KEGG   ENZYME: 4.1.1.4
Entry
EC 4.1.1.4                  Enzyme                                 
Name
acetoacetate decarboxylase;
acetoacetic acid decarboxylase;
acetoacetate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
acetoacetate carboxy-lyase (acetone-forming)
Reaction(IUBMB)
acetoacetate + H+ = acetone + CO2 [RN:R01366]
Reaction(KEGG)
R01366
Substrate
acetoacetate [CPD:C00164];
H+ [CPD:C00080]
Product
acetone [CPD:C00207];
CO2 [CPD:C00011]
History
EC 4.1.1.4 created 1961
Pathway
ec00650  Butanoate metabolism
ec01100  Metabolic pathways
Orthology
K01574  acetoacetate decarboxylase
Genes
SODSant_2149
XBCELE36_05380
DJAHY57_02905
DTXATSB10_30600
DYEEO087_12185
DCSISN74_00485
DTADYST_02988
VHAVIBHAR_01634
VCAM892_04960
VNIVIBNI_A1549
PMAICF386_02380
PAPPSPA7_3628
PCAVD3880_11750 D3880_11760
ABYABAYE1742
ABNAB57_2158
ABBABBFA_01610(adc)
ACALBUM88_10390
ASEII8T81_08885
ACDAOLE_08860
ADSFPL17_09310
AGYLFPL18_01805
MOSAXE82_10470
ZALAZF00_04640
OSGBST96_08300 BST96_14785
HJABST95_04415 BST95_09935
HALCEY643_12670 EY643_18075
ALGAQULUS_15330(adc)
ASIPAQUSIP_11420(adc)
LPNlpg0672
LPHLPV_0792
LPOLPO_0752
LPULPE509_02541
LPMLP6_0655(adc)
LPFlpl0708
LPPlpp0728
LPCLPC_2621(adc)
LPAlpa_01052(adc)
LPElp12_0680
LLOLLO_0619 LLO_1749
LFALFA_2607(adc)
LHALHA_0922(adc)
LOKLoa_02267
LCDclem_10470(adc)
LSHCAB17_07330 CAB17_13380
LLG44548918_01965(adc)
LIBE4T55_09670
LJRNCTC11533_02131(adc)
LCJNCTC11976_01373(adc)
LWASAMEA4504053_0998(adc)
LSSNCTC12082_00433(adc)
LADLNCTC12735_00965(adc)
LANTTUM19329_28970(adc)
LLYJ2N86_04795
TMCLMI_1009(adc)
MMOBF6R98_20790
FTQRO31_1069
FTRNE061598_05330
FTLFTL_1279
FTHFTH_1252(adc)
FTSF92_07090
FTCDA46_1493
FTVCH67_1654
FTZCH68_1385
FTNFTN_0808
FTXAW25_1211
FTDAS84_1732 AS84_221(adc)
FTYCH70_1214 CH70_1602
FCFFNFX1_0817
FCNFN3523_0977
FHIFSC454_05175
FPHFphi_1806
FPTBZ13_182
FPIBF30_62
FPMLA56_367
FPXKU46_1489
FPZLA55_976
FPJLA02_1504
FRTF7308_1310
FRFLO80_01300
FRXF7310_04975
FRMBBG19_0835
FRCKX01_1314
FADCDH04_04930
FMIF0R74_03580
FOOCGC45_04235
FSRKQR59_05150
FGUSD28_05150
THIPN838_24315
GAIIMCC3135_28100(adc)
OMEOLMES_2715
AEMCK911_01335
NBACUN60_01510
CVICV_3520
CVCBKX93_08355
CHROCXB49_03930
CHRIDK842_02525
CHRBDK843_08005
CRZD1345_14140
CHRMFYK34_12015
CHAECH06BL_29750(adc)
AMAHDLM_2798
AQSDKK66_13055
RSORSp1058(adc)
RSLRPSI07_mp1091(adc)
RSNRSPO_m01367(adc)
RSMCMR15_mp20167(adc)
RSEF504_4138
RSYRSUY_42550
RPIRpic_4271
RPFRpic12D_4381
RMNTK49_22010
RINACS15_4215
RPUCDC45_22940
RSGJK151_21925
CUHBJN34_28440
CBWRR42_m0247
CPAUEHF44_02675
CCAMM5D45_28725
BMABMAA0018(adc)
