KEGG   ENZYME: 4.1.3.26
Entry
EC 4.1.3.26                 Enzyme                                 
Name
3-hydroxy-3-isohexenylglutaryl-CoA lyase;
beta-hydroxy-beta-isohexenylglutaryl CoA-lyase;
hydroxyisohexenylglutaryl-CoA:acetatelyase;
3-hydroxy-3-isohexenylglutaryl coenzyme A lyase;
3-hydroxy-3-isohexenylglutaryl-CoA isopentenylacetoacetyl-CoA-lyase;
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
Sysname
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase (7-methyl-3-oxooct-6-enoyl-CoA-forming)
Reaction(IUBMB)
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 7-methyl-3-oxooct-6-enoyl-CoA + acetate [RN:R08090]
Reaction(KEGG)
R08090
Substrate
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA [CPD:C04675]
Product
7-methyl-3-oxooct-6-enoyl-CoA [CPD:C16466];
acetate [CPD:C00033]
Comment
Also acts on the hydroxy derivative of farnesoyl-CoA.
History
EC 4.1.3.26 created 1972
Pathway
ec00907  Pinene, camphor and geraniol degradation
ec01120  Microbial metabolism in diverse environments
Reference
1  [PMID:14339651]
  Authors
SEUBERT W, FASS E.
  Title
[STUDIES ON THE BACTERIAL DEGRADATION OF ISOPRENOIDS. IV. THE PURIFICATION AND PROPERTIES OF BETA-ISOHEXENYLGLUTACONYL-COA-HYDRATASE AND BETA-HYDROXY-BETA-ISOHEXENYLGLUTARYL-COA-LYASE.]
  Journal
Biochem Z 341:23-34 (1964)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.26
IUBMB Enzyme Nomenclature: 4.1.3.26
ExPASy - ENZYME nomenclature database: 4.1.3.26
BRENDA, the Enzyme Database: 4.1.3.26
CAS: 37290-69-0

KEGG   REACTION: R08090
Entry
R08090                      Reaction                               
Name
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase (7-methyl-3-oxooct-6-enoyl-CoA-forming)
Definition
3-Hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA <=> 7-Methyl-3-oxo-6-octenoyl-CoA + Acetate
Equation
Reaction class
RC01118  C00033_C04675
RC01946  C04675_C16466
Enzyme
4.1.3.4         4.1.3.26
Pathway
rn00907  Pinene, camphor and geraniol degradation
rn01120  Microbial metabolism in diverse environments
Orthology
K01640  hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]
Reference
1  [PMID:16272386]
  Authors
Hoschle B, Gnau V, Jendrossek D.
  Title
Methylcrotonyl-CoA and geranyl-CoA carboxylases are involved in leucine/isovalerate utilization (Liu) and acyclic terpene utilization (Atu), and are encoded by liuB/liuD and atuC/atuF, in Pseudomonas aeruginosa.
  Journal
Microbiology 151:3649-56 (2005)
DOI:10.1099/mic.0.28260-0
Other DBs
RHEA: 23087

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