KEGG ENZYME: 3.6.1.12

ENZYME: 3.6.1.12

Entry

EC 3.6.1.12                 Enzyme

Name

dCTP diphosphatase;
DCTPP1 (gene name);
deoxycytidine-triphosphatase;
dCTPase;
dCTP pyrophosphatase;
deoxycytidine triphosphatase;
deoxy-CTPase

Class

Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides

Sysname

dCTP nucleotidohydrolase

Reaction(IUBMB)

dCTP + H2O = dCMP + diphosphate [RN:R01668]

Reaction(KEGG)

R01668;
(other) R01667

Substrate

dCTP [CPD:C00458];
H2O [CPD:C00001]

Product

dCMP [CPD:C00239];
diphosphate [CPD:C00013]

Comment

The mammalian enzyme also displays weak activity against dTTP and dATP, but none against dGTP. Activity is highest with analogs including 5-iodo-dCTP and 5-methyl-dCTP.

History

EC 3.6.1.12 created 1965

Pathway

ec00240

Pyrimidine metabolism

ec01100

Metabolic pathways

Orthology

K16904

dCTP diphosphatase

K21503

Escherichia phage dCTP pyrophosphatase

Genes

HSA:	79077(DCTPP1)

PTR:	467948(DCTPP1)

PPS:	100980571(DCTPP1)

GGO:	101138322(DCTPP1)

PON:	112129388(DCTPP1)

NLE:	100584469(DCTPP1)

HMH:	116470252(DCTPP1)

MCC:	710500(DCTPP1)

MCF:	102118443(DCTPP1)

MTHB:

126944255

MNI:	105482916(DCTPP1)

CSAB:

103230924(DCTPP1)

PANU:

101023286(DCTPP1)

TGE:	112614007(DCTPP1)

MLEU:

105541436(DCTPP1)

RRO:	104681570(DCTPP1)

RBB:	108535403(DCTPP1)

TFN:	117087647(DCTPP1)

PTEH:

111525725(DCTPP1)

CANG:

105505671(DCTPP1)

CJC:	100408453(DCTPP1)

SBQ:	101051189(DCTPP1)

CIMI:

108293876(DCTPP1)

CSYR:

103270176(DCTPP1)

MMUR:

105871087(DCTPP1)

LCAT:

123632737(DCTPP1)

PCOQ:

105823146(DCTPP1)

OGA:	100966488(DCTPP1)

MMU:	66422(Dctpp1)

MCAL:

110298995(Dctpp1)

MPAH:

110333566(Dctpp1)

RNO:	192252(Dctpp1)

MCOC:

116100913(Dctpp1)

ANU:	117710786(Dctpp1)

MUN:	110547975(Dctpp1)

CGE:	100769832(Dctpp1)

MAUA:

110339856(Dctpp1)

PROB:

127228381(Dctpp1)

PLEU:

114704431(Dctpp1)

MORG:

121457746(Dctpp1)

MFOT:

126506769 126515893

AAMP:

119817500 119826835(Dctpp1)

NGI:	103726355(Dctpp1)

CPOC:

100729302(Dctpp1)

CCAN:

109682528(Dctpp1)

DORD:

105982043(Dctpp1)

DSP:	122096260(Dctpp1)

NCAR:

124970418

OCU:

100357182

OPI:	101536427(DCTPP1)

TUP:	102469976(DCTPP1)

GVR:	103609596(DCTPP1)

CFA:	489903(DCTPP1)

CLUD:

112640096(DCTPP1)

VVP:	112929235(DCTPP1)

VLG:	121488164(DCTPP1)

AML:	100479684(DCTPP1)

UMR:	103657859(DCTPP1)

UAH:	113267679(DCTPP1)

UAR:	123784640(DCTPP1)

ELK:

111162272

LLV:

125090939

MPUF:

101689977(DCTPP1)

NVS:	122895755(DCTPP1)

ORO:	101370099(DCTPP1)

EJU:	114214531(DCTPP1)

ZCA:	113932236(DCTPP1)

MLX:	117999599(DCTPP1)

