Entry
Name
choloylglycine hydrolase;
glycocholase;
bile salt hydrolase;
choloyltaurine hydrolase;
3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine amidohydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
glycocholate amidohydrolase
Reaction(IUBMB)
glycocholate + H2O = cholate + glycine [RN:
R05835 ]
Reaction(KEGG)
Substrate
Product
Comment
Also acts on the 3alpha,12alpha-dihydroxy-derivative, and on choloyl-taurine.
History
EC 3.5.1.24 created 1972
Pathway
ec00120 Primary bile acid biosynthesis
ec00121 Secondary bile acid biosynthesis
Orthology
K01442 choloylglycine hydrolase
Genes
ADP : NCTC12871_00060(cbh)
LSS : NCTC12082_00361(yxeI)
LADL : NCTC12735_00521(yxeI)
HCL : NCTC13205_00078(cbh)
DMS : E8L03_12800 E8L03_19155
OPS : A8A54_06885 A8A54_20325
APRA : G3A50_02730 G3A50_18980
METG : HT051_01810 HT051_01815 HT051_02635
MEY : TM49_03610 TM49_20510
MAAD : AZF01_03040 AZF01_05250 AZF01_16710
MMED : Mame_02037(cbh_1) Mame_02196(cbh_2)
MLUT : JET14_06540 JET14_18915
LMOC : LMOSLCC5850_2128(bsh)
LMW : LMOSLCC2755_2129(bsh)
LMX : LMOSLCC2372_2133(bsh)
LMZ : LMOSLCC2482_2125(bsh)
LMON : LMOSLCC2376_2021(bsh)
LMOS : LMOSLCC7179_2038(bsh)
LMOO : LMOSLCC2378_2091(bsh)
LMOY : LMOSLCC2479_2130(bsh)
LMOT : LMOSLCC2540_2160(bsh)
LMOA : LMOATCC19117_2087(bsh)
LJF : FI9785_1052 FI9785_854
LAC : LBA0892(bshA) LBA1078(bshB)
LAF : SD55_0913(bshA) SD55_1090(bshB)
LAI : LAC30SC_04505 LAC30SC_05780
LAY : LAB52_04465 LAB52_05565
EFD : EFD32_0436 EFD32_1847(cbh1) EFD32_1916(cbh3)
EFC : EFAU004_01766 EFAU004_01892
EFAU : EFAU085_01787 EFAU085_01918
EFU : HMPREF0351_11722(cbh2) HMPREF0351_11857(cbh3)
EFM : M7W_1078 M7W_1119 M7W_1156
ECEC : NCTC12421_02229(cbh_1) NCTC12421_02387(cbh_2)
PBIF : KXZ80_01940 KXZ80_16485(bsh)
AMUO : KWG62_00310(bsh) KWG62_12690(bsh)
TUR : AT726_06045 AT726_08870
TSG : HLK68_04930 HLK68_07680 HLK68_08040
NAD : NCTC11293_00282(yxeI)
RCR : NCTC10994_01103(cbh)
FVA : FV113G1_28320 FV113G1_29080
BOA : Bovatus_02350(cbh_2)
AIT : AI2BBH_10610 AI2BBH_19080
FYA : KMW28_05260 KMW28_06095
» show all
Taxonomy
Reference
Authors
Nair PP, Gordon M, Reback J
Title
The enzymatic cleavage of the carbon-nitrogen bond in 3-alpha, 7-alpha, 12-alpha-trihydroxy-5-beta-cholan-24-oylglycine.
Journal
J Biol Chem 242:7-11 (1967)
Reference
Authors
Stellwag EJ, Hylemon PB.
Title
Purification and characterization of bile salt hydrolase from Bacteroides fragilis subsp. fragilis.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.24
ExPASy - ENZYME nomenclature database: 3.5.1.24