KEGG   ENZYME: 3.5.1.12
Entry
EC 3.5.1.12                 Enzyme                                 
Name
biotinidase;
amidohydrolase biotinidase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
biotin-amide amidohydrolase
Reaction(IUBMB)
biotin amide + H2O = biotin + NH3 [RN:R01076]
Reaction(KEGG)
R01076;
(other) R01077 R06134
Substrate
biotin amide [CPD:C01893];
H2O [CPD:C00001]
Product
biotin [CPD:C00120];
NH3 [CPD:C00014]
Comment
Also acts on biotin esters.
History
EC 3.5.1.12 created 1961
Pathway
ec00780  Biotin metabolism
ec01100  Metabolic pathways
Orthology
K01435  biotinidase
Genes
HSA686(BTD)
PTR470760(BTD)
PPS100983934(BTD)
GGO101131296(BTD)
PON100458389(BTD)
NLE100584490(BTD)
MCC677722(BTD)
MCF101926326(BTD)
MTHB126946874
CSAB103241707(BTD)
CATY105578326(BTD)
PANU101018867(BTD)
TGE112617641(BTD)
RRO104656449(BTD)
RBB108535861(BTD)
TFN117084205(BTD)
PTEH111539502(BTD)
CJC100409568(BTD)
SBQ101042865(BTD)
CSYR103249273(BTD)
MMUR105872706(BTD)
LCAT123628581(BTD)
OGA100943917(BTD)
MMU26363(Btd)
MCAL110309042(Btd)
MPAH110325552(Btd)
RNO306262(Btd)
MCOC116084403(Btd)
MUN110551270(Btd)
CGE100755324(Btd)
MAUA101832998(Btd)
PLEU114708166(Btd)
MORG121455239(Btd)
MFOT126499146
AAMP119827426(Btd)
NGI103747521(Btd)
HGL101716226(Btd)
CPOC100723421(Btd)
CCAN109694811(Btd)
DORD105989900(Btd)
DSP122107949(Btd)
NCAR124968278 124968503
OCU100341187(BTD)
OPI101524102(BTD)
TUP102476912(BTD)
CFA477059(BTD)
CLUD112660942(BTD)
VVP112925620(BTD)
VLG121478712(BTD)
AML100483327(BTD)
UMR103679387(BTD)
UAH113253913(BTD)
UAR123788358(BTD)
ELK111155099
LLV125104704
MPUF101679447(BTD)
ORO101380238(BTD)
EJU114205726(BTD)
ZCA113915824(BTD)
MLX118003387(BTD)
NSU110570752(BTD)
FCA101094289(BTD)
PYU121033648(BTD)
PBG122492012(BTD)
LRUF124526160
PTG102952175(BTD)
PPAD109258837(BTD)
AJU106971609(BTD)
HHV120238470(BTD)
BTA537669(BTD)
BOM102282711(BTD)
BIU109561800(BTD)
BBUB102398640(BTD)
CHX102179988(BTD)
OAS101113196(BTD)
ODA120880376(BTD)
CCAD122445508(BTD)
SSC100737057(BTD)
CFR102506341(BTD)
CBAI105077624(BTD)
CDK105096612(BTD)
VPC102536252(BTD)
BACU103004341(BTD)
LVE103080922(BTD)
OOR101278082(BTD)
DLE111168158(BTD)
PCAD102983963(BTD)
PSIU116753297(BTD)
ECB100063800(BTD)
EPZ103561484(BTD)
EAI106842762(BTD)
MYB102258405(BTD)
MYD102759604(BTD)
MMYO118668202(BTD)
MLF102419448(BTD)
MNA107542412(BTD)
PKL118715367(BTD)
HAI109395825(BTD)
DRO112309951(BTD)
SHON118997593(BTD)
AJM119048309(BTD)
PDIC114502076(BTD)
PHAS123830655(BTD)
MMF118633287(BTD)
RFQ117037188(BTD)
PALE102894216(BTD)
PGIG120582056(BTD)
PVP105288551 111739437(BTD)
RAY107508454(BTD)
MJV108398575(VNN1) 108403192(BTD)
TOD119256862(BTD)
SARA101555521(BTD)
LAV100663934(BTD)
TMU101354864
MDO100030538(BTD)
GAS123249200(BTD)
SHR100922840(BTD)
PCW110209057(BTD)
OAA100084040(BTD)
GGA420639(BTD)
PCOC116227086(BTD) 116240276
MGP100540232(BTD)
CJO107309167(BTD)
NMEL110394953(BTD)
APLA101796688(BTD) 101798228
ACYG106030251(BTD)
AFUL116486767(BTD)
TGU100226458(BTD)
LSR110474622(BTD)
SCAN103812912(BTD)
PMOA120502675(BTD)
OTC121339587(BTD)
PRUF121352913(BTD)
GFR102043957(BTD)
FAB101821386(BTD)
PHI102104565(BTD)
PMAJ107199918(BTD)
CCAE111923444(BTD)
CCW104689076(BTD)
CBRC103614134(BTD)
ETL114055684(BTD)
ZAB102075280(BTD)
ACHL103797008(BTD)
FPG101914603(BTD)
FCH102056176(BTD)
CLV102085390(BTD)
EGZ104126131(BTD)
NNI104013909(BTD)
PLET104623708(BTD)
PCRI104036901(BTD)
PCAO104045793(BTD)
ACUN113476796(BTD)
TALA104359643(BTD)
PADL103918399(BTD)
AFOR103906634(BTD)
ACHC115339769(BTD)
HALD104323793(BTD)
CCRI104156679(BTD)
CSTI104556663(BTD)
EHS104504847(BTD)
CMAC104483065(BTD)
MUI104542479(BTD)
FGA104072840(BTD)
GSTE104254419(BTD)
LDI104341838(BTD)
MNB103777184(BTD)
