KEGG ENZYME: 3.5.1.24

ENZYME: 3.5.1.24

Entry

EC 3.5.1.24                 Enzyme

Name

choloylglycine hydrolase;
glycocholase;
bile salt hydrolase;
choloyltaurine hydrolase;
3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine amidohydrolase

Class

Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides

Sysname

glycocholate amidohydrolase

Reaction(IUBMB)

glycocholate + H2O = cholate + glycine [RN:R05835]

Reaction(KEGG)

R05835;
(other) R02797 R03975 R03977 R04486 R04487

Substrate

glycocholate [CPD:C01921];
H2O [CPD:C00001]

Product

cholate [CPD:C00695];
glycine [CPD:C00037]

Comment

Also acts on the 3alpha,12alpha-dihydroxy-derivative, and on choloyl-taurine.

History

EC 3.5.1.24 created 1972

Pathway

ec00120

Primary bile acid biosynthesis

ec00121

Secondary bile acid biosynthesis

ec01100

Metabolic pathways

Orthology

K01442

choloylglycine hydrolase

Genes

EUN:	UMNK88_pK8826

ECY:	ECSE_P3-0046

END:	A4308_12525

ADP:	NCTC12871_00060(cbh)

VHA:	VIBHAR_02193

VCA:	M892_02375

VHR:	AL538_01075

VOW:	A9237_00885

VRO:	BSZ04_16345

VSC:	VSVS12_01375

VSH:	BSZ05_14500

VAF:	D1115_07550

VFI:

VF_A0241

VFM:	VFMJ11_A0276

PDS:	CAY62_18360

SHL:

Shal_0591

SWD:

Swoo_2365

SKH:	STH12_02744

THAP:

FNC98_05995

HJA:	BST95_01440

LOK:

Loa_02519

LIB:	E4T55_08905

LSS:	NCTC12082_00361(yxeI)

LADL:

NCTC12735_00521(yxeI)

FPH:

Fphi_1659

FPT:

BZ13_337

FPI:

BF30_1937

FPM:

LA56_512

FPX:

KU46_1638

FPJ:

LA02_1356

FRT:	F7308_1470

FMI:	F0R74_02775

FSR:	KQR59_04385

AFRI:

E3E15_03970

HTR:	EPV75_08300

HMAR:

HVMH_1071

THIO:

AYJ59_05605

TSY:	THSYN_15570

HCS:	FF32_04300

HAG:	BB497_10035

HALK:

CUU95_07905

NBA:	CUN60_05670

PEW:	KZJ38_25220

PTRP:

DCO17_08270

PUD:	G9Q38_03850

AAQU:

D3M96_12145

PHN:	PAEH1_09890

BOZ:	DBV39_15650

CKE:	B5M06_12040

HCL:	NCTC13205_00078(cbh)

SPAL:

FM071_02045

NSA:	Nitsa_1273

SUN:

SUN_1118

DSD:	GD606_11185

DCB:	C3Y92_01835

DMS:	E8L03_12800 E8L03_19155

PSEL:

GM415_09795

DSX:	GD604_14285

PBIZ:

LWC08_15255

DPS:

DP1182

DBK:	DGMP_22020(cbaH)

DWD:	DSCW_29670

DBR:

Deba_2031

KMN:	HW532_10045

KAI:	K32_37770 K32_46880

BME:

BMEI0543

BMEL:

DK63_882

BMI:	BMEA_A1518

BMZ:	BM28_A1479

BMG:	BM590_A1467

BMW:	BMNI_I1418

BMEE:

DK62_2064

BMF:

BAB1_1488

BMB:	BruAb1_1463

BMC:	BAbS19_I13900

BAA:	BAA13334_I01625

BABO:

DK55_1449

BABR:

DO74_441

BABT:

DK49_1206

BABB:

DK48_671

BABU:

DK53_1432

BABS:

DK51_27

BABC:

DO78_1353

BMS:

BR1468

BSI:	BS1330_I1462

BSF:	BSS2_I1426

BSUI:

BSSP1_I1486

BSUP:

BSPT1_I1500

BSUV:

BSPT2_I1483

BSUC:

BSSP2_I1489

BMT:	BSUIS_A1521

BSZ:

