EC                 Enzyme                                 

5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase;
m7GpppX pyrophosphatase;
m7GpppN m7GMP phosphohydrolase;
m7GpppX diphosphatase;
m7G5'ppp5'N m7GMP phosphohydrolase
Acting on acid anhydrides;
In phosphorus-containing anhydrides
5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] N7-methylguanosine 5'-phosphate phosphohydrolase
a 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] + H2O = N7-methylguanosine 5'-phosphate + a 5'-diphospho-[mRNA]
(other) R04368
5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] [CPD:C02339];
H2O [CPD:C00001]
N7-methylguanosine 5'-phosphate;
5'-diphospho-[mRNA] [CPD:C02100]
The enzyme removes (decaps) the N7-methylguanosine 5-phosphate cap from an mRNA degraded to a maximal length of 10 nucleotides [3,6]. Decapping is an important process in the control of eukaryotic mRNA degradation. The enzyme functions to clear the cell of cap structure following decay of the RNA body [2]. The nematode enzyme can also decap triply methylated substrates, 5'-(N2,N2,N7-trimethyl 5'-triphosphoguanosine)-[mRNA] [4].
EC created 2012, modified 2013
K12584  m7GpppX diphosphatase
HSA: 28960(DCPS)
PTR: 451655(DCPS)
PPS: 100974902(DCPS)
GGO: 101145375(DCPS)
PON: 100441593(DCPS)
NLE: 100601639(DCPS)
MCC: 717749(DCPS)
MCF: 102120410(DCPS)
CSAB: 103248789(DCPS)
CATY: 105582621(DCPS)
PANU: 100997052(DCPS) 116268623
RRO: 115893594(DCPS)
RBB: 108542316(DCPS)
TFN: 117080847(DCPS)
PTEH: 111540312(DCPS)
CJC: 100410129(DCPS)
SBQ: 101040093(DCPS)
MMUR: 105875361(DCPS)
MMU: 69305(Dcps)
MCAL: 110301822(Dcps)
MPAH: 110327897(Dcps)
RNO: 266605(Dcps)
MCOC: 116073396(Dcps)
MUN: 110555278(Dcps)
CGE: 100761162(Dcps)
PLEU: 114699776(Dcps)
NGI: 103735398(Dcps)
HGL: 101715664(Dcps)
CCAN: 109698463(Dcps)
OCU: 100338456 108175353(DCPS)
OPI: 101528582(DCPS)
TUP: 102484523(DCPS)
CFA: 609536(DCPS)
VVP: 112920265(DCPS)
VLG: 121500392(DCPS)
AML: 100470542(DCPS)
UMR: 103660653(DCPS)
UAH: 113259881(DCPS)
ORO: 101375494(DCPS)
ELK: 111153955
MPUF: 101671617(DCPS) 101692260
EJU: 114222324(DCPS)
MLX: 118013384(DCPS)
FCA: 101088950(DCPS)
PYU: 121035615(DCPS)
PBG: 122483131(DCPS)
PTG: 102969848(DCPS)
PPAD: 109250349(DCPS)
AJU: 106974920(DCPS)
BTA: 282640(DCPS)
BOM: 102278216(DCPS)
BBUB: 102407028(DCPS)
CHX: 102190586(DCPS)
OAS: 101114475(DCPS)
ODA: 120874444(DCPS)
CCAD: 122431227(DCPS)
SSC: 396689(DCPS)
CFR: 102519944(DCPS)
CBAI: 105074190(DCPS)
CDK: 105094264(DCPS)
BACU: 103009141(DCPS)
LVE: 103078579(DCPS)
OOR: 101284952(DCPS)
DLE: 111165468(DCPS)
PCAD: 102979201(DCPS)
ECB: 100064530(DCPS)
EPZ: 103549022(DCPS)
EAI: 106834017(DCPS)
MYB: 102251721(DCPS)
MYD: 102774242(DCPS)
MNA: 107530600(DCPS)
HAI: 109391391(DCPS)
DRO: 112301771(DCPS)
SHON: 118981478(DCPS)
AJM: 119041088(DCPS)
MMF: 118640052(DCPS)
PALE: 102879340(DCPS)
PGIG: 120610444(DCPS)
RAY: 107507803(DCPS)
MJV: 108399048(DCPS)
TOD: 119240833(DCPS)
LAV: 100656614(DCPS)
TMU: 101343348
MDO: 100019554(DCPS)
SHR: 100935301(DCPS)
PCW: 110218146(DCPS)
OAA: 100089721(DCPS) 114815064
GGA: 419716(DCPS)
PCOC: 116233046(DCPS)
MGP: 100544934(DCPS)
CJO: 107324199(DCPS)
NMEL: 110387711(DCPS)