BMVBMASAVP1_1168(adc)
BMLBMA10229_1447(adc)
BMNBMA10247_A0022(adc)
BMALDM55_3681
BMAEDM78_4554
BMAQDM76_4377
BMAIDM57_05105
BMAFDM51_3796
BMAZBM44_3641
BMABBM45_4418
BPSBPSS0018(adc)
BPMBURPS1710b_A1525
BPLBURPS1106A_A0022
BPDBURPS668_A0024
BPSEBDL_5849
BPSMBBQ_3727
BPSUBBN_5873
BPSDBBX_5018
BPZBP1026B_II0019(adc)
BPQBPC006_II0021
BPKBBK_5157
BPSHDR55_5353
BPSABBU_3615
BPSOX996_5124
BUTX994_4674
BTEBTH_II0020
BTQBTQ_3309
BTJBTJ_4341
BTZBTL_5142
BTDBTI_4738
BTVBTHA_5074
BTHEBTN_4803
BTHMBTRA_5071
BTHADR62_4906
BTHLBG87_5138
BOKDM82_3936
BOCBG90_4090
BUUWS70_17385
BSAVWS86_30990
BHGI6G56_29340
BVIBcep1808_3777 Bcep1808_4583
BVEAK36_4334 AK36_4932
BURBcep18194_B1397 Bcep18194_B3166
BCMBcenmc03_4525
BCHBcen2424_5714
BCJBCAM0023(adc)
BCENDM39_4984
BCEWDM40_3428
BCEOI35_4023(adc)
BAMBamb_4983
BACBamMC406_3126 BamMC406_5563
BMUBmul_5311
BMKDM80_4524
BMULNP80_3407
BCTGEM_5548
BCEDDM42_5124
BCEPAPZ15_24935 APZ15_36175
BDLAK34_4944
BPYRABD05_21330 ABD05_30610
BCONNL30_25410
BUBBW23_4035
BDFWI26_15450
BLATWK25_15965 WK25_19575
BTEIWS51_00085
BSEMWJ12_20710
BPSLWS57_12915
BMECWJ16_19915
BSTGWT74_20460 WT74_24130
BSTLBBJ41_28100
BANNJFN94_18330
BGLbglu_2g00230
BGUKS03_3618
BGDbgla_2g00270
BGOBM43_6753
BYIBYI23_D003570
BUKMYA_3434 MYA_4654
BUEBRPE67_DCDS05300
BULBW21_4268
BUQAC233_25510
BGPBGL_2c00230
BPLAbpln_2g00230
BUDAQ610_19580
BURKDM992_22035 DM992_26110 DM992_34560
BXEBxe_A2916 Bxe_A3367
BXBDR64_1067 DR64_598
BPHBphy_3919 Bphy_5526
BPYBphyt_1567 Bphyt_2412
BUZAYM40_23020 AYM40_28035
BFNOI25_154
BCAIK788_0000336 K788_0005690
PARABTO02_31245
PARBCJU94_17225
PHSC2L64_26230 C2L64_27150
PTERC2L65_22200 C2L65_28160
PGPCUJ91_30705
PTSCUJ90_25220
PCAFDSC91_006665
PMEGFNZ07_10510
PTROG5S35_27335
PGISI6I06_05885
PACPFAZ97_23835 FAZ97_28595
PEWKZJ38_25620 KZJ38_33460
PDIOPDMSB3_0240.1 PDMSB3_1576
PTXABW99_09945
HYFDTO96_102460(adc)
BUOBRPE64_DCDS09330
BAVBAV0264(adc)
BTRMSAMEA390648701655(adc)
BBROBAU06_24145
BFZBAU07_19180
PUSCKA81_13060
BOZDBV39_10855
PARKLSG25_13730
RHYRD110_13955
RHFEUB48_06495
AAAAcav_3657
VPEVarpa_3667
VAAAX767_00600
VAMC4F17_03210
HYCE5678_14280
RDPRD2015_2872
JAGGJA_1480(adc)
HHTF506_04135
HEEhmeg3_06130
CFUCFU_1420(adc)
CARELT85_3349
CPRACPter91_3559
GLCJQN73_14705
TINTint_0561
THITHI_0731(adc)
FPHOSHINM1_016820(adc)
DALDalk_0253 Dalk_5186
DTIDesti_0617
RBTNOVO_06325(adc)
MLOmll5917 mlr2399 mlr3634
MLNA9174_07425 A9174_32420
MCIMesci_1460
MOPMesop_1502
MAMMesau_01515
MAMOA6B35_01070
MESWA9K65_007490
MESMEJ066_12285
MESPC1M53_17115 C1M53_17410
MHUAMCHK_5016
MJREB229_07635 EB229_33140
