| Entry |
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|---|
| Name |
dimethylargininase;
dimethylarginine dimethylaminohydrolase;
NG,NG-dimethylarginine dimethylaminohydrolase;
NG,NG-dimethyl-L-arginine dimethylamidohydrolase;
omega,omega'-di-N-methyl-L-arginine dimethylamidohydrolase;
Nomega,Nomega'-methyl-L-arginine dimethylamidohydrolase (incorrect)
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| Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amidines
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| Sysname |
Nomega,Nomega'-dimethyl-L-arginine dimethylamidohydrolase
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| Reaction(IUBMB) |
Nomega,Nomega'-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline [RN: R02513]
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| Reaction(KEGG) |
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| Substrate |
Nomega,Nomega-dimethyl-L-arginine [CPD: C03626];
H2O [CPD: C00001]
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| Product |
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| Comment |
Also acts on Nomega-methyl-L-arginine.
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| History |
EC 3.5.3.18 created 1992
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| Orthology |
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| Genes |
| HSA: | 23564(DDAH2) 23576(DDAH1) |
| PTR: | 736613(DDAH1) 745121(DDAH2) |
| PPS: | 100970662(DDAH2) 100977375(DDAH1) |
| GGO: | 101145079(DDAH2) 101145856(DDAH1) |
| PON: | 100445894(DDAH1) 100456957(DDAH2) |
| NLE: | 100590781(DDAH2) 100592733(DDAH1) |
| HMH: | 116460278(DDAH2) 116469826(DDAH1) |
| MCC: | 711395(DDAH1) 716356(DDAH2) |
| MCF: | 102117010(DDAH2) 102134245(DDAH1) |
| MTHB: | 126943305 126953132 |
| MNI: | 105482769(DDAH1) 105497616(DDAH2) |
| CSAB: | 103221752(DDAH2) 103224515(DDAH1) |
| CATY: | 105573438(DDAH2) 105593583(DDAH1) |
| TGE: | 112619486(DDAH1) 112622150(DDAH2) |
| MLEU: | 105541194(DDAH1) 105554181(DDAH2) |
| RRO: | 104677506(DDAH1) 104678139(DDAH2) |
| RBB: | 108514733(DDAH1) 108520234(DDAH2) |
| TFN: | 117086954(DDAH2) 117092186(DDAH1) |
| PTEH: | 111523916(DDAH2) 111540220(DDAH1) |
| CANG: | 105513746(DDAH2) 105521788(DDAH1) |
| CJC: | 100404013(DDAH2) 100414415(DDAH1) |
| SBQ: | 101041581(DDAH1) 101052990(DDAH2) |
| CIMI: | 108283484(DDAH1) 108299831(DDAH2) |
| CSYR: | 103267196(DDAH1) 103270166(DDAH2) |
| MMUR: | 105858113(DDAH2) 105861776(DDAH1) |
| LCAT: | 123631743(DDAH2) 123635458(DDAH1) |
| PCOQ: | 105817887(DDAH2) 105823879(DDAH1) |
| OGA: | 100941248(DDAH2) 100962016(DDAH1) |
| MMU: | 51793(Ddah2) 69219(Ddah1) |
| MCAL: | 110283857(Ddah2) 110290988(Ddah1) |
| MPAH: | 110319974(Ddah1) 110335639(Ddah2) |
| RNO: | 294239(Ddah2) 64157(Ddah1) |
| MCOC: | 116074329(Ddah2) 116093909(Ddah1) |
| ANU: | 117706788(Ddah1) 117724563(Ddah2) |
