2-keto-3-deoxygluconate aldolase (ambiguous);
2-dehydro-3-deoxy-6-phospho-D-gluconate/2-dehydro-3-deoxy-6-phospho-D-galactonate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)
(1) 2-dehydro-3-deoxy-6-phospho-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate [RN:
(2) 2-dehydro-3-deoxy-6-phospho-D-galactonate = pyruvate + D-glyceraldehyde 3-phosphate [RN:
D-glyceraldehyde 3-phosphate [CPD:
In the archaeon Sulfolobus solfataricus the enzyme is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway. It utilizes 2-dehydro-3-deoxy-6-phosphate-D-gluconate and 2-dehydro-3-deoxy-6-phosphate-D-galactonate with similar catalytic efficiency. In vitro the enzyme can also catalyse the cleavage of the non-phosphorylated forms 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate with much lower catalytic efficiency. cf. EC
, 2-dehydro-3-deoxy-6-phosphogalactonate aldolase, and EC
, 2-dehydro-3-deoxy-phosphogluconate aldolase.
EC 18.104.22.168 created 2014
ec01120 Microbial metabolism in diverse environments
K11395 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
ABRI: DFR85_02045 DFR85_14740 » show all
Buchanan CL, Connaris H, Danson MJ, Reeve CD, Hough DW
An extremely thermostable aldolase from Sulfolobus solfataricus with specificity for non-phosphorylated substrates.
Lamble HJ, Theodossis A, Milburn CC, Taylor GL, Bull SD, Hough DW, Danson MJ
Promiscuity in the part-phosphorylative Entner-Doudoroff pathway of the archaeon Sulfolobus solfataricus.
Wolterink-van Loo S, van Eerde A, Siemerink MA, Akerboom J, Dijkstra BW, van der Oost J
Biochemical and structural exploration of the catalytic capacity of Sulfolobus KDG aldolases.
ExplorEnz - The Enzyme Database: 22.214.171.124
ExPASy - ENZYME nomenclature database: 126.96.36.199