MERDEB233_07550 EB233_30785
MOHIHQ72_12815 IHQ72_12890 IHQ72_13400 IHQ72_34110
PHTBLM14_18370
PHYLHB779_05205
SFDUSDA257_c17320 USDA257_c17360
SIXBSY16_5136
RLEpRL90174(adc)
RLGRleg_6203
RTRRTCIAT899_PC07610
RHLLPU83_pLPU83d0937
RHRCKA34_24375
RIIFFM53_006555 FFM53_034345
RRGJ3P73_36675
KAIK32_06370(adc)
BJAbll7763(bll7763) blr3945(blr3945) blr7028(blr7028)
BJUBJ6T_16150 BJ6T_58910 BJ6T_62570
BJPRN69_07975 RN69_30325
BBTBBta_1411(adc)
BRCBCCGELA001_06320
BRADBF49_0522 BF49_1107
BICLMTR13_18410
BRKCWS35_01220 CWS35_27820
BOTCIT37_17685 CIT37_22400 CIT37_34260 CIT37_35815
BGQX265_23275
BGZXH91_31050
BARHWN72_21245
BVZBRAD3257_2299(adc)
BELBE61_63130 BE61_85850 BE61_87570
BDGLPJ38_10445
BSEPHAP48_0021020 HAP48_0022790 HAP48_0034650
BQBJ4P68_0003745 J4P68_0013070 J4P68_0017465
VGOGJW-30_1_03383(adc_1) GJW-30_1_03970(adc_2)
TRBHB776_20345 HB776_20960
BOPAXW83_05225
BVVBHK69_03865
BOIBLM15_25975
BOFFQV39_15580 FQV39_29260
XAUXaut_2132
XDIEZH22_06805 EZH22_22120
AZCAZC_0288
SNOSnov_2828
STARG3545_25075
LNEFZC33_29985
ANCGBB76_08680
APRAG3A50_05825
APOLK9D25_10500
MNOMnod_4592 Mnod_7618
MAQUMaq22A_2p40725 Maq22A_c24380(adc)
MEEDA075_16590
MTEADK419_22800
MINDmvi_07160(adc)
MOCBB934_02595 BB934_11530 BB934_31395 BB934_36525
BIDBind_1938 Bind_2695
MSLMsil_2114
MTUNMTUNDRAET4_2027(adc)
MLGCWB41_08665
CHELAL346_14825
HDNHden_0804
HDTHYPDE_33703
HMCHYPMC_1385(adc)
RHZRHPLAN_16330 RHPLAN_31430
NTDEGO55_03040
MSCBN69_0254
MBRYB1812_03945
MHEYH2LOC_018525
MPARF7D14_04450
MTWCQW49_20700
CMETK6K41_05010
MMEDMame_04573(adc)
AALMLUX29_01500
PSINCAK95_21710
NOHG5V57_06280
PSFPSE_4743(adc)
PSTGE8M01_28145 E8M01_28150
LIZLGH83_00970
ACUTMRB58_04025
OCTFTO60_03710
PALXGQA70_19890
PTPRCA23_c23280
THWBMG03_19400
PSEBEOK75_19330
NSMJO391_14155
SPHKSKP52_08055(adc1)
SPHXE5675_08905
SPHDHY78_18210
SPHMG432_16970
SSANNX02_07810
SPKCKC8_10265
SJPSJA_C1-05680(adc)
SUFLFIL70_04295
BLASBSY18_3376 BSY18_3377
BFWB5J99_07755 B5J99_07760
SPHJBSL82_17630
ACRAcry_0495
AMVACMV_05700(adc)
STELSTAQ_24930(adc)
ATIAL072_27465
NAOY958_21525
HTQFRZ44_16710(adc2) FRZ44_20890
HADHFRZ61_26150
BAYRBAM_030030
BAQBACAU_3026(adc)
BYABANAU_3191(adc)
BAMPB938_15370
BQYMUS_3595(adc)
BAMLBAM5036_2915(adc)
BAMARBAU_3134(adc)
BAMNBASU_2921(adc)
BAMBBAPNAU_3182(adc)
BAMTAJ82_16990
BAMYV529_32620
BMPNG74_03152(adc)
BAMIKSO_004145
BAMCU471_31140
BAMFU722_16140
BAEBATR1942_11245
BVMB9C48_15350
BACPSB24_13720
BACBOY17_18340
PKSIE339_16525
TAPGZ22_05505
VNECFK40_04275 CFK40_04285
RMFD5E69_14540
BOUI5818_14270
SCASCA_2369(adc)
SSIFAL483_11335
SCVA4G25_08380
SCARDWB96_00205