OHA104333320(BTD)
NNT104411675(BTD)
DPUB104307530(BTD)
PGUU104467522(BTD)
ACAR104529906(BTD)
AVIT104273902(BTD)
CVF104289893(BTD)
CUCA104059167(BTD)
AAM106483475(BTD)
AROW112977278(BTD)
NPD112957226(BTD)
TGT104568400(BTD)
DNE112985275(BTD)
SCAM104145078(BTD)
ASN112549578
AMJ102566286(BTD)
CPOO109310413(BTD)
GGN109291601(BTD)
PSS102458076(BTD)
CMY102946514(BTD)
CPIC101939105(BTD)
TST117872360(BTD)
CABI116837034(BTD)
MRV120398935(BTD)
ACS100556978(btd)
PVT110072153(BTD)
SUND121934088(BTD)
PBI103068246(BTD)
PMUR107282909(BTD)
CTIG120307312(BTD)
TSR106545056(BTD)
PGUT117655107(BTD)
VKO123033836(BTD)
PMUA114607098(BTD)
ZVI118092351(BTD)
STOW125441284(BTD)
XLA108718912(btd.L)
XTR100489727(btd)
NPR108803235(BTD)
RTEM120940232(BTD)
BBUF121002205(BTD)
BGAR122938308(BTD)
DRE555376(btd)
SRX107732456(btd)
SANH107694759(btd)
SGH107559753
CCAR109080426(btd)
CAUA113062563 113062564
MAMB125275859 125276131
IPU108256913(btd)
PHYP113536296(btd)
SMEO124375894(btd)
TFD113661654(btd)
AMEX103037138
EEE113590652(btd)
TRU101069377(btd)
TNGGSTEN00032985G001
LCO104939816 109139331 109139332
NCC104944686 104944699(btd)
CGOB115015920
ELY117263564 117264124 117264125 117264127 117264131
EFO125904495 125905085 125905086 125905087 125905088 125905089 125905092 125905093 125905095
PLEP121958319(btd)
SLUC116066869 116066871 118493288(btd)
ECRA117956338 117956339(btd)
ESP116701988
PFLV114567763 114567944 114568312
GAT120826662(btd)
PPUG119218862(btd)
MSAM119906734 119906832 119907789
CUD121523277 121523334 121523416 121524115 121524298 121524362
ALAT119014975 119014987
MZE101466121 101475752
ONL100694007 102082273(btd) 109194532 109197882 109198139 109198141 109200911 109200913 109200914 109204954
OAU116318428 116333647 116333669(btd) 116333671
OLA101173953
OML112136498 112136509
XMA102233822(btd)
XCO114155352(btd)
XHE116731274(btd)
PRET103472253 103472511
PFOR103134997 103135181
PLAI106936832(btd) 106943235
PMEI106922082 106922093
GAF122843529(btd)
CVG107085879
CTUL119785857(btd)
GMU124879401(btd)
NFU107383317
KMR108240453(btd)
ALIM106521953 106530461
NWH119425694(btd)
AOCE111573358(btd)
MCEP125019389(btd)
CSEM103394637(btd)
POV109642670(btd)
SSEN122786435(btd)
HHIP117770677 117770876 117770877
HSP118124941 118124942 118124943
LCF108877741 108877753
SDU111223068
SLAL111656913
XGL120786265(btd)
HCQ109527670(btd)
BPEC110175184
MALB109968104
BSPL114865773(btd)
SASA106570600 106588721 106588750
STRU115173883 115175361
OTW112240210(btd) 112264467
OMY110489374(btd) 110496519
OGO124011966 124012249 124043172
ONE115132671
SALP112074045(btd)
SNH120021968 120041045
CCLU121572271 121586635
ELS105012460(btd)
SFM108933388
PKI111846924(btd)
AANG118234546 118234547 118234548 118234549 118234550
LOC102695279(btd)
PSPA121315128(btd)
ARUT117394718(btd)
LCM102358398 102358664(BTD)
CMK103181262(btd)
RTP109911552 109933343
SPU575770
APLC110985242
DGR6565785
PTRU123518658
HAZT108668034
CSCU111631973 111642029
PTEP107449055 107449061
SDM118201733 118203125
PMAX117333923
OSN115226121
XEN124446359
 » show all
Reference
1  [PMID:14087327]
  Authors
KNAPPE J, BRUEMMER W, BIEDERBICK K.
  Title
[PURIFICATION AND PROPERTIES OF BIOTINIDASE FROM SWINE KIDNEY AND LACTOBACILLUS CASEI.]
  Journal
Biochem Z 338:599-613 (1963)
Reference
2  [PMID:13211594]
  Authors
THOMA RW, PETERSON WH.
  Title
The enzymatic degradation of soluble bound biotin.
  Journal
J Biol Chem 210:569-79 (1954)
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.12
IUBMB Enzyme Nomenclature: 3.5.1.12
ExPASy - ENZYME nomenclature database: 3.5.1.12
BRENDA, the Enzyme Database: 3.5.1.12
CAS: 9025-15-4

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