| MUN: | 110560099(Ddah2) 110565331(Ddah1) |
| CGE: | 100761676(Ddah2) 100767722(Ddah1) |
| MAUA: | 101826685(Ddah2) 101844324(Ddah1) |
| PROB: | 127224336(Ddah2) 127229812(Ddah1) |
| PLEU: | 114698281(Ddah1) 114705880(Ddah2) |
| MORG: | 121435291(Ddah2) 121447801(Ddah1) |
| MFOT: | 126494888 126512397 |
| AAMP: | 119800738(Ddah1) 119822501(Ddah2) |
| NGI: | 103724432(Ddah2) 103728109(Ddah1) |
| HGL: | 101703578(Ddah2) 101712219(Ddah1) |
| CPOC: | 100720724(Ddah2) 100729503(Ddah1) |
| CCAN: | 109694564(Ddah2) 109695039(Ddah1) |
| DORD: | 105987050(Ddah1) 105997074(Ddah2) |
| DSP: | 122105667(Ddah1) 122111485(Ddah2) |
| NCAR: | 124960114 124989506 |
| OPI: | 101521596(DDAH2) 101525341(DDAH1) |
| TUP: | 102473164(DDAH2) 102490171(DDAH1) |
| CFA: | 474846(DDAH2) 490182(DDAH1) |
| CLUD: | 112640958(DDAH1) 112641312(DDAH2) |
| VVP: | 112913607(DDAH2) 112924491(DDAH1) |
| VLG: | 121486653(DDAH1) 121491888(DDAH2) |
| AML: | 100468383(DDAH2) 100473269(DDAH1) |
| UMR: | 103662954(DDAH1) 103682299(DDAH2) |
| UAH: | 113243755(DDAH2) 113254466(DDAH1) |
| UAR: | 123790996(DDAH2) 123795257(DDAH1) |
| MPUF: | 101676117(DDAH2) 101683455(DDAH1) |
| NVS: | 122900148(DDAH1) 122911573(DDAH2) |
| ORO: | 101374468(DDAH2) 101385744(DDAH1) |
| EJU: | 114208488(DDAH1) 114222140(DDAH2) |
| ZCA: | 113910364(DDAH1) 113927742(DDAH2) |
| MLX: | 118019204(DDAH1) 118027328(DDAH2) |
| NSU: | 110580443(DDAH1) 110586825(DDAH2) |
| FCA: | 101089769(DDAH2) 101099817(DDAH1) |
| PYU: | 121022365(DDAH2) 121027402(DDAH1) |
| PCOO: | 112848662(DDAH1) 112853640(DDAH2) |
| PBG: | 122478289(DDAH2) 122480720(DDAH1) |
| LRUF: | 124516509 124528103 |
| PTG: | 102951655(DDAH2) 102965770(DDAH1) |
| PPAD: | 109246202(DDAH1) 109260551(DDAH2) |
| AJU: | 106973317(DDAH1) 106983973(DDAH2) |
| HHV: | 120221922(DDAH2) 120241660(DDAH1) |
| BTA: | 537391(DDAH1) 540386(DDAH2) |
| BOM: | 102273960(DDAH1) 102284073(DDAH2) |
| BIU: | 109556118 109577319(DDAH2) |
| BBUB: | 102397847(DDAH1) 102413067(DDAH2) |
| BBIS: | 104983790(DDAH2) 105003271(DDAH1) |
| CHX: | 102179431(DDAH2) 102188184(DDAH1) |
| OAS: | 101113635(DDAH1) 101118391(DDAH2) |
| ODA: | 120856927(DDAH1) 120870556(DDAH2) |
| CCAD: | 122429314(DDAH2) 122436752(DDAH1) |
| SSC: | 100153814(DDAH1) 110261496(DDAH2) |
| CFR: | 102515493(DDAH2) 102522940(DDAH1) |
| CBAI: | 105074057(DDAH2) 105075480(DDAH1) |
| CDK: | 105087455(DDAH2) 105095054(DDAH1) |
| VPC: | 102525338(DDAH2) 102545821(DDAH1) |
| BACU: | 103000902(DDAH2) 103016110(DDAH1) |
| LVE: | 103075172(DDAH1) 103076378(DDAH2) |
| OOR: | 101279934(DDAH1) 101286266(DDAH2) |
| DLE: | 111170715(DDAH2) 111178365(DDAH1) |
| PCAD: | 102975166(DDAH2) 102993703(DDAH1) |
| PSIU: | 116742762(DDAH1) 116761663(DDAH2) |
| NASI: | 112395453(DDAH2) 112415098(DDAH1) |
| ECB: | 100050594(DDAH2) 100064154(DDAH1) |
| EPZ: | 103548952(DDAH1) 103562487(DDAH2) |