EXMU719_06385
EXUESP131_08780
EACEKKI46_06565
PPYPPE_01174
PPMPPSC2_06055(adc1) PPSC2_12620(adc3)
PPOPPM_1145(adc1) PPM_2419(adc3)
PPOLX809_06080
PPQPPSQR21_012350(adc)
PPOYRE92_05830 RE92_24155
PTAHPL003_14115
PGMPGRAT_02175
PODPODO_04285
PAENP40081_05090
PRIPRIO_0485(adc) PRIO_1671
PSONJI735_13490
PPEOABE82_06170
PBVAR543_07805
PXLBS614_18985
PDHB9T62_37500
PKBB4V02_16110
PAIHASL14_05605
PBACHUB98_01770
RSTATY39_08040
LJEBUE77_06840
LCALSEI_0716
LCZLCAZH_0655
LCSLCBD_0791
LCELC2W_0790
LCWBN194_07850
LCLLOCK919_0817
LPILBPG_02782
LPAPLBPC_0634
LCBLCABL_07810
LCXLCA12A_1743
LRHLGG_00705(adc)
LRGLRHM_0682
LZEKG087_03340
LPLlp_0061(adc)
LPJJDM1_0071
LPTzj316_0277(adc)
LPSLPST_C0050
LPRLBP_cg0051
LPZLp16_0063
LPBSH83_00270
LPXASU28_03095
LPGBB562_00270
LARGLPA65_00260
LLEAYR59_02500
LFVLF543_00935
LSLLSL_0135
LSIHN6_00115
LSJLSJ_0164
LCYLC20004_00610
LROSLROSL1_1927
WVRIE337_06635
CACCA_P0165(adc)
CAESMB_P163(adc)
CAYCEA_P0163(adc)
CBKCLL_A2135
CBECbei_3835
CBZCbs_3835
CBEILF65_04320
CSRCspa_c56910(adc)
CPASClopa_1770
CPATCLPA_c15190(adc)
CPAECPAST_c15190(adc)
CSBCLSA_c33610(adc)
CEUA7L45_02865
CTAEBGI42_07960
CDYF3K33_19600
CGASJ1C67_05790
CMAHC1I91_22765
CRWCROST_023590(adc)
CFBCLFE_022500(adc)
CAUNCLAUR_007390(adc)
ACELacsn021_01220(adc)
VGUHYG85_06270
MHWACT01_12400
PFTJBW_00069
MPAMAP_2773c
MAOMAP4_1040
MAVIRC58_05130
MAVURE97_05125
MAVMAV_3542
MITOCO_33770
MIAOCU_33790
MIDMIP_05085
MYOOEM_34150
MCHIAN480_17900
MIROCQ_34990
MMALCKJ54_15770
MMANMMAN_04210
MSAMycsm_01688
MMIMMAR_4819
MMAEMMARE11_46490
MLIMULP_05051
MPSEMPSD_50000
MSHOMSHO_58400
MMMW7S_16890
MKNMKAN_10550
MYEAB431_17560
MSAKMSAS_14200(adc)
MXEMYXE_48460
MNVMNVI_17560
MNMMNVM_19640
MBAIMB901379_04218(adc)
MSEOMSEO_30090
MHEKJMUB5695_04669(adc)
MBRDMBRA_35050
MPAEK0O64_16780
MSPGF6B93_19995
MOTLTS72_01115
MCROMI149_17690
MNED174_26230
MYNMyAD_07535
MRHMycrhN_4709
MMORMMOR_48590
MAICMAIC_30970
MSARMSAR_05920
MANYMANY_41130
MFGK6L26_16690
MCHEBB28_12545
MJDJDM601_4221
MTER4434518_04159(adc)
ASDAS9A_2277
NSLBOX37_13000
NADNCTC11293_03327
RHARHA1_ro08625
RAVAAT18_24735
RTMG4H71_04245
SMASAVERM_1349(adc)
SCBSCAB_9691
SVLStrvi_5947
SHYSHJG_1786
SHOSHJGH_1551
SRCM271_42575
SBHSBI_00526 SBI_08674
SCIB446_09495
SALUDC74_2332
SALLSAZ_13010
STREGZL_06678 GZL_08372
SLDT261_6320
STRMM444_09535
STRTA8713_00885
SGSAVL59_35935
STSIA4E84_21340
SALWCP975_07680
SLSSLINC_8478
SNRSNOUR_31080
SPLULK06_006090
SPUNBFF78_32205
SGVB1H19_11245
SALFSMD44_01968(adc)
SALJSMD11_6826
SLXSLAV_28250(adc)
STROSTRMOE7_32465
SFKKY5_1742c KY5_2595c
SGEDWG14_01131(adc_2)