DK67_843

BSV:	BSVBI22_A1462

BSW:	IY71_07215

BSG:	IY72_06965

BOV:

BOV_1422

BCS:	BCAN_A1503

BSK:	BCA52141_I2834

BOL:	BCOUA_I1468

BCAR:

DK60_1494

BCAS:

DA85_07030

BMR:

BMI_I1480

BPP:

BPI_I1520

BPV:

DK65_2014

BCET:

V910_100537

BVL:	BF3285c1_0073

BRU:	BFS01_07065

BRJ:	BKD03_14560

OIN:	IAR37_14585

BIO:	BR141012304_11248

OAN:

Oant_1703

OAH:

DR92_1186

OPS:	A8A54_06885 A8A54_20325

OCH:	CES85_1617

OCR:	HGK82_07795

OCL:	GTN27_08150

PSCQ:

KHQ08_06870

STAR:

G3545_07605

ANC:	GBB76_05275

APRA:

G3A50_02730 G3A50_18980

MSL:

Msil_3557

MTUN:

MTUNDRAET4_3160

MLG:	CWB41_15845

MCG:

GL4_0503

METG:

HT051_01810 HT051_01815 HT051_02635

BLAG:

BLTE_23450(cbaH)

MHEY:

H2LOC_004005

MEY:	TM49_03610 TM49_20510

MAAD:

AZF01_03040 AZF01_05250 AZF01_16710

MMED:

Mame_02037(cbh_1) Mame_02196(cbh_2)

MLUT:

JET14_06540 JET14_18915

PSIN:

CAK95_26095

NOH:	G5V57_14685

PSF:

PSE_3526

SIW:	GH266_09320

ACUT:

MRB58_00230

PRD:	F7984_02150

LMO:

lmo2067

LMN:	LM5578_2268

LMY:	LM5923_2219

LMT:	LMRG_01217

LMOC:

LMOSLCC5850_2128(bsh)

LMOD:

LMON_2137

LMOW:

AX10_04575

LMOQ:

LM6179_2838(cbh)

LMR:	LMR479A_2178(cbh)

LMOM:

IJ09_14875

LMF:	LMOf2365_2098(cbH)

LMC:	Lm4b_02088

LMOG:

BN389_20960(cbh)

LMP:

MUO_10605

LMOL:

LMOL312_2080(bsh)

LMOJ:

LM220_01025

LMOZ:

LM1816_13317

LMOX:

AX24_08170

LMH:	LMHCC_0491

LMQ:	LMM7_2157(bsh)

LML:	lmo4a_2118(bsh)

LMG:	LMKG_00256

LMS:

LMLG_0361

LMJ:	LMOG_01160

LMW:	LMOSLCC2755_2129(bsh)

LMX:	LMOSLCC2372_2133(bsh)

LMZ:	LMOSLCC2482_2125(bsh)

LMON:

LMOSLCC2376_2021(bsh)

LMOS:

LMOSLCC7179_2038(bsh)

LMOO:

LMOSLCC2378_2091(bsh)

LMOY:

LMOSLCC2479_2130(bsh)

LMOT:

LMOSLCC2540_2160(bsh)

LMOA:

LMOATCC19117_2087(bsh)

LMOK:

CQ02_10710

LMV:	Y193_05195

LSG:	lse_2056(bsh)

LIV:	LIV_2050(bsh)

LII:	JL52_10765

LIW:	AX25_10935

LMAR:

LAX80_010100(bsh)

PKU:	AUO94_08995

PFAE:

AJGP001_08295

SPAT:

A0O21_03545

SCHJ:

DDV21_007255

LJO:	LJ_1147 LJ_1412

LJF:	FI9785_1052 FI9785_854

LJH:	LJP_0828 LJP_1011c

LJN:	T285_05035

LAC:	LBA0892(bshA) LBA1078(bshB)

LAD:	LA14_0914 LA14_1092

LAF:	SD55_0913(bshA) SD55_1090(bshB)

LGA:

LGAS_0959

LHL:	LBHH_1220(cbh)

LHH:	LBH_0786(cbh)

LCR:	LCRIS_00906(cbh)