| EAI: | 106824044(DDAH1) 106825020(DDAH2) |
| MYB: | 102239763(DDAH2) 102244147(DDAH1) |
| MYD: | 102754773(DDAH1) 102771584(DDAH2) |
| MMYO: | 118676137(DDAH1) 118679532(DDAH2) |
| MLF: | 102419678(DDAH1) 102426770(DDAH2) |
| MNA: | 107539001(DDAH2) 107543201(DDAH1) |
| PKL: | 118705331(DDAH2) 118722729(DDAH1) |
| HAI: | 109372906(DDAH1) 109373102(DDAH2) |
| DRO: | 112302227(DDAH2) 112309335(DDAH1) |
| SHON: | 118987567(DDAH2) 118997350(DDAH1) |
| AJM: | 119042761(DDAH1) 119051783 119053751(DDAH2) |
| PDIC: | 114495352(DDAH2) 114497782(DDAH1) |
| PHAS: | 123810439(DDAH2) 123816517(DDAH1) |
| MMF: | 118621171(DDAH2) 118626532(DDAH1) |
| RFQ: | 117020450(DDAH2) 117027554(DDAH1) |
| PALE: | 102882082(DDAH1) 102882104(DDAH2) |
| PGIG: | 120583292(DDAH1) 120618918(DDAH2) |
| PVP: | 105289078(DDAH1) 105305308(DDAH2) |
| RAY: | 107498487(DDAH2) 107511571(DDAH1) |
| MJV: | 108397863(DDAH2) 108403777(DDAH1) |
| TOD: | 119235471(DDAH1) 119252212(DDAH2) |
| SARA: | 101539740(DDAH2) 101559290(DDAH1) |
| LAV: | 100654418(DDAH1) 100670955(DDAH2) |
| ETF: | 101646536(DDAH1) 101658707(DDAH2) |
| DNM: | 101420691(DDAH1) 101440700(DDAH2) |
| MDO: | 100011815(DDAH1) 100023401(DDAH2) |
| GAS: | 123244309(DDAH1) 123245112(DDAH2) |
| SHR: | 100914303(DDAH1) 100922653(DDAH2) |
| PCW: | 110199452(DDAH2) 110209947(DDAH1) |
| OAA: | 100085468(DDAH1) 114808027(DDAH2) |
| PHI: | 102110194(DDAH1) 102112152 |
| AROW: | 112961935(DDAH1) 112964678(DDAH2) |
| ASN: | 102370187(DDAH1) 102376662(DDAH2) |
| AMJ: | 102558215(DDAH1) 102567267(DDAH2) |
| PSS: | 102448716(DDAH1) 102460447 |
| CMY: | 102941670(DDAH2) 102945675(DDAH1) |
| CPIC: | 101942635(DDAH1) 101946295 |
| CABI: | 116823738 116835758(DDAH1) 116835990 |
| MRV: | 120370734(DDAH1) 120392491 |
| ACS: | 100564332(ddah1) 100566711(ddah2) |
| PVT: | 110079737(DDAH1) 110090961 |
| SUND: | 121923308 121928020(DDAH1) |
| PBI: | 103052382(DDAH1) 103055478 |
| PMUR: | 107285243(DDAH1) 107293287 |
| CTIG: | 120297860(DDAH1) 120314249(DDAH2) |
| TSR: | 106550646 106554502(DDAH1) |
| PGUT: | 117667932 117677148(DDAH1) |
| VKO: | 123017915(DDAH2) 123024574(DDAH1) |
| PMUA: | 114592030 114598798(DDAH1) |
| ZVI: | 118080964 118088343(DDAH1) 118097163 |
| HCG: | 128323890(DDAH1) 128346755(DDAH2) |
| STOW: | 125429356(DDAH2) 125432709(DDAH1) |
| XLA: | 108715489(ddah1.S) 380577(ddah1.L) 447158(ddah2.S) 447573(ddah2.L) |
| XTR: | 100145661(ddah1) 448306(ddah2) |
| NPR: | 108790389(DDAH2) 108791377(DDAH1) |
| RTEM: | 120913520(DDAH2) 120945961(DDAH1) |
| BBUF: | 120978003(DDAH2) 120979267(DDAH1) |
| BGAR: | 122919931(DDAH2) 122943916(DDAH1) |
| DRE: | 406561(ddah1) 799954(ddah2) |
| SRX: | 107708732 107740686(ddah1) 107747920 107753385 |
| SANH: | 107655743 107660989 107679035 107702139 |
| SGH: | 107563339 107570409 107570659(ddah1) 107579727 |
| CCAR: | 109061845 109061854 |