APLA: 101792448(DCPS)
ACYG: 106040558(DCPS)
TGU: 100217679(DCPS)
LSR: 110468147(DCPS)
SCAN: 103822804(DCPS)
PMOA: 120508342(DCPS)
OTC: 121340875(DCPS)
PRUF: 121360569(DCPS)
GFR: 102035714(DCPS)
FAB: 101821090(DCPS)
PHI: 102102643(DCPS)
PMAJ: 107214434(DCPS)
CCAE: 111939373(DCPS)
CCW: 104692219(DCPS)
ETL: 114064607(DCPS)
FPG: 101910550(DCPS)
FCH: 102047627(DCPS)
CLV: 106145844(DCPS)
EGZ: 104129234(DCPS)
NNI: 104016674(DCPS)
ACUN: 113488429(DCPS)
PADL: 103916421(DCPS)
AAM: 106498500(DCPS)
AROW: 112968909(DCPS)
NPD: 112947250(DCPS)
DNE: 112981575(DCPS)
ASN: 102384846(DCPS)
AMJ: 102564856(DCPS)
CPOO: 109317986(DCPS)
GGN: 109291832(DCPS)
PSS: 102454492(DCPS)
CMY: 102947472(DCPS)
CPIC: 101942376(DCPS)
TST: 117868609(DCPS)
CABI: 116818781(DCPS)
ACS: 100567351(dcps)
PVT: 110088810(DCPS)
PBI: 103066095(DCPS)
PMUR: 107292369(DCPS)
TSR: 106556634
PGUT: 117668198(DCPS)
PMUA: 114585279(DCPS)
ZVI: 118096820(DCPS)
GJA: 107119892(DCPS)
XLA: 394400(dcps.L)
XTR: 100216298(dcps)
NPR: 108794017(DCPS)
DRE: 402850(dcps)
SRX: 107758690
CCAR: 109098029(dcps)
CAUA: 113110030(dcps)
IPU: 108276556(dcps)
PHYP: 113544859(dcps)
AMEX: 103034238(dcps)
EEE: 113580713(dcps)
TRU: 115252309 445993(dcps)
LCO: 104932284(dcps)
NCC: 104948373(dcps)
CGOB: 115015165(dcps)
ELY: 117260698(dcps)
PLEP: 121948156(dcps)
SLUC: 116036614(dcps)
ECRA: 117951987(dcps)
PFLV: 114562779(dcps)
GAT: 120817091(dcps)
PPUG: 119210912(dcps)
MSAM: 119889163(dcps)
CUD: 121516485(dcps)
MZE: 101484626(dcps)
ONL: 100707834(dcps)
OAU: 116328134(dcps)
OLA: 101158538(dcps)
OML: 112153019(dcps)
XMA: 102224706(dcps)
XCO: 114139758(dcps)
XHE: 116714962(dcps)
PRET: 103471025(dcps)
CVG: 107093834(dcps)
CTUL: 119797263(dcps)
NFU: 107382541(dcps)
KMR: 108240022(dcps)
ALIM: 106533196(dcps)
AOCE: 111567332(dcps)
CSEM: 103391261
POV: 109627365(dcps)
LCF: 108878927(dcps)
SDU: 111226662(dcps)
SLAL: 111646433(dcps)
XGL: 120785385(dcps)
HCQ: 109524308(dcps)
BPEC: 110172173(dcps)
MALB: 109957539(dcps)
SASA: 106603769(dcps)
OTW: 112228342(dcps)
OMY: 110533428(dcps)
SALP: 111950644(dcps)
SNH: 120056935(dcps)
ELS: 105028750(dcps)
SFM: 108921345(dcps)
PKI: 111860786(dcps)
AANG: 118235091(dcps)
LOC: 102688135(dcps)
PSPA: 121309528(dcps)
LCM: 102361941(DCPS) 102366682
CMK: 103180338(dcps)
RTP: 109916492(dcps)
BFO: 118421283
BBEL: 109484414
CIN: 100175982
SPU: 587255
APLC: 110983458
SKO: 100367637
DME: Dmel_CG2091(CG2091)
DER: 6552743
DSE: 6614022
DSI: Dsimw501_GD19585(Dsim_GD19585)
DAN: 6501420
DSR: 110187776
DPE: 6588316
DMN: 108156456
DWI: 6650349
DGR: 6564358
DAZ: 108608805
DNV: 108650800
DHE: 111603030
DVI: 6630459
CCAT: 101461473
BOD: 106627741
MDE: 101893363
SCAC: 106096354
LCQ: 111682688
ACOZ: 120955081
AARA: 120903292
AAG: 5571000
CPII: 120414888
AME: 552284
ACER: 107999990
BIM: 100746156
BBIF: 117217115
BVK: 117236526
BVAN: 117154605
BTER: 100643261
CCAL: 108630216
OBB: 114872246
MGEN: 117221088
NMEA: 116425822
CGIG: 122397240
SOC: 105202710
MPHA: 105830142
AEC: 105153426
ACEP: 105619523
PBAR: 105425029
VEM: 105564814
HST: 105187533
DQU: 106746690
CFO: 105258276
FEX: 115238894
LHU: 105678394
PGC: 109863073
OBO: 105276707
PCF: 106787996
PFUC: 122516956
NVI: 100121865
