAWR26_18640
KRDA3780_05640
KPSEIP581_05815
SERASer39006_016950
SERQCWC46_16950
RAHRahaq_4604
RACEJHW33_23725
RAQRahaq2_4609
RAAQ7S_23546
RVCJ9880_22585
GQUAWC35_06995
DDDDda3937_00843
DDCDd586_2920
DSOA4U42_15820
CEDLH89_05385
DFNCVE23_07335
DDQDDI_1138
BNGEH206_07870
LBQCKQ53_11670
LPOPI6N93_10105
SLIGGTU79_20040
XCCXCC2817
XCBXC_1296
XCAxcc-b100_1343(pip2)
XCPXCR_3189
XCVXCV3134(pip)
XAXXACM_2921(pip)
XACXAC2987
XCIXCAW_03265(mhpC)
XCTJ151_03172
XCJJ158_03151
XCUJ159_03147
XCNJ169_03170
XCWJ162_03151
XCRJ163_03147
XCMJ164_03147
XCFJ172_03163
XFUXFF4834R_chr16470
XAOXAC29_15190
XOMXOO1168(XOO1168)
XOOXOO1269(MhpC)
XOPPXO_02210
XOYAZ54_18135
XORXOC_1423
XOZBE73_16275
XFRBER92_14595
XVEBJD12_05830
XPEBJD13_01695
XHRXJ27_05680
XGABI317_11050
XPHXppCFBP6546_20825(XppCFBP6546P_20825)
XVAC7V42_15270
XANAC801_14995
XARXB05_09680
XCZEBN15_12930
XEUXSP_002905
XHDLMG31886_13690(laaA)
PMOSO165_010230
PORAPT59_04755
PMOLCLJ08_25840
PSTPSPTO_4540
PSBPsyr_4217
PSPPSPPH_4239
PSAVPSA3335_04415
PAMGBKM19_024880
PAVLBKM03_24635
PVDCFBP1590__4609(laaA)
PCABJGS08_22200
PCOFPOR16_04210
PTREI9H09_20020
PSYIMME58_21650
PFLPFL_5297(pip)
PPRCPFLCHA0_c52700(laaA)
PPROPPC_5275(pip)
PFEPSF113_0791
PFNHZ99_07905
PFSPFLU_1629
PFCPflA506_1682(pip)
PPZH045_04550
PFBVO64_4751
PTVAA957_06030
PVRPverR02_08430
PAZOAYR47_15300
POIBOP93_07740
PRXHRH33_08950
PFWPF1751_v1c15970(laaA)
PFFPFLUOLIPICF700330
PFXA7318_07180
PBAPSEBR_a719
PSKU771_09205 U771_12490
PCHEY04_24170
PSECCCOS191_2563(laaA)
PANRA7J50_1787
PPSLBJP27_19480
PYMAK972_4184
PVKEPZ47_03710
PBZGN234_14390
PDWBV82_2015
PSEPC4K39_0796
PVWHU752_017225
PTRTHU722_0009115
PSAMHU731_024105
PQIKH389_12755
PSHHHU773_019305
PASGKSS96_08660
PMUYKSS95_10710
PMAMKSS90_13220
PTKEXN22_13070
PZAHU749_004700
GNIGNIT_0098(pip)
GSNYC6258_04460
AAAAcav_2489
MLOmll0601
MLNA9174_22600
MCIMesci_3948
MOPMesop_4294
MAMMesau_04059
MAMOA6B35_25265
MESWA9K65_022035
MHUAMCHK_2307
MJREB229_22625
MERDEB233_19525
MESRFGU64_10600
PHTBLM14_24110
KMNHW532_10240
SMESMc04031(pip2)
SMKSinme_2869
SMQSinmeB_2645
SMXSM11_chr2980(pip2)
SMIBN406_02672(laaA)
SMEGC770_GR4Chr2941
SMELSM2011_c04031(pip2)
SMERDU99_15550
SIXBSY16_462
ARAArad_8444(pipb1)
AVIAvi_5637
ARUIG6M88_15690
RETRHE_PB00088(pipb1)
RECRHECIAT_PC0000238(pipc2)
RELREMIM1_PA00099(laaA)
REPIE4803_PD00432(laaA)
REIIE4771_PE00449(laaA)
RLEpRL90179(pip)
RLTRleg2_6377
RLGRleg_6197
RLBRLEG3_00090
RLURLEG12_06370
RTRRTCIAT899_PC01400
RHLLPU83_pLPU83d1219(laaA)
RGARGR602_PC00694(laaA)
RPHAAMC79_PD00249(laaA)
RHKKim5_PD00408(laaA)
RJGCCGE525_23010
RHRCKA34_22965
RADCO657_33210
RIIFFM53_034240
RHIDFFM81_021600
RLNJ0663_22245
RBANJ2J98_29890
RRGJ3P73_33040
RLSHB780_09105
NEOCYG48_17735
NENNCHU2750_50590
OCHCES85_4734(laaA)
LNEFZC33_08855
APOLK9D25_16860
METXA3862_29015
