KEGG ENZYME: 3.6.1.18

ENZYME: 3.6.1.18

Entry

EC 3.6.1.18                 Enzyme

Name

FAD diphosphatase;
FAD pyrophosphatase;
riboflavin adenine dinucleotide pyrophosphatase;
flavin adenine dinucleotide pyrophosphatase;
riboflavine adenine dinucleotide pyrophosphatase;
flavine adenine dinucleotide pyrophosphatase

Class

Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides

Sysname

FAD nucleotidohydrolase

Reaction(IUBMB)

FAD + H2O = AMP + FMN [RN:R00160]

Reaction(KEGG)

R00160

Substrate

FAD [CPD:C00016];
H2O [CPD:C00001]

Product

AMP [CPD:C00020];
FMN [CPD:C00061]

Comment

The plant enzyme also hydrolyses NAD+ and NADH; the animal enzyme hydrolyses NAD+ and CoA at about half of the rate of hydrolysis of FAD. May be identical with EC 3.6.1.9 nucleotide diphosphatase.

History

EC 3.6.1.18 created 1972

Pathway

ec00740

Riboflavin metabolism

ec01100

Metabolic pathways

Orthology

K18453

ADP-ribose/FAD diphosphatase

Genes

ATH:	AT2G42070(NUDX23)

ALY:

9316033

CRB:

17887807

CSAT:

104782695 104785169 104793124

EUS:	EUTSA_v10017043mg

BRP:	103858010 103866609

BNA:	106385468 106390989 106428102 106450637

BOE:	106329362 106339762

RSZ:

108806323

THJ:	104802583 104824477

CPAP:

110811796

CIT:

102624667

CIC:	CICLE_v10013558mg

PVY:

116114527

MINC:

123222905

TCC:

18599110

GRA:

105799553

GHI:	107887230 107889499 107891253 121203763

GAB:	108456960 108474919

DZI:

111311580

EGR:

104425498

GMX:	100777180 100783108 100808417

GSJ:	114366876 114400577 114406783

PVU:	PHAVU_001G142700g PHAVU_007G260200g

VRA:	106757709 106771021

VAR:	108324319 108327071

VUN:	114163854 114190221

CCAJ:

109791355 109797714

APRC:

113863012 113872759

MTR:

11437937

TPRA:

123892625

CAM:

101510027

PSAT:

127126226

LJA:	Lj1g3v4327730.1(Lj1g3v4327730.1) Lj1g3v4327730.2(Lj1g3v4327730.2)

ADU:	107464793 107492889

AIP:	107619422 107645415

AHF:	112696122 112710398 112754995 112779666

LANG:

109328857

PCIN:

129305071

FVE:

101313330

RCN:

112193132

PPER:

18771727

PMUM:

103339411

PAVI:

110770737

PDUL:

117633436

MDM:	103411488 114821097

MSYL:

126594388 126600927

PXB:

103958904

ZJU:

107409700

MNT:

112094478

CSAV:

115701105

CSV:

101220971

CMO:

103486759

BHJ:

120091125

MCHA:

111024856

CMAX:

111481706

CMOS:

111441496

CPEP:

111790315

RCU:

8267074

JCU:

105646524

HBR:	110668396 110668419

MESC:

110620131

POP:	7455643 7483972

PEU:	105111228 105117323 105131764

PALZ:

118043890 118052516

JRE:

109011950

CILL:

122277555

QSU:

112015319

QLO:

115954112

TWL:	119995661 120012786

VVI:

100245297

VRI:

117919763

SLY:

101263980

SPEN:

107014865

SOT:

102605083

SSTN:

125859727

NTA:	107813369 107829675

NSY:

104249700

NTO:

104089616

NAU:

109235668

INI:

109180922

ITR:

116006039

SIND:

105162491

OEU:	111380209 111384273

EGT:

105976763

SSPL:

121746837 121750506

SMIL:

130988800

APAN:

127257956

HAN:	110897573 110936585

ECAD:

122581838

LSV:

111908841

CCAV:

112512286 112513475

DCR:

108224652

CSIN:

114269621

RVL:

131323171

BVG:

104889186

SOE:

110806030

CQI:	110689228 110734505

MOF:

131167969

NNU:

104603559

MING:

122064594 122088429

TSS:	122641500 122643848

PSOM:

113310051 113320838

OSA:

4347801

DOSA:

Os09t0553300-01(Os09g0553300)

OBR:

102702690

OGL:

127784484

BDI:

100829230

ATS:

109772291

TDC:	119302839 119311529

TAES:

123104747 123113034 123122545

TUA:

125510369

LPER:

127325920

LRD:	124654883 124655677

SBI:

8074182

ZMA:	100192798 100272585

SITA:

101755363

SVS:

117846615

PVIR:

120658396 120686365

PHAI:

112881392

PDA:	103717961 103723373

EGU:	105055262 105058872

MUS:	103970625 104000488

ZOF:	121971374 121976292

DCT:

110092687

PEQ:	110021215 110036702

AOF:

109850360

NCOL:

116260270

ATR:

18445418

SMO:	SELMODRAFT_127731 SELMODRAFT_80228

PPP:

112289210

CRE:	CHLRE_06g285200v5

VCN:	VOLCADRAFT_44814

MNG:

MNEG_7550

CSL:	COCSUDRAFT_10765 COCSUDRAFT_40300

CVR:	CHLNCDRAFT_18991

APRO:

F751_4893

» show all

Reference

1 [PMID:5810832]

Authors

Ravindranath SD, Rao NA.

Title

Nucleotidases in plants. 3. Effect of metabolites on the enzyme hydrolyzing flavine adenine dinucleotide (FAD) from Phaseolus radiatus.

Journal

Arch Biochem Biophys 133:54-9 (1969)
DOI:10.1016/0003-9861(69)90487-1

Reference

2 [PMID:2848456]

Authors

Shin HJ, Mego JL.

Title

A rat liver lysosomal membrane flavin-adenine dinucleotide phosphohydrolase: purification and characterization.

Journal

Arch Biochem Biophys 267:95-103 (1988)
DOI:10.1016/0003-9861(88)90012-4

Other DBs

ExplorEnz - The Enzyme Database:

3.6.1.18

IUBMB Enzyme Nomenclature:

3.6.1.18

ExPASy - ENZYME nomenclature database:

3.6.1.18

BRENDA, the Enzyme Database:

3.6.1.18

CAS:	37289-30-8

DBGET integrated database retrieval system