KEGG   ENZYME: 4.1.1.99
Entry
EC 4.1.1.99                 Enzyme                                 
Name
phosphomevalonate decarboxylase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
ATP:(R)-5-phosphomevalonate carboxy-lyase (adding ATP; isopentenyl-phosphate-forming)
Reaction(IUBMB)
ATP + (R)-5-phosphomevalonate = ADP + phosphate + isopentenyl phosphate + CO2 [RN:R10561]
Reaction(KEGG)
R10561
Substrate
ATP [CPD:C00002];
(R)-5-phosphomevalonate [CPD:C01107]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
isopentenyl phosphate [CPD:C20345];
CO2 [CPD:C00011]
Comment
The enzyme participates in a mevalonate pathway that occurs in halophilic archaea. The activity is also present in eubacteria of the Chloroflexi phylum. cf. EC 4.1.1.33, diphosphomevalonate decarboxylase, and EC 4.1.1.110, bisphosphomevalonate decarboxylase.
History
EC 4.1.1.99 created 2014, modified 2018
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17942  phosphomevalonate decarboxylase
Genes
HALVNG_0593G(dmd)
HSLOE_1893F(mvaD)
HDLHALDL1_07090
HHBHhub_1732(mvaD)
HAGSJT689_03750(mvaD)
HABOJRZ79_02255(mvaD)
HNOLT974_03595(mvaD)
HLULT972_09845(mvaD)
HANRLJ422_02475(mvaD)
HJEHacjB3_11155
HALHHTSR_1043(mvaD) HTSR_1765
HHSRHSR6_1076(mvaD) HSR6_1831(pmd)
HSUHLASF_0833(mvaD)
HSFHLASA_0830(mvaD)
SALRFQU85_11735
HALREFA46_007505
HAADMW046_05125(mvaD)
HALXM0R89_12935(mvaD)
HAXZM0R88_13290(mvaD)
SALIL593_12340
SAIMK0C01_09265
HARAAArcS_1922(mvd1)
HMArrnAC1489(dmd)
HHIHAH_2062(dmd)
HHNHISP_10500
HABSG26_02805
HTABVU17_10065
HALJG9465_15195
HSINKDQ40_03130
NPHNP_1580A(mvaD)
NMONmlp_1993(mvaD)
NHOHWV23_04855
NSALHWV07_03955(mvaD)
HUTHuta_0691
HTIHTIA_0600
HALAHrd1104_09580(mvaD)
HMUHmuk_2128
HALZE5139_13780
HALLLC1Hm_1696(dmd)
HAZPGBQ70_13795
HALIBV210_02915
HSNDV733_13305
HDSHSR122_1854(mvd1)
HRRHZS55_09955(mvaD)
HPELHZS54_15200
HLTI7X12_03205
HARCHARCEL1_02615
HDOMUK72_12405(mvaD) MUK72_18300
SSAIN0B31_03695(mvaD)
HWAHQ_1525A(mvaD)
HWCHqrw_1624(mvaD)
HVOHVO_1412(mvaD)
HMEHFX_1486(dmd)
HGIABY42_06940
HALEG3A49_10265
HLSKU306_11920
HBOHbor_18190
HAQDU484_10010
HAJDU500_10255
HAERDU502_07420
HRAEI982_06245
HLMDV707_07860
HALMFCF25_13955(mvaD)
HLAHlac_1434
HALPDOS48_06945
HALBEKH57_03095
HEZZEO776_08350
HALQHrr1229_014665
HSSJ7656_08105
HSAIHPS36_13615
HAZZKI388_06040
SRUBC2R22_08520
HAEhalTADL_3034
HALNB4589_002050(mvaD)
HALGHUG10_06730
HALUHUG12_08730
HMPK6T50_02775
HREK6T36_02605
HRMK6T25_11895
HACBHbl1158_11835
HDFAArcSl_0776(mvaD)
HAHHalar_1389
HTUHtur_1087
HDABB347_03210
HSALJMJ58_03305(mvaD)
HLOJ0X27_03355
HAKZJ0X25_09245 J0X25_13120(mvaD)
NMGNmag_3235(mvaD)
HXAHalxa_3857
NATNJ7G_3246
NPENatpe_2790
NVRFEJ81_12855
NPLFGF80_13460
NAYHYG81_17075
HALYHYG82_18705
HJTDVR14_03890
NGENatgr_0456
HRUHalru_0775
NOUNatoc_1020
HLRHALLA_08960
HLCCHINAEXTREME19995
NAJB1756_18005
NAGAArcMg_1739
NANAArc1_1936
NBGDV706_01870(mvaD)
NASGCU68_11880(mvaD)
SAWLNGM29_17685(mvaD)
CSUCSUB_C1629
 » show all
Reference
1  [PMID:24327557]
  Authors
Dellas N, Thomas ST, Manning G, Noel JP
  Title
Discovery of a metabolic alternative to the classical mevalonate pathway.
  Journal
Elife 2:e00672 (2013)
DOI:10.7554/eLife.00672
Reference
2  [PMID:24375100]
  Authors
Vannice JC, Skaff DA, Keightley A, Addo JK, Wyckoff GJ, Miziorko HM
  Title
Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an  archaeal alternate mevalonate pathway.
  Journal
J Bacteriol 196:1055-63 (2014)
DOI:10.1128/JB.01230-13
  Sequence
[hvo:HVO_1412]
Reference
3  [PMID:31268677]
  Authors
Thomas ST, Louie GV, Lubin JW, Lundblad V, Noel JP
  Title
Substrate Specificity and Engineering of Mevalonate 5-Phosphate Decarboxylase.
  Journal
ACS Chem Biol 14:1767-1779 (2019)
DOI:10.1021/acschembio.9b00322
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.99
IUBMB Enzyme Nomenclature: 4.1.1.99
ExPASy - ENZYME nomenclature database: 4.1.1.99
BRENDA, the Enzyme Database: 4.1.1.99

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