| Entry |
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| Name |
guanidinobutyrase;
gamma-guanidobutyrase;
4-guanidinobutyrate amidinobutyrase;
gamma-guanidinobutyrate amidinohydrolase;
G-Base;
GBH;
guanidinobutyrate ureahydrolase
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| Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amidines
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| Sysname |
4-guanidinobutanoate amidinohydrolase
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| Reaction(IUBMB) |
4-guanidinobutanoate + H2O = 4-aminobutanoate + urea [RN: R01990]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Requires Mn2+. Also acts, very slowly, on 5-guanidinopentanoate and 6-guanidinohexanoate.
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| History |
EC 3.5.3.7 created 1972
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| Pathway |
| ec00330 | Arginine and proline metabolism |
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| Orthology |
| K25365 | guanidinobutyrase / D-arginase |
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| Genes |
| REE: | electrica_01085(gbh_2) |
| SFJ: | SAMEA4384070_1662(gbh) |
| PAEB: | NCGM1900_5165(gbuA) |
| PVD: | CFBP1590__2756(AGMAT) |
| PPRC: | PFLCHA0_c16100(gbh2) |
| PFW: | PF1751_v1c40070(speB) |
| PPUU: | PputUW4_03956(speB3) |
| PSEC: | CCOS191_1384(AGMAT) |
| PGY: | AWU82_23665(speB) AWU82_28130(speB) |
| PTRT: | HU722_0021210(speB) |
| PPRG: | HU725_013465(speB) HU725_013490(speB) HU725_016570(speB) |
| PTW: | TUM18999_40360(gbuA) |
| PTAE: | NCTC10697_03024(gbh) |
| AAL: | EP13_00765 EP13_00785 |
| AAUS: | EP12_00750 EP12_00770 |
| GAI: | IMCC3135_19630(gbuA_4) |
| HAXI: | HAALTHF_16850n(speB) |
| HSV: | HNO53_05720(speB) HNO53_10865(speB) |
| BMN: | BMA10247_A0674(speB) |
| BPL: | BURPS1106A_A2157(speB) |
| BPD: | BURPS668_A2243(speB) |
| BPSE: | BDL_4939(speB) BDL_5498(speB) |
| BPSD: | BBX_4100(speB) BBX_4664(speB) |
| BUR: | Bcep18194_B0366 Bcep18194_B2787 |
| BCJ: | BCAM0416(AGMAT) BCAM2482(speB) |
| BCEN: | DM39_4700(speB) DM39_5361(speB) |
| BCEW: | DM40_3132(speB) DM40_3560(speB) |
| BCEO: | I35_4325 I35_6382(speB) |
| BMK: | DM80_4388(speB) DM80_4825(speB) |
| BMUL: | NP80_3537(speB) NP80_5107(speB) |
| BCED: | DM42_4734(speB) DM42_5497(speB) |
| BCEP: | APZ15_22940 APZ15_26745 |
| BPYR: | ABD05_19605 ABD05_23170 |
| BCON: | NL30_00145 NL30_23860 |
| BDF: | WI26_16390 WI26_25220 |
| BLAT: | WK25_20235 WK25_28240 |
| BTEI: | WS51_00995 WS51_09355 |
| BSEM: | WJ12_22115 WJ12_32440 |
| BPSL: | WS57_01735 WS57_11520 |
| BMEC: | WJ16_21170 WJ16_30915 |
| BSTG: | WT74_21470 WT74_31290 |
| BSTL: | BBJ41_26355 BBJ41_29565 |
| BANN: | JFN94_16730(speB) JFN94_19760(speB) |
| BARI: | NLX30_20890(speB) NLX30_24725(speB) |
| PTRO: | G5S35_27735(speB) G5S35_36790(speB) |
| PACP: | FAZ97_21420(speB) FAZ97_23625(speB) |
| PLG: | NCTC10937_04007(gbh) |
| BUO: | BRPE64_ACDS06980 BRPE64_CCDS05640 |
| HYC: | E5678_02100(speB) E5678_02345(speB) |
| HPSE: | HPF_16425(gbh2) HPF_16680(gbh4) |
| CCRO: | CMC5_066500 CMC5_070430(rocF) |
| RLI: | RLO149_c023590(speB2) |
| PHP: | PhaeoP97_01991(speB1) |
