KEGG   ENZYME: 3.6.1.61
Entry
EC 3.6.1.61                 Enzyme                                 
Name
diadenosine hexaphosphate hydrolase (ATP-forming);
Ndx1
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
Sysname
P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (ATP-forming)
Reaction(IUBMB)
(1) P1,P6-bis(5'-adenosyl)hexaphosphate + H2O = 2 ATP [RN:R09879];
(2) P1,P5-bis(5'-adenosyl)pentaphosphate + H2O = ATP + ADP [RN:R09880];
(3) P1,P4-bis(5'-adenosyl)tetraphosphate + H2O = ATP + AMP [RN:R00184]
Reaction(KEGG)
Substrate
P1,P6-bis(5'-adenosyl)hexaphosphate [CPD:C20190];
H2O [CPD:C00001];
P1,P5-bis(5'-adenosyl)pentaphosphate [CPD:C04058];
P1,P4-bis(5'-adenosyl)tetraphosphate [CPD:C01260]
Product
ATP [CPD:C00002];
ADP [CPD:C00008];
AMP [CPD:C00020]
Comment
The enzyme requires the presence of the divalent cations (Mn2+, Mg2+, Zn2+, and Co2+). It hydrolyses P1,P4-bis(5-guanosyl) tetraphosphate very slowly [cf. EC 3.6.1.17, bis(5-nucleosyl)-tetraphosphatase (asymmetrical)].
History
EC 3.6.1.61 created 2012
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
Orthology
K18445  diadenosine hexaphosphate hydrolase (ATP-forming)
Genes
TCOTheco_2395
BTSBtus_1250
AHKNCTC10172_00318
DGEDgeo_1007
DMRDeima_2556
DPDDeipe_3189
DPUSU48_08635
DPHEHF33_03030
TRATrad_2852
TTHTT_C1519
TTJTTHA1880(TTHA1880)
TTSThthe16_1884
TTLTtJL18_1964
TSCTSC_c24030
THCTCCBUS3UF1_21630
TOSTheos_0154
TAQTO73_2290
TBCA0O31_00827
TANTKNN15_03610
MRBMrub_1608
MREK649_14515
MSVMesil_0927
MTAIMtai_v1c13500
OPROcepr_0595
MHDMarky_0630
 » show all
Reference
1  [PMID:15024014]
  Authors
Iwai T, Kuramitsu S, Masui R
  Title
The Nudix hydrolase Ndx1 from Thermus thermophilus HB8 is a diadenosine hexaphosphate hydrolase with a novel activity.
  Journal
J Biol Chem 279:21732-9 (2004)
DOI:10.1074/jbc.M312018200
  Sequence
[ttj:TTHA1880]
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.61
IUBMB Enzyme Nomenclature: 3.6.1.61
ExPASy - ENZYME nomenclature database: 3.6.1.61
BRENDA, the Enzyme Database: 3.6.1.61

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