KEGG   ENZYME: 3.5.1.24
Entry
EC 3.5.1.24                 Enzyme                                 

Name
choloylglycine hydrolase;
glycocholase;
bile salt hydrolase;
choloyltaurine hydrolase;
3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine amidohydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
glycocholate amidohydrolase
Reaction(IUBMB)
glycocholate + H2O = cholate + glycine [RN:R05835]
Reaction(KEGG)
Substrate
glycocholate [CPD:C01921];
H2O [CPD:C00001]
Product
cholate [CPD:C00695];
glycine [CPD:C00037]
Comment
Also acts on the 3alpha,12alpha-dihydroxy-derivative, and on choloyl-taurine.
History
EC 3.5.1.24 created 1972
Pathway
ec00120  Primary bile acid biosynthesis
ec00121  Secondary bile acid biosynthesis
ec01100  Metabolic pathways
Orthology
K01442  choloylglycine hydrolase
Genes
EUN: UMNK88_pK8826
ECY: ECSE_P3-0046
END: A4308_12525
ADP: NCTC12871_00060(cbh)
VHA: VIBHAR_02193
VCA: M892_02375
VHR: AL538_01075
VOW: A9237_00885
VRO: BSZ04_16345
VSC: VSVS12_01375
VFI: VF_A0241
SHL: Shal_0591
SWD: Swoo_2365
LOK: Loa_02519
LSS: NCTC12082_00361(yxeI)
LADL: NCTC12735_00521(yxeI)
FPH: Fphi_1659
FPT: BZ13_337
FPI: BF30_1937
FPM: LA56_512
FPX: KU46_1638
FPJ: LA02_1356
HMAR: HVMH_1071
HCL: NCTC13205_00078(cbh)
SUN: SUN_1118
DPS: DP1182
DBR: Deba_2031
BME: BMEI0543
BMEL: DK63_882
BMEE: DK62_2064
BMF: BAB1_1488
BABO: DK55_1449
BABR: DO74_441
BABT: DK49_1206
BABB: DK48_671
BABU: DK53_1432
BABS: DK51_27
BABC: DO78_1353
BMS: BR1468
BSZ: DK67_843
BOV: BOV_1422
BCAR: DK60_1494
BCAS: DA85_07030
BMR: BMI_I1480
BPP: BPI_I1520
BPV: DK65_2014
OAN: Oant_1703
OAH: DR92_1186
MSL: Msil_3557
MCG: GL4_0503
BLAG: BLTE_23450(cbaH)
MMED: Mame_02037(cbh_1) Mame_02196(cbh_2)
PSF: PSE_3526
LMO: lmo2067
LMOC: LMOSLCC5850_2128(bsh)
LMOD: LMON_2137
LMOW: AX10_04575
LMOQ: LM6179_2838(cbh)
LMR: LMR479A_2178(cbh)
LMOM: IJ09_14875
LMF: LMOf2365_2098(cbH)
LMOG: BN389_20960(cbh)
LMP: MUO_10605
LMOL: LMOL312_2080(bsh)
LMOX: AX24_08170
LMQ: LMM7_2157(bsh)
LML: lmo4a_2118(bsh)
LMS: LMLG_0361
LMW: LMOSLCC2755_2129(bsh)
LMX: LMOSLCC2372_2133(bsh)
LMZ: LMOSLCC2482_2125(bsh)
LMON: LMOSLCC2376_2021(bsh)
LMOS: LMOSLCC7179_2038(bsh)
LMOO: LMOSLCC2378_2091(bsh)
LMOY: LMOSLCC2479_2130(bsh)
LMOT: LMOSLCC2540_2160(bsh)
LMOA: LMOATCC19117_2087(bsh)
LMOK: CQ02_10710
LSG: lse_2056(bsh)
LIV: LIV_2050(bsh)
LAC: LBA0892(bshA) LBA1078(bshB)
LAF: SD55_0913(bshA) SD55_1090(bshB)