| PPIC: | PhaeoP14_01802(speB1) |
| OAT: | OAN307_c27270(speB2) |
| SPSE: | SULPSESMR1_01311(gbuA) |
| LVS: | LOKVESSMR4R_01630(gbuA) |
| SPHM: | G432_07330 G432_07335 |
| SSAN: | NX02_06990 NX02_07030 |
| SPHR: | BSY17_2361 BSY17_2363 BSY17_469 |
| HTQ: | FRZ44_03990 FRZ44_30840(speB) |
| HADH: | FRZ61_04250 FRZ61_16770(speB) |
| AMIC: | Ami3637_02740(speB) |
| MSA: | Mycsm_00782 Mycsm_03012 Mycsm_03393 |
| MMC: | Mmcs_2256 Mmcs_3024 Mmcs_3283 Mmcs_5283 |
| MKM: | Mkms_2303 Mkms_3083 Mkms_3345 Mkms_5372 |
| MJL: | Mjls_2295 Mjls_2764 Mjls_3040 Mjls_3294 Mjls_5662 |
| MYE: | AB431_18205 AB431_24465 AB431_24470 |
| MGO: | AFA91_00110 AFA91_18150 |
| MDX: | BTO20_01005 BTO20_16160 BTO20_17680 BTO20_32620 |
| MGRO: | FZ046_12310(speB) FZ046_22845(speB) |
| MDF: | K0O62_01610(speB) K0O62_04660(speB) K0O62_15435(speB) |
| MRF: | MJO55_04710(speB) MJO55_20505(speB) |
| MSM: | MSMEG_1072(speB) MSMEG_4374(speB) MSMEG_4459(speB) |
| MSG: | MSMEI_1039 MSMEI_4270 MSMEI_4349 |
| MSB: | LJ00_05325 LJ00_17590 LJ00_21660 LJ00_22065 |
| MSN: | LI99_05325 LI99_17595 LI99_21665 LI99_22070 |
| MSH: | LI98_05325 LI98_17600 LI98_21670 LI98_22075 |
| MSP: | Mspyr1_00320 Mspyr1_26310 |
| MCB: | Mycch_2858 Mycch_5293 |
| MPHL: | MPHLCCUG_02504(gbh_2) MPHLCCUG_04427(gbh_3) MPHLCCUG_05121(gbh_6) |
| MVQ: | MYVA_0033 MYVA_0156(speB1) MYVA_2466(speB2) |
| MLL: | B1R94_13185 B1R94_23805 B1R94_23810 B1R94_28035 |
| MCHT: | MCHIJ_05070(speB_1) MCHIJ_14350(speB_2) MCHIJ_24790(speB_3) |
| MAUU: | NCTC10437_00160(gbh_1) NCTC10437_01906(gbh_2) NCTC10437_02918(speB) NCTC10437_05657(gbh_3) |
| MMAG: | MMAD_13490(speB_1) MMAD_20140(speB_3) MMAD_22900(speB_4) MMAD_29580(speB_5) |
| MAIC: | MAIC_08660(speB_1) MAIC_08670(speB_2) MAIC_32130(speB_4) |
| MTY: | MTOK_00780(speB_1) MTOK_13990(speB_2) |
| MPSC: | MPSYJ_55000(speB_2) |
| MARZ: | MARA_20300(speB_2) MARA_21220(speB_3) MARA_60940(speB_4) |
| MHEV: | MHEL_30900(speB_1) MHEL_56060(speB_3) |
| MANY: | MANY_12060(speB_1) MANY_13970(speB_2) MANY_40040(speB_3) |
| MPOF: | MPOR_13010(speB_1) MPOR_21230(speB_2) |
| MMUC: | C1S78_013605(speB) C1S78_014095(speB) |
| MMAT: | MMAGJ_32780(speB_1) MMAGJ_39620(speB_2) MMAGJ_62780(speB_3) MMAGJ_66140(speB_5) |
| MBOK: | MBOE_01830(speB_1) MBOE_07310(speB_2) MBOE_18400(speB_3) MBOE_35220(speB_4) |
| MSEI: | MSEDJ_09660(speB_1) MSEDJ_47630(speB_3) |
| CPRE: | Csp1_18370(gbh_1) Csp1_22000(gbh_2) |
| CCYC: | SCMU_09750(speB_1) SCMU_38810(speB_2) |
| ROP: | ROP_26680(speB) ROP_33210(speB) |
| RCR: | NCTC10994_01291(gbh) |
| RKO: | JWS14_15425(speB) JWS14_18520(speB) |
| RPSK: | JWS13_25960(speB) JWS13_29190(speB) JWS13_44155(speB) |
| TPUL: | TPB0596_31210(speB) |
| SVL: | Strvi_4322 Strvi_5250 |
| SRC: | M271_03685 M271_46280 |
| SMAL: | SMALA_0333 SMALA_7636 |
| SSOI: | I1A49_05170(speB) I1A49_41955(speB) |
| STRM: | M444_04750 M444_13270 |
| SLE: | sle_44730(sle_44730) |
| SGM: | GCM10017557_53120(speB) |
| SGV: | B1H19_15595 B1H19_37270 |
| SLX: | SLAV_08155(gbh1) SLAV_23995(gbh2) |
| STSU: | B7R87_09970 B7R87_31585 |
| SNF: | JYK04_03379(gbh_1) JYK04_07283(gbh_2) |
| STUI: | GCM10017668_24900(speB) |