LAM:	LA2_04690 LA2_06130

LAI:	LAC30SC_04505 LAC30SC_05780

LAY:	LAB52_04465 LAB52_05565

LPW:	LpgJCM5343_07940

LUU:	H4B44_06670

LPL:	lp_3536(bsh1)

LPJ:	JDM1_2822(bsh1)

LPT:	zj316_0150(cbh)

LPS:	LPST_C2886(bsh1)

LPR:	LBP_cg2864

LPZ:

Lp16_2762

LPB:	SH83_14665

LARG:

LPA65_15095

LRE:

Lreu_0730

LRF:

LAR_0701

LRT:

LRI_1179

LRR:	N134_04300

LMU:	LBLM1_10135

LVA:	LV515_03785

LFN:	LF145_03730

LPAS:

KZE55_04905(bsh)

LSL:

LSL_1801

LSI:

HN6_01574

LSJ:	LSJ_0788 LSJ_2111

LAGL:

BEN83_06190

LANI:

FAX13_01030

LMUR:

CPS94_09990

EFA:

EF0521

EFL:	EF62_0879(cbh)

EFD:	EFD32_0436 EFD32_1847(cbh1) EFD32_1916(cbh3)

EFS:

EFS1_0461

EFN:	DENG_00539

EFC:	EFAU004_01766 EFAU004_01892

EFAU:

EFAU085_01787 EFAU085_01918

EFU:	HMPREF0351_11722(cbh2) HMPREF0351_11857(cbh3)

EFM:	M7W_1078 M7W_1119 M7W_1156

EFT:	M395_05290

EHR:	EHR_09940 EHR_11510

ECAS:

ECBG_02025

EMU:

EMQU_1455

EDU:

LIU_08430

EGA:	AL523_11285

ETH:	CK496_06880

ELAC:

I4Q40_04945

ECEC:

NCTC12421_02229(cbh_1) NCTC12421_02387(cbh_2)

EIE:	ENLAB_30050

VFV:	K5K99_06205

CML:	BN424_2909(cbH)

CPE:

CPE0709

CPF:	CPF_0705(cbh)

CBB:

CLD_2374

CBF:

CLI_2250

CBM:

CBF_2236

CBJ:	H04402_02216

CLT:	CM240_1766(cbh)

CLD:	CLSPO_c22400

CNN:	CNEO_1150(cbh)

PBIF:

KXZ80_01940 KXZ80_16485(bsh)

PFAA:

MM59RIKEN_19130

VFA:	MM35RIKEN_11690

CLE:	Clole_2713

CEW:	EKH84_16375

WCP:	H9Q76_10825

SSUN:

H9Q77_06840

ROC:	HF520_07105

PHX:	KGNDJEFE_01093(cbh)

FWA:	DCMF_14235

ELM:

ELI_1322

EMT:	CPZ25_011475

ELIM:

B2M23_16225

CMIU:

B1H56_09150

AARG:

Aargi30884_20240

ABSI:

A9CBEGH2_18120

AMUO:

KWG62_00310(bsh) KWG62_12690(bsh)

ALLO:

KWG61_09625

TUR:	AT726_06045 AT726_08870

TSG:	HLK68_04930 HLK68_07680 HLK68_08040

CCHO:

CCHOA_10235(cbh)

NAD:	NCTC11293_00282(yxeI)

RHQ:	IM25_02745

RRT:	4535765_04107(cbh)

RCR:	NCTC10994_01103(cbh)

DIZ:	CT688_16215

DPC:	A6048_10685

MPAL:

BO218_13760

MWA:	E4K62_09545

MOY:	CVS54_00163(cbh)

MSF:	IT882_10130

MCAW:

F6J84_01105

MLZ:	F6J85_09165

MICS:

C1N74_13405

MYL:	C3E77_00485

SALD:

FVA74_05805

MANT:

BHD05_03695

NOI:	FCL41_09945

AEZ:	C3E78_15230

AEF:	GEV26_07670

BLO:

BL0796

BLJ:	BLD_0536(cbaH)

BLN:

Blon_1453

BLON:

BLIJ_1499

BLF:

BLIF_0937

BLL:

BLJ_0948

BLB:	BBMN68_536(cbaH)

BLM:

BLLJ_0817

BLK:	BLNIAS_01547

BLG:

BIL_10200

BLZ:	BLGT_05070

BLX:	GS08_04925

BAD:

BAD_0856

BADL:

BADO_0911

BADO:

BBMN23_0992

BLA:

BLA_1379

BLC:	Balac_0863(bsh)

BLT:	Balat_0863(bsh)

BBB:

BIF_00207

BBC:

BLC1_0823

BNM:	BALAC2494_00268

BLV:	BalV_0829(bsh)

BLW:

W7Y_0865

BLS:

W91_0886

BANI:

Bl12_0805

BANL:

BLAC_04390

BNI:	BANAN_04270

BANM:

EN10_04380

BDE:	BDP_1106(cbh)

BDN:

BBDE_1060

BBP:	BBPR_0850(cbh)

BBI:	BBIF_0879(cbh)

BBF:	BBB_0854(cbh)

BBV:	HMPREF9228_0895

BBRU:

Bbr_0971(cbh)

BBRE:

B12L_0890

BBRV:

B689b_0983

BBRJ:

B7017_1020

BBRC:

B7019_1045

BBRN:

B2258_0935

BBRS:

BS27_0970(cbh)

BBRD:

BBBR_0919

BTP:

D805_0402

BKA:	AH68_05530

BKS:

BBKW_0991

BCAT:

BBCT_0907

BPSP:

AH67_04680

BPSC:

BBPC_0908

BCHO:

BcFMB_07045

AHAT:

ADCFC_10310

SYNC:

CB0101_03470

SNG:	SNE_A17210

RUFI:

K0V07_01085

RML:	FF011L_31620

ROL:	CA51_28730(cbh)

GMR:	GmarT_23860

ULI:	ETAA1_63420

PCOR:

KS4_01870(cbh)

SCOR:

J3U87_31995

FVA:	FV113G1_28320 FV113G1_29080

FUL:	C4N20_09600

FMO:	C4N19_07925

CSOM:

MKD34_01085

BFS:	BF9343_1433(cbh)

BFB:	VU15_14395

BXY:

BXY_10230

BOA:	Bovatus_02350(cbh_2)

BCAE:

A4V03_14545

BIS:	DXK01_017585

BUN:	Bun01g_25460

BEG:	INE88_03395(cbh_1)

BVU:

BVU_2699

BSA:	Bacsa_1560

BDO:	EL88_06530

BDH:	GV66_14440

PCOP:

I6J50_16520

DYS:	G7050_12935

PDI:

BDI_1550

PARC:

CI960_12015

PGOL:

K6V26_16620

BVS:	BARVI_00680

COPR:

Cop2CBH44_13780

BVIR:

I6J59_00230

AFD:

Alfi_1795

ACOU:

A5CBH24_17950

ADA:	A5CPEGH6_23320

AIT:	AI2BBH_10610 AI2BBH_19080

COY:	HF329_17165

FLM:

MY04_4579

FYA:	KMW28_05260 KMW28_06095

WIN:

WPG_3359

PRS:	B9H02_11275

METV:

K4897_06545(bsh)

MFC:

BRM9_1563

MFI:	DSM1535_2252(cbh)

MCUB:

MCBB_0969(cbh)

MSUB:

BK009_01470

METN:

BK008_09455

METO:

CIT02_03540

MEUZ:

KRP56_01830

» show all

Reference

1 [PMID:6016335]

Authors

Nair PP, Gordon M, Reback J

Title

The enzymatic cleavage of the carbon-nitrogen bond in 3-alpha, 7-alpha, 12-alpha-trihydroxy-5-beta-cholan-24-oylglycine.

Journal

J Biol Chem 242:7-11 (1967)

Reference

2 [PMID:10993]

Authors

Stellwag EJ, Hylemon PB.

Title

Purification and characterization of bile salt hydrolase from Bacteroides fragilis subsp. fragilis.

Journal

Biochim Biophys Acta 452:165-76 (1976)
DOI:10.1016/0005-2744(76)90068-1

Other DBs

ExplorEnz - The Enzyme Database:

3.5.1.24

IUBMB Enzyme Nomenclature:

3.5.1.24

ExPASy - ENZYME nomenclature database:

3.5.1.24

BRENDA, the Enzyme Database:

3.5.1.24

CAS:	37289-07-9

DBGET integrated database retrieval system