KEGG   ENZYME: 3.5.2.20
Entry
EC 3.5.2.20                 Enzyme                                 
Name
isatin hydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amides
Sysname
isatin amidohydrolase
Reaction(IUBMB)
isatin + H2O = isatinate [RN:R11181]
Reaction(KEGG)
R11181
Substrate
isatin [CPD:C11129];
H2O [CPD:C00001]
Product
isatinate [CPD:C21155]
Comment
Requires Mn2+. This enzyme, found in several bacterial species, is involved in the degradation of indole-3-acetic acid.
History
EC 3.5.2.20 created 2014
Orthology
K01475  isatin hydrolase
Genes
MLOmlr5444
MLNA9174_00460
MCIMesci_0097
MOPMesop_0095
MAMMesau_00095
MAMOA6B35_07205
MESWA9K65_000460
MESMEJ066_10680
MHUAMCHK_6468
MJREB229_00465
MERDEB233_00585
MESRFGU64_14930
HOEIMCC20628_01387
AAKAA2016_0631
NIYFQ775_20805
NKIKW403_08075
ARUIG6M88_19260
AVQHRR99_18905
RTRRTCIAT899_CH14200
RJGCCGE525_16410
RHRCKA34_17105
NGLRG1141_CH38180
NGGRG540_CH38830
NEOCYG48_14400
OANOant_4027
OAHDR92_4228
OCRHGK82_22890
OCLGTN27_15015
DEQXM25_21530
YTIFNA67_02980
PLEOOHA_1_04291(kynB)
MMEDMame_00264
NOHG5V57_08305
PSFPSE_p0022
LAPACP90_18835
LABRCHH27_27205
LAGGB0E33_02605
CEHCEW89_04495
YPACCEW88_22200
SUAMBOO69_18165
SULZC1J03_22255
SMEDJNX03_20175
SINLDSM14862_03887(kynB_2)
RMBK529_021595
GEHHYN69_07175
PALWPSAL_021610
NSMJO391_13035
RUBGBA63_16870 GBA63_17100
RMARGBA65_08610
 » show all
Reference
1
  Authors
Sommer, M.R. and Jochimsen, B.
  Title
Identification of enzymes involved in indole-3-acetic acid degradation.
  Journal
Plant Soil 186:143-149 (1996)
Reference
2  [PMID:24917679]
  Authors
Bjerregaard-Andersen K, Sommer T, Jensen JK, Jochimsen B, Etzerodt M, Morth JP
  Title
A proton wire and water channel revealed in the crystal structure of isatin hydrolase.
  Journal
J Biol Chem 289:21351-9 (2014)
DOI:10.1074/jbc.M114.568824
Other DBs
ExplorEnz - The Enzyme Database: 3.5.2.20
IUBMB Enzyme Nomenclature: 3.5.2.20
ExPASy - ENZYME nomenclature database: 3.5.2.20
BRENDA, the Enzyme Database: 3.5.2.20

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