SRJSRO_3431
SLKSLUN_08815
SDXC4B68_38780
SCYAEJ357_37715
SNQCP978_02645
SKACP970_33955
SVNCP980_25620
SHAWCEB94_21475
SVRCP971_02470
SFYGFH48_31020
SAQUEJC51_43195
SGFHEP81_03643
SSEOD0Z67_27000
SBYH7H31_00240
SSUBCP968_25430
SCHACP983_05185
SGXH4W23_09265
SCOECP976_23035
SSPBCP982_10830
SNFJYK04_02504(adc)
SBROGQF42_41280
SDWK7C20_31690
SMOBJ7W19_28345
SANUK7396_05745
SDECL3078_44055
SCTSCAT_p0752(adc) SCAT_p1328(adc)
SCYSCATT_p03950 SCATT_p09870
STRIC7M71_000890
CUMNI26_09280
CUGC1N91_09425
ASOIMTP13_02930
MSPOKXZ72_05145
ARIUM93_15800
RSARSal33209_0180
SATKSA2016_2865
SROSros_7640
FRIFraEuI1c_1622
SENSACE_5407(adc)
AMDAMED_6368(adc)
AMNRAM_32650
AMMAMES_6277(adc)
AMZB737_6277(adc)
AOIAORI_2197(adc)
AJAAJAP_28300(adc)
AMQAMETH_6177(adc)
AMYCCU254_20680
AMYBBKN51_03565
AMYYYIM_22705(adc)
AORISD37_11975
AACDLWP59_35165
APRTMUY14_04270
AROONQK81_11375
PSEAWY02_01425
PSEHXF36_09655
SESPBN6_44810(adc)
KALKALB_2691
KPHYAOZ06_28490
LEDBBK82_28450
CAICaci_2286
AEYCDG81_08725
CWOCwoe_0117
AYMYM304_17700
SHIShel_02690
CYCPCC7424_0744
CYJCyan7822_5322
MPROBJP34_34195
CEPCri9333_2345
ACYAnacy_5651
PLPPle7327_1006
CPHCpha266_0763
MPGTheba_2376
MINFMESINF_2459
ALAMRT761_01615(adc)
METHMBMB1_0670
MSUBBK009_01580
METNBK008_09345
AFGAFULGI_00012750
GAHGAH_01811
MHORMSHOH_3722
MCJMCON_0375
MHUMhun_2366
MRTJKHC33_03765
MEMMemar_1128
MBGBN140_1595
MEMAMMAB1_2041
MCHKMchiMG62_12800
MPIMpet_0201
SSHIJ5U23_02278
SCASSACC_14500(adc)
SISLS215_0799
SIAM1425_0807
SIMM1627_0812
SIDM164_0838
SIYYG5714_0828
SINYN1551_2026
SIILD85_1037
SULABFU36_12620
SULOGFS33_09675
SULLEWF20_01110
VDIVdis_0265 Vdis_2137
VMOVMUT_0534 VMUT_1368
 » show all
Reference
1  [PMID:16747621]
  Authors
Davies R.
  Title
Studies on the acetone-butanol fermentation: 4. Acetoacetic acid decarboxylase of Cl. acetobutylicum (BY).
  Journal
Biochem J 37:230-8 (1943)
DOI:10.1042/bj0370230
Reference
2  [PMID:5911291]
  Authors
Zerner B, Coutts SM, Lederer F, Waters HH, Westheimer FH.
  Title
Acetoacetate decarboxylase. Preparation of the enzyme.
  Journal
Biochemistry 5:813-6 (1966)
DOI:10.1021/bi00867a001
Reference
3  [PMID:19458715]
  Authors
Ho MC, Menetret JF, Tsuruta H, Allen KN
  Title
The origin of the electrostatic perturbation in acetoacetate decarboxylase.
  Journal
Nature 459:393-7 (2009)
DOI:10.1038/nature07938
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.4
IUBMB Enzyme Nomenclature: 4.1.1.4
ExPASy - ENZYME nomenclature database: 4.1.1.4
BRENDA, the Enzyme Database: 4.1.1.4
CAS: 9025-03-0

DBGET integrated database retrieval system