NSU:	110589879(DCTPP1)

LWW:	102727322(DCTPP1)

FCA:	101094313(DCTPP1)

PYU:	121022164(DCTPP1)

PBG:	122471452(DCTPP1)

LRUF:

124517981

PTG:	102950940(DCTPP1)

PPAD:

109258999(DCTPP1)

PUC:

125928077

AJU:	106979130(DCTPP1)

HHV:	120242208(DCTPP1)

BTA:	614103(DCTPP1)

BOM:	102282512(DCTPP1)

BIU:	109578812(DCTPP1)

BBUB:

102413550(DCTPP1)

BBIS:

104986659(DCTPP1)

CHX:	102171294(DCTPP1)

OAS:	101121995(DCTPP1)

ODA:	120877392(DCTPP1)

CCAD:

122432991(DCTPP1)

SSC:	100621901(DCTPP1)

CFR:	102520187(DCTPP1)

CBAI:

105082806(DCTPP1)

CDK:	105102738(DCTPP1)

VPC:	102530076(DCTPP1)

BACU:

103015138(DCTPP1)

LVE:	103086998(DCTPP1)

OOR:	101278397(DCTPP1)

DLE:	111182144(DCTPP1)

PCAD:

102996735(DCTPP1)

PSIU:

116739494(DCTPP1)

NASI:

112399372(DCTPP1)

ECB:	100065556(DCTPP1)

EPZ:	103547216(DCTPP1)

EAI:	106831921(DCTPP1)

MYB:	102241958 102244697(DCTPP1)

MYD:	102753729(DCTPP1)

MMYO:

118656764(DCTPP1)

MLF:	102436112(DCTPP1)

MNA:	107545786(DCTPP1)

PKL:	118704932(DCTPP1)

HAI:	109374219(DCTPP1)

DRO:	112304734(DCTPP1)

SHON:

119000462(DCTPP1)

AJM:	119058954 119058995

PDIC:

114499420(DCTPP1) 114506604

PHAS:

123825448 123825498

MMF:	118642168 118642506(DCTPP1)

RFQ:	117019421(DCTPP1)

PALE:

102878907(DCTPP1)

PGIG:

120620094(DCTPP1)

PVP:	105304534(DCTPP1)

RAY:	107515866(DCTPP1)

TOD:	119240174(DCTPP1)

SARA:

101541636(DCTPP1)

TMU:

101349736

ETF:	101641215(DCTPP1)

DNM:	101427601(DCTPP1)

MDO:	100017749(DCTPP1)

GAS:	123231152(DCTPP1) 123249541

SHR:	100932588(DCTPP1)

AFZ:

127563074

PCW:	110223138(DCTPP1)

OAA:	100093573(DCTPP1)

CMY:	119566278(DCTPP1)

CPIC:

103306816(DCTPP1)

CABI:

116840192(DCTPP1)

MRV:	120403349(DCTPP1)

ACS:	100558769(dctpp1)

PVT:	110090066(DCTPP1)

SUND:

121932764(DCTPP1)

PBI:	103056195(DCTPP1)

PMUR:

107282745 107299273

CTIG:

120302307(DCTPP1)

TSR:	106557264(DCTPP1)

PGUT:

117666796(DCTPP1)

VKO:	123032254(DCTPP1)

PMUA:

114581674(DCTPP1)

ZVI:	118094306(DCTPP1)

GJA:	107106259(DCTPP1)

STOW:

125445091(DCTPP1)

XLA:	444233(dctpp1.L)

XTR:	493314(dctpp1)

NPR:	108803495(DCTPP1)

BBUF:

120982963(DCTPP1)

BGAR:

122945239(DCTPP1)

DRE:	393744(dctpp1)

SRX:	107745859(dctpp1)

SANH:

107695562 107695896

SGH:	107600637(dctpp1)

CAUA:

113044140(dctpp1)

CGIB:

127948809

PPRM:

120494586(dctpp1)

MAMB:

125272682(dctpp1)

CIDE:

127516859

MASI:

127445204

IPU:	108260658(dctpp1)

PHYP:

113544246(dctpp1)

SMEO:

124381512(dctpp1)

TFD:	113649961(dctpp1)

AMEX:

103022470(dctpp1)

EEE:	113582232(dctpp1)

TRU:	101062264(dctpp1)

TNG:	GSTEN00004075G001

LCO:	104917965(dctpp1)

NCC:	104963069(dctpp1)

CGOB:

115014382(dctpp1)

ELY:	117255952(dctpp1)

EFO:	125885596(dctpp1)

PLEP:

121942310(dctpp1)

SLUC:

116034219(dctpp1)

ECRA:

117960131(dctpp1)

ESP:	116703917(dctpp1)

PFLV:

114572235(dctpp1)

GAT:	120825120(dctpp1)

PPUG:

119217525(dctpp1)

MSAM:

119898839(dctpp1)

CUD:	121508595(dctpp1)

ALAT:

119020394(dctpp1)

MZE:	101486589(dctpp1)

ONL:	100690302(dctpp1)

OAU:	116333718(dctpp1)

OLA:	101157671(dctpp1)

OML:	112137346(dctpp1)

XMA:	102238234(dctpp1)

XCO:	114143870(dctpp1)

XHE:	116719813(dctpp1)

PRET:

103457678(dctpp1)

PFOR:

103136413(dctpp1)

PLAI:

106949051(dctpp1)

PMEI:

106932187(dctpp1)

GAF:	122830392(dctpp1)

CVG:	107102830(dctpp1)

CTUL:

119774399(dctpp1)

GMU:	124868609(dctpp1)

NFU:	107395640(dctpp1)

KMR:	108237872(dctpp1)

ALIM:

106526180(dctpp1)

NWH:	119422469(dctpp1)

AOCE:

111562500(dctpp1)

MCEP:

125003787(dctpp1)

POV:	109638313(dctpp1)

SSEN:

122770517(dctpp1)

HHIP:

117761815(dctpp1)

HSP:	118125483(dctpp1)

LCF:

108893079

SDU:	111216683(dctpp1)

SLAL:

111655062(dctpp1)

XGL:	120800374(dctpp1)

HCQ:	109511341(dctpp1)

SSCV:

125968816

BPEC:

110167623(dctpp1)

MALB:

109955505(dctpp1)

BSPL:

114859044(dctpp1)

SASA:

100196870(xtp3a)

STRU:

115202222

OTW:	112235798(dctpp1) 112261303

OMY:	110497382(dctpp1) 110534510

OGO:	124001146 124013366

ONE:

115145603

SALP:

111958349 112071580

SNH:	120035039 120053044

CCLU:

121560267(dctpp1)

ELS:	105020920(dctpp1)

SFM:	108924365(dctpp1)

PKI:	111837229(dctpp1)

AANG:

118227868(dctpp1)

LOC:	102682302(dctpp1)

PSPA:

121306835(dctpp1)

ARUT:

117967163(dctpp1)

PSEX:

120536619(dctpp1)

LCM:	102360709(DCTPP1)

BFO:

118425796

BBEL:

109467214 109482818

SPU:

574993

APLC:

110987035

AJC:

117105266

SKO:

100372648

PVM:

113811682

PJA:

122244890

PCHN:

125033989

PMOO:

119598205

HAME:

121875073

PTRU:

123499862

ESN:

126986132

PPOI:

119096815 119099506

ISC:	IscW_ISCW010553

DSV:

119446143

RSAN:

119390018

RMP:

119161364

VDE:

111246886

VJA:

111270085

DPTE:

113799359

DFR:	124492898 124500233

CSCU:

111618405

PTEP:

107455944

SDM:

118198095

LGI:	LOTGIDRAFT_163415

PCAN:

112561110

BGT:

106053030

GAE:

121368264

HRF:

124133434

HRJ:

124256647

CRG:

105341436

MYI:

110452454

PMAX:

117329756

MCAF:

127712531

MMER:

123533978

DPOL:

127839851

OBI:	106878263 106878264

OSN:	115226079 115226080

LAK:

106152627

NVE:	5500722 5516876

EPA:

110250962

ATEN:

116293975

ADF:

107341540

AMIL:

114957627

PDAM:

113686406

SPIS:

111322689

HMG:

100201866

AQU:	100641006 100641260

ATH:

AT3G25400

ALY:

9321770

CRB:

17893269

CSAT:

104747081 104766450 104790097

EUS:	EUTSA_v10002718mg

BRP:

103828559

BNA:	106405862 106405863 111213284

BOE:

106306802

RSZ:

108862644

THJ:	104808635 104808811 104826650

CPAP:

110821737

CIT:	102607840 102620578 102624370

CIC:	CICLE_v10006144mg CICLE_v10022875mg CICLE_v10032689mg

PVY:	116107741 116112979 116121545 116124394

MINC:

123203821 123204915 123204918 123204932 123210921 123216711 123221299 123222991

TCC:	18602584 18603250 18604767 18612647

GRA:	105775030 105788325 105790578 105796430 105803336 105804233

GHI:	107912523 107915870 107923131 107927354 107934822 107949257 107953463 107956611 107956868 121232099 121232152

GAB:	108472868 108475578 108485684 108486281 108486546

DZI:	111280017 111283907 111305468 111307263 111307408 111314446 111317569

EGR:	104414477 104425685 104425991 104456332

GMX:	100306684 100500214 100500294 100527076 100784040 106798062

GSJ:	114389644 114406367 114409473 114411829 114414086 114423680

PVU:	PHAVU_003G187100g PHAVU_008G1376001 PHAVU_010G031100g

VRA:	106758825 106767643 106773936

VAR:	108319209 108327961 108340421

VUN:	114166575 114177013 114183163

CCAJ:

109793847 109808527 109809928

APRC:

113850417 113851943

MTR:

11431912

CAM:

101508420

PSAT:

127127827

LJA:	Lj0g3v0107379.1(Lj0g3v0107379.1) Lj4g3v1683160.1(Lj4g3v1683160.1)

ADU:	107460276 107463489 107468380 107484717

AIP:	107608022 107619257 107637858

AHF:	112705749 112708497 112709899 112722548 112740426 112766665 112784070 112794303

LANG:

109352748 109359141 109359939 109362544

FVE:	101295813 101296657 101299723

RCN:	112174699 112179412 112198410 112200318

PPER:

18767882 18776906 18776965 18792420

PMUM:

103324073 103338459 103342826

PAVI:

110748989 110757036 110762368

PDUL:

117615292 117628500 117637846

MDM:	103408302 103412147 103415799 103435914 103437858 103455383 114824593

PXB:	103927095 103931104 103931371 103948695 103949595 103960372 103961366 103965659

ZJU:	107419174 107422862 107422874 107426632

MNT:	21386673 21398339 21398922

CSV:	101204836 101207880 101213795 105436154

CMO:	103483579 103494015 103494554 103497635

BHJ:	120070149 120070722 120072296 120083515 120085363

MCHA:

111006893 111008645 111014625 111019587 111024481

CMAX:

111471548 111479227 111479510 111484985 111488146 111492910 111497558

CMOS:

111429911 111432179 111441066 111452418 111455958 111457533 111461259

CPEP:

111778404 111779721 111789627 111790535 111793865 111807624

RCU:	8263755 8266766 8284483

JCU:	105632157 105640582

HBR:	110643453 110647948 110651061 110655560

MESC:

110601466 110612236 110617322 110627918 110629698 110630806

POP:	7459513 7468483 7473465 7475400 7488587

PEU:	105107698 105115787 105125701 105129433 105129910 105138391

PALZ:

118040736 118043847 118048862 118049961 118057381

JRE:	108987684 108991197 108996200 109010564 109011531 109011532 109011533 109017696 109019411 109020279

CILL:

122280766 122291238 122294812 122303041 122315211

QSU:	111987019 112009978 112011113 112021061 112026408 112033465 112033471 112033473

QLO:	115950632 115950857 115959133 115965510 115965604

TWL:	119987546 119999796 120003148

VVI:	100241572 100247693 100263025 100266931

VRI:	117904456 117904771 117913861 117914944 117914997 117918876

SLY:	101255503 101256037 101256598 101266563

SPEN:

107022715 107022856 107030584 107030710

SOT:	102581660 102583324 102589138 102593064

SSTN:

125851381 125871549 125873035 125873399

CANN:

107855433 107864480 107866467 107874589

NTA:	107765557 107766741 107788382 107792941 107804914 107804932 107819551 107831666

NSY:	104212087 104227044 104246273 104247658

NTO:	104087000 104097054 104102260 104102261 104113637

NAU:	109205877 109210852 109221228 109221271

INI:	109149450 109162414 109173748 109173749 109175171 109175291

ITR:	116002863 116005058 116005063 116005179 116015492 116015581 116023131

SIND:

105157961 105166477 105170100 105171800

OEU:	111369236 111390570 111396645 111402690 111405925 111408248

EGT:	105955948 105959879

SSPL:

121762857

APAN:

127239385 127253034

HAN:	110867777 110870449 110908631 110941891

ECAD:

122587143 122605931 122608129

LSV:	111883285 111887751 111896801 111903965

CCAV:

112514179 112518441 112523474

DCR:	108198715 108220743

CSIN:

114258536 114269991 114302655 114317937

BVG:	104887918 104889715 104893990 104894365

SOE:	110775089 110777408 110787342

CQI:	110700315 110700317 110711749 110718132 110727565 110733248

NNU:	104586285 104598028 104598499 104600908 104602822

MING:

122077484 122088407 122089863 122092026

TSS:	122655891 122657051 122659654 122669444

PSOM:

113283876 113314244 113314253 113314261

OSA:	4329363 4335533 4336398

DOSA:

Os02t0479300-01(Os02g0479300) Os04t0346800-01(Os04g0346800) Os04t0515400-00(Os04g0515400)

OBR:	102706375 102721832

OGL:	127761335 127769632 127769878

BDI:	100839966 100840842

ATS:	109745662 109759876

TDC:	119354879 119355865 119364015 119365009

TAES:

123041311 123041697 123049667 123053065 123185761 123188971

TUA:	125539152 125541660

LPER:

127330334 127334601 127335607

SBI:	8054275 8084526

ZMA:	100281061 100282064 103646230

SITA:

101753293 101759124 101782075

SVS:	117841595 117862909 117862990

PVIR:

120640577 120642569 120655733 120682616 120701761

PHAI:

112889045 112899722 112900283

PDA:	103700453 103703930 103716088

EGU:	105033616 105034711 105051224 105054481

MUS:	103968474 103971165 103981938 103982464 103983033 103984947 103987608

ZOF:	121982896 121987467 122019008 122020935 122021726 122023935 122024740 122025421 122044089

DCT:	110096720 110102748 110111666

PEQ:	110027711 110036494

AOF:	109824555 109839691

NCOL:

116249852 116266191

ATR:	18434935 18438491 18447181 18447991 18447993 18447994

SMO:	SELMODRAFT_105525 SELMODRAFT_115605 SELMODRAFT_98770

PPP:	112286416 112292825

VCN:	VOLCADRAFT_47255

CVR:	CHLNCDRAFT_14766

MIS:	MICPUN_113203(XTP3A)

FGR:	FGSG_09100

FPU:	FPSE_06770

NHE:	NECHADRAFT_93899

TET:	TTHERM_00522540

PTM:	GSPATT00006322001

FCY:	FRACYDRAFT_254541

AAF:	AURANDRAFT_30607

SPAR:

SPRG_03566

EHX:	EMIHUDRAFT_58748 EMIHUDRAFT_66958

GTT:	GUITHDRAFT_113648

NGR:	NAEGRDRAFT_5223

VJP:	NP165_18905

PPUN:

PP4_47220

PSAV:

PSA3335_04500

PFL:

PFL_3843

PSEM:

TO66_12470

PBZ:	GN234_21930

PVW:	HU752_028825

PALV:

KSS97_25555

PCAS:

LOY40_25440

MSX:	AU14_02600

MARQ:

MARGE09_P2510

TSY:	THSYN_16685

TBOG:

LT988_11425

TGR:

Tgr7_0591

TNI:	TVNIR_1788

TTI:	THITH_08055

WMA:	WM2015_2838

THIC:

TspCOW1_24220

EPS:	L0Y14_15895

ENM:	EBS_0088(mazG)

CVC:	BKX93_11315

CHAE:

CH06BL_25240

DTS:	BI380_08260

DHK:	BO996_13880

DLA:	I6G47_08300

CODO:

LAD35_09585

JAS:	FJQ89_21230

JLV:	G3257_04370

JAH:	JAB4_008860

HSE:	Hsero_0516

HSZ:	ACP92_02565

HRB:	Hrubri_0506

HHF:	E2K99_03010

HFR:	G5S34_02640

MNR:	ACZ75_15785

MASY:

DPH57_23715

MUM:	FCL38_23825

MPLI:

E1742_19385

DUG:	HH213_14235

UND:	UNDKW_3306

TCT:	PX653_25255

FKU:	FGKAn22_14820

SULF:

CAP31_09545

AIQ:	Azoinq_03395

EBA:

ebA6173

ABRE:

pbN1_37350

APET:

ToN1_49610

AZD:	CDA09_12385

AZQ:	G3580_09690

ACOM:

CEW83_07045

DBK:	DGMP_29940

DDU:

GF1_29070

DEK:	DSLASN_03180

MFOL:

DXT68_01060

LVI:	G7068_11580

CEJ:	GC089_00590

CELH:

GXP71_19995

CDON:

KKR89_16290

CFEN:

KG102_00640

JME:	EEW87_008910

PEI:	H9L10_07455

DEM:	LGT36_012795

KQI:	F1D05_37575

IPA:

Isop_1194

SACI:

Sinac_2833

LPRO:

PQO03_08850

CAQA:

MICH65_0258

» show all

Reference

1 [PMID:13788541]

Authors

ZIMMERMAN SB, KORNBERG A.

Title

Deoxycytidine di- and triphosphate cleavage by an enzyme formed in bacteriophage-infected Eschrichia coli.

Journal

J Biol Chem 236:1480-6 (1961)

Reference

2 [PMID:15740738]

Authors

Moroz OV, Murzin AG, Makarova KS, Koonin EV, Wilson KS, Galperin MY

Title

Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions.

Journal

J Mol Biol 347:243-55 (2005)
DOI:10.1016/j.jmb.2005.01.030

Reference

3 [PMID:17320107]

Authors

Wu B, Liu Y, Zhao Q, Liao S, Zhang J, Bartlam M, Chen W, Rao Z

Title

Crystal structure of RS21-C6, involved in nucleoside triphosphate pyrophosphohydrolysis.

Journal

J Mol Biol 367:1405-12 (2007)
DOI:10.1016/j.jmb.2007.01.057

Sequence

[mmu:66422]

Reference

4 [PMID:19220460]

Authors

Nonaka M, Tsuchimoto D, Sakumi K, Nakabeppu Y

Title

Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate pyrophosphohydrolase that prefers 5-iodocytosine.

Journal

FEBS J 276:1654-66 (2009)
DOI:10.1111/j.1742-4658.2009.06898.x

Reference

5 [PMID:24467396]

Authors

Requena CE, Perez-Moreno G, Ruiz-Perez LM, Vidal AE, Gonzalez-Pacanowska D

Title

The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells.

Journal

Biochem J 459:171-80 (2014)
DOI:10.1042/BJ20130894

Other DBs

ExplorEnz - The Enzyme Database:

3.6.1.12

IUBMB Enzyme Nomenclature:

3.6.1.12

ExPASy - ENZYME nomenclature database:

3.6.1.12

BRENDA, the Enzyme Database:

3.6.1.12

CAS:

9024-87-7

DBGET integrated database retrieval system