KEGG   ENZYME: 3.5.5.4
Entry
EC 3.5.5.4                  Enzyme                                 
Name
cyanoalanine nitrilase;
beta-cyanoalanine nitrilase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In nitriles
Sysname
3-cyano-L-alanine aminohydrolase
Reaction(IUBMB)
3-cyano-L-alanine + 2 H2O = L-aspartate + NH3 (overall reaction) [RN:R00486];
(1a) 3-cyano-L-alanine + H2O = L-asparagine [RN:R01267];
(1b) L-asparagine + H2O = L-aspartate + NH3 [RN:R00485]
Reaction(KEGG)
Substrate
3-cyano-L-alanine [CPD:C02512];
H2O [CPD:C00001];
L-asparagine [CPD:C00152]
Product
L-aspartate [CPD:C00049];
NH3 [CPD:C00014];
L-asparagine [CPD:C00152]
Comment
L-Asparagine is formed as an intermediate. cf. EC 4.2.1.65, 3-cyanoalanine hydratase and EC 3.5.1.1, asparaginase.
History
EC 3.5.5.4 created 1986
Pathway
ec00460  Cyanoamino acid metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13035  beta-cyano-L-alanine hydratase/nitrilase
Genes
AJM119059097
PJA122252283
ATHAT5G22300(NIT4)
ALY9310128
CRB17881917
CSAT104706517 104736238 104770558
EUSEUTSA_v10013949mg
BRP103851433(NIT-T4)
BNA106384710 106427339
BOE106327565
RSZ108843167
THJ104810929
CPAP110806828 110810608
CIT102624718 102626612
CICCICLE_v10020864mg CICLE_v10028755mg
PVY116105637
MINC123209435
TCC18590263 18598346
GRA105766626 105792876
GHI107948779 107953166 107954122
GAB108458448 108468291
DZI111284196 111302070 111304380 111311679
EGR104421327 104421328
GMX100778110 100810230
GSJ114373604 114380588
PVUPHAVU_011G096700g
VRA106775914
VAR108339531
VUN114168387
CCAJ109799314
APRC113858884
MTRMTR_4g052380 MTR_4g052390
CAM101500877
LJALj3g3v2981810.1(Lj3g3v2981810.1) Lj3g3v2981810.2(Lj3g3v2981810.2) Lj3g3v2981810.3(Lj3g3v2981810.3) Lj3g3v2981810.4(Lj3g3v2981810.4)
ADU107478319
AIP107630108
AHF112737863 112789992
LANG109351736(NIT4) 109353638(NIT4B)
FVE101314432
RCN112165679
PPER18770202 18774569
PMUM103329255 103341728
PAVI110746687 110761217
PDUL117631340 117633648
MDM103424813
PXB103936462 103966370
ZJU107409663 107415031
MNT21399366
CSV101209360
CMO103501743
BHJ120083021
MCHA111012712
CMAX111471660
CMOS111434356
CPEP111784116
RCU8263319 8263320 8263321 8263322
JCU105635907
HBR110639704 110640140
MESC110613972 110623491 110626532
POP18098088 7465247 7466016
PEU105112584 105139048 105141407
PALZ118030656 118038453 118038950
JRE108990509 108998921 108998953
QSU111990566 111993928 111993929 111993937
QLO115953695 115973063 115978888 115978896
TWL119990443 119998437 120002126
VVI100240765 100241354 100241359 100243086 100248203 100250098 100253338 100263621 100265384 100853652
VRI117906526 117909783 117909785 117916262 117927253 117928568 117928647
SLY101266793
SPEN107004945
SOT102595618
CANN107847983
NTA107804379(NIT4A) 107812524 107832013(NIT4B)
NSY104235794
NTO104091838 104099483
NAU109229286
INI109160194
ITR116004786
SIND105170044
OEU111383075
EGT105970138
SSPL121742196 121743274 121743340 121743509 121790517 121790911 121811014 121811478
HAN110899901 110930882
ECAD122599842
LSV111896404
CCAV112529711
DCR108215255
CSIN114287616
BVG104899831
SOE110798812
CQI110683592 110688144
NNU104589516 104597484 104601345 104603451
MING122061235 122068215 122068216 122077137 122077139 122085695
TSS122642463 122642544 122649163
PSOM113309654 113313402 113322008 113323580
NCOL116267212
OSA4330076 4330077
DOSAOs02t0635000-01(Os02g0635000) Os02t0635200-01(Os02g0635200)
OBR102701789 102702164
BDI100822233 100822856
ATS109746316 109746318
TDC119317215 119317216 119317218 119318148 119322478 119322675 119323118
TAES100682473 123127803 123127804 123128638 123137562 123137563 123137564 123142683 123144908 123144909
SBI110434689 8056027 8074792 8074793
ZMA542093 542573
SITA101766965 101767363
SVS117863514 117863518
PVIR120656561 120709983 120709990 120710000 120710008 120710018 120710030
PHAI112891912 112891922
PDA103705226
EGU105042779
MUS103994490
DCT110107670
PEQ110023533
AOF109825016
ATR18426973 18444517
SMOSELMODRAFT_133005(NIT4-2) SELMODRAFT_171766(NIT4-1)
PPP112274445
SCMSCHCODRAFT_255433
 » show all
Reference
1
  Authors
Yanase, H., Sakai, T. and Tonomuro, K.
  Title
Purification, crystallization and some properties of beta-cyano-L-alanine-degrading enzyme in Pseudomonas sp. 13.
  Journal
Agric Biol Chem 47:473-482 (1983)
Other DBs
ExplorEnz - The Enzyme Database: 3.5.5.4
IUBMB Enzyme Nomenclature: 3.5.5.4
ExPASy - ENZYME nomenclature database: 3.5.5.4
BRENDA, the Enzyme Database: 3.5.5.4
CAS: 85638-44-4

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