LGA: LGAS_0959
LHL: LBHH_1220(cbh)
LHH: LBH_0786(cbh)
LCR: LCRIS_00906(cbh)
LPL: lp_3536(bsh1)
LPJ: JDM1_2822(bsh1)
LPT: zj316_0150(cbh)
LPS: LPST_C2886(bsh1)
LPZ: Lp16_2762
LRE: Lreu_0730
LRF: LAR_0701
LRT: LRI_1179
LSL: LSL_1801
LSI: HN6_01574
EFA: EF0521
EFL: EF62_0879(cbh)
EFD: EFD32_0436 EFD32_1847(cbh1) EFD32_1916(cbh3)
EFS: EFS1_0461
ECAS: ECBG_02025
EMU: EMQU_1455
EDU: LIU_08430
ECEC: NCTC12421_02229(cbh_1) NCTC12421_02387(cbh_2)
CML: BN424_2909(cbH)
CPE: CPE0709
CPF: CPF_0705(cbh)
CBB: CLD_2374
CBF: CLI_2250
CBM: CBF_2236
CLT: CM240_1766(cbh)
PHX: KGNDJEFE_01093(cbh)
ELM: ELI_1322
CCHO: CCHOA_10235(cbh)
NAD: NCTC11293_00282(yxeI)
RRT: 4535765_04107(cbh)
RCR: NCTC10994_01103(cbh)
MOY: CVS54_00163(cbh)
BLO: BL0796
BLJ: BLD_0536(cbaH)
BLN: Blon_1453
BLON: BLIJ_1499
BLF: BLIF_0937
BLL: BLJ_0948
BLB: BBMN68_536(cbaH)
BLM: BLLJ_0817
BLG: BIL_10200
BAD: BAD_0856
BADL: BADO_0911
BLA: BLA_1379
BLC: Balac_0863(bsh)
BLT: Balat_0863(bsh)
BBB: BIF_00207
BBC: BLC1_0823
BLV: BalV_0829(bsh)
BLW: W7Y_0865
BLS: W91_0886
BANI: Bl12_0805
BANL: BLAC_04390
BANM: EN10_04380
BDE: BDP_1106(cbh)
BDN: BBDE_1060
BBP: BBPR_0850(cbh)
BBI: BBIF_0879(cbh)
BBF: BBB_0854(cbh)
BBRU: Bbr_0971(cbh)
BBRE: B12L_0890
BBRV: B689b_0983
BBRJ: B7017_1020
BBRC: B7019_1045
BBRN: B2258_0935
BBRS: BS27_0970(cbh)
BBRD: BBBR_0919
BTP: D805_0402
BKS: BBKW_0991
BCAT: BBCT_0907
BPSP: AH67_04680
BPSC: BBPC_0908
ROL: CA51_28730(cbh)
PCOR: KS4_01870(cbh)
BFS: BF9343_1433(cbh)
BXY: BXY_10230
BOA: Bovatus_02350(cbh_2)
BVU: BVU_2699
PDI: BDI_1550
AFD: Alfi_1795
FLM: MY04_4579
WIN: WPG_3359
MFC: BRM9_1563
MFI: DSM1535_2252(cbh)
MCUB: MCBB_0969(cbh)
 » show all
Reference
1  [PMID:6016335]
  Authors
Nair PP, Gordon M, Reback J
  Title
The enzymatic cleavage of the carbon-nitrogen bond in 3-alpha, 7-alpha, 12-alpha-trihydroxy-5-beta-cholan-24-oylglycine.
  Journal
J Biol Chem 242:7-11 (1967)
Reference
2  [PMID:10993]
  Authors
Stellwag EJ, Hylemon PB.
  Title
Purification and characterization of bile salt hydrolase from Bacteroides fragilis subsp. fragilis.
  Journal
Biochim Biophys Acta 452:165-76 (1976)
DOI:10.1016/0005-2744(76)90068-1
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.24
IUBMB Enzyme Nomenclature: 3.5.1.24
ExPASy - ENZYME nomenclature database: 3.5.1.24
BRENDA, the Enzyme Database: 3.5.1.24
CAS: 37289-07-9

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