| CAUA: | 113041361 113065750 113119119 |
| CGIB: | 127934896 127944430 127979218 128011802 |
| MAMB: | 125259526(ddah1) 125275340(ddah2) |
| CIDE: | 127501095 127505575 |
| MASI: | 127419862 127421069 |
| IPU: | 108274841(ddah2) 108276116(ddah1) |
| PHYP: | 113523842 113530478(ddah1) |
| SMEO: | 124392094(ddah2) 124398750(ddah1) |
| TFD: | 113656585(ddah2) 113658694(ddah1) |
| AMEX: | 103027873(ddah1) 103041625 |
| EEE: | 113589070 113592369(ddah1) |
| TRU: | 101063607(ddah1) 101071962(ddah2) 115248142 |
| TNG: | GSTEN00009805G001 GSTEN00033562G001 |
| LCO: | 104919041(ddah1) 104922515 |
| NCC: | 104953773(ddah2) 104958380(ddah1) |
| CGOB: | 115006666(ddah1) 115015469 |
| ELY: | 117253644(ddah1) 117263705(ddah2) |
| EFO: | 125895278(ddah1) 125904797(ddah2) |
| PLEP: | 121957993(ddah2) 121964279(ddah1) |
| SLUC: | 116039198(ddah1) 116047275(ddah2) |
| ECRA: | 117951023(ddah1) 117956297(ddah2) |
| ESP: | 116695097(ddah1) 116701230(ddah2) |
| PFLV: | 114561921(ddah1) 114568088 |
| GAT: | 120823583(ddah1) 120826259(ddah2) |
| PPUG: | 119216430(ddah1) 119219657(ddah2) |
| MSAM: | 119900384(ddah1) 119907268(ddah2) |
| CUD: | 121512002(ddah1) 121524341(ddah2) |
| ALAT: | 119017378(ddah2) 119028472(ddah1) |
| MZE: | 101474335 101474952 112436258(ddah1) |
| ONL: | 100703366(ddah2) 100711677(ddah1) |
| OAU: | 116318476(ddah2) 116336357(ddah1) |
| OLA: | 101157285(ddah1) 101158865 |
| OML: | 112150644(ddah1) 112162397(ddah2) |
| XMA: | 102218425 102227700(ddah1) |
| XCO: | 114150360(ddah1) 114156143 |
| XHE: | 116725469(ddah1) 116730731 |
| PFOR: | 103137199(ddah1) 103154543 |
| PLAI: | 106941096 106958227 |
| PMEI: | 106905404 106928141 |
| GAF: | 122838905(ddah1) 122843405(ddah2) |
| CVG: | 107086164 107095202(ddah1) |
| CTUL: | 119778016(ddah2) 119789873(ddah1) |
| GMU: | 124873661(ddah1) 124879592(ddah2) |
| NFU: | 107392941(ddah1) 107394531 |
| KMR: | 108238430(ddah1) 108241690(ddah2) |
| ALIM: | 106520836(ddah2) 106528250(ddah1) |
| NWH: | 119407723(ddah1) 119425229(ddah2) |
| AOCE: | 111571161 111578439(ddah1) |
| MCEP: | 125009923(ddah1) 125020435(ddah2) |
| CSEM: | 103394073 103396124(ddah1) |
| POV: | 109636660(ddah1) 109639167 |
| SSEN: | 122781089(ddah1) 122786561(ddah2) |
| HHIP: | 117760322(ddah1) 117770118(ddah2) |
| HSP: | 118120887(ddah1) 118124755(ddah2) |
| LCF: | 108890315(ddah2) 108895284 |
| SDU: | 111223080 111225356(ddah1) |
| SLAL: | 111645325(ddah1) 111651737 |
| XGL: | 120786552(ddah2) 120791266(ddah1) |
| HCQ: | 109516327(ddah2) 109530539(ddah1) |
| SSCV: | 125974398 125987533 |
| BPEC: | 110172294(ddah1) 110173325(ddah2) |
| MALB: | 109958743 109961759(ddah1) |
| BSPL: | 114853603(ddah1) 114865555(ddah2) |
| SASA: | 100194775(ddah2) 106560449(ddah1) 106570066 106584046 |
| STRU: | 115158702(ddah1) 115173320 115176025 115192254 |
| OTW: | 112229953 112246464 112250485 112264971 |
