KEGG   ENZYME: 4.1.2.54
Entry
EC 4.1.2.54                 Enzyme                                 
Name
L-threo-3-deoxy-hexylosonate aldolase;
GAAC;
LGA1
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
Sysname
2-dehydro-3-deoxy-L-galactonate L-glyceraldehyde-lyase (pyruvate-forming)
Reaction(IUBMB)
2-dehydro-3-deoxy-L-galactonate = pyruvate + L-glyceraldehyde [RN:R10550]
Reaction(KEGG)
R10550
Substrate
2-dehydro-3-deoxy-L-galactonate [CPD:C20680]
Product
pyruvate [CPD:C00022];
L-glyceraldehyde [CPD:C02426]
Comment
The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina).
History
EC 4.1.2.54 created 2013
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K18103  L-threo-3-deoxy-hexylosonate aldolase
Genes
SLBAWJ20_3293
NCRNCU09532
NTENEUTE1DRAFT115768(NEUTE1DRAFT_115768)
SMPSMAC_06596
PANPODANSg8696
TTTTHITE_2107318
MTMMYCTH_87557
CTHRCTHT_0029160
MGRMGG_07462
PPEIPpBr36_02373
TMNUCRPA7_6928
SSCKSPSK_00854 SPSK_04450
FGRFGSG_05128
FPUFPSE_06524
FVRFVEG_04796
FOXFOXG_07874
NHENECHADRAFT_96312
TRETRIREDRAFT_60067
TRRM419DRAFT_7860
MAWMAC_02116
MAJMAA_01503
CMTCCM_03105
PLJVFPFJ_08155
VALVDBG_00212
VDAVDAG_08496
CFJCFIO01_06981
CHIGCH63R_04290
ELAUCREL1_9196
PFYPFICI_07764
SSLSS1G_00738
BFUBCIN_03g01490(Bclga1)
MBEMBM_04252
PSCOLY89DRAFT_579725
GLZGLAREA_12881
ANIAN2859.2
AFMAFUA_3G11920
ACTACLA_039780
NFINFIA_065390
AORAO090003000752
ANGANI_1_1080024(An02g07720)
AFVAFLA_000931
ALUCAKAW2_10640S
ACHEACHE_21180S
APUUAPUU_30710A
PCSPc18g00500
PDPPDIP_74980
TMFPMAA_023890
TRGTRUGW13939_03810
ABEARB_05689
TVETRV_03692
PNOSNOG_11734
PTEPTT_12089
BZECOCCADRAFT_6119
BSCCOCSADRAFT_40160
BORCOCMIDRAFT_33737
AALTCC77DRAFT_687369
BCOMBAUCODRAFT_28953
NPAUCRNP2_4054
FMEFOMMEDRAFT_21161
PFPPFL1_04596
 » show all
Reference
1  [PMID:17609199]
  Authors
Hilditch S, Berghall S, Kalkkinen N, Penttila M, Richard P
  Title
The missing link in the fungal D-galacturonate pathway: identification of the L-threo-3-deoxy-hexulosonate aldolase.
  Journal
J Biol Chem 282:26195-201 (2007)
DOI:10.1074/jbc.M704401200
  Sequence
Reference
2  [PMID:18768163]
  Authors
Martens-Uzunova ES, Schaap PJ
  Title
An evolutionary conserved d-galacturonic acid metabolic pathway operates across filamentous fungi capable of pectin degradation.
  Journal
Fungal Genet Biol 45:1449-57 (2008)
DOI:10.1016/j.fgb.2008.08.002
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.54
IUBMB Enzyme Nomenclature: 4.1.2.54
ExPASy - ENZYME nomenclature database: 4.1.2.54
BRENDA, the Enzyme Database: 4.1.2.54

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