KEGG   ENZYME: 4.1.2.55
Entry
EC 4.1.2.55                 Enzyme                                 
Name
2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase;
2-keto-3-deoxygluconate aldolase (ambiguous);
KDGA (ambiguous)
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
Sysname
2-dehydro-3-deoxy-6-phospho-D-gluconate/2-dehydro-3-deoxy-6-phospho-D-galactonate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)
Reaction(IUBMB)
(1) 2-dehydro-3-deoxy-6-phospho-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate [RN:R05605];
(2) 2-dehydro-3-deoxy-6-phospho-D-galactonate = pyruvate + D-glyceraldehyde 3-phosphate [RN:R01064]
Reaction(KEGG)
R01064 R05605;
(other) R08570 R10616
Substrate
2-dehydro-3-deoxy-6-phospho-D-gluconate [CPD:C04442];
2-dehydro-3-deoxy-6-phospho-D-galactonate [CPD:C01286]
Product
pyruvate [CPD:C00022];
D-glyceraldehyde 3-phosphate [CPD:C00118]
Comment
In the archaeon Sulfolobus solfataricus the enzyme is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway. It utilizes 2-dehydro-3-deoxy-6-phosphate-D-gluconate and 2-dehydro-3-deoxy-6-phosphate-D-galactonate with similar catalytic efficiency. In vitro the enzyme can also catalyse the cleavage of the non-phosphorylated forms 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate with much lower catalytic efficiency. cf. EC 4.1.2.21, 2-dehydro-3-deoxy-6-phosphogalactonate aldolase, and EC 4.1.2.14, 2-dehydro-3-deoxy-phosphogluconate aldolase.
History
EC 4.1.2.55 created 2014
Pathway
ec00030  Pentose phosphate pathway
ec00052  Galactose metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K11395  2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
Genes
MSPOKXZ72_06515
VBSEGM51_13350
RLCK227x_10950(dapA_2)
HNOLT974_13500
HLULT972_01265
HALXM0R89_04735
HMPK6T50_07750
HREK6T36_07560
HRMK6T25_08235
TACTa0619
TVOTVG0663048(TVG0663048)
PTOPTO1026
FACFACI_IFERC01G1727
FAIFAD_0700
STOSTK_24790(kdgA)
SOHD1869_13570
SSOSSO3197(eda)
SOLSsol_0934
SSOASULA_0967
SSOLSULB_0969
SSOFSULC_0968
SSHIJ5U23_00301
SCASSACC_31320
SAISaci_0225
SACNSacN8_01090
SACRSacRon12I_01090
SACSSUSAZ_01130
SISLS215_2326
SIAM1425_2163
SIMM1627_2243
SIDM164_2166
SIYYG5714_2289
SINYN1551_0626
SIILD85_2429
SIHSiH_2108
SIRSiRe_2040
SICSiL_2015
SULABFU36_06090
SULEGFS03_11780
SULOGFS33_03590
SULLEWF20_14570
MSEMsed_1296
MCNMcup_0949
MHKDFR87_12295
MPRUDFR88_11840
MTENGWK48_00445
MJNMjAS7_2363
AHOAhos_0260
AMANB6F84_04920
ABRIDFR85_02045 DFR85_14740
ASULDFR86_04380
AAMBD1866_07690
ACIHHS5_15430
SACDHS1genome_1556
SAZOD1868_10845
CSTYKN1_14740
STEPIC006_2133
SAHSHS7_04580
PASPars_1388
PYRP186_1933
POGPogu_0825
CMACmaq_0935
TTNTTX_1156a(kdgA)
TUZTUZN_0957
VDIVdis_1187
VMOVMUT_2035
 » show all
Reference
1  [PMID:10527934]
  Authors
Buchanan CL, Connaris H, Danson MJ, Reeve CD, Hough DW
  Title
An extremely thermostable aldolase from Sulfolobus solfataricus with specificity for non-phosphorylated substrates.
  Journal
Biochem J 343 Pt 3:563-70 (1999)
DOI:10.1042/bj3430563
  Sequence
Reference
2  [PMID:16330030]
  Authors
Lamble HJ, Theodossis A, Milburn CC, Taylor GL, Bull SD, Hough DW, Danson MJ
  Title
Promiscuity in the part-phosphorylative Entner-Doudoroff pathway of the archaeon Sulfolobus solfataricus.
  Journal
FEBS Lett 579:6865-9 (2005)
DOI:10.1016/j.febslet.2005.11.028
  Sequence
Reference
3  [PMID:17176250]
  Authors
Wolterink-van Loo S, van Eerde A, Siemerink MA, Akerboom J, Dijkstra BW, van der Oost J
  Title
Biochemical and structural exploration of the catalytic capacity of Sulfolobus KDG aldolases.
  Journal
Biochem J 403:421-30 (2007)
DOI:10.1042/BJ20061419
  Sequence
[sso:SSO3197] [sai:Saci_0225] [sto:STK_24790]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.55
IUBMB Enzyme Nomenclature: 4.1.2.55
ExPASy - ENZYME nomenclature database: 4.1.2.55
BRENDA, the Enzyme Database: 4.1.2.55

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