| OMY: | 110488496 110496042 110521789 110524712(ddah1) |
| OGO: | 123996669(ddah1) 124012641 124038042 124043648 |
| ONE: | 115108647(ddah1) 115128241 115131737 115145357 |
| SALP: | 111954754 111956135 111971343 111976025(ddah1) |
| SNH: | 120022556 120027012 120051900 120054995(ddah1) |
| CCLU: | 121533829(ddah1) 121540460 121571455 121585554 |
| ELS: | 105028026 105029008(ddah1) |
| SFM: | 108923475 108935167 108935636 114911328 |
| PKI: | 111833986 111842836(ddah2) 111847633(ddah1) |
| AANG: | 118225531(ddah1) 118233388(ddah2) |
| LOC: | 102686832(ddah1) 102694329 |
| PSPA: | 121298712 121304361 121326692 121330957 |
| ARUT: | 117412687(ddah1) 117433696 117962329 |
| PSEX: | 120514824(ddah1) 120539062(ddah2) |
| LCM: | 102350774 102363752(DDAH1) |
| RTP: | 109921018 109937311(ddah1) |
| CPLA: | 122541415 122554693(ddah1) |
| BFO: | 118404422 118405636 118405637 118406269 118411076 118413372 118417522 118418073 118418577 118421479 118421604 118421879 118422129 118430032 118430674 118430994 |
| BBEL: | 109462263 109462728 109462822 109464182 109464183 109470361 109470362 109470363 109471656 109472733 109475501 109476667 109478983 109480556 109482531 109484155 109484159 109484572 109484580 109484673 |
| DSI: | Dsimw501_GD28087(Dsim_GD28087) |
| AALB: | 109402451 109423547 115254059 |
| HRO: | HELRODRAFT_185727 HELRODRAFT_65821 HELRODRAFT_96321 |
| LGI: | LOTGIDRAFT_119867 LOTGIDRAFT_170725 |
| PCAN: | 112564612 112574984 |
| GAE: | 121384525 121384804 121391565 |
| DPOL: | 127837740 127837741 |
| SMO: | SELMODRAFT_119546 SELMODRAFT_449771(NIA7-1) |
| SRE: | PTSG_08644 PTSG_08646 |
| LMA: | LMJF_08_1225 LMJF_08_1270 |
| PBUT: | DTO10_14850 DTO10_22065 |
| PSYO: | PB01_04430 PB01_08460 |
| IRU: | M0R79_05180 M0R79_05190 |
| AMIJ: | EQM06_00585 EQM06_05700 EQM06_08970 |
| AMIC: | Ami3637_00345 Ami3637_11940 |
| ABUT: | Ami103574_08190 Ami103574_12890 |
| ETM: | CE91St48_23260 CE91St48_29330 CE91St48_39940 |
| SPOA: | EQM13_09490 EQM13_16775 |
| BULL: | JOS54_02375 JOS54_02390 |
| MPHE: | HGG69_01180 HGG69_01185 |
| MPHC: | DMC14_000925 DMC14_003270 |
| MSAI: | NCTC10113_01205 NCTC10113_01499 |
| SLE: | sle_11100(sle_11100) |
| SGM: | GCM10017557_11880(ddaH) |
| STUI: | GCM10017668_60730(ddaH) |
|
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| Reference |
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| Authors |
Ogawa T, Kimoto M, Sasaoka K. |
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| Title |
Purification and properties of a new enzyme, NG,NG-dimethylarginine dimethylaminohydrolase, from rat kidney. |
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| Journal |
J Biol Chem 264:10205-9 (1989) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.5.3.18 |
| ExPASy - ENZYME nomenclature database: | 3.5.3.18 |
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