KEGG   ENZYME: 4.1.1.107
Entry
EC 4.1.1.107                Enzyme                                 
Name
3,4-dihydroxyphenylacetaldehyde synthase;
DHPAA synthase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
L-dopa carboxy-lyase (oxidative-deaminating)
Reaction(IUBMB)
L-dopa + O2 + H2O = 3,4-dihydroxyphenylacetaldehyde + CO2 + NH3 + H2O2 [RN:R11916]
Reaction(KEGG)
R11916
Substrate
L-dopa [CPD:C00355];
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
3,4-dihydroxyphenylacetaldehyde [CPD:C04043];
CO2 [CPD:C00011];
NH3 [CPD:C00014];
H2O2 [CPD:C00027]
Comment
A pyridoxal 5'-phosphate protein. The enzyme, isolated from the mosquito Aedes aegypti, catalyses the production of 3,4-dihydroxylphenylacetaldehyde directly from L-dopa. Dopamine is not formed as an intermediate (cf. EC 4.1.1.28, aromatic-L-amino-acid decarboxylase). The enzyme is specific for L-dopa and does not react with other aromatic amino acids with the exception of a low activity with alpha-methyl-L-dopa.
History
EC 4.1.1.107 created 2017
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
Orthology
K01618  3,4-dihydroxyphenylacetaldehyde synthase
Genes
DMEDmel_CG10501(amd)
DER6549501
DSE6614648
DSIDsimw501_GD24184(Dsim_amd)
DYADyak_GE13232
DAN6497523
DSR110181428
DPO117183959 4816707
DPE6597981 6597983
DMN108161124 117189005
DWI6644459
DGR6566401
DMODmoj_GI13977
DAZ108611006
DNV108658087
DHE111600249
DVI6634249
CCAT101454786 101462480
BOD106615364 106616425
RZE108357276 108373418
MDE101888467
SCAC106085354
LCQ111685139
LSQ119607392
HIS119650590
AGAAgaP_AGAP009090
ACOZ120959634
AARA120904565
ASTE118509868
AAG5573809
AALB109404823 109423887
CQUCpipJ_CPIJ013308
CPII120415581
CNS116343658 116343942
BCOO119072247 119072248 119074606
TPRE106649945 106654040
CGLO123272459
FAS105273510
DAM107038037
LHT122507894
SOY115875383
CSET123310893
AGB108909329
APLN108739719 108739728 108739729 112904224
PPYR116172347
MSEX115445053 115445067
BANY112044897 112044903
NIQ126781437
PRAP111000456
HZE124646041
OFU114354472 114354577
CFEL113372214
DCI103513799 108252376
 » show all
Reference
1  [PMID:21283636]
  Authors
Vavricka C, Han Q, Huang Y, Erickson SM, Harich K, Christensen BM, Li J
  Title
From L-dopa to dihydroxyphenylacetaldehyde: a toxic biochemical pathway plays a vital physiological function in insects.
  Journal
PLoS One 6:e16124 (2011)
DOI:10.1371/journal.pone.0016124
  Sequence
[aag:5573809]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.107
IUBMB Enzyme Nomenclature: 4.1.1.107
ExPASy - ENZYME nomenclature database: 4.1.1.107
BRENDA, the Enzyme Database: 4.1.1.107

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