KEGG   ENZYME: 4.1.2.56
Entry
EC 4.1.2.56                 Enzyme                                 
Name
2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate synthase;
griI (gene name)
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
Sysname
2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate L-aspartate 4-semialdehyde-lyase (glycerone phosphate-forming)
Reaction(IUBMB)
2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate = glycerone phosphate + L-aspartate 4-semialdehyde [RN:R10673]
Reaction(KEGG)
R10673
Substrate
2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate [CPD:C20644]
Product
glycerone phosphate [CPD:C00111];
L-aspartate 4-semialdehyde [CPD:C00441]
Comment
Part of the pathway for the biosynthesis of grixazone, a mixture of yellow pigments produced by the bacterium Streptomyces griseus.
History
EC 4.1.2.56 created 2014
Pathway
ec00997  Biosynthesis of various other secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K18287  2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate synthase
Genes
BURBcep18194_C6861
BCEPAPZ15_32405 APZ15_37520
BSTLBBJ41_35540
MCHTMCHIJ_41750
NIEKV110_28200
RTMG4H71_04120
GPOGPOL_c23170
GOCCXX93_17250
GOMD7316_02313(griI)
GAMGII34_12230
GPDGII33_11540
SGRSGR_4249(griI)
SCBSCAB_69871
SRCM271_02970
SBHSBI_01604
SVESVEN_5126
SVTSVTN_26400
SLDT261_2095
SPRISPRI_1929
STSIA4E84_17120
SLSSLINC_4428 SLINC_5463
SNRSNOUR_07205
SPLULK06_031745
SGVB1H19_08405
SFKKY5_6732
SLKSLUN_21415
SKACP970_06995
SGALCP966_31000
SPADDVK44_19840
STUIGCM10017668_29380
SFEUIM697_30800
SDWK7C20_14905
SROIIAG44_38350
SMAOCAG99_20775
SLFJEQ17_24465
STRIC7M71_007300
MIOAOA12_03105
MPHMLP_27040
FRAFrancci3_2070 Francci3_4205
SACGFDZ84_06740 FDZ84_27225
APRECNX65_15995
AMIAmir_3141
SESPBN6_21360(griI1) BN6_63900(griI2)
SSYIEKG83_17795 EKG83_36325
KALKALB_2249
KPHYAOZ06_26455
LEDBBK82_37155
MICBMicB006_2904
MSAGGCM10017556_11900
ACTNL083_5377
PFLAPflav_059810
PSUUPsuf_020560 Psuf_091150
DVCDvina_29180 Dvina_40330
GLYK3N28_00690
AEYCDG81_10245
 » show all
Reference
1  [PMID:17003031]
  Authors
Suzuki H, Ohnishi Y, Furusho Y, Sakuda S, Horinouchi S
  Title
Novel benzene ring biosynthesis from C(3) and C(4) primary metabolites by two enzymes.
  Journal
J Biol Chem 281:36944-51 (2006)
DOI:10.1074/jbc.M608103200
  Sequence
[sgr:SGR_4249]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.56
IUBMB Enzyme Nomenclature: 4.1.2.56
ExPASy - ENZYME nomenclature database: 4.1.2.56
BRENDA, the Enzyme Database: 4.1.2.56

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