PLEOOHA_1_01329(laaA)
HDIHDIA_0226(laaA)
MEYTM49_08475
AUAM673_21805
NOHG5V57_33305
PPHRAPZ00_24540
LIZLGH83_13390
CFHC1707_05615
PALXGQA70_23855
RCPRCAP_rcc01087(pip2)
RBLB6K69_12300
RMBK529_009255
PPRUFDP22_06065
THASC6Y53_03865
SPKCKC8_00275
SPAIFPZ24_06105
SSYSLG_35840
CIJWG74_13570
SMICSmB9_08520
PORLBG023_112182
POTE2E27_10080
AMVACMV_P3_00110
GXLH845_766
RAPRHOA_5680
RRURru_A2180
RRFF11_11230
HTQFRZ44_27060
HADHFRZ61_20380
ECOGFIV45_08545
BACAFAY30_12585
BCOHBC6307_08045
CSUAIM538_12165
CSOALIS82_13845
VIRX953_06840
POWIJ21_37490
PXLBS614_16020
COHEAV92_10510
COHNKCTCHS21_28200
PRTAUC31_06355
PPLABBI15_15495
PLXCW734_05035
CPYCphy_0973
MAOMAP4_3180
MAVIRC58_15760
MAVURE97_15790
MAVMAV_0868
MITOCO_07220
MIAOCU_07230
MIDMIP_01253
MYOOEM_07290
MCHIAN480_04765
MIROCQ_07370
MMALCKJ54_03625
MMANMMAN_50260(pip)
MSAMycsm_02514
MULMUL_0358(pip)
MMAEMMARE11_46190(pip)
MMMW7S_03530
MLIMULP_05019(pip)
MYVG155_12595
MGOAFA91_26070
MHADB586_01120
MDXBTO20_22275
MGROFZ046_16795
MSENK3U95_17245
MRFMJO55_10690
MSMMSMEG_2681
MSGMSMEI_2616
MSBLJ00_13340
MSNLI99_13345
MSHLI98_13350
MFTXA26_25880
MLLB1R94_17600
MMAGMMAD_23060
MTYMTOK_34120
MARZMARA_16870
MANYMANY_06600
MAUBMAUB_56150
MMUCC1S78_011900
MMATMMAGJ_56780
MBOKMBOE_49000
MFGK6L26_19640
MSEIMSEDJ_35290
CVACVAR_1950(pepI)
SSXSACTE_5568
SHYSHJG_1916
SHOSHJGH_1681
SFASfla_0992
STRPF750_5856
SRWTUE45_pSRc_0416(laaA)
STRFASR50_28100
SLSSLINC_1026
SALJSMD11_1692(pip)
SGEDWG14_07620(laaA)
SQZFQU76_00620
SRKFGW37_02675
SPADDVK44_00460
SAQUEJC51_45260
STSUB7R87_32915
SBROGQF42_08770
SATAC5746_38380
SMOBJ7W19_32140
SDDD9753_32025
SMAOCAG99_19720
SLFJEQ17_40490
MTSMTES_2595
CUMNI26_07625
CUGC1N91_07470
FRPAX769_04370
AARCG127AT_05645 G127AT_12080
FRNF1C15_11020
AGXAGREI_2852(laaA)
MIKFOE78_19355
NPSKRR39_20910
NGVCDO52_23315
SROSros_2123
NOABKM31_00700
KRAKrad_0552
AMYCCU254_30230
AMYYYIM_11610(laaA)
AACDLWP59_31795
APRECNX65_13600
AMIAmir_2685
SSYIEKG83_33040
KALKALB_1476
STPStrop_2777
MICHFJK98_09430
ASEACPL_6077(pip2)
ACTSACWT_5945
NHYJQS43_06710
PLIMPHILAsVB114_04815
RUBGBA63_01610
SHIShel_16440 Shel_21290
EGDGS424_005360
SYDSyncc9605_0830
KBSEPA93_36860
DEINDAAJ005_04790
GGRHKW67_10070 HKW67_18510
MRTJKHC33_06970
 » show all
Reference
1  [PMID:15066172]
  Authors
Komeda H, Harada H, Washika S, Sakamoto T, Ueda M, Asano Y
  Title
S-stereoselective piperazine-2-tert-butylcarboxamide hydrolase from Pseudomonas azotoformans IAM 1603 is a novel L-amino acid amidase.
  Journal
Eur J Biochem 271:1465-75 (2004)
DOI:10.1111/j.1432-1033.2004.04056.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.101
IUBMB Enzyme Nomenclature: 3.5.1.101
ExPASy - ENZYME nomenclature database: 3.5.1.101
BRENDA, the Enzyme Database: 3.5.1.101

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