CSOL: 105364356
TPRE: 106655657
MDL: 103577054
FAS: 105273354
DAM: 107046049
CCIN: 107270176
TCA: 658490
ATD: 109602175
AGB: 108906051
NVL: 108563755
APLN: 108736635
PPYR: 116180940
OTU: 111421559
BMOR: 101739862
BMAN: 114248421
PMAC: 106720528
PPOT: 106100188
PRAP: 111000036
ZCE: 119835975
HAW: 110381189
TNL: 113505511
API: 100163679(Dcps)
DNX: 107168087
AGS: 114129532
RMD: 113555575
BTAB: 109035356
DCI: 103511802
CLEC: 106665736
HHAL: 106684577
FOC: 113210192
ZNE: 110833667
CSEC: 111866175
DMK: 116928537
PVM: 113809607
HAME: 121863847
EAF: 111711782
DSV: 119431036
RSAN: 119407265
RMP: 119163629
VDE: 111244496
VJA: 111267145
TUT: 107359431
DPTE: 113797724
CSCU: 111623446
CEL: CELE_Y113G7A.9(dcs-1)
CBR: CBG12933(Cbr-dcs-1)
BMY: BM_BM7299(Bma-dcs-1)
TSP: Tsp_13171
PCAN: 112556716
BGT: 106066742
GAE: 121390407
CRG: 105342540
OBI: 106868479
OSN: 115217210
LAK: 106179651
EGL: EGR_00336
EPA: 110233505
ATEN: 116297305
ADF: 107337033
AMIL: 114975814
PDAM: 113666852
SPIS: 111331430
HMG: 100205537
AQU: 100632526
ERC: Ecym_3126
KMX: KLMA_40182(DCS1)
NCS: NCAS_0D02700(NCAS0D02700) NCAS_0F00320(NCAS0F00320)
NDI: NDAI_0I02210(NDAI0I02210) NDAI_0K02850(NDAI0K02850)
TPF: TPHA_0F02580(TPHA0F02580) TPHA_0K01170(TPHA0K01170)
TBL: TBLA_0A09660(TBLA0A09660) TBLA_0G00540(TBLA0G00540)
TDL: TDEL_0G04070(TDEL0G04070)
KAF: KAFR_0A05030(KAFR0A05030) KAFR_0G02510(KAFR0G02510)
CAL: CAALFM_C701190WA(CaO19.6901)
NCR: NCU06998
MGR: MGG_15696
SSCK: SPSK_00555
MAW: MAC_06415
MAJ: MAA_05059
ANI: AN7492.2
ANG: ANI_1_3306024(An02g13910)
ABE: ARB_03877
TVE: TRV_06634
PTE: PTT_17752
SPO: SPBP4H10.20(nhm1)
CNE: CNN00850
TASA: A1Q1_03343
MGL: MGL_3756
MRT: MRET_1723
EHI: EHI_169590(223.t00003)
SPAR: SPRG_07731
 » show all
1  [PMID:16963086]
Malys N, McCarthy JE
Dcs2, a novel stress-induced modulator of m7GpppX pyrophosphatase activity that locates to P bodies.
J Mol Biol 363:370-82 (2006)
2  [PMID:18441014]
Liu SW, Rajagopal V, Patel SS, Kiledjian M
Mechanistic and kinetic analysis of the DcpS scavenger decapping enzyme.
J Biol Chem 283:16427-36 (2008)
3  [PMID:12198172]
Liu H, Rodgers ND, Jiao X, Kiledjian M
The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases.
EMBO J 21:4699-708 (2002)
[hsa:28960] [sce:YLR270W]
4  [PMID:14523240]
van Dijk E, Le Hir H, Seraphin B
DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway.
Proc Natl Acad Sci U S A 100:12081-6 (2003)
[hsa:28960] [sce:YLR270W]
5  [PMID:15769464]
Chen N, Walsh MA, Liu Y, Parker R, Song H
Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping.
J Mol Biol 347:707-18 (2005)
6  [PMID:15383679]
Cohen LS, Mikhli C, Friedman C, Jankowska-Anyszka M, Stepinski J, Darzynkiewicz E, Davis RE
Nematode m7GpppG and m3(2,2,7)GpppG decapping: activities in Ascaris embryos and  characterization of C. elegans scavenger DcpS.
RNA 10:1609-24 (2004)
7  [PMID:22985415]
Wypijewska A, Bojarska E, Lukaszewicz M, Stepinski J, Jemielity J, Davis RE, Darzynkiewicz E
7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity.
Biochemistry 51:8003-13 (2012)
[ag:ADB92583] [cel:CELE_Y113G7A.9] [hsa:28960] [sce:YLR270W]
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