| SGOB: | test1122_07255(speB) |
| LSE: | F1C12_09570(speB) F1C12_17090(speB) |
| AMAU: | DSM26151_06990(gbh) |
| ASOI: | MTP13_00435(speB) MTP13_10770(speB) |
| LEU: | Leucomu_00485(speB) Leucomu_02130(speB) Leucomu_06045(speB) Leucomu_11425(speB) |
| LTR: | EVS81_02940(speB) EVS81_06505(speB) |
| LLUT: | K1X41_05800(speB) K1X41_11775(speB) |
| AGG: | C1N71_00690(speB) C1N71_13145(speB) |
| MANT: | BHD05_03190 BHD05_04495 |
| GMN: | GMOLON4_2216(gbh) GMOLON4_241(gbh) |
| ARR: | ARUE_c10130(gbh1) ARUE_c41490(gbh2) |
| ARE: | AL755_04920 AL755_17820 |
| ACRY: | AC20117_11050 AC20117_14835 |
| ARTP: | E5206_18510(speB) E5206_18975(speB) |
| AAGI: | NCTC2676_1_00537(gbh) |
| PNV: | JMY29_04980(speB) JMY29_19230(speB) |
| PSNI: | NIBR502771_00450(speB) |
| PSEY: | GU243_13805(speB) GU243_20690(speB) |
| GCR: | GcLGCM259_0488(gbh) GcLGCM259_2640 |
| MICK: | B1A86_00001910(speB) |
| BLUT: | EW640_06090(speB) EW640_06610(speB) |
| PSIM: | KR76_09460 KR76_11725 |
| AGRA: | AGRA3207_005722(speB) |
| SEN: | SACE_6015 SACE_6017(speB) |
| PLIM: | PHILAsVB114_02380 PHILAsVB114_04785 |
| ABAM: | B1s21122_04450(speB) |
| JTL: | M6D93_07515(speB) M6D93_11655(speB) |
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| Reference |
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| Authors |
Mora J, Tarrab R, Martuscelli J, Soberon G. |
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| Title |
Characteristics of arginases from ureotelic and non-ureotelic animals. |
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| Journal |
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| Reference |
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| Authors |
Nguyen Van Thoai, Thome-Beau F, Olomucki A. |
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| Title |
[Induction and specificity of enzymes of the new catabolic arginine pathway] |
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| Journal |
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| Reference |
3 |
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| Authors |
Yorifuji, T., Kato, M., Kobayashi, T., Ozaki, S. and Ueno, S. |
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| Title |
4-Guanidinobutyrate amidinohydrolase from Pseudomonas sp ATCC 14676: purification to homogeneity and properties. |
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| Journal |
Agric Biol Chem 44:1127-1134 (1980) |
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| Reference |
4 |
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| Authors |
Yorifuji, T., Kobayashi, T., Tabuchi, A., Shiritani, Y. and Yonaha, K. |
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| Title |
Distribution of amidinohydrolases among Pseudomonas and comparative studies of some purified enzymes by one-dimensional peptide mapping. |
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| Journal |
Agric Biol Chem 47:2825-2830 (1983) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.5.3.7 |
| ExPASy - ENZYME nomenclature database: | 3.5.3.7 |
| BRENDA, the Enzyme Database: | 3